Metabolites: the key to treating Alzheimer's? - with Priyanka Joshi

Ғылым және технология

Metabolites are small molecules that grow within cells and tissues, influencing protein structure and function to maintain life - and the way they function has implications for treating aging, Alzheimer’s disease, and long-COVID.
Watch the Q&A here: • Q&A: Metabolites: the ...
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Priyanka Joshi is a Research Fellow and Lecturer at University of California Berkeley, where she is studying the mechanisms of calorie restriction-mediated lifespan and healthspan extension. Her research interests combine the biophysics of protein aggregation with metabolism and aging to identify the molecular underpinnings of healthy aging and age-related neurodegenerative diseases. Previously, she was the Everitt Butterfield Research Fellow at Downing College, University of Cambridge and an independent postdoctoral research fellow at the Centre for Misfolding Diseases in the University of Cambridge with Late Sir Professor Christopher Dobson and Prof Michele Vendruscolo.
At Cambridge, her work elaborated on the role of metabolites in the aggregation of Alzheimer’s disease-associated amyloid-beta, and broadly on linking metabolite homeostasis with protein homeostasis. For her PhD work on designing a small molecule library to target intrinsically disordered proteins in neurodegenerative diseases, she was listed in Forbes 30 under 30 Science and Healthcare Europe in 2018 and 25 most influential women in Britain by British Vogue. She is also the Founding Team member and Chief Scientific Officer of NeuroAge Therapeutics, a pharmatech company that is targeting brain aging to reverse neurodegenerative diseases. Outside of research, she actively mentors and is involved in a range of outreach activities with school children and older adults in India, Africa, UK and USA.
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Пікірлер: 38

  • @dmd7472
    @dmd7472 Жыл бұрын

    I remember so many laughing with the Duke of Edinburgh saying “looked like it was put in by Indians”. One only need google to see the contribution of Indians to science. Thank you 🇮🇳 keep up the great work

  • @pushpkumar3906
    @pushpkumar3906 Жыл бұрын

    Wonderful talk. Keep it up Priyanka.

  • @savage22bolt32
    @savage22bolt328 ай бұрын

    27:55 so cool how she kept composure & handled the situation! "Sorry, I dropped an atom...."

  • @ForeignerD
    @ForeignerD Жыл бұрын

    Excellent lecture. Thank you

  • @yastikajoshi9860
    @yastikajoshi9860 Жыл бұрын

    I am so proud of you 🥺 You aced it.

  • @philipmurphy2
    @philipmurphy2 Жыл бұрын

    Great presentation and sorry for your loss.

  • @AnimeshSharma1977
    @AnimeshSharma1977 Жыл бұрын

    Awespiring talk! Wondering if sound can perturb metabolome in a predictable way? If so, can we map these specific metabolic patterns of change to the type of music?

  • @wktodd
    @wktodd Жыл бұрын

    Fascinating lecture, thanks

  • @MissMarilynDarling
    @MissMarilynDarling Жыл бұрын

    So terribly sorry for your loss Great lecture :)

  • @thomasbailey6328
    @thomasbailey6328 Жыл бұрын

    Wonderful! Well done. Running and cycling and skiing have always felt to me to be a for of dancing. And I am metabolizing in a positive way. Playing music comes to mind as a healthy way to engage our brain. Thank you so much!

  • @tracyhuber3290
    @tracyhuber3290 Жыл бұрын

    Great presentation

  • @carpathiangirl8460
    @carpathiangirl8460 Жыл бұрын

    Great lecture!

  • @mayankjoshi4043
    @mayankjoshi4043 Жыл бұрын

    So proud of you di.

  • @yianniskanellopoulos6719
    @yianniskanellopoulos6719 Жыл бұрын

    my condolences for your loss. Great lecture, amazing work. Thank you

  • @eric212234
    @eric212234 Жыл бұрын

    Is the volume really low on this or what?

  • @chinesewhispers1
    @chinesewhispers1 Жыл бұрын

    Fascinating and a fun ending. Would love Priyanka Joshi to do the RI Christmas lectures this year.

  • @savage22bolt32

    @savage22bolt32

    8 ай бұрын

    The two who gave us a quick salsa dance lesson were good sports.

  • @prasanna2589
    @prasanna2589 Жыл бұрын

    I can understand from this lecture that as "healthy diet and exercise" is a consistently prescribed practise for managing and averting a huge variety of ailments and diseases we should try to understand how these practices help in the regulation of various energy biomolecule metabolites and if there is a significant change to the transcriptome over a period of time i.e. if it is at all possible to alter our blueprint instruction conveying mechanisms. We should find out how different things in our day to day lives can influence these lasting changes so that we can manage them more precisely and tailor relevant practices to our lifestyles.

