Motor Neuron Disease, Animation
Upper and lower motor neuron diseases: Amyotrophic lateral sclerosis (ALS), Progressive bulbar palsy (PBP), Primary lateral sclerosis (PLS), Spinal muscular atrophy (SMA) - Werdnig-Hoffmann disease, Kugelberg-Welander disease, Spinobulbar muscular atrophy (SBMA) - Kennedy’s disease, Post-polio syndrome (PPS). Symptoms, diagnosis, progression, expected lifespan.
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Motor neuron disease is a group of rare neurological conditions in which motor neurons - the nerve cells that control skeletal muscle movement - are progressively degenerated. Loss of motor neurons results in muscle weakness that gradually worsens over time, impairing the body’s ability to move, eat, speak, or even breathe.
Usually, motor instructions from the brain are transmitted to the muscles via 2 neurons: an upper motor neuron starts in the primary motor cortex of the cerebrum; and a lower motor neuron continues from the brainstem or spinal cord, forming the corticobulbar and corticospinal tracts, respectively. The corticobulbar tracts control muscles of the face, head, and neck and are responsible for facial expression, speech, swallowing, among others. The corticospinal tracts control muscles of the torso and limbs.
Lesions of upper and lower motor neurons affect the muscles in different ways. A loss of upper motor neuron function often leads to increased muscle tone, muscle stiffness, known as spasticity, and overresponsive reflexes. On the other hand, lower motor neuron lesions often result in reduced muscle tone, flaccid paralysis, and muscle wasting and twitching.
The many forms of motor neuron disease are classified according to whether the loss of neuron function is inherited or sporadic, and whether the condition affects upper or lower motor neurons.
The most common form is amyotrophic lateral sclerosis, ALS, which affects both upper and lower motor neurons. Patients typically present with spastic paralysis and overactive reflexes in the lower limbs; and flaccid paralysis and reduced responses in the upper limbs, along with tongue twitching. In the later stage, symptoms may also include slurred speech, and difficulty swallowing and breathing. Most people with ALS die from respiratory failure, typically within a few years from diagnosis, although a small number of patients may survive for a much longer time. ALS usually strikes in midlife, but it can occur in people of any age. Most ALS cases are sporadic, only about 10% are inherited, with at least a dozen of genes involved.
Progressive bulbar palsy, PBP, affects the lower motor neurons that originate from the brainstem, also known as the bulbar region. Symptoms include difficulty chewing, swallowing, and speaking. PBP is sometimes considered a subtype of ALS, because most PBP patients eventually also develop widespread muscle weakness.
Primary lateral sclerosis, PLS, affects only upper motor neurons. PLS progresses much more slowly than ALS and is not usually fatal. However, because a number of ALS cases start out as PLS, a PLS diagnosis is considered definitive only after at least 4 years.
Spinal muscular atrophy, SMA, is a group of genetic disorders affecting lower motor neurons. There are many different forms of SMA, caused by mutations in different genes, with different modes of inheritance. The three main forms are due to defects in the same SMN1 gene (autosomal recessive), but differ in age of onset, severity.
Spinobulbar muscular atrophy, or Kennedy’s disease, is a form of SMA caused by mutations in the androgen receptor gene on the X chromosome. This disease typically strikes in adulthood and affects mostly men (X-linked inheritance). Early symptoms include tremor, lower limb weakness, and tongue twitching. Late symptoms include widespread muscle weakness and wasting. The disease however progresses very slowly, with most patients having a normal lifespan.
Post-polio syndrome, PPS, is a condition that affects polio survivors, sometimes decades after the initial illness. Symptoms include muscle and joint weakness and pain, twitches, muscle wasting, and intolerance to cold. Some patients may also have difficulty breathing and swallowing. PPS is usually not fatal.
There is no cure for motor neuron disease, but supportive treatments can relieve symptoms and may help maintain quality of life.
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My mother have this disease... We tried to get treated for her condition but we are helpless no medicine for this disease...she is still alive ...have difficulty in speeching, sollowing , muscle twitching ...I pray to god no one should not affected by this disease.....I requested all researchers pls find a cure for this deadly slow killing disease ...
