Thnx for the tutorial, gotta try it on the basement kids.

@Chemiolis

2 ай бұрын

Tell them I said hi

@swastik3423

2 ай бұрын

@@Chemiolis 👍

@Willrocs

2 ай бұрын

Wtf 😂😂😂

@isaacthedestroyerofstuped7676

2 ай бұрын

Make sure they subscribe when they are old enough to graduate from the basement and use KZread!

@matthewellisor5835

2 ай бұрын

You peeps are effed up in your humour. I think I'll fit right in.

for some reason I have no agency in withholding how good this video was

@Chris47368

2 ай бұрын

Hey! Nice seeing you here! 👍 Agreed! 😂

@TheDexCrafter

2 ай бұрын

Curious who would could be behind this

@BillBird-df3pf

2 ай бұрын

It's because they all know damn well "truth serums" don't work.

@eustab.anas-mann9510

2 ай бұрын

Do you need a special license to buy these organic substances like thiourea?

@lordrichard64

Ай бұрын

What?

I love chemistry that’s firmly rooted in a legal gray area or loophole. Great video!

@Chris47368

2 ай бұрын

It's stuff like this that shows just how obsolete/ineffective the world wide prohibition stance has been. Thats also just ignoring the overall negative impacts these laws have on both individuals and broader communities as a whole!

@Sniperboy5551

2 ай бұрын

That’s how we got PiHKAL and TiHKAL… at least until the Federal Analogs Act

@InconspicuousOwl

2 ай бұрын

Username checks out.

@timecode37

2 ай бұрын

@@Chris47368But prohibiting barbiturates was rather effective wasn't it? Less people overdosed on them because doctors didn't hand them out anymore like it was candy, they just switched to Methaqualone if im not mistaken.

@chemistryofquestionablequa6252

2 ай бұрын

@@Chris47368 yep, people will always find a way to make drugs no matter what they ban. “Oh no, that’s a watched precursor? Just gonna have to make it myself”

Never in my life did I think that I would see a chemistry youtuber making barbiturates on main.

@hexagonist23

2 ай бұрын

Download the video, because youtube will probably take it down

@BillBird-df3pf

2 ай бұрын

Shhhh..... its "truth serum", which technically doesn't exist.

@alfredsmith1182

2 ай бұрын

Bets for this video being played in court just after thaiamylal starts appearing on the street?

@BigwestO328

2 ай бұрын

been searching for the tutorial recently

@420moby

Ай бұрын

YEAH

Quick correction for 1:01 : while this plant does belong to the family of nightshades it is in fact called datura and not nightshade.

@EddieTheH

2 ай бұрын

Indeed. Datura Stramonium.

@Chemiolis

2 ай бұрын

I'm just a poor chemist who doesn't know plants

@margodphd

2 ай бұрын

​@@Chemiolistis' alright, plants are scary even for biologists

@isaacthedestroyerofstuped7676

2 ай бұрын

One evil little plant, toxic, covered in thorns, but abolutely beautiful and the bees love it 😂

@SciDOCMBC

2 ай бұрын

​​@@margodphdI can't confirm this and I am a biologist (I don't mean the plant genus, but the fear of plants). Since I have now come out as a biologist I hope that I won't be crucified now. 🥺

Btw, if you want to skip a bunch of steps, barbituric acid isn’t scheduled in most places and can be bought on eBay.

@amanitaocreata4401

2 ай бұрын

Good to know

@baiseduezcke2295

2 ай бұрын

Yikes dude

@pieterveenders9793

2 ай бұрын

It's pretty limited what you can do with it though, no thiobarbiturates like the one made in this video, only the same 5,5-disubstituted barbiturates like 5,5-diethylbarbituric acid (aka Barbital), or 5,5-dipropylbarbituric acid, and 5,5-diallylbarbituric acid (Allobarbital). All the good ones have one short and one longer branched substitute at the 5,5 position, the short one is almost always either an ethyl or allyl group, and the longer one between propyl and pentyl.

@teknofreak2387

2 ай бұрын

Thats terrible…where?😂

@chemistryofquestionablequa6252

2 ай бұрын

@@pieterveenders9793 yeah, it’s limited but easy to get if you’re curious about barbiturates since they’re not commonly prescribed these days.

History fat: During Victorian England, many noble lady's had brugmansia (angles trumpet) plants on their tables. Although brugmansia is deadly poisonous and comes from the same family as deadly night shade, it also contain hallucinogenic chemicals (scopolamine included). The noble lady's would invite their 'friends' round for tea and would sprinkle some pollen into the tea, thus making them become more loose lipped and share more gossip. EDIT: Spelling ffs 😂

@ElPsyCongroo.

