Olanzapine vs Risperidone for Bipolar and Schizophrenia

In today's video, we are comparing 2 older second-generation antipsychotics, olanzapine, and risperidone. Time stamps of each topic covered are listed below:
Intro 00:00
How do olanzapine and risperidone work? 00:23
What are olanzapine and risperidone used for? 03:27
Side effects of olanzapine and risperidone 04:53
Considerations of taking olanzapine and risperidone 07:36
- Black box warning 07:50
- Monitor Labs 08:25
- Neuroleptic Malignant Syndrome 10:31
- Extra Pyramidal Symptoms 11:03
- Orthostatic Hypotension 12:39
- Seizures 13:20
Final thoughts 14:02
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🎥 This video was edited by:
Rahul Kanchi / rahulkanchi24
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References:
Alsherbiny MA, Li CG. Medicinal Cannabis-Potential Drug Interactions. Medicines (Basel). 2018 Dec 23;6(1):3. doi: 10.3390/medicines6010003. PMID: 30583596; PMCID: PMC6473892.
He, S., Yu, W. J., Wang, X., Zhang, L., Zhao, N., Li, G., Shen, Y. F., & Li, H. (2020). Risk factors of hyperprolactinemia induced by risperidone and olanzapine and their correlations with plasma glucose and lipids. General psychiatry, 33(4), e100206. doi.org/10.1136/gpsych-2020-1...
Olanzapine FDA Label (2009). Retrieved from www.accessdata.fda.gov/drugsa...
Risperdal FDA Label (2009). Retrieved from www.accessdata.fda.gov/drugsa...
Shoja Shafti, S., & Gilanipoor, M. (2014). A Comparative Study between Olanzapine and Risperidone in the Management of Schizophrenia. Schizophrenia research and treatment, 2014, 307202. doi.org/10.1155/2014/307202
Stahl, S. M., Grady, M. M., & Muntner, N. (2021). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications. Cambridge University Press.
Stahl, S. (2017). Stahl’s Essential Psychopharmacology: Prescriber’s Guide, 6th Ed. Cambridge University Press.
Uptodate (2022). Olanzapine: Drug Information. Retrieved from www-uptodate-com.libproxy.eku...
UptoDate (2022). Risperidone: Drug information. Retrieved from www-uptodate-com.libproxy.eku...
Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.

Пікірлер: 54

  • @xy101
    @xy1017 ай бұрын

    Great video! Detailed and very important info, for patients and providers as well. Thanks! Much appreciated

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    Thank you! I am glad you found it helpful.

  • @nerdbamarich2063
    @nerdbamarich20637 ай бұрын

    Thank you so incredibly much as always. Happy Sunday. 💙🙏🏾

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    You are very welcome! Thank you for watching 🙏

  • @nerdbamarich2063

    @nerdbamarich2063

    7 ай бұрын

    @@LevelheadedMind you're welcome 💙

  • @lisagrace667
    @lisagrace6675 ай бұрын

    I am new to your channel and happy to have found you. I don’t see any videos about clozapine. Can you please make one? Thank you.

  • @aleksanderwaskowski1862
    @aleksanderwaskowski18622 ай бұрын

    I think main usage of risperidone is psychosis in mania and manic psychosis at bipolar

  • @amyjones8613
    @amyjones86137 ай бұрын

    I have been binge watching your videos today. So glad to find your channel. In the future, could you do a video for Invega Sustanna? Every three weeks I get a dose. Also I supplement the pill form peripalidone sp? When it's past the 3 week and I can't make it to the doctor. I would appreciate it if you consider talking about injections.

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    I did make a video about invega here kzread.info/dash/bejne/ip94lsizdNTLf5M.htmlsi=JIU0HDOv15TQuraW

  • @amyjones8613

    @amyjones8613

    7 ай бұрын

    Thank you for showing me this. Very informative stuff 😊

  • @ozjthomas
    @ozjthomas7 ай бұрын

    Thanks for comparing. Im looking forward to the lab video, just requested my PAC do b12 and vitamins(my thyroid and glucose are normal). I like learning about meds to be empowered but often feel like its just like throwing darts bc i dont have a clear primary target. What do you do for more complex cases where theres a lot of depression and anxiety but also mild schizotypy and autism. I often feel like one med helps depression makes anxiety worse or vice versa.

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    You're on the right track with looking for root causes. Make sure b12 is above 500. When they check thyroid you have to check TSH, free t3 and free t4 as well as thyroid antibodies, TPO and thyroglobulins. I explain this in the labs video. Also, look for inflammatory markers. Get on an anti inflammatory diet, start getting out in nature, walking or exercising. External vagus nerve stimulation may also help. You should also look for other nutrient deficiencies since having Autism as well as food allergies. I wish you all the best 🙏

  • @nagarajuchukkala

    @nagarajuchukkala

    6 ай бұрын

    I told my doctor the same thing and then he laughed at me

  • @thedronesperspective
    @thedronesperspective7 ай бұрын

    I have bipolar depression and My nurse practitioner recently put me on Trileptal/Oxcarbazepine and was curious do you have any videos on it and if you don’t can you make one. It cleared up my brain fog but these constant stomach pains are killing me! I was on Lamotrigine for years but my anger and crying spells were out of control.

