NEOPLASIA 4: p53 gene: The Guardian of the genome. functions, regulation and inactivation

This Short tutorial explains p53 Gene.
click • NEOPLASIA 3: TUMOR SUP... for understanding the Retinoblastoma Gene
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p53 GENE
This is a tumor suppressor gene ( its activity stops the formation of tumors)
Located on 17p13, first discovered in 1979
The p53 protein is the product of p53 gene
P-protein
53- weight of the protein, 53 kDa
Located in almost all normal tissues
Unstable and degrades very quickly
Is one of the most commonly mutated gene in cancer
Function
Regulation of Cell cycle
DNA repair
Apoptosis
Prevents neoplastic transformation either by cell cycle arrest or by triggering apoptosis.
In cases of DNA damage, there is triggering of expression of p53 gene whcich increases the production of p53 proteins. These preoteins Prevent Cell from entering S phase of cell cycle
and Allows time for the DNA repair to take place. also p53 induces DNA repair genes. If the DNA is repaired,the p53 degrades and the cell cycle continues. if the DNA is not repaired, the p53 induces permanent arrest in the cell or activates pro apoptotic proteins bax and bad thereby promoting apoptosis. By these mechanisms, it is understood that the p53 conserves the stability of the cell and thus aptly called as ' THE GAURDIAN OF THE GENOME"
How p53 causes cell cycl arrest?
P53 is the transcriptional regulator of one of the genes named WAF 1
Resulting in increased WAF proteins named as p 21
P21 blocks CDK4/CyclinD complex ….. Cell cycle is halted in G1 stage resulting in cell cycle arrest.
Regulation of p53 protein: by formation of p53 and mdme protein complex which is degraded by ubiquitin mediated pathway.
What happens when p53 is inactivated?
There will be no cell cycle arrest in cases of damaged DNA and the cell cycle progresses with damaged DNa which results in genomic instability and the neoplastic transformation.
How p53 is inactivated??
Mutations
Heterozygous and homozygous loss of alleles
What are the cancers associated with p53 mutations??
Most human cancers!
MC breast, colorectal, liver, lung, and ovarian cancers.
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Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
• NEOPLASIA 6: WARBURG E...
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Пікірлер: 228

  • @naomiirhontumhan1544
    @naomiirhontumhan15443 ай бұрын

    And 7 year later your videos are still saving lives👏 Thank you 🙏

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    3 ай бұрын

    Thank you😊 glad it still helps😊

  • @haripriyar8291
    @haripriyar82916 жыл бұрын

    You're the reason I'm passing exams with a clear concept instead of just writing what's in the book. Thankyou so much :)

  • @nathaamruth9751

    @nathaamruth9751

    5 жыл бұрын

    😂🙌me too

  • @dariofilipovic893

    @dariofilipovic893

    4 жыл бұрын

    Harsh truth

  • @tharunkumar5587

    @tharunkumar5587

    2 жыл бұрын

    so cutee haripriya

  • @Arcanescrunchies99

    @Arcanescrunchies99

    Жыл бұрын

    me too

  • @janefrancesayogu2806
    @janefrancesayogu2806 Жыл бұрын

    5 years ago and still very helpful. I can now go into the exam hall in a few hours with more confidence. Thank you.

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    Жыл бұрын

    Thank you 😊 best wishes 😊

  • @janefrancesayogu2806

    @janefrancesayogu2806

    Жыл бұрын

    @@ilovepathologyVijayPatho Thank you

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    3 ай бұрын

    Thank you 😊 am glad it helps😊

  • @zcameron_
    @zcameron_3 ай бұрын

    I’m a week out from a huge pathology exam and I really wish I’d just studied from your videos from the beginning. I read all this info in a textbook and never retained it, and now it makes so much more sense to me. You break concepts up really well and you also keep it focused on the important stuff. Thank you!

  • @umairhabib4618
    @umairhabib4618 Жыл бұрын

    Just 10 minutes lecture give alot of information is a miracle Thanks sir Our prayer always with your dedication and hardwork.