2 ай бұрын

I like how you edited the comment for spelling but still left "history FAT" in it lol

@blueredbrick

2 ай бұрын

I like that you forgot to end the sentence with a . Easy picking on the form and it's more difficult to go for the content and ideas someone is trying to convey. Add to that some ppl have English only as their second l, third or fourth etc language and just want to communicate and not get distracted by trivial typos. After all this is not the front page of a PhD thesis or with page of another book by a famous writer. Have a nice day. ​@@ElPsyCongroo.

@blueredbrick

2 ай бұрын

In that same era some woman in the upper class would also use droplets containg atropine (from the same plant family as you are mentioning) to widen the pupils as it was seen beautiful and fashionable. Today it is used still by medical proffesials when inspecting the eyes for various medical reasons, I cannot remember the exact list of medical conditions but I know it's still being used. Thank you for the info about the tea parties.

@ElPsyCongroo.

2 ай бұрын

@blueredbrick it's literally a joke, I'm not laughing at him committing a mistake, I just think is funny that he edited the comment for spelling yet he still left the most obvious one there. You don't need to take everything so seriously in life, and try to learn how to make better arguments because first of all, english isn't my first language either, and second, my joke was about him EDITING the comment and leaving it there, not because he had that mistake, and as you can see my comment is not edited.

@blueredbrick

2 ай бұрын

@@ElPsyCongroo. Ok it is a joke. Seems we got a little different taste of humour and that's fine. Body language doesn't arrive well though this medium either 😅, I'm sure seeing the twinkle in your eyes while you wrote the joke would made me grin as well irl. Tnxs for explaining.🤜🖖

Was a pharmacist for a long time and you’re the first person I’ve seen get the mechanism right when it comes to the difference between benzos and barbiturates (i.e. particularly the channel duration part) And the physiology side was just context for the rest of the video, nice work chief

I really love how you go threw each step of what is going on in each part of the reaction.

@nervonabliss2071

2 ай бұрын

Love it when reaction mechanisms are included.

This guy is literally teaching how to make psychoactive substancea on youtube. This is amazing.

“Barbiturate synth speed run” has got to be the most niche thing I’ve read all day 1:27

@BillAnt

2 ай бұрын

Put the video on slow-mo if the speed run is too fast for ya. lol jk Chemiolis' humor is one of the best among YT chemists, and the reaction mechanism diagrams are the cherry on top. ;)

Best chemistry content on KZread right now

@timecode37

2 ай бұрын

Poor Mans Chemist is the best one, don't @ me🥸😤😤😤 at least when it comes to inorganic chemistry and 'fumehoods'

great video. unavoidable yellow chemistry strikes again

@jonpopelka

2 ай бұрын

*an Aussie backyard chemist has entered the chat*

@barfbot

2 ай бұрын

@@jonpopelka the shed is on borrowed time innit

@davysmith1934

2 ай бұрын

Dammit, it's yellow!

You always know it is going to be a good one if there is a disclaimer before the video

next up: making an ADHD medication ;)

@williamackerson_chemist

2 ай бұрын

Hahaha haha but seriously it's some of my FAVORITE chem of all time no joke... it's so beautiful in person

@christianterrill3503

2 ай бұрын

Making ADHD meds from KHAT

@christianterrill3503

2 ай бұрын

​​@williamackerson_chemist amphetamines? I saw my old heroin dealer recrystalize 4 oz's of methamphetamine once that he had cut to add weight. It was kinda like making rock candy without the string lol HUGE crystals

@PotionsMaster666

2 ай бұрын

This ❤

@Mp57navy

2 ай бұрын

Lithium. You're welcome.

Are you aware that 2-pentanol isomerizes in hydrobromic acid via a 1,2-hydride shift to generate a mixture of 2- and 3-bromopentane? The only way to prepare pure 2-bromopentane is via phosphorus tribromide in anhydrous conditions. See 'Preparation of 2-bromopentane" in Journal of Chemical Education.

@colin351

2 ай бұрын

I'm unsure if it happens with this particular side product, but certain barbiturate derivatives, made by tweaking the side chains only slightly, lead to toxic compounds with strychnine-like convulsant activity. This, along with things like your materials rearranging unexpectedly, show how drug syntheses can go awry if you don't know exactly what you're doing.

