Murali Doraiswamy - When Brains Go Bad

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How do injured brains help explain normal brains? One of the most powerful ways of learning about normal brain function is to examine what functions are lost when parts or areas of the brain are degraded or destroyed due to injury or disease. The subtle variations of different brain problems reveal the remarkable strands that make normal brain work so well.
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Murali Doraiswamy is a leading physician scientist in the areas of brain health and personalized medicine at Duke Medicine where he is a Professor in the Division of Translational Neuroscience and Director of the Neurocognitive Disorders Program in Psychiatry. He also serves as a member of the Duke Institute for Brain Sciences and the Duke Center for Personalized Medicine.
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Closer To Truth, hosted by Robert Lawrence Kuhn and directed by Peter Getzels, presents the world’s greatest thinkers exploring humanity’s deepest questions. Discover fundamental issues of existence. Engage new and diverse ways of thinking. Appreciate intense debates. Share your own opinions. Seek your own answers.

Пікірлер: 62

  • @chrisgriffiths2533
    @chrisgriffiths253321 күн бұрын

    CTT, I Recall a Few Decades Back Talking to a Elderly Female Friend in Her Seventies, I was in My Thirties. She was a Clear Thinker but did represent the Education of Her Time. One Day She said to Me :- " I Think I am Losing My Memory" " I Don't Know what Day it is" I said, I Sometimes Don't Know what Day it is. In the End Her Memory did Not cause Her Death. RIP FRIEND. Interesting Topic.

  • @JonSebastianF
    @JonSebastianF20 күн бұрын

    What a great speaker Doraiswamy is! Whoah!

  • @todrichards1105
    @todrichards110521 күн бұрын

    Excellent vid!

  • @jamesspero5884
    @jamesspero588420 күн бұрын

    Thank you for this very timely and important video, my wife has Altseimers and is in a memory care unit, i always suspected that there was a strong genetic component causing the disease, any treatment breakthrough will be too late for her but being able to keep brains healthy for a longer period of time will relieve caregivers of the emotional and enormous financial burden that goes along with memory loss, there is no point in living longer if your brain is malfunctioning so badly that you become as helpless as an infant its a fate older people fear, curing cancer is great but curing or preventing brain disease is equally important.

  • @ghaderpashayee8334
    @ghaderpashayee833421 күн бұрын

    Meditation is that magic bullet!

  • @stellarwind1946
    @stellarwind194621 күн бұрын

    The death of neurons is triggered by the inflammatory response to the aggregation of misfolded proteins.

  • @mikes2120

    @mikes2120

    21 күн бұрын

    Google?

  • @asta3457
    @asta345720 күн бұрын

    last sentence is massive

  • @futurehistory2110
    @futurehistory211019 күн бұрын

    1:00 Does this mean when reaching your 40s' we should get brain scans for this as a health checkup? I'm 29 but I do like to think ahead as Ik I won't be young forever. Doing good when it comes to eating healthy but one thing I'm working on is getting my stress levels down and now being on meds for ADHD is definitely helping. Gotta save some money now too, that will definitely help me relax!

  • @mrbr0skii923
    @mrbr0skii92320 күн бұрын

    I feel like the missing link here is that we're not talking about how emotional problems in a person's mind can influence their brain health and physical health. For some reason I feel like I'm not seeing enough people talking about the lasting impact of environment driven wounding events that happen to us emotionally.

  • @wagfinpis
    @wagfinpis21 күн бұрын

    Robert didn't ask him how he thinks old timers with advanced alzheimers sometimes have temporary clarity, usually not too long before they die. It is a well known occurrence that some people with alzheimers will for a few hours or so, all of a sudden, achieve perfect clarity in their memory recall. It's like their "holographic whole memory bits" temporarily achieve "critical mass" or something and magic[!!!] they remember who everyone is and they remember events, names, dates etc. This happened with my Grandma like a year before she left her earthly consciousness-transmitter/body/"died".

  • @stellarwind1946

    @stellarwind1946

    21 күн бұрын

    Yes that’s called terminal lucidity, or “the rally” as caretakers refer to it.

  • @wagfinpis

    @wagfinpis

    21 күн бұрын

    @@stellarwind1946 I am familiar with those terms and references, but the idea is massive and the idea was nowhere to be found in this closer to truth conversation that advances a lot of left-brain dominant psychopic social disease. I wasn't looking for a label for my left brain. My right brain was pursuing an idea.

  • @andrewmoran7353
    @andrewmoran735321 күн бұрын

    🤔 Great interview, recalling your former life persnickety on questions 🤭, looked like you enjoyed rebooting and getting some new ideas as usual, 👍

  • @stoictraveler1
    @stoictraveler121 күн бұрын

    Lion's Mane mushrooms help with plaques.

