Phosphonium Ylide for The Wittig Reaction! - Organic Chemistry
Hey guys! You've heard me talk a bunch about the Wittig Reaction already but do you know actually how to make the Phosphonium Ylide that is used in the reaction? If not, check out this video that discusses the two important steps (SN2 and Deprotonation) necessary to create the awesome Phosphonium Ylide molecule. It's 8 minutes but it will go by fast, I promise ;). Also if anyone is interested in private tutoring either in person or via Skype, please contact me through my Orgo Made Easy Facebook page or email (FrankMWong@gmail.com)
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Wittig Reaction Bloopers/Outtakes: Coming Soon
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Пікірлер: 45
videos are sooooooooo much better than my class!
It's surprisingly hard to find a reaction mechanism this well constructed. Thanks.
Thank you so much!! You are truly great at simplifying the concepts!!
Clear and organized explanation! Thank you! 🙂
Brilliant video, thank you so much. Very clear and well explained, subbed
Thank you for uploading video Very simple to understand
Thank you so much, this was super helpful for me.
You rock, thank you for these videos
You are awesome at this! Thank you so much!
@OrgoMadeEasy
10 жыл бұрын
Thanks Brian! I'm glad you like the explanation. It just clicked how simple it was actually one day for me in a tutoring session and I just wanted to share it with everyone.
Very helpful! Thanks!
Good education vidios ... preparing ylides 👍🏻
Thx for uploading so many useful videos! Hopefully u could make more Orgo 2 videos later on.! And it would be best if u could leave the board alone for a sec since i wanna take a snapshot of all these notes !! u r so good at teaching, keep it up!!
@OrgoMadeEasy
10 жыл бұрын
Lexi W Haha thanks for the support! Yeah more Orgo 2 videos is definitely a goal but it'll just take some time =X. Gluck in the meantime ;)
very helpful!
Thank you so much!!!!!
useful video👍
Nice video !
Thank you!!!!
Your video was very simple and east to understand, thank you! Except I have one question about the alkyl halide. You listed that Fluorine could be one of the halogens for the SN2 reaction, but I thought Fluorine was a bad leaving group because it's rarely observed.
@OrgoMadeEasy
10 жыл бұрын
Ah good catch! Fluorine is not so great of a leaving group so you'd probably see either Cl, Br, I as the halide. Sorry about the late response!
Hey! Really nice video.. Just wondering where the halide goes.. especially when you have a stable phosphonium salt, so one can deprotonate with a weak base such as NaOH, which forms water?
@OrgoMadeEasy
9 жыл бұрын
Caylee Luden Thanks! And good question Caylee. I believe it's just sitting in solution as either a Cl-, Br-, or I-. (As someone noted F is not a good leaving group and should not be used). I don't usually see NaOH being used for this reaction, it might be good to check with your professor about that. I usually see NaH being used or a grignard organometallic like the other one I used.
Great
Question: since Fluorine isn't the best leaving group in the world, would this reaction work with it?
Can water be count as one of the bases? Can you also use -OH or is it unlikely to have -OH by itself?
Excuse me sir could be kind enough to make a video for the preparation of Gilman reagent
thanks
Hi Frank, what causes the base to be selective towards deprotonating the carbon adjacent to the phosphorous? Thanks!
@OrgoMadeEasy
10 жыл бұрын
Hi Pyrogore! So the base is selective to deprotonating that carbon adjacent to the phosphorus because of the positive charge on the Phosphorus which makes it tug on the electron density of the carbon. This weakens the bonds between the C-H and makes the H more acidic and likely to react with a base and be pulled off. Does that make more sense? :]
@Pyrogore
10 жыл бұрын
Makes perfect sense now, thanks Frank!
@OrgoMadeEasy
10 жыл бұрын
Perfect! Glad to hear :]
I don't understand where the extra Hydrogen from the carbon chain ends up that was replaced by the protons from the hydrogen part of the base?
Respect with thanths
phosphorus is a penta coordinating element (pcl5) then why does it not make a double bond with carbon? what is the reason of the occurance of charge on c and p?
@OrgoMadeEasy
10 жыл бұрын
True it is a penta coordinating element but in this reaction Phosphorus only has two spare electrons which can only form a single bond with carbon when it attacks via SN2 and kicks out Carbon's leaving group halogen. Phosphorus is positive because it was neutral before when it had 3 bonds and a lone pair before the attack. But then it lost an electron to carbon when it attacked carbon and formed a bond. Carbon becomes negative because it gained an electron from the C-H bond after the base pulls off the hydrogen.
thank you so much, please be a teacher🤗
Ugh...why do O Chem teachers always over complicate things? Your explanation is SO much easier to understand!
sir why only sn2
Good luck with the "super"primary alkyl fluoride🙄
@manishmayank4199
5 жыл бұрын
Is it even a term in organic chemistry😅 I heard it just here
they moved the like button...awkward... :/
Very informative thank you! I cringe everytime I watch you though; you're a litle awkward
Thank you. Very helpful :-)