@shilpashivigupta527
2 жыл бұрын
This is a horrible disease,,, I lost my mom ,
@mariavega5395
2 жыл бұрын
@@shilpashivigupta527 I am so sorry for your loss, may she RIP
@eraldosari7843
2 жыл бұрын
My father has the same disease and his condition is rapidly deteriorating.. He has pneumonia and is only breathing through artificial respiration. I contacted an Indian doctor who has a sanatorium in India. He told me that if he is in the early stages before he gets pneumonia, I can treat him, but if he reaches pneumonia, I cannot do anything. Him.. If your mother did not have pneumonia, I will give you his number, email and health card, and contact him, and I hope you treat her quickly because it is a malignant disease.
@mildredsophia7122
2 жыл бұрын
My mom too. The depression is worse. May God heal them.
@omkale6541
2 жыл бұрын
My mom also suffering from this disease since an year it horrible not understanding what to do and where to take her for better treatment condition is getting worst day by day infront my eyes but not able to do anything...
I have Motor Neurone Disease/ALS and this is one of the best videos around. Most talks/videos ignore mentioning spasticity which is a major symptom. Thanks so much🙏🏼
@michaelbelsky5435
Жыл бұрын
I've seen your videos. So nice. My first girlfriend had this. I don't know what else to say except I care.
@elodieleaf
Жыл бұрын
@@michaelbelsky5435 thankyou so much Michael, that means a lot to me 🙏🏼I am really sorry to hear that your first girlfriend had this disease. Take care
@ujjwalbaroota5892
Жыл бұрын
9315984906
@getmoney3806
10 ай бұрын
❤
@TahaAlZadjali
26 күн бұрын
Wishing you good days ahead.
Exactly useful information thanks alot
Great video had so much information.. Especially PLS and SMA seems most amazing to me.
My father had Amyotrophic lateral sclerosis (ALS) . He survived only for 1 year after the diagnosis of disease. 😢
@factsinshorts9653
Жыл бұрын
Symptoms pls?
@Karen-qx7jw
Жыл бұрын
Sorry for that 😮💨🙏
@AllInOne-bv1ti
Жыл бұрын
@@factsinshorts9653 full paralysis,
@JahoSelamaj
10 ай бұрын
Im sorry for your loss 😔 hopefully you don't inherit it 🙏
@butoolfatemahrizvi6841
10 ай бұрын
@@JahoSelamaj Aameen.. Hopefully..plzz pray for us.
Most useful information
You are wonderful
Good information
Thank you
My uncle just diagnosed this disease, his muscles become weak, both of his hands are affected. The dr told me, no cure for this disease, He can’t even hold utensils. Really sad for him, no one look after my uncle his condition is getting worse. Good thing i have lot of time to accompany him for chek up.
@Vrayanderson6018
2 жыл бұрын
Sorry to hear mate my good friend also just had this said to him 2days ago which country are u inn?
@swapnamukherjee2314
2 жыл бұрын
Ami nije ei pesent lala jhore all taim likuid chamoch kore khai haph bar hoi majhe golai atke jai kosto hoi dom nite।kotha joriye jai।phijiyo theraphi kori।valo hobar medisin ache।jodi Janan to gretful hoi।
@mohtesib
9 ай бұрын
What happened is your uncle ok now ?????
@t.n.h.ptheneohumanpatterna8334
3 ай бұрын
@@mohtesibhe is dead
ALS is commonly known as Lou Gehrig’s disease, after the baseball player whose diagnosis and eventual death brought wide public attention to the illness.
Have you looked into the Deanna Protocol? The father (surgeon) came up with the supplements to help his daughter, who has ALS
My first dear girl friend died from this. It's so depressing!
Is having trouble with breathing while sleeping or in general unavoidable after year(s)- decades living with a disease like this ? And is it individual how sudden and fast the progress is or is it pretty much the same for each and everyone of the illnesses-impairments coming with this fate?