  • @user-if1ly5sn5f
    @user-if1ly5sn5f21 күн бұрын

    9:23 this is what i been saying. It’s felt by the differences like the ocean and a drip sharing the energy.

  • @gettaasteroid4650
    @gettaasteroid465021 күн бұрын

    Why should a man die who has salvia growing in his garden?

  • @TorgerVedeler
    @TorgerVedeler21 күн бұрын

    I think this supports the idea that kindness is healthy for our brains.

  • @rodneymacomber6337
    @rodneymacomber633721 күн бұрын

    Are there study’s on mero génesis

  • @S3RAVA3LM
    @S3RAVA3LM21 күн бұрын

    Great video. I myself don't trust my mind and am careful regarding memory because of condition, states of mind, and how sometimes we take an aspect from one memory and coalesce it with one from another memory. And i don't trust everything i see, especially what is apparent.

  • @wagfinpis

    @wagfinpis

    21 күн бұрын

    This is a perfect example of how left-brain dominance is vastly inferior to right-brain dominace. Episodic memory has greater context than the mear rote memory details the left brain is good at processing. I have memories from a very young age where I remember remembering, what my mental process context was like at the time, and the other events that relate to the never ending chains of questions my right brain has been asking my whole life.

  • @r2c3
    @r2c321 күн бұрын

    9:07 some people are able to remember specific details, from any event, many years later, with amazing accuracy... and according to some studies, this has been been linked to mainly structural differences around the medial temporal area... so, advanced memory formation must relate to specific neuronal configurations which are negatively affected by the plaque buildup, in this case...

  • @S3RAVA3LM

    @S3RAVA3LM

    21 күн бұрын

    so, is this like the seldom story when a man involved in an accident, maybe put into coma, and when he comes out of it, he's now a mathematics expert or can play piano as if he's been doing it for his whole life? Thinking about neuronal patterns or formations, I wonder how much an impact certain music, like harp music, or anything of a high and pure frequency, like from the example of 'sound hz and sand' forming geometrical formations, might have on the brain. It might help us reach, touch, or grasp a higher level in intellect and consciousness. You know, many persons are there that study biological evolution, but spiritual or mental evolution to them has never once been considered. From apes to man, mental activity and intellect has transformed.... perhaps, soon we may be able to recon the Divine.

  • @r2c3

    @r2c3

    21 күн бұрын

    ​@@S3RAVA3LMwe're not the first and not even the last to see the light, hear the wind, and feel the gentle rain for a minute moment in existence... there's many variations and extremes but overall that's it S3R...

  • @kumar7359
    @kumar735921 күн бұрын

    Great interview 👍

  • @user-pc7kp9py3s
    @user-pc7kp9py3s21 күн бұрын

    Luv your channel !! .. my favorite

  • @0-by-1_Publishing_LLC
    @0-by-1_Publishing_LLC21 күн бұрын

    This was a very interesting episode, and one I have concerns about. It's outside the normal scope of physics, the cosmos and philosophy.

  • @jackwt7340
    @jackwt734021 күн бұрын

    Choline, inositol, carnitine, pantothenic acid, dimethylsulfone, pyridoxine, lecithin, bromelain, taurine, CoQ10, creatine, ibuprofen, GABA, NMN, thiamine, lipoic acid, branched chain amino acid, which is best for Alzheimer's disease?🧠

  • @tomazflegar
    @tomazflegar21 күн бұрын

    And yet something observes in first person experience that there is nothing to say or lack of object to describe. So we don't know what happened. But we know it. Rather to explain correlation, seek for that which is beyond of it. Rather teach people how to access that part, so there wont be forgetting

  • @aaronrobertcattell8859
    @aaronrobertcattell885921 күн бұрын

    “induced pluripotent stem cells (iPSC)

  • @MegaDonaldification
    @MegaDonaldification18 күн бұрын

    The lower limbs are not close to the brain. The upper limb that'sand closer to the brain requires your daily input, but man have decided to fight against himself by spreading rumours rather than break down information containing sound subtitles and title plus real time evidence to jokes and broken science

  • @brothermine2292
    @brothermine229221 күн бұрын

    Does Alzheimer's have any implications about the viability of dualist or idealist postulates about the nature of consciousness?

  • @simonhibbs887

    @simonhibbs887

    21 күн бұрын

    I don’t think it can refute them, but I do think it puts constraints on how they can reasonably be formulated or expressed. For example the fact that patients conscious experience is constrained and altered in various ways implies that those faculties are in some way dependent on activities of the physical brain. However idealists and dualists can claim that these effects only change the contents of consciousness and not consciousness itself. That claim is logically viable, but it’s also a big step down from maximal idealist and dualist claims because it forces a distinction between consciousness itself and the experiences we are conscious of. All IMHO though, I’d love to hear what someone holding those views has to say.