@Quinazolineking

2 ай бұрын

@@colin351methyl on nitrogen like hexobarbital indeed, strong muscle spasms in high doses

@Quinazolineking

2 ай бұрын

Not under strong acidic conditions big boy

@vooooooooooooo

2 ай бұрын

I agree

@WVWYONATANWVW

2 ай бұрын

@Chemiolis

Welcome to the watchlist

@blueredbrick

2 ай бұрын

Way past that, I'm proud of my collection of watched videos. Ever since a kid I knew I was going to become a scientist and engineer and still love learning about the world. Never hurt a soul and nevel will. Having knowledge is not the same as doing inappropriate actions with that knowledge. Science, physics chemistry social topics are plainly interesting. And the specific information presented here is open information for anyone to read. It Is a pity that indeed the most loved visual forum on the planet got more rigid risking of trowing out the baby with bath water. By sometimes pruning to actively to be (trying) a good boy or girl. Like another person mentioned it is wise to get the well made content on a local drive for archival purposes. It might even help the platform getting it back when cosmic rays happen to cause memory loss. I'm being playfull with my wordings obviously.

@alextrebek5237

2 ай бұрын

@@blueredbrickcope. As your Agent, I can confirm

Im really loving this new video format of yours, where you explain the history of the compound and what effects rgey have on human body

It is fantastic to see the evolution of your channel. greetings from Spain

I’d like to say it’s extremely unethical to use truth serum to extract information. It also has to problem of making people admit to crimes they never committed by causing an altered state of mind where they’ll essentially agree with no ability to disagree because those centers are shut off.

@redactedname5038

2 ай бұрын

Shut up, nerd.

@crppledizzle9374

2 ай бұрын

I'd like to say 🤓

@gaelr.s7123

2 ай бұрын

muh ethics for criminals

@crix_h3eadshotgg992

2 ай бұрын

What the fuck are these dumbasses in the replies doing here

@rangerrick5660

2 ай бұрын

Thank goodness our government usess it on us to find the bad guys beyond a shadow of a doubt. Just like the good ol polygraph

At first I was thinking, “This might not should be on KZread”, but after getting stuck on the first step, I think if you can follow this, you already know how to make it. I had one of the sodium drugs for oral surgery about 45 years ago. Absolutely terrible drug for that use. I woke up in a room full of knocked out people feeling hung over. Going to the dr was more dangerous back then.

The main source of scopalamine is the plant is Datura aka thorn apple, devil's apple, or angel's trumpets. Wouldnt recommend chemical synthesis unless you take extremely severe precautions it is wickidly potent.❤

@The_alchemistress

2 ай бұрын

Datura is honestly one of the scariest deliriants out in the world and it’s crazy how some people will take it recreationally as a psychedelic

@chemistryofquestionablequa6252

2 ай бұрын

That stuff grows wild all over here, scary stuff.

@Chris47368

2 ай бұрын

​​​​​@@The_alchemistressDatura(and similar "drugs" of its deliriant class) are not even psychedelic...they just induce what is essentially a state of psychosis... Lol. That's also not to mention how freaking dangerous deliriants as a whole are! There have been many deaths attributed to deliriant use - mainly via having fatal seizures and/or fatal heart arythmias. Even assuming that one is not hospitalised or die from an experience: I have even heard many stories of people taking a single "recreational dose" of a deliriant and still having residual effects like weeks to months later! Overall: They are a terrifying drug classification 😬 For anyone who wants to have an actual psychedelic trip IMHO: It's more worth risking the potential legal consequences of obtaining an actual psychedelic, than risk being hospitalised or worse....not that psychedelics are 100% safe mind you(as with most drugs), but still atleast a magnitude safer than any deliriant...i mean heck, even something as notorious as PCP is a walk in the park compared to a deliriant 😅

@christopherleubner6633

2 ай бұрын

@The_alchemistress yup it is beyondvhorrifying, yet very small doses well below the delirium threashold are used medically to help with motion sickness and nausea in general, I've seen people use it to get high off of and one ended up going crazy, totally LOSING IT at a Quick Trip, at first they were actibg drunk and guzzling the soda then started screaming and taking their clothes off,, breaking stuff, growling like an animal attacking one of the workers,, cops got called, he got tased, pepper sprayed and kicked a cop so hard they flew through the glass on the door and he almost shot. Took 6 cops to arrest him. That drug will do you. 💀💀💀

@masonga1995

2 ай бұрын

I think everyone in that kinda scene knows someone who was never quite the same after a nice cup of home brewed datura flower tea (do NOT try this lol)

Amazing video I love to see that kind of synthesis

I have no clue what you're talking about when explaining the reactions but I love what you're doing.