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    Trileptal can be used for Bipolar. With stomach pains, try taking it with food to see if that helps. Oftentimes, increased side effects are seen with higher doses as well. I don't have a video on this medication since I don't use it often, but I will consider it. Thank you.

  • @shelley9304
    @shelley9304Ай бұрын

    Hello, thanks for your video. My daughter is 20 and she’s suffering from bipolar 2 and she refuses to take Risperidone for several reasons and she won’t tell me why, but she can’t sleep without it. She’s also taking duloxetene , lamotrigene. Is there any safe medications that could replace risperidone with fewer side effects and helps her with her sleep?

  • @Maxxx26-zx4sp
    @Maxxx26-zx4sp12 күн бұрын

    Is it good for anxiety ? Currently im taking Prozac in the morning, can you please advise at what time I should take it, many thanks

  • @JagdishPatel-wy2ee
    @JagdishPatel-wy2ee5 ай бұрын

    Hi can you tell me what is the best medicine for paranoid personality disorder

  • @manojshukla7354
    @manojshukla73547 ай бұрын

    you are putting me off all my meds!!

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    Talk with your provider before stopping any medication!

  • @user-rk8cn4ck5y

    @user-rk8cn4ck5y

    4 ай бұрын

    ​​@@LevelheadedMindyet you still hearted their comment, yikes...😶‍🌫️

  • @invinciblefarhan2698
    @invinciblefarhan26987 ай бұрын

    Ma'am I started vortixetine 10 mg last year in December( later increased to 20 mg in march) till October this year and then back to 15 to 10 mg for my depressive and cognition purpose. Now i stopped it before a week and realised that my cognitive indecisiveness has improved. Shall those cognitive domains like processing speed etc will again be same if I won't take vortixetine.I mean does vortixetine has permenant positive effects on cognition or is it only till you take medicine.

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    It is hard to say, however, some studies show the effect of serotonin on BDNF which can help your brain to learn and make new neural connections. It is possible that with this action, you have improved your brain function. To continue to nourish this, do things that will improve your neuroplasticity, which I discuss in this video here: kzread.info/dash/bejne/Z5Oguqqbpqy8hqg.htmlsi=h1tp2gxY75TdFDa3

  • @MohamedEnnams
    @MohamedEnnams6 ай бұрын

    Peace be upon you, doctor. Best regards. My question is: what is most effective for the mind? We suffer from manic mood swings and intermittent lack of sleep. Is it Risperdal (Risp) or a medication? Dr. Solian (Amisulpride) wants the answer. Thank you 💚

  • @LevelheadedMind

    @LevelheadedMind

    6 ай бұрын

    Both of these medications can help treat those symptoms. Discuss this with your doctor to determine if either of these would be a good fit you.

  • @temoignagesstockalimentair9009
    @temoignagesstockalimentair90097 ай бұрын

    Good afterrnoon sister. My child had catetonia she is taking médication Lorazepam for 1years but now she's keep repeting things for exemple: if she open de Doors close and open again. Please help me

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    Catatonia is a medical emergency and should be treated by experienced psychiatrists. Typically an IV infusion of medication is required.

  • @Johnnash4678
    @Johnnash467822 күн бұрын

    How they works on fertility? The effect is reversible?

  • @naseermushtaq4968
    @naseermushtaq49687 ай бұрын

    Which one of is safe in borderline creatinine level? And negative symptoms of schizophrenia

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    Olanzapine is safest in this population (renal disease). Dose adjustments would need to made for Risperidone.

  • @Maxxx26-zx4sp
    @Maxxx26-zx4sp12 күн бұрын

    Is Olanzapine good for anxiety with Prozac ?

  • @cricketarena4926
    @cricketarena49267 ай бұрын

    Ma'am i started taking olanzapine+flouxetine for bipolar Disorder what is duration of medicine for bipolqr Disorder

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    If you have a true Bipolar diagnosis, then you will need to be on medication for life. However, there are things you can do to support your mood to help you stay on the least amount of medications possible. Such as exercise, getting enough Omega-3's, eating clean whole food, and sticking too anit-inflammatory diet.

