Renin angiotensin system regulates blood pressure

One of the proteins present in the blood is called angiotensinogen. This is a short protein produced by the liver and is inactive; it just circulates in the blood. However, when renin acts on angiotensinogen it converts it into another shorter protein called angiotensin I. As angiotensin I passes through the lungs it is converted into angiotensin II by an enzyme called angiotensin converting enzyme (ACE). Angiotensin II is a powerful vascular vasoconstrictor; this will increase peripheral resistance which will in turn increase blood pressure.
In addition to increasing BP by direct vasoconstriction angiotensin II also stimulates the secretion of aldosterone from the adrenal cortex. This will increasethe amount of sodium reabsorbed from the renal tubules and so increase levels of sodium in the blood. As mentioned, increased levels of sodium increases the osmotic potential of the blood and so it attracts more water. This means more water is retained in the plasma increasing blood volumes. These increased volumes will increase venous return and so blood pressure. Conversely, lower amounts of angiotensin II will reduce aldosterone secretion leading to more sodium excretion. This will lower sodium levels in the blood leading to lowered blood volumes and so lower BP.
If the systemic blood pressure is increased the pressure in the afferent arteriole will also be increased. This will be detected by the JGA cells which will respond by reducing renin secretion. When less renin is present in the blood, more angeotensionogen will remain in inactive form.
This renin-angiotensin-aldosterone mechanism allows the kidneys to regulate their own blood flow to an extent. When an organ regulates itself in this way it is called autoregulation.
If for any reason the kidneys over-secrete renin blood pressure will be raised. An abnormally high BP is termed hypertension. Renin excess probably explains most cases of chronic hypertension. You may have come across ACE inhibiting drugs; these inhibit ACE (angiotensin converting enzyme) and so inhibit the conversion of angiotensin I into angiotensin II. If there is less angiotensin II there will be less vasoconstriction and less secretion of aldosterone and so blood pressure will be lowered.

Пікірлер: 162

  • @socialworkwithmuhib6709
    @socialworkwithmuhib67097 ай бұрын

    My name is Md Muhibur Rahman. A student of pathophysiology at wayne state university. After watching this vedio , i am surprised !!! What an excellent presentation about RAAS . Really he is in one in trillion. Long live with ur nice delivery.....

  • @kathleenfinn222
    @kathleenfinn2227 жыл бұрын

    I always watch John Campbell's videos when I want to learn something well. He is an excellent teacher. I find him to be clear and logical. His small lectures on youtube have helped me very much in passing my tests. I prefer his videos over any others on line.

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    @raygames8712

    3 жыл бұрын

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    3 жыл бұрын

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    Жыл бұрын

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    @gillianworrell8612

    Жыл бұрын

    Dr John campbell, excellent videos

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    @cloud.orangeltd94852 жыл бұрын

    I wouldn't even be able to go to my exams without your lectures. Our in lass lectures are too fast, individual research too complex, time is short. The way you expose the information is absolutly brilliant. Thank you

  • @Campbellteaching
    @Campbellteaching8 жыл бұрын

    You can now get all of the current videos and podcasts on a 64 Gig flash drive. About 420 video files and 100 podcasts. You can order one from campbellteaching.co.uk This saves ordering individual disks, its all on the one flashdrive. Best wishes, John

  • @aliimran4958

    @aliimran4958

    6 жыл бұрын

    Dr Najeeb lecture on angiotensin receptor blockers utube

  • @Ghanaba23

    @Ghanaba23

    3 жыл бұрын

    Dr. Campbell, do you still have the videos and podcasts for sale?

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    @bahelr

    Жыл бұрын

    Dr Campbell I would love to buy the flash drive. How do i get it? Your website isn't working anymore.

  • @EmberTalentTigressSky
    @EmberTalentTigressSky Жыл бұрын

    I have lived my whole life with kidney issues and at 45 this is the first time I understand what is happening with the kidneys. I have watched several of your videos about the heart and kidneys now and I am grateful to you for the information you are providing. You present information detailed but not dumbed down and that is key to allowing all of us to have a better understanding of how our bodies function. Thank you so much!