@BillAnt

2 ай бұрын

That's actually the best part, make ya think. ;)

Hey where do you get those non-rearranging carbenium ions? Would have loved to have those back in my day ;)

you can properly implant memories with this stuff so they can convince you that you buried a body that didn't exist

@tessxu8367

Ай бұрын

😂

@AKuTepion

Ай бұрын

Jokes on them then, I have burried many bodies in my garden.

Awesome video, like always. Quick question though: why not reverse the alkylation order and do the reaction with bromopentane first? I suspect it would give a better yield due to less sterics since malonic enolates are rather moody when reacting with secondary alkyl halides if they already have other stuff sitting on them.

@captainkyle1158

2 ай бұрын

I like your funny words magic man

Great video, I like the mechanisms

Best chem KZreadr by far

Thank you Chemolios Now make some Quaalude

@janoutuber1069

2 ай бұрын

Waiting for OxyMorohone synthesis 🔥🔥🔥

@FriendlyChemist907

2 ай бұрын

Actually a fairly easy synthesis. Im surprised more clandestine chemists dont do it

@chemistryofquestionablequa6252

2 ай бұрын

@@janoutuber1069oxymorphone is pretty easy, assuming you have a source of one of the opiates it can be made from. Total synthesis is just not worth it, it’s something like 16 or 18 steps with an overall yield under 5%.

@DeltaReviews420

2 ай бұрын

@@FriendlyChemist907 they do check r/theehive

@pieterveenders9793

2 ай бұрын

Haha, that's banned under Dutch law, so no way Chemiolis will be making that ;-) there are however plenty of other qualones besides Methaqualone which are not covered under the Opium Law.

I have a question about N.I.A.S. (Non Intentionally Added Substances). Is it common that during the process of making substances NIAS are produced? And are they avoidable?

Ok can you explain how they make stuff sterile and safe for injection? Also what would happen if you were to snort the solid form of this instead on injecting the liquid?

Man ive always thought barbiturates are so neat. Great vid.

Chemiolis is the best channel! Wait is that truth serum working on me?

The ending was really cool 👍🏻

What was your yield before the recrystallization?

Just made my day

I love the history lesson in addition to the chemistry part

how match of the side prodact, 3 bromopentane, do u think u made?

Superb video..Good job

Thanks, Chem-olius!

Never thought I would ever see a full video on this, the massive balls on this madman! complete with reaction mechanisms and the sodium ethoxide reaction I’ve been dying to see no less! Brought a tear to my eye seeing sodium metal getting used for anything other than throwing it in water 🥹

Hahaha!!!!! Awesome!!! You are my hero, once again Thanks for an awesome upload!!!!!!

Why doesn't the allyl chloride get attacked by the other resonant structure of the deprotonated malonate (charge on the oxygen), forming some sort of ether?

Great video illustrating the principles very well! Only two questions: why the different solvents and bases used? Would NaOEt/EtOH not work for the allylation? And why the specific order, why not start with the bromopentane?

@aman_2002

2 ай бұрын

To stop byproducts.

Hey there! Can someone link the paper he used in this synthesis? I need it for a college class.

wait can some one explain why the more stable resonance structure of the intermediate in the reaction with the allyl chloride wouldn’t predominate and then the oxygen would attach the allyl chloride knocking off the chlorine and forming an ether. sort of like the williamson ether synthesis mechanism. i’m curious

😵‍💫 ok i admit it. It's True. I get confused between Chemiolis and Chemdelic 😟 so i usually stick with Extractions & Ire and Amateur Chemistry 😂

1:53 what is the difference between the Na notation regarding the positioning of the + symbol?

@Chemiolis

2 ай бұрын

It's an error, it should be superscript

The end is gold 😂❤

Bro’s literally the most chill super villain to ever exist

Mechanisms are soo clean 🧠

Haven’t gotten to the reveal yet, is it propofol?

You broke all your separatory but in second work up you got it.😂 On a serious note, please make video on crystallization techniques/precipitation of compound from crude, so that chemist can avoid columns/RP purifications/lyophilization.

This guy does not miss

So is it legal to synthise and not use? Or do were u just not going to do a shot of homade barbiturates?

Good job and yield!

What is that stock footage in the beginning

Amazing video

Man you read my mind. I thought today about how to make barbeturates and voilà ahaha

@rattmcpossum

2 ай бұрын

Legit same lmao I can’t wait for the next video: “making secobarbital bc I’ve given up on trying to keep it legal”

Truth serum? Just give me 6-7 drinks, i'll tell you stuff you don't even wanna know

@LindseyBunting

9 күн бұрын

lol same here!