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    Жыл бұрын

    Thank you 😊

  • @MDISLAM-qw7ic
    @MDISLAM-qw7ic3 жыл бұрын

    P53 is guardian of the genome / old man of the genome/ police man of the genome / care taker / gate keeper of the genome . The information which did not get from dr.sparsh gupta & dr.najeeb but i have found amazing & very effective information from your channel. It is why i have subscribed and followed your you tube channel. Thank you sir and i really love " i love pathology " channel..😊

  • @marioaraprotopapa1503
    @marioaraprotopapa15034 жыл бұрын

    You are a really good teacher , thank you for all the time and energy put in to make these videos extremely clear and concise ♡♡ .

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    4 жыл бұрын

    Marioara Protopapa thanks so much 😊

  • @andreapella4234
    @andreapella42346 жыл бұрын

    I love you. This is so well explained i'm in tears.

  • @asmitajain7201
    @asmitajain7201 Жыл бұрын

    U are a really wonderful teacher, making the basics so understandable in a simple way, thanks for taking all the efforts in making such wonderful presentations

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    Жыл бұрын

    Thank you very much 😊.glad the video was of help 😊 Best wishes.

  • @pinrani98794
    @pinrani987947 жыл бұрын

    i already have subscribed to this channel and gave thumbs up to this channel/video. He will be fool who will not do this ... great work and proper guidance provided .... bravo....

  • @drabdul86
    @drabdul862 жыл бұрын

    Thank you Sir , I am from Pakistan , u made this tough topic much easy to understand , love you

  • @parthjobanputra3742
    @parthjobanputra37426 жыл бұрын

    I have my exam tomorrow n this video helped me to drill the concept really quick... ty ... great explanation...😎🤘

  • @Josef2820
    @Josef28205 жыл бұрын

    Man i really have to thank you so much for your Video. Somehow we dont have anything that easy to understand in germany related to p53 Thanks a lot !!!!!

  • @irem0090

    @irem0090

    5 жыл бұрын

    Josef Boy Björn same hab nix gefunden

  • @shaileshrao8694
    @shaileshrao86943 жыл бұрын

    Neoplasia was one of the hardest topics i've ever studied and thanks to your videos my concepts are very clear!! please keep uploading more videos on pathology it is indeed very very helpful!!❤❤❤

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    3 жыл бұрын

    Thanks so much..glad these videos are helping 😊 do share with your friends

  • @OvErShadOweDaZn
    @OvErShadOweDaZn7 жыл бұрын

    Keep up the good work! I love this video and it was very helpful in understanding. You are a great instructor.

  • @kniiknoi6197
    @kniiknoi61974 жыл бұрын

    Wow ... Great video. Excellent, detailed yet simplified tuition. Thanks a lot

  • @Artsylove4
    @Artsylove43 жыл бұрын

    I'm super thankful that I found ur channel sir..

  • @mahfuzajebun5968
    @mahfuzajebun59687 жыл бұрын

    Best pathology tutorials site I have ever seen.. Really grateful to u .

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    7 жыл бұрын

    Thank you.

  • @samina9199
    @samina91993 ай бұрын

    Thank you so much sir for making Neoplasia too much easy and understandable😊🎉

  • @cindysababa0204
    @cindysababa02044 жыл бұрын

    I was reading my book, but it makes no sense to me. You made it clearer! thank you so much!

  • @ayokcomfort729

    @ayokcomfort729

    3 жыл бұрын

    I can relate

  • @84-pavithradevi2

    @84-pavithradevi2

    3 жыл бұрын

    yass!!!

  • @chinmayeechhotaray7116
    @chinmayeechhotaray71164 жыл бұрын

    Thanks dude...i was searching for p53 explanation and ended up in your video with perfect explanation.....you helped me a lot.

  • @animeloverXinuyasha
    @animeloverXinuyasha6 жыл бұрын

    Very good job at outlining this topic - this is a perfect and easy to understand introduction to p53, so now I can go and delve deeper! I do wish you had explained a bit more as to what causes p53 inactivation and how, but all in all great video!

