Multi-step Synthesis of Substituted Benzenes
00:00 Introduction
00:51 Retrosynthesis of a Disubstituted Benzene
06:17 Drawing the Synthetic Scheme
08:02 Anilines are Problematic in EAS Reactions
11:48 Limitations of Friedel-Crafts Reactions
00:00 Introduction
00:51 Retrosynthesis of a Disubstituted Benzene
06:17 Drawing the Synthetic Scheme
08:02 Anilines are Problematic in EAS Reactions
11:48 Limitations of Friedel-Crafts Reactions
Пікірлер: 3
But can we alkylate in the presebce of an electron dobating group luke NO2 pliz revise
Wanted to say can we perfom fiedel crafts in the presence of NO2
@mevansthechemist
5 ай бұрын
Generally, this is not synthetically useful. Under Friedel-Crafts conditions, the nitro group is frequently reduced to an NH2 group. The benzene ring is just too electron poor in that case.