I don't understand much but I still watch your videos. I hope one day I can be as knowledgeable as you✌️

@justinwatson1510

2 ай бұрын

Janice Gorzynsky Smith made an excellent organic chemistry textbook. If you buy an old copy then work your way through the book, drawing all the examples yourself and working though the homework problems, I honestly believe that it's a subject that a motivated person can teach themselves. It would help if you did the same for general chemistry prior to trying organic, but I cannot recommend a good book.

Selling instructions on the DW is something you should consider

@ashe1.070

2 ай бұрын

Why would anyone do that when Rhodium, The Hive, etc. exists?

Was that stock footage in the begining?

why you have those messed up graduated cylinders? can i send you some replacement glass pieces? what do you need?

@m7rtim532

Ай бұрын

Not today cia

I know this is pretty simple chemistry. But I would have liked to see some type of characterization, nmr, barb test, anything. I would have also enjoyed seeing a proper recrystallization.

so you live in the netherlands... where can i buy it?

I thought thiamylal was a List II drug under the Opiumwet? Or is that the non-sulfur version amobarbital?

@JohnnyBGood-cv1bg

Ай бұрын

Dunno, dude. Sounds like the perfect question for g o o g l e.

I legit made this a year ago for my bachelors project but messed up halfway thinking i made the product but instead made some realllly flammable substance that caught fire...

@Chad-Giga.

Ай бұрын

Lol

@AKuTepion

Ай бұрын

That's how many big discoveries have been made. Keep messing up!

Legend.

And Chemiolis definitely did not party later on with this potent recreational euphoria inducing GABAa receptor modulator.

We cookin tha fire tranq dope with this one bois!

8:15 this reaction follows the same principles as a michael addition, would it be classified as a michael addition or is it something slightly different?

That´s some good stuff

@Angusticlavius

2 ай бұрын

Any plans to make barbiturate analogs yourself? I remember you had a video on barbituric acid. Or maybe something like suxamethonium chloride?

Can you not buy a used rotovap? I feel like you always end up doing a short path vacuum distillation.

Will it work on my cat?

@definty

18 күн бұрын

There's only one way to find out!

Thanks, now i can extract truth from myself

It`s better to use MTBE for extraction from DMF/water mixture. Then with som brine washing you can get rid of DMF completely.

Can you make allopraganolone derivatives?

I wish we could see you test certain substances on yourself. If I had the means and confidence in my understanding of what I was doing, I'd give it shot lol it feels like unlocking a cheat code in a video game

@manitoba-op4jx

2 ай бұрын

i don't want him or anyone to test things on themselves unless they can be sure it's not dangerous

@CarbonatedGravy

2 ай бұрын

Doubt that would fly on this site if this vid even does long term, but to safely do that You at least need an HPLC/GCMS to make sure your product is pure and there are no toxic side products you accidentally produced or didn’t filter out/neutralize entirely. Im sure this guy has access to chromatography equipment and could do so, but posting it online would also possibly encourage your viewers to consume their own reaction products and knowing some governments, could possibly see you held liable for the next barry kidston that gets messed up and dies from doing exactly that. He ended up giving himself parkinsons from something as simple as the temperature being a little too high in one of the synthesis steps creating a previously unknown toxin that attacks dopaminergic neurons. Surprisingly rare thing to happen but it’s a risk nonetheless

For years, I had wondered what the yellow liquid was that was given to me i.v. to induce general anesthesia for eardrum reconstruction as a teen on the mid 1990's. I believe it was Thiamylal. I have never seen it used since I became a nurse in 2010 in the U.S. as mostly Propofol + Dexmedetomidine + Lidocaine is used or occasionally, Ketamine and Etomidate for i.v. anesthesia induction alongside other meds. Propofol and Etomidate both really sting compared with barbiturates, which are hard to find for human anesthesia currently.

@Quinazolineking

Ай бұрын

Interesting!

Thank you. I can finally make those cia glow in the dark talk now

Could you make modafinil or the likes?

hypothetically can you use truth serum on yourself to help yourself remember an event or moment in your life that you only have faded details about?

@bentuttle9170

2 ай бұрын

No, only stuff you actually know could theoretically end up coming out.

@lavahawk

Ай бұрын

​@bentuttle9170 I mean you can know something but have it deep within your memories. But yeah it doesn't make sense those would occur

@dinadaughtry8993

Ай бұрын

​@@lavahawkDelsid might

Bro really read my mind

Correct me if I'm wrong but I believe that it's the datura flower, not night shades that produce scopolamine.

@thecavesys107

2 ай бұрын

Datura is a