  • @thickassunicorn
    @thickassunicorn5 жыл бұрын

    Best video ever...pathology would never been so interesting

  • @080mirdhulak9
    @080mirdhulak92 жыл бұрын

    Just an amazing clear cut concept I have ever seen🤩

  • @vaishnavik7367
    @vaishnavik73676 жыл бұрын

    You're a gem sir. Pls upload some more videos. I have my uni exams in 10 days and your videos on neoplasia are a saviour. Keep it up, good luck :)

  • @zoyawinfield3011
    @zoyawinfield30115 жыл бұрын

    Thank you so much you made this concept so easy to understand. I was really struggling with this concept. Really helped with studying for my exam!

  • @ChukimeRMarak
    @ChukimeRMarak Жыл бұрын

    One of the besttttt explanations I've come across. So systematic and made easy to grasp the concept. So grateful to have found this.

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    Жыл бұрын

    Thank you 😊

  • @alienatedaliens
    @alienatedaliens4 жыл бұрын

    This was so helpful and clear, thank you!

  • @shubhamkushwaha8513
    @shubhamkushwaha85133 жыл бұрын

    Thank you for the amazing video sir! You explain things so simply!

  • @lucelence6312
    @lucelence63123 жыл бұрын

    Thank you so much for making the concept clear and easy to understand

  • @songbaolin5479
    @songbaolin54795 жыл бұрын

    Thanks to the author,I will finish my paper easily.

  • @cossav2560
    @cossav2560 Жыл бұрын

    Thank you from London. Great work.

  • @divyamachevar9156
    @divyamachevar91562 жыл бұрын

    You are doing a great job. Please continue doing it, your videos are of great help. Thank you ❤️

  • @roohullahaminsafi2240
    @roohullahaminsafi22403 жыл бұрын

    Thanks sir, really appreciate your hard work and hope to keep loving pathology. Lots of love from Afg🇦🇫

  • @dartanveer2046
    @dartanveer20467 жыл бұрын

    really a good art of teaching...Amazing...

  • @krishnamanikalita1612
    @krishnamanikalita16126 ай бұрын

    You are doing great work sir... thank you so much ❤

  • @20imke
    @20imke6 жыл бұрын

    Thanks for helping me understand it so easily. Textbooks are just overcomplicating everything.

  • @bayanalkhalifa1853
    @bayanalkhalifa18537 жыл бұрын

    the most helpful video! Thank u so much!

  • @maryamaslam1612
    @maryamaslam16124 жыл бұрын

    These are so helpful and easy to understand :) THANK YOU!!!!

  • @priyachakraborty2260
    @priyachakraborty22606 жыл бұрын

    It was great.... 2moro is my exam nd this video worked for me a lot....

  • @kishori4621
    @kishori46214 ай бұрын

    You have made us love Pathology ❤️

  • @shahidulhchowdhury6411
    @shahidulhchowdhury64117 жыл бұрын

    wonderful illustration of role of p53 gene

  • @sanaakbar3663
    @sanaakbar3663 Жыл бұрын

    Well explained sir. Neoplasia is one chapter that scares me but you have made it more interesting. Your videos have made it more easy for me to go through the text and understand it in a clear way. No amount of paid online classes have made me understand neoplasia as well as these videos . Please keep posting regularly sir!! 🙂

  • @euge6994
    @euge69945 жыл бұрын

    Thank you so much! This was really helpfull and clear.

  • @farihahamid7580
    @farihahamid75807 жыл бұрын

    amazing video! you kept it simple and not too complicated ! :)

  • @svartmetall48
    @svartmetall484 жыл бұрын

    I realise this is a very brief look at p53, so I'll leave out some of the simplifications, but I would say one thing needs to be corrected regarding the molecular weight. p53 was named because it ran on an SDS-PAGE gel at 53 kDa, not because its molecular weight is 53 kDa. Due to the fact that p53 is quite proline rich it is a more rigid structure with annoying "kinks" in it, and thus it migrates differently on SDS-PAGE. As I am sure you know, proteins don't necessarily migrate at their actual mass (and there are a plethora of reasons for this). p53 is around 44 kDa.