  • @judyb1222
    @judyb12223 жыл бұрын

    You are a brilliant teacher, Dr Campbell. So many KZread science videos are too fast, monotone/shouty, distractingly flashy, and ultimately lacking in any humanity. Your videos allow people the time to establish the thought processes needed to understand and visualise the subject with the imagination needed to retain the information, and ultimately sit back in awe at what an incredible thing the human body is. Thank you so much for making these videos free, and without interrupting advertisements. I also hope with everything you have done during Covid is sending a knighthood your way. You are a hero!

  • @1Raheem

    @1Raheem

    2 жыл бұрын

    “Ultimately lacking in any humanity” You’re not totally wrong, but holy shit😂

  • @leavinoneday
    @leavinoneday Жыл бұрын

    Best explanation about The RAAS System

  • @melissaparada2447
    @melissaparada24475 жыл бұрын

    Dr. Campbell you are an amazing teacher; thank you for making these videos .

  • @rishipl3559
    @rishipl35592 жыл бұрын

    Great Lecturer One of the most difficult topic in kidney explained within 10 minutes....Thanks a lot sir...!!! Love from India....!!

  • @sajasajanakkomen
    @sajasajanakkomen4 жыл бұрын

    You are one in a million, very inspiring teacher

  • @sudhakartanksale9401
    @sudhakartanksale94019 ай бұрын

    Sir , you make the subject so attractive and simple to understand With your awful skill of drawing the figures.....wonderful! I am a 82 years family physician, still practicing. Your lectures refresh and updates our knowledge.

  • @mandyvidembozie8779
    @mandyvidembozie87792 жыл бұрын

    Really appreciate the pace at which he delivered that brief lecture. I have a better understanding of the mechanism now

  • @workyworkwork824
    @workyworkwork8242 жыл бұрын

    Thank you John!! So glad these videos remain available.

  • @ogechiugwudi-alilonu6601
    @ogechiugwudi-alilonu66014 жыл бұрын

    If you want to learn anything, understand it very well and have it stay in your brain for life, watch Dr. Campbell's videos and listen to his podcasts. I cant thank you enough Dr. , you make these learning and understanding very clear and easy. The best lecturer anyone can have!

  • @Campbellteaching

    @Campbellteaching

    4 жыл бұрын

    Thanks Ogechi, this is great to know. Which country are you in?

  • @ogechiugwudi-alilonu6601

    @ogechiugwudi-alilonu6601

    4 жыл бұрын

    @@Campbellteaching I am in United States. Thanks.

  • @kirti.chhabra
    @kirti.chhabra3 жыл бұрын

    This is amazing, I've gone through multiple articles and was never able to understand this concept!

  • @aneke1991
    @aneke19917 жыл бұрын

    such a fantastic video, thank you! I've been really struggling with this concept and your methodical approach really helps to break it down into manageable steps

  • @juliearlow5910
    @juliearlow59105 жыл бұрын

    Thank you Dr John Campbell. Your logical and concise contribution to KZread has benefited my studies. I am about to graduate BaNursing and owe an awful lot of my accumulation of knowledge, to your videos. Thank you. Thank you. Thank you!

  • @kaladore1982
    @kaladore19827 жыл бұрын

    I wish someone explained this process as well as this man has at every family practice provider. I was always afraid to take these types of medication, but if I had the before explanation put to as well as this video has put it I personally would feel reasonably comfortable.

  • @tastedpurple1492
    @tastedpurple14924 жыл бұрын

    I feel stupid reading textbooks, but I feel inspired by Dr John Campbell.💗💗💗

  • @vanessaschofield7927
    @vanessaschofield79274 жыл бұрын

    john thankyou so much your teaching is brill. I am nurse I trained back in 1977. I love your presentations as they are clear concise. visual in your bullet points and you re go back over points relating to the topic and previous videos. I retain information visually and by simplicity. thankyou so much

  • @sonfillewis9281
    @sonfillewis92815 жыл бұрын

    this man is a legend

  • @mattazmy
    @mattazmy3 жыл бұрын

    Thank you Dr Campbell. Your explanation is clear and direct.