  • @865style
    @865style7 ай бұрын

    Have you ever had patients respond to antidepressants but build up a tolerance after awhile?? For instance if i take a new cant mainly a ssri or snri i will feel great the next day after the first dose. But the next day the benefit will disappear. Then it gets upped and i feel better for a day. Then my depression comes right back. Then i am at the max dose. I know if medications will work within a day or 2. Their is no wait 4-6 weeks. If i miss a dose i get brainzaps. If a dont take it exactly at the same time each day and say i take it 6 hours later ill get zaps. Which tells me my body is metabolizing drugs insanely fast. Have you seen this before? Thanks in advance.

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    Yes, this can be caused by several factors. The two most common being MTHFR gene variant or a CYP enzyme- rapid metabloizer snip. Both can be assessed with a genetic test like genomind. Some insurances may cover this so look into that. Genesight is another test, but I prefer genomind because you get more genes tested beyond medication pathways.

  • @865style

    @865style

    7 ай бұрын

    @@LevelheadedMind thank you. I'm actually getting the test done by clarity-x. Have you heard of them?

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    @@865style No I have not heard of clarity-X, but will have to look them up. Glad to hear you are getting this checked out as it is very important.

  • @865style

    @865style

    7 ай бұрын

    @@LevelheadedMind thanks. I know I am sensitive to glutamate or anything that activates nmda receptors ( msg, aspartame ). If I drink any kind of protein shake I get a bad migraine. If I drink aspartame (aspartic acid) I get a migraine. If I drink soup or anything with msg I get a migraine. If I eat to much meat at one time I get a headache. Obviously all of those have high amounts of glutamic acid. I cant take glutamine for muscle building because I'll get a migraine. There's actually a supplement that has D-aspartic acid to increase testosterone for weight lifting. It gave me bad migraines. So anything that has to do with activating nmda receptors I have issues with. In my opinion I no doubt have a imbalance of excitatory neurotransmitters and inhibitory neurotransmitters receptors. Obviously I have way too much excitatory neurotransmitters (glutamate), nmda. I'm gonna tell my psychiatrist to try auvelity because it blocks glutamate (nmda receptors) or excitatory neurotransmitters. As it is I'm taking supplements to help reduce glutamate along with reducing glutamate consumption and eliminating any free forms of glutamate like msg, aspartame. Have you seen this or heard of Similar cases?? Thanks.

  • @matt-nz3739
    @matt-nz37394 ай бұрын

    I have been diagnosed as Austism by the GP here in NZ and have been given Risperidone. Does anyone know if this is a correct diagnosis???? I don't feel or do have any type of autistic tendancies in me but just wondering what others think??? Matt

  • @Polisb-gt3hk

    @Polisb-gt3hk

    3 ай бұрын

    How many mg are you taking? My son is 17 years old and is on Risperidone for autism aggression

  • @matt-nz3739

    @matt-nz3739

    3 ай бұрын

    @@Polisb-gt3hk Thanks for the reply. I have not been taken them for a little while now. I have got 1mg dosage, that our local GP gave to me, well I have been "diagnosed" as Autism, but I don't believe I have been properly diagnosed as this condition. Autism aggression???? That must be hard. Is this working for your son, or is the medication made things worse for your son???? You should do some research as well as I have with the long term use of psychiatric drugs. There is actually NO proof that these types of meds are doing any good for any person in the long term run. My older brother has been on 4mg and the 2mg (backups) of Olanzipine/Zyprexa, at home, and I have seen a real evil side to this drug, literally. If Risperidone is working for your son, continue for him to use this, but if this isn't, go back to the GP or local doctor and say what YOU as the parent have experienced with the drug and its dosage. KZread search Peter Breggin, Joanna Moncrieff and Robert Whitaker ( on separate KZread search of course), they are major experts of this field of psychiatric drugs, and their alarming results will shock any person about what the drugs are doing to people and what DAMAGE can be done to anyone's BRAIN in the long term run. Hope this helps. Matt (I am from NZ, if you wanted to know where I am commenting from).

  • @shirleycropanese9807
    @shirleycropanese98077 ай бұрын

    Can you talk about vraylar

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    I already made that video here:kzread.info/dash/bejne/ZX6CrtCJd63LcZM.htmlsi=hcy_NY_Yi5vQvfw0

  • @ETH-xr9cr
    @ETH-xr9cr4 ай бұрын

    Can olanzapine be used with aripiprazole?

  • @pkblackbelt

    @pkblackbelt

    3 ай бұрын

    Yes

  • @awais2148
    @awais21487 ай бұрын

    Ma'am, I'm still waiting for your email reply.

  • @LevelheadedMind

    @LevelheadedMind

    7 ай бұрын

    I prioritize my patients' and clients' emails, so I am sorry about that. I plan on getting to other emails later this week when I have some free time.

  • @awais2148

    @awais2148

    7 ай бұрын

    @@LevelheadedMind bless you 🙏

  • @annbarclay3825

    @annbarclay3825

    7 ай бұрын

    and so in a few months you will be like the side of a house