  • @gettaasteroid4650

    @gettaasteroid4650

    21 күн бұрын

    @@simonhibbs887 classic, you think numbers are contingent, it would follow from your conclusion that numerically identical ideas are possible, except that Thomas Reid criticized John Locke for just such a reason, that your conclusion "dependent on activities of the physical brain" is not sufficient for an explanation. The discussion of memory in classical modern thought, however, primarily depends on the types of memory. Reid distinguished between semantic and episodic memory, Henri Bergson and Bertrand Russell also differentiated, Russell used the terms factual and personal memory respectively. Sven Bernecker (2010) has claimed that memory is purely semantic, seemingly in direct contradiction with your claim of "constrained and altered"

  • @simonhibbs887

    @simonhibbs887

    21 күн бұрын

    @@gettaasteroid4650 I didn’t mention either numbers or memory, so I’m not sure what you’re talking about.

  • @gettaasteroid4650

    @gettaasteroid4650

    21 күн бұрын

    @@simonhibbs887 nice try but it was only three days ago you wrote "just to be super technical...countable numbers are contingent and not fundamental". Too bad John Locke didn't think of that argument eh? You are right though in as much as I presumed that alzheimer's disease is a memory disease,

  • @simonhibbs887

    @simonhibbs887

    21 күн бұрын

    @@gettaasteroid4650 What I was trying to do is figure out what relevance your comment has to the context of the thread you are commenting on, which turns out to be hardly any. But ok. Yes I did write that. The line of thinking is that countable numbers are descriptive of the things they count. Can descriptions of things be fundamental? Maybe, maybe not, I'm not entirely sure, but I think it may be that all informational relational structures like mathematics might be an emergent property of structure itself. That is, physical structure. After all, can you show me a mathematical expression that isn't a physical artefact?

  • @aaronrobertcattell8859
    @aaronrobertcattell885921 күн бұрын

    get it when in mom's womb

  • @user-yh1co3gc4h
    @user-yh1co3gc4h21 күн бұрын

    Yoga, meditation,....,nobody has really benefitted from these two things.

  • @r2c3

    @r2c3

    21 күн бұрын

    they do help to keep both body and mind in good shape...

  • @simonhibbs887

    @simonhibbs887

    21 күн бұрын

    I don’t agree, I’ve dabbled with meditation and found it a positive experience. I wish I’d pursued it further.

  • @pigzrus397

    @pigzrus397

    21 күн бұрын

    @@simonhibbs887you can always pick it up again. I started meditating about 12 years ago and dropped it for a few years. I picked it back up just over a year ago and my life has changed drastically in such positive ways.

  • @aaronrobertcattell8859
    @aaronrobertcattell885921 күн бұрын

    fibroblasts or blood cells

  • @TheLuminousOne
    @TheLuminousOne21 күн бұрын

    When brains go bad: enter Western Governments 😂

  • @simonhibbs887

    @simonhibbs887

    21 күн бұрын

    As against all the other governments that have done so much better for their people, hence the huge flows of young people flooding out of western countries for better lives elsewhere… er…

  • @stephenbesley3177
    @stephenbesley317721 күн бұрын

    I guess I'm already a lost cause

  • @sujok-acupuncture9246

    @sujok-acupuncture9246

    21 күн бұрын

    What it means...

  • @r2c3

    @r2c3

    21 күн бұрын

    aging has been inevitable thus far... but hopes are high nowdays with the advent of AI systems that can theoretically dismantle even a structure as complex as a brain in the near future... there's hope...

  • @stoictraveler1

    @stoictraveler1

    21 күн бұрын

    Lions Mane mushrooms.

  • @aporist
    @aporist20 күн бұрын

    Cows.

  • @evaadam3635
    @evaadam363521 күн бұрын

    "When Brains Go Bad?" Your free immortal soul remains intact and aware when your physical brain goes bad or dies.... .. however, because the physical brain is the soul's window to the physical world, your perceptions would be affected or would end when the brain dies but your spiritual being still exist and still aware that will leave the body... ..it is like your computer that when it crashes, you can no longer browse the internet but you are still there, still exists, watching your dead computer helplessly...

  • @tomjackson7755

    @tomjackson7755

    21 күн бұрын

    Do you realize that you have a case of "When Brains Go Bad"?

  • @BajaJones-iq2cp
    @BajaJones-iq2cp19 күн бұрын

    as neuroscientists.... BLAH, BLAH, BLAH....

  • @user-ie9ov6tp6r
    @user-ie9ov6tp6r21 күн бұрын

    no u dont

  • @S3RAVA3LM

    @S3RAVA3LM

    21 күн бұрын

    What?