  • @brodericksmith01
    @brodericksmith017 жыл бұрын

    You are wonderful! I watch your videos all the time. God bless you and thank you for what you do.😍

  • @dylanboye05
    @dylanboye055 жыл бұрын

    Excellent video Dr. Campbell!

  • @victoriavonitor743
    @victoriavonitor7432 жыл бұрын

    Thank you doctor for always assisting us in anatomy and physiology

  • @user-he3oc1cl7u
    @user-he3oc1cl7u2 ай бұрын

    such a legend for giving this information and knowledge out for free thanks loads

  • @shayj4312
    @shayj43122 ай бұрын

    I am finding it very interesting as someone who after a virus in 2021 now diagnosed with dysautonomia/POTS, now have low blood pressure and abnormal low renin, I’m trying to figure it all out with no medical knowledge so videos like this really help

  • @g.annasmith9834
    @g.annasmith98344 жыл бұрын

    Many thanks for Professor John Campbell!!for his brilliantly explained lectures!

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    @cessy259 Жыл бұрын

    Wow you have helped me as a nurse student thanks alot😍

  • @israeljohnson3135
    @israeljohnson31354 жыл бұрын

    God bless you sir I understood you in a special way

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    @tsqm1123 жыл бұрын

    Dr. John Campbell, thank you for this video. I got 100% on my essay by watching this video of yours.

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    @fatmaelzahraamohammed4964 жыл бұрын

    yes this amazing ......i hope you do write all the content in each video below it like this please Dr. campbell this is so helpful

  • @dudusolaoyinkansola9587
    @dudusolaoyinkansola95873 күн бұрын

    Thank you soo much Dr. John Campbell , you are an amazing teacher ❤😊

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    @elliotpaige84334 жыл бұрын

    Well worth the subscription! Thank you so much for this gem doctor!

  • @Campbellteaching

    @Campbellteaching

    4 жыл бұрын

    Thanks, do click a 'like', this really helps the channel to grow.

  • @mohammedkhalid9317
    @mohammedkhalid93176 жыл бұрын

    thank you too much Dr. John Campbell

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    @galthenalexander399710 ай бұрын

    Your lectures caused me to earn the best haematology seminar presenter leading me to earn A Grade

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    @norbertok19287 жыл бұрын

    Outstanding!!!

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    @tharukazkt84133 жыл бұрын

    Clear and simple to understand.❤️

  • @mosesngigi328
    @mosesngigi3288 ай бұрын

    Thanks a lot Dr. Campell for this video.

  • @lizarosa156
    @lizarosa1563 ай бұрын

    WOW!!! Excellent intelligent presentation. Thanks you!

  • @rethijja3331
    @rethijja33312 жыл бұрын

    Thank you from the bottom of my heart

  • @qamarkhan4101
    @qamarkhan41015 жыл бұрын

    Tnx a lot Sr.. u r great .may u live long

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    @lydiairabor762 Жыл бұрын

    Thank you Sir, Your videos helped me in my last semester exams and I'm currently prepping for a mid semester test. Thank you so much.

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    @natalieforster43693 жыл бұрын

    Thankyou your education videos are invaluable, keep up your brilliant work

  • @g.annasmith9834
    @g.annasmith98344 жыл бұрын

    Many thanks for the great tutorial!!!

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    @chodingkng46374 жыл бұрын

    thank you for this video, i'm gonna be be acing my exams tomorrow❤❤❤

  • @iGlimmyr
    @iGlimmyr7 ай бұрын

    Just got a positive high lab result for very high renin. This explains more than everything

  • @autumnrose3943
    @autumnrose39435 жыл бұрын

    So helpful. Thank you.

  • @isaacyawagyapong8310
    @isaacyawagyapong83105 жыл бұрын

    thank you very much well understood.

  • @JihadAlAnsari
    @JihadAlAnsari7 жыл бұрын

    Thank you! I like your teaching :)

  • @onlinechemistry3350
    @onlinechemistry33506 жыл бұрын

    Thank you very much. now I can understand.