What the solution please tell me
Cảm ơn bạn đã chia sẻ thông tin, rất vui được kết nối với bạn😍😍😍💥💥💥💥💥💥🔥🔥🔥
I suggest making a video about polio
Make a video on height growing
My wife is suffering the MND,she was suffering speaking and swallowing the food in its first stage itself,but she is frequently demanding food,and eating several time a day itself.All treatment has completed,but no result.Her health is losing everyday even after such hug food.
@DealsAlertDaily
Жыл бұрын
Pls call Jesus Christ this is the only way to survive
@shreyanshuprusty3021
Жыл бұрын
Have you tried ayurveda... Patanjali has claimed they have cured patients with motor neuron disease
@joelthambi2705
18 күн бұрын
How's your wife feeling now?
My father in law is also suffering from this disease now after three years he is unable to move muscles and speech properly.
I have mmn. And my treatment dedicated help me to lead a normal life. I've been diagnosis 12 yrs ago
@Jlosworldng
11 ай бұрын
How did you manage it ,thank God you survived
@Parvathi6876
10 ай бұрын
How did you managed it please reply my husband also suffered MNd problem please reply
@JasonMaly
7 ай бұрын
@@Parvathi6876I hope your husband heals
@racelmarasigan9772
6 ай бұрын
May we know ,how to survived the MND my friend diagnosed. Please can u tell us , 🙏🥺🥺
Why there is spasticity of lower limbs muscles while flaccid paralysis of UL muscles in ALS??
@Alilamedicalmedia
2 жыл бұрын
Because both lower and upper neurons are damaged in ALS, each set of symptoms is characteristic of either upper or lower neuron disease. See at 1:08
Good video. However, along with physiotherapy, it is important to consider the root cause of Motor Neuron Diseases. Various studies have revealed that during motor neuron disease due to progressive degeneration of brain cells; a person gradually loses his ability to coordinate, walk, eat and maintain the right posture balance. Along with physiotherapy, it has been suggested that stem cell therapy can be an effective solution to promote brain cells in the body, delay the loss of functional cells, and initiate an anti-inflammatory response to manage functional attributes of the muscles.
My mother is affected in this disease.her left lef should not working Plz help is there any treatment for this disease
@shreyanshuprusty3021
Жыл бұрын
My sister is also suffering from this disease her legs are not working We are treating her from patanjali wellness centre they have claimed that they have cured motor neuron disease patients
Could SMA also strike in Teenagehood? Or earlier than adult?
Correction: cortico bulbar and cortico spinal are the umn's and not the lmn's 0:42
@Alilamedicalmedia
10 ай бұрын
Those are names of tracts, which include both upper and lower neurons
My mother passed away two days before ...her suffering came to an end ..she was 28 to 30 kg while passed away ..what kind of disease is this ? Beg all researchers pls find at least medicine for this mnd ...deadly disease....may her soul rest and peace ...,😭😭😭😭
@anokh7353
Жыл бұрын
Sorry to hear about your loss brother.
@getmoney3806
10 ай бұрын
Sorry for your loss brother.
Unfortunately there is no cure at the moment 😢 its a long painful journey all one can do is mange the disease as far and as long as possible and make the patient comfortable.
Maintain quality of life? You got to be kidding me
My mom's sick with that. Is there no cure for this disease? 😭
@annastyles5783
2 жыл бұрын
Apparently a cure hasn’t yet been found
@MG-dr5mf
2 жыл бұрын
People have reversed ms on an all meat diet. Haven’t found any stories yet about mn but still searching.
@MohamedAli-rm2md
2 жыл бұрын
@@MG-dr5mf We hope they will reach the drug asap
@MohamedAli-rm2md
2 жыл бұрын
@@annastyles5783 We hope they will reach the drug asap
@shilpashivigupta527
2 жыл бұрын
Where r u from ,?