  • @svartmetall48

    @svartmetall48

    4 жыл бұрын

    @johnny torres Probably a good thing if you attend KI. I should know, I taught some of the undergraduate labs that med students took! ;)

  • @debigdogk9563
    @debigdogk95637 ай бұрын

    Great teaching and illustrations thank you for teaching and sharing ❤❤❤❤❤

  • @pradyumnakumar6988
    @pradyumnakumar69886 жыл бұрын

    Really helpful. I'm impressed sir. Thank you so much🙂

  • @Rotzfresh89
    @Rotzfresh893 жыл бұрын

    Thank you so much for your efforts. Much appreciated!

  • @elijahsikazwe5342
    @elijahsikazwe53423 күн бұрын

    Your videos really helps me alot🤝

  • @CytochromeC
    @CytochromeC6 жыл бұрын

    I m actually dealing a while with p53 but the Video is Great

  • @alaaeltayeb9213
    @alaaeltayeb92134 жыл бұрын

    this is a great time saving explanation thanks alot

  • @tarunarjunbk8247
    @tarunarjunbk82474 жыл бұрын

    Thank u so much sir saw this video before going into exam.. got this question today

  • @jordan4441
    @jordan44416 жыл бұрын

    Thank you for this info sir!

  • @clarksims3776
    @clarksims37763 жыл бұрын

    Thanks for posting this. It was very informative.

  • @VijayKumar-ee2si
    @VijayKumar-ee2si2 жыл бұрын

    Me studying in PG . really u r explained very well and it's very helpfull to understand easily without confusing tq so much sir❤️

  • @intigutierrez5557
    @intigutierrez55573 жыл бұрын

    Thanks for ur videos! I loved them, now i can do my essay easily hehe

  • @ahmedkhan1560
    @ahmedkhan15602 жыл бұрын

    Excellent presentation. You made this complex topic so simple that I should recommend that it should be used as a template by the Authors of Molecular pathology Books. Thanks a million, Amjad Ali Khan MD USA

  • @erdemakturk9574
    @erdemakturk95744 жыл бұрын

    Well done man. I got all of it. 👍

  • @danzlebronr9807
    @danzlebronr98077 жыл бұрын

    Very helpful sir! Thank You :)

  • @RuchiKumari-lu7cg
    @RuchiKumari-lu7cg3 ай бұрын

    Thanku sir a lot i really get concept from ur video thn i can make concept

  • @Artsylove4
    @Artsylove43 жыл бұрын

    U make all the concepts really easy to understand ... thank you so much sir!!

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    3 жыл бұрын

    Thanks 😊 Glad you liked them

  • @mananvaid2304
    @mananvaid23047 жыл бұрын

    Lovely video! Thanks man! Keep uploading more videos. Greetings from Gujarat.

  • @Aman-hk4ov
    @Aman-hk4ov3 жыл бұрын

    Such a great video!

  • @shahmaf1768
    @shahmaf17683 жыл бұрын

    Thank you so much for the video because I was very tired with p53

  • @vrog
    @vrog5 жыл бұрын

    Amazingly done.

  • @oviya7715
    @oviya77154 жыл бұрын

    The concept is clear and easy to understand thanks to the author

  • @solangecontreras8325
    @solangecontreras83254 жыл бұрын

    Thank you!!!! The information helped me a lot with my classes

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    4 жыл бұрын

    I'm so glad that it helped

  • @disloyaltyovercovid8350
    @disloyaltyovercovid83503 жыл бұрын

    Thank you! The video is very clear!

  • @drbiologyarun
    @drbiologyarun4 жыл бұрын

    Amazing explanation.. Thank you 😊

  • @yashkumarprajapati9648
    @yashkumarprajapati9648 Жыл бұрын

    Beautifully explained!! Thank you sir 😊

  • @haroldkumar4766
    @haroldkumar47666 жыл бұрын

    Good stuff and explanation! However I wish p53 videos also mention that it's part of the BAX/BAK pathway and Bcl2 as that can be a point of confusion.

