Summary: Mark D'Esposito and Andrew Huberman discuss the potential of dopamine agonists like bromocriptine in enhancing working memory and cognitive function. Mark explains that dopamine depletion impairs working memory and that dopamine agonists, including bromocriptine, have been shown to improve cognitive function in some studies. However, he expresses frustration that pharmaceutical companies have not focused on developing drugs to improve cognition, despite the clear potential and safety of these drugs. He also discusses the role of other neurotransmitters like norepinephrine and serotonin in cognitive function and suggests that a combination of these neurotransmitters may be more effective than single-target drugs. Mark emphasizes the need for further research to understand how different neurotransmitters interact and how individual differences in neurochemistry may affect treatment outcomes.

@SonOvThunder

Ай бұрын

Thanks bud

@carloscontreras3633

24 күн бұрын

@@SonOvThunderI’m not your bud….pal.

@Christian_Prepper

18 күн бұрын

🧐 *CONSPIRACY? Since "they", the "powers-that-be", already control the world and the majority of the money and resources, why would they ever want a drastically smarter general population with better memory?* 🤔 😂 *'No. Such cognitive and memory enhancing drugs are a threat. And improvement in intelligence and memory must be regulated.' - They (1912)* 😉

Someone recommended a good drug for memory to me the other day but I can't remember what it's called.

@davidt4053

Ай бұрын

Someone bought me a good drug for memory to me but I can't ever remember to take it.

@FloorTiles300

Ай бұрын

😭😭

@Syndr0me0faD0wn

Ай бұрын

Ba dum tss

@mariusle3385

Ай бұрын

Someone, uuh.. nevermind

@bigzachful

Ай бұрын

Dihexa, Idra 21, PRL 853, Bacopa, Cerebrolysin.

Extremely interesting. I will explore that topic further. Thanks

Beef, liver, eggs, tallow, butter, sunlight exposure, intense calisthenics, cardio and weight lifting.

@jakubolewicz4187

19 күн бұрын

Exactly. But also add good sleep, healthy vast social network and avoidance of toxins like alcohol / cigarettes.

@Christian_Prepper

18 күн бұрын

Also daily mediation, fasting and cold exposure.

@jakubolewicz4187

17 күн бұрын

@@Christian_Prepper Perfect, except I would change fasting for sauna. But I’m bulking so ymmv.

Interesting. Will need to dissect this more 💕

I would really be interested in your take on DNA expression tests from companies like Viome and using AL to calculate supplement needs to support areas with lower scores

hey thanks

Pharma may not be interested in researching bromocriptine and other mentioned agonists because they are currently cheap and easily assessable. Combining agonists might provide a path to an acceptable ROI - but one with risks of competition from cheap single source alternatives.

Bacopa monnieri, ginkgo may help ???

How is bromocriptine different from any other stimulants that increase catecholamine levels like adderall for example which is well known for its effects in memory and concentration?

Wasn’t the movie Awakening all about this? I met the British doctor about whom the movie was. He explained how it is hard to make that long lasting

How about NAC and Choline?

What about lion mane & choline?

Could you do an episode on mental health,anxieties, depression, ADHD, sleep etc and DNA testing? Mental health is genetic in my family. So is hypermobility, which is often found in people with the mental health issues I mentioned. Few months back i wondering how they were connected and the what could be done. Apparently it can be inked to genetic faulty Gene's like MTHFR etc. Which makes it hard for the body to convert certain nutrients into the usuable methalated form. Making you deficient and have mental health symptoms and poor collagen production. So will hopefully be getting tested to find out for sure. But maybe that all I need is a methylated form of a nutrient in a supplement like folate or b12 and not all the other harmful drugs that get chucked at us. I really hope I'm right. It would be a game changer for my whole family. Especially one of my brothers who has attempted suicide many times. Not saying it will cure it but hopefully make living more manageable. Would love an episode on this.

@bigzachful

Ай бұрын

Methylated nutrients helped me

@maxg.7337

2 күн бұрын

Would be interested on that subject too !

What about Cerebrolysin?

@janetstauffer9138

Ай бұрын

For sure!

Ketamine is pretty good

So it correlates with dopamin, i think everybodys household of dopamin is out of control due to quick and easy releases from media / technology / food etc. With the normal lifestyle we cant fix the root cause, so we need another drug?

From what I ve seen the trend is to mix 1 part hypocritaline with 5 parts alcohol and don't stare into the mirror too closely...no(?)-you re getting better already...!

0:40 what?

Andrew huberman 🎶🥁 Andrew huberman 🤍

Has the whole world lost its mind? A brave new world.

I wannit!

F the Pharmaceutical companies

A raise in testosterone will boost memory.

These drugs seem like they would be useful in treating cocaine, and similar drugs; addictions.

@janetstauffer9138

Ай бұрын

Perhaps GLP-1 agonists as well. Lots of research in that area coming out. Also, plant medicine.

9mebc

A healthy thyroid gland will improve memory. The rest is superfluous

@geekspeak1066

Ай бұрын

Close….its more accurate to say that improving a damaged or disease could improve memory.

@denisaleksandrovich6182

Ай бұрын

@@geekspeak1066 right

Pseudo science boy