Im 47 yr old. I have too. What should ido? Pls help me
Pray for my grandfather pls 🙏
My Father Have also MND an year
My grandpa had this disease and he passed away because of it
My father was also suffering from this disease but i lost him in January 😭😭😭
I want to medicine of this disies
0:25,1:08,1:30,1:36,2:32,2:58,3:28,4:27
Any reference where we can get supportive treatment for this disease?
@dhanwantarineurocare9189
Жыл бұрын
MND is a vata disease, we have got very good results from Nadi Chikitsa. This is a cheap and effective therapy, changes have to be made in the diet and routine of the patient, many patients are cured here, please consult a qualified Marm medical expert, if you want, you can also mail me, there is no charge, My aim is that my advice may improve someone's life
@anokh7353
Жыл бұрын
@@dhanwantarineurocare9189 hi can you please share with me details
@dhanwantarineurocare9189
Жыл бұрын
Mail your query with complete symptoms
@anokh7353
Жыл бұрын
@@dhanwantarineurocare9189 can I please have your mail id
@anokh7353
Жыл бұрын
@@dhanwantarineurocare9189 hi please send me your contact
Hello my brother has been suffering this disease for an year he became weak day by day,as doctor said there is no medicine for these disease😢😢😢😢😢😢
@dhanwantarineurocare9189
Жыл бұрын
MND is a vata disease, we have got very good results from Nadi Chikitsa. This is a cheap and effective therapy, changes have to be made in the diet and routine of the patient, many patients are cured here, please consult a qualified Marm medical expert, if you want, you can also mail me, there is no charge, My aim is that my advice may improve someone's life
@foujiboy3050
Жыл бұрын
@@dhanwantarineurocare9189 how can I contact u bro plz
@shreyanshuprusty3021
Жыл бұрын
You can also check for patanjali and some ayurvedic centres of Kerala For mnd My sister is suffering from mnd we are treating her at patanjali
@SowmyaGodha-tt5cd
10 ай бұрын
@@dhanwantarineurocare9189 please share me the details pls
My father passed away with this disease its awful may Allah forgive us
@mysticalglowtv1796
2 жыл бұрын
Why would Allah forgive?
@rami3952
Жыл бұрын
Allah yr7mo
@t.n.h.ptheneohumanpatterna8334
3 ай бұрын
allah 😂 grow up
My full body muscle twitching. It's MND disease s iam 39 years . .my right side waist pain and back side a pain one type of burn. . Gastric problems also.pls reply me
I have motor neuron disease it's not fun it hurts it's even hard to sleep
@Sumeria_9
9 ай бұрын
I'm so sorry.Where do u hurt?
just a question (also its pretty dumb cuz im very bad at this stuff) can we technically donate motor neurons?
@dasdough
2 жыл бұрын
Not as of yet, the technology isn't there.
Just want to say I lost my mum 😢 to mnd
@Karen-qx7jw
Жыл бұрын
🙏🙏🙏🙏🌹💕
@t.n.h.ptheneohumanpatterna8334
3 ай бұрын
😂😊
এই রোগের চিকিৎসা কি?
@mdkhairul9215
2 жыл бұрын
এই রোগের কোন চিকিৎসা নাই
Why is it when famous people get it then its top of the engender. My dad worked all his life. Then one day he started tripping over his own feet. He eas gone after 18 months 😢
My husband cure from this disease thank you God
@Saki1287-u5k
4 ай бұрын
How mam..can you please tell me
@barkhasudhaker5025
3 ай бұрын
Please tell us what you did for him .... Radhey radhey 🙏🏼
Stephen Hawking 😔
We lost our dad 18 years this month. Only seems like yesterday 😢 if there is a God then why does he take good people...................
My father died bcoz of this disease 😭😭😭😭
Raj
So That’s what Stephen Hawking had Diagnosed
V knl
Jesus Christ is only way to escape MND disease pls go and prayer to Jesus Christ Amen
@DealsAlertDaily
Жыл бұрын
I m also playing for my mom And all mdn patients I believe Jesus Christ give back my mom
Who else is thinking of Stephen Hawking?
OMG, this is horrible.
medicine is a joke in most conditions.