  • @manavkavathiya3078
    @manavkavathiya30786 жыл бұрын

    Exellent videos regarding neoplasia ,injury etc . But we require more videos regarding other pathological conceptual topics basis Thank you

  • @sanmeetkour8777
    @sanmeetkour87773 жыл бұрын

    Thank you sir ..god bless ..you made it so easy to understand 😊

  • @fatimarushwan
    @fatimarushwan7 жыл бұрын

    Great explanation, thanks

  • @yousifmajid8187
    @yousifmajid81876 жыл бұрын

    very useful videos thank you for your efforts )

  • @imanalkole919
    @imanalkole9195 жыл бұрын

    Thansk for the great overview!!

  • @karishmadeegan8297
    @karishmadeegan82973 жыл бұрын

    Thank you so much Sir for such a beautiful explanation. I wish you all the best, may you continue to educate lots of students like me. I study at Imperial College London and will tell my friends about your channel. Thank you!!!

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    3 жыл бұрын

    Thank you 😊

  • @karenbeard7040
    @karenbeard70406 жыл бұрын

    Fantastic video, thank you :)

  • @sanjeevnirala2020
    @sanjeevnirala20206 жыл бұрын

    Great explanation sir .Keep providing us lectures related to ias syllabus like nucleic acid topology, signal molecules, rna processing, ribozume technology, proteomics genomics ,rflp aflp etc. It would b of great help

  • @MuhammadHawler98
    @MuhammadHawler985 жыл бұрын

    You rock, sir! Subscribed

  • @yaqeenyousef8094
    @yaqeenyousef80944 жыл бұрын

    thank youu sooo much you arethe best in pathology :)

  • @ilovepathologyVijayPatho

    @ilovepathologyVijayPatho

    4 жыл бұрын

    Yaqeen Yousef Thank you very much 😊

  • @rusulkeshwan9297
    @rusulkeshwan92973 жыл бұрын

    Many thanks for you, you make it very easy

  • @DrAasthaKalra
    @DrAasthaKalra6 жыл бұрын

    Very nice Crisp and precise

  • @gargichakraborty1083
    @gargichakraborty10832 жыл бұрын

    Great explanation !

  • @Interestingworld4567
    @Interestingworld45675 жыл бұрын

    Thank you this helps a ton.

  • @rikkigupta9546
    @rikkigupta95464 жыл бұрын

    Thank u so much sir 🙏very clear explanation may god bless u 😇

  • @aqibsyed8198
    @aqibsyed81987 жыл бұрын

    thanks for best explanations.

  • @rohit_roars
    @rohit_roars4 жыл бұрын

    Thank you for your explanation sir...

  • @GauravSharma-ok4gz
    @GauravSharma-ok4gz5 жыл бұрын

    Great explaination.

  • @davidgregorich2701
    @davidgregorich27015 жыл бұрын

    That was great! Thank you

  • @diya4939
    @diya49396 жыл бұрын

    really very helpful thanks a lots sir

  • @sugu239
    @sugu2395 жыл бұрын

    Great presentation

  • @md.monirulislam1765
    @md.monirulislam17656 жыл бұрын

    very good work, thanks

  • @pavansharma8966
    @pavansharma89663 жыл бұрын

    Nicely illustrated about p53 gene regulation in tumor suppression

  • @MA-zo5jl
    @MA-zo5jl Жыл бұрын

    Wow so amazing and very clear ty so much ❤

  • @SHERLOCKED_ARMY
    @SHERLOCKED_ARMY6 жыл бұрын

    Very helpful..thank you sir

  • @AliKhan-sr1cm
    @AliKhan-sr1cm4 жыл бұрын

    Great work bro

  • @rakshanas3960
    @rakshanas39602 жыл бұрын

    Pls do more videos ,its very helpful 🥺

  • @riyaan1089
    @riyaan10893 жыл бұрын

    Tqs so much for this very easy explanation