Regioselective Enolization and Thermodynamic vs. Kinetic Control

We know how to make enolates, but when two structurally different enolates are possible, how do we get the one we want? It has to do with selecting the right base. In explaining this, we will also discuss the difference between thermodynamic vs. kinetic control during a reaction.
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Пікірлер: 30

  • @ShahinAhmed-tl7tw
    @ShahinAhmed-tl7tw3 жыл бұрын

    Man you are the coolest chemistry teacher I have seen in my 4 years of bachelor degree

  • @ponnusamisaravanan4673
    @ponnusamisaravanan46734 жыл бұрын

    Outstanding explanation

  • @Nicole-on3qt
    @Nicole-on3qt3 жыл бұрын

    Thank you so much for your content! Due to Corona virus there were no lectures in organic chemistry at my university and you're helping so much to learn the basics! Thank you!

  • @valentingallier6147
    @valentingallier61475 жыл бұрын

    Thank you professor !

  • @Textbook000
    @Textbook0005 жыл бұрын

    Truly incredible

  • @Morfeucomvoce
    @Morfeucomvoce4 жыл бұрын

    Excellent video.

  • @Merciless204
    @Merciless2043 жыл бұрын

    I'm in graduation and watching his channel I've been watching him for years now

  • @EpmMaxim
    @EpmMaxim4 жыл бұрын

    thank you!

  • @indrathapa1752
    @indrathapa17525 жыл бұрын

    thanks🙏🙏

  • @thechemistlife
    @thechemistlife5 жыл бұрын

    You are awesome. I'm from India and your language is so clear..one more reason to love Chemistry ☺

  • @Alchemist_171

    @Alchemist_171

    4 жыл бұрын

    Lol

  • @Alchemist_171

    @Alchemist_171

    4 жыл бұрын

    go home

  • @abdulhaif9112
    @abdulhaif91124 жыл бұрын

    A brilliant explanation. Thank you so much 😊,

  • @safwanhassan8076
    @safwanhassan80765 жыл бұрын

    highly appreciated

  • @sniperammow4865

    @sniperammow4865

    5 жыл бұрын

    Safwan Hassan lol

  • @sciencenerd7639
    @sciencenerd76392 жыл бұрын

    amazing

  • @sniperammow4865
    @sniperammow48655 жыл бұрын

    Lol we are doing this is class today, I am ahead boi!

  • @rassimsimou1594
    @rassimsimou1594Ай бұрын

    Good

  • @giuliascalzo512
    @giuliascalzo512 Жыл бұрын

    Hi! What would happen if we formed a double enolate? Which site would react?

  • @edonSG
    @edonSG4 жыл бұрын

    Why is the thermodynamic enolate more stable? What are the effects of the methyl group, what are they actually stabilizing?

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    4 жыл бұрын

    more substituted alkenes are more stable in general, hyperconjugation

  • @edonSG

    @edonSG

    4 жыл бұрын

    @@ProfessorDaveExplains thanks for your quick answer. I still dont get it, as far as i know hyperconjugation means the alkyl Groups are able to push electrones to a carbon that has electrone deficite, but in this case the negative oxygen is already pushing negative charge to the double bound that has a high electrone density. So why should that be stable? If it was a carbocation then it would make sense, propably im not getting where a carbocation is being formed here?

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    4 жыл бұрын

    No carbocation, the same principle applies to any sp2 carbon.

  • @nirvikpaul9603
    @nirvikpaul96033 жыл бұрын

    Sir in case for thermodynamically controlled reaction the two possible enolates have approximately the same free energy of activation as you said , so if the free energy of activation is same then both have equal rates . And if both have equal rates then there is no way that one is major and the other is minor.

  • @dang.5258

    @dang.5258

    2 жыл бұрын

    Theoretically yes, but you are missing the Alkene stability. Hydroxide can de-protonate forming an Alkene that has 4 groups and the other 3. Therefore the one with four groups will form in higher percent.

  • @Surajbabar7272
    @Surajbabar72724 жыл бұрын

    What if NaOEt

  • @ProfessorDaveExplains

    @ProfessorDaveExplains

    4 жыл бұрын

    ethoxide is still fairly sterically unhindered, once you introduce branching you see steric effects

  • @anzakhan2242
    @anzakhan22425 жыл бұрын

    Hi

  • @satbirsingh7269
    @satbirsingh72695 жыл бұрын

    Hii

  • @VyvienneEaux
    @VyvienneEaux4 жыл бұрын

    I want to marry Professor Dave. T-T