NEOPLASIA 3: TUMOR SUPPRESSOR GENES: Retinoblastoma Gene, Knudson's Two Hit Hypothesis.
This short tutorial explains the general concepts of tumor suppressor genes and a detailed explaination of Retinoblastoma gene
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Tumor suppression genes- general aspects
Retinoblastoma gene
Knudson’s two Hit Hypothesis
Role of RB in regulation of cell cycle
Mechanism of inactivation of RB
Tumors associated with RB gene mutations
Tumor suppressor proteins( products of TSG)
Regulate cell growth by applying brakes to cell proliferation ( Growth Inhibition)
Failure of growth inhibition is seen in carcinogenesis
Loss of function of these genes is a key event in carcinogenesis
Retinoblastoma Gene ( RB Gene)
First discovered Tumor suppressor gene
Chromosome 13q14
Retinoblastoma: is a childhood tumor with inactivation of this gene.
Knudson’s two-hit hypothesis
Two mutations ( hits) involving both the alleles of TSG ( here RB gene) is a basic requisite for the development of tumor
Retinoblastoma can occur as hereditary or sporadic form
Explanation for the same is given by Knudson’s two-hit hypothesis
RB protein- product of RB gene
Key role in regulation of the cell cycle
“Governor” of the cell cycle
So, How does RB gets inactivated ?OrHow does the Antiproliferative activity of RB is nullified?
1. Germline & somatic
Loss of function Mutations of RB Gene
2. Gene Amplifications of CDK 4 and
Cyclin D genes
3. Functional inactivation of RB
Tumors associated with RB Gene mutations
Retinoblastoma
Osteosarcoma
Glioblastomas
Small cell carcinomas of lung
Breast cancers &
Bladder cancers
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Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
• NEOPLASIA 6: WARBURG E...
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Пікірлер: 128
Absolutely brilliant sir. As a practicing surgical oncologist since more than 25 years, as also a teaching faculty in a medical college, I really appreciate the clarity and lucidity of your excellent presentation. Thank you so much.
Sir Pls do not get inactive. Pls continue ur proliferative potential of spreading knowledge. This type of mutation in u is welcome sir. Pls do continue generating such interesting videos
@ilovepathologyVijayPatho
3 жыл бұрын
😂 😂 👌 👍 thank you 😊
@mjayreign6699
8 ай бұрын
Fr you’re amazing I can’t even shouttttt!!!!
Easy to understand... concept clear .... Respect & love from core of my heart
Randomly came here and WOW , u have made difficult topic capable of understanding , Thanks
You explanations of complicated topics makes it so much easy to understand and comprehend the topics that are discussed in dozens of pages. I've been always looking forward for your tutorials. THANK YOU SO MUCH for all the effort.
@ilovepathologyVijayPatho
6 жыл бұрын
Albaraa Alfaraidi thanks for those kind words :-)
@albertranglong
2 жыл бұрын
Is there any notes available and is it helpful in university exam ? Please let me know
Your explanations r making my preparation very easy. Thanks a lot sir 😊😊
Its never a boring subject if u have a great teacher
Thanks a lot, I was struggling a lot with this concept for my cancer biology exam :)
very good explanation, , thank you sir
Your content is so good I don’t even skip the ads.
Your make everything so simple to understand , thank you Sir
never understood retinoblastoma gene this better
@crazyrobin5
4 жыл бұрын
Haha.. That's the problem sir.. We being an oncologist... Just are entangled with the trials... Basics and core fundamentals, I feel are given the least weightage.. 🙏
Thanks alot..Very informative and easy to understand video on this topic.It helped me a lot .
Finally understood the topic ❤️ Thank you sir.
I couldn’t be more grateful🙏🏽🙏🏽🙏🏽😩😩
Thank you doctor 🌸 i call this simplicity 👌🏻
Clear explanation and easy to grasp the information 🙏🏼
This is absolutely fantastic! Very well explained thank you sir.
YOU’RE THE BEST! Thankyou so much
Thank u so much ...it was very useful 👏🏼
thank you so much for this, you are a lifesaver
Very happy to the vedio..you made easy for me as preparing for oncosurgery
Great teaching and illustrations thank you for teaching and sharing ❤❤❤❤❤
Your explanation is mind-blowing. Very useful thanks alooottt
Thank you so much.. It really helpful
very helpful
Beautiful explanation
I love the way you teach sir .. god bless you with still more knowledge 💖... If possible plz upload more videos tqvm sir
Thank you sir.. It helped me a lot..😌😌
Crystal clear topics ...tq...excepting more videos from hematology
Sir I m very grateful ..very nice explaination
Great job!, thanks!
Really helpful video. Thank you😊
Very useful... thank u so much sir ..
felt very grateful thank you so much
Excellent explanation.thankyou sir
Thank you Sir🙌🏻
very useful video thx from the heart
Finally understanding the topic..tons of pages made soo easy thank you sir..
@ilovepathologyVijayPatho
Жыл бұрын
😊 thank you
Thank you so much sir!!!
Excellent explanation sir! 👏
Beautiful explanation..
Awesome content 🔥
Great video, thank you!
I love these ❤️
Thank u soo much sir!
Great explanation thank you
10000% solid concept
Good explanation easy to understand useful for my exams
Well played !! Thank you
Awesome. ❤
thank u, great explanation
Conceptual approach 👌
Great explanation.. Thanks...
Very good thanks
Very well explained
Thank you so much for this
Excellent. Thank you sir.
Thank you sooooo much ... robbins is a piece of cake cuz of you
Very helpful
Excellent video
Thankyou so much sir
Excellent!
The gene for retinoblastoma is transmitted along with a gene for esterase D to which it is closely linked. However, either of the two alleles for esterase D can be transmitted with either allele for retinoblastoma. How do you know that retinoblastoma is not the direct effect of the esterase D genotype? Please give explanation....
Great explanation....Thanks for helping
@ilovepathologyVijayPatho
4 жыл бұрын
You are most welcome
Super explanation
Thanks for this
Aaah people are missing out on content 🤩
good presentation
Too good 🙌
Excellent
Thank you sir for this beautiful explanation. Please do a video series on wbc malignancies
A plenty of thanks sir.... waiting for systematic pathology videos
@ilovepathologyVijayPatho
4 жыл бұрын
Very soon
Very useful 👍
Great explanation.... Too good.... Robbins can be made so simple?
Thank you.
Thank you
You are amazing thank you sir thank you very much
Gracias
thanks so much
thanks a lot
Thankew you so much
Thank you! Why is the retinoblastoma unilateral in 60% of cases? Since there are ×2 hits (in both chromosomes) it should be bilateral. (Affects both retinas).
Thanks 💚😊
U r ossm sir
which is more common inherited or acquired retinoblastoma??
thanku sir
Awesome
thank you saar
Thanks
Thank you but please make more videos
Damn good ...!
Sir, what is loss of function mutations for RB protein ? Can you please make a video on this topic 😢
May I know your specific references, for example for the pictures, please?
Awesome. Thanks a lot
@ilovepathologyVijayPatho
7 жыл бұрын
Thanks. Glad you liked it. Any suggestions are welcome.
How normal cell divided? If RB gene is inhibit the cell to go S phase of cell cycle.??
Wishes from madurai medical college😇
So wonderful . Thank you. You can also checkout my article in pediatriconcall on the same topic
What happens if you eat food containing cancer cells or tumor?
Your explanations are very good but if you speak more slowly it will be better to understand