  • @lynnecota9103
    @lynnecota91037 жыл бұрын

    Dr. Campbell, Thank you so much for such a wonderful video. I just subscribed to your channel. This future nurse appreciates your teaching methods. It was easy to understand and very well done.

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    @christophercampbell5045

    3 жыл бұрын

    I, myself can testify to the usefulness of this BloodPressureControl99.blogspot.com treatment plan.The other treatment I have personally tried out aren`t long lasting in maintaining my blood pressure level. This is actually the first which really does what it claims. I simply require the brief period of time, my high blood pressure had gone down to 145/90 and looked after it for a short time

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    @BobtheBuilder249

    2 жыл бұрын

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  • @BobtheBuilder249

    @BobtheBuilder249

    2 жыл бұрын

    that profile pic be having high glucose concentration in blood

  • @shashimoghe3920
    @shashimoghe39202 жыл бұрын

    Dr john Campbell sir your every video is very simple and you explain all points in detail hence easy to follow my good wishes to you 25/06/2021

  • @danielmsimuko
    @danielmsimuko8 ай бұрын

    Sir you are a blessing....I salute you

  • @madhuristark4654
    @madhuristark46544 жыл бұрын

    Really helpful videos..I wonder how I missed them all these years Thank you dr

  • @Campbellteaching

    @Campbellteaching

    4 жыл бұрын

    You are welcome 😊

  • @flyhighseeall8271
    @flyhighseeall82715 жыл бұрын

    Thank you dr campbell

  • @muhamadissaka1990
    @muhamadissaka1990 Жыл бұрын

    Your really excellent teacher thanks very much

  • @bluesandals2007
    @bluesandals20073 жыл бұрын

    Thank you very much sir , really understand the topic now

  • @nathanielamanda2958
    @nathanielamanda29582 жыл бұрын

    U are an excellent teacher sir wish you were the person that taught me in school much love Daddy💓

  • @moondajay
    @moondajay2 жыл бұрын

    अविश्वसनीय, बहुत बहुत अच्छा 🙏🙏🙏🙏

  • @bloop8691
    @bloop86917 ай бұрын

    excellent explanation! thank you!

  • @muhammadkhalid2232
    @muhammadkhalid22322 жыл бұрын

    Thanks!!! sir is teaching v well and give a clear concepts!!

  • @clarissearmada
    @clarissearmada4 жыл бұрын

    THANK YOU!!!!❤

  • @HalfPinoyPride
    @HalfPinoyPride7 жыл бұрын

    thank you mate

  • @salimshaima
    @salimshaima4 жыл бұрын

    Dr Campbell, how would u explain the occurence of hypertension in Nephritic syndrome? And the correlation with RAAS

  • @nuruclark3460
    @nuruclark34608 жыл бұрын

    Thank you Dr Campbell, do we all produce renin?

  • @socialworkwithmuhib6709
    @socialworkwithmuhib67097 ай бұрын

    Thanks a lot .❤❤❤❤

  • @lisaorubo5070
    @lisaorubo50702 жыл бұрын

    You're an awesome teacher

  • @MrDionsmother
    @MrDionsmother5 жыл бұрын

    Thank you, This was perfect!

  • @mohanreddyryala
    @mohanreddyryala6 жыл бұрын

    That's awesome dr👏:)

  • @estherkapenda4384
    @estherkapenda4384 Жыл бұрын

    Always proud of you

  • @abdelrahmannabil6150
    @abdelrahmannabil61504 жыл бұрын

    Thank you Dr john

  • @marvinodhiambo8362
    @marvinodhiambo836210 ай бұрын

    Thank you Dr. for the elaborate explanation. Is there an explanation for why we have excess renin production in essential hypertension???

  • @OldRuggedMedia
    @OldRuggedMedia3 жыл бұрын

    Thanks a lot Doctor.

  • @ellebn5120
    @ellebn51203 жыл бұрын

    Thank you sir!

  • @hendriksaldua8208
    @hendriksaldua82087 жыл бұрын

    Renal Denervation (non-invasive) would be the best solution to correct the renal nerves not to produce renin that much. I hope they finish their clinicl study soon.

  • @Campbellteaching

    @Campbellteaching

    7 жыл бұрын

    I guess it would have to be pharmacological? However, would this mean that the patient produced almost no renin at all, and so be hypotesive?

  • @Campbellteaching

    @Campbellteaching

    5 жыл бұрын

    Amazing possibilities

  • @alaaaboalnaseef3688
    @alaaaboalnaseef368824 күн бұрын

    thank you💖

  • @Ana-xo7if
    @Ana-xo7if2 жыл бұрын

    Overwhelming 🙏🙏

  • @lushusabato9823
    @lushusabato9823 Жыл бұрын

    I like the lectures of Dr John Campbell

  • @mnswz3140
    @mnswz31402 жыл бұрын

    thank you so much

  • @tonymoulton4346
    @tonymoulton43464 жыл бұрын

    God bless u .Excellent..

  • @jjunjufred2398
    @jjunjufred23985 жыл бұрын

    Thank you do much.

  • @jjunjufred2398

    @jjunjufred2398

    5 жыл бұрын

    Thank you so much

  • @Humanity12_34
    @Humanity12_342 жыл бұрын

    Great explanation.

  • @irenerambau9145
    @irenerambau91453 жыл бұрын

    Amazing😍...i enjoyed the lesson😊

  • @kathybrady4033
    @kathybrady40334 жыл бұрын

    Dr. Campbell, why does the king have ACE 2 receptors for you think?

  • @leticiaolivera-castillo8638
    @leticiaolivera-castillo86384 жыл бұрын

    The best teacher

  • @LucasSilva-kv3km
    @LucasSilva-kv3km4 жыл бұрын

    Great video 👏👏👏

  • @davidkorako8009
    @davidkorako8009 Жыл бұрын

    Powerful tutorials

  • @leavinoneday
    @leavinoneday Жыл бұрын

    WOW AMAZING!!!

  • @rushikeshsonke1041
    @rushikeshsonke10413 жыл бұрын

    Best explaination sir.

  • @sultananbar6750
    @sultananbar67502 жыл бұрын

    Excellent lecture

  • @user-fh4yj2mw9c
    @user-fh4yj2mw9c4 жыл бұрын

    Perfect 👌

  • @carrey527
    @carrey527 Жыл бұрын

    This guy is genius

  • @syree4084
    @syree40842 жыл бұрын

    THANK UUUU SOOO MUCH FOR THISSSS SIR JOHN U SAVE ME FROM PHARMACOLOGY HUEHUE

  • @filmic1
    @filmic15 жыл бұрын

    Why do the kidneys lie outside the coelomic cavity? Is blood pressure regulation temperature dependant? Thanks.

  • @jahidahamad8894
    @jahidahamad88944 жыл бұрын

    I am currently a final year MBBS student..... Before reading any system in MEDICINE subject i always see your vedio to clear my basics physiology...A big thanks to you dr. Campell for such an amazing type of teaching style😍😍😍....& special thanks for the CVS topics

  • @rashmiaggarwal4497
    @rashmiaggarwal44974 жыл бұрын

    Amazing

  • @Sportliveonline
    @Sportliveonline3 жыл бұрын

    brilliant

  • @cliveworth
    @cliveworth7 жыл бұрын

    Thank you Dr Campbell as i think I have this problem and this is why my Doctor has taken me off Ramipril and Bisoprolol but now on Losartan Potassium 25mg Film Coated Tablets and Vera-Til SR Tablets.

  • @JoseRivera-rl3qv

    @JoseRivera-rl3qv

    4 жыл бұрын

    Clive Worth Shut that off, You just need to low your insulin secretion rate by going into a good diet, you must be overweight? idk. It is happening to me now. Basically more salt should be fixing it, but your should consult with a goood physician

  • @dankbudwoi871

    @dankbudwoi871

    Жыл бұрын

    Why would ramipril not work for this?

  • @edwinodus
    @edwinodus2 жыл бұрын

    How does Calcium Channel Blocker fit into these?