  • @benjamindover4337

    @benjamindover4337

    Жыл бұрын

    Yes we constantly hear about the importance of eating healthy and getting excercise.. While simultaneously not being able to afford healthy food and being told to stay inside because it's unsafe to leave.

  • @savage22bolt32

    @savage22bolt32

    8 ай бұрын

    @@benjamindover4337 we have to wear our mask and re-breath all the moisture & microorganisms..

  • @rajeevgangal542
    @rajeevgangal542 Жыл бұрын

    So in a nutshell, overexpressed metabolites need to be supplemented? Not inhibited?

  • @michaelogden5958
    @michaelogden5958 Жыл бұрын

    I spent a good portion of my working life studying human physiology, cell biology, and microbiology. That is to say LOTS of chemical pathways, including positive feedback and negative feedback, etc. I loved the stuff! Back when I had to outrun a dinosour or two on the way to the lab, the library (i.e., paper) was pretty much the only way to see what other perple were doing in order to avoid reinventing whe wheel and to get inspiration from related research. VERY time-consuming. It's good to see "whippersnappers" being able to make progress much more rapidly with the incredible access they have to relevant information.

  • @OorieLynch
    @OorieLynch11 ай бұрын

    Though there were many parts that I don't understand, being not very well educated, this video sounds more or less what I have always thought about the mechanics of cancer. My theory is that a gene is altered after getting hit by some sort of ionizing radiation particle and it tricks your body to produce the wrong proteins and due to a blockage (fats) or the lack of resources (illness) to remove the wrongly structured proteins, a tumor is formed. The wrongly structured proteins then accumulates and depending on what kind of protein that is, it may even be identified as hostile and is then attacked by your body (malignant).

  • @MrElvis1971
    @MrElvis1971 Жыл бұрын

    Nice video

  • @edgarcastillo2804
    @edgarcastillo2804 Жыл бұрын

    Very very engaging lecture. I saw the title and thought of my Granma, so i click it right away. She is like a little girl with 90+ years now but i remember when she could interact with me and her beloved animals.

  • @memeuchiha115
    @memeuchiha115 Жыл бұрын

    they’re not hiding it, they make you pay you can find it either way you’ll see the effect of this new 3 days ago

  • @MsElke11
    @MsElke11 Жыл бұрын

    In conclusion, more PROTEIN less PROCESSED FOODs and more MOVEMENT. The cure for ALL DISEASES!!

  • @flor.7797
    @flor.7797 Жыл бұрын

    so fasting should help

  • @flor.7797

    @flor.7797

    Жыл бұрын

    called it 36:00

  • @roscocsa
    @roscocsa Жыл бұрын

    Heart disease, lung disease, brain disease, liver disease. We really are a mess. I wonder if we don’t need yet another broad category, protein disease, or dna disease.

  • @sunahangrai3601
    @sunahangrai3601 Жыл бұрын

    i am feeling proud seeing an indian looking woman professor there in royal institution

  • @NJ-wb1cz

    @NJ-wb1cz

    Жыл бұрын

    Doesn't this imply that you consider "Royal Institution" to be is superior to whatever India has? Otherwise you would've instead felt that Royal Institution was lucky manage to get one of people of Indian ethnicity. This persistent submissive disposition of some Indian people towards England and the West in general is really peculiar. India hasn't been a colony for quite a few years already, and is already far more powerful than the UK

  • @sunahangrai3601

    @sunahangrai3601

    Жыл бұрын

    @@NJ-wb1cz there are millions of people having their individual perspective royal institution is historica*place where michael faraday and other great scietists appeared in the past do y!think RI is the only symbol of power ?

  • @NJ-wb1cz

    @NJ-wb1cz

    Жыл бұрын

    @@sunahangrai3601 when it comes to scientific history India is more important and foundational than England since Indian mathematicians created the entire basis for modern mathematics on which other sciences were built. Without India there would've been no Faraday

  • @NJ-wb1cz

    @NJ-wb1cz

    Жыл бұрын

    @@sunahangrai3601 I'm not even from India, it's just weird when people dismiss their own country that way. I have never seen English people do the same and venerate Indian history of scientific discoveries up to a point of being proud if an English person is ever allowed to speak in India

  • @nHans

    @nHans

    Жыл бұрын

    ​@@NJ-wb1cz Whoa-you've completely misconstrued the OP's words. He said nothing about dismissing his own country or considering the English as superior to Indians. Those are _your_ words-are you projecting or something? The RI has a reputation for providing a platform for high-quality lectures. Acknowledging it doesn't diminish any Indian institutions. The RI is highly selective in whom they invite to lecture. Not many people of Indian origin lecture there. We're all justifiably proud that Dr. Priyanka Joshi presented this lecture. Just as much as the contributions of other Indians. Our pride has nothing to do with past colonialism, economic and military power, history of math and science, or a "persistent submissive disposition." Those are your misinterpretations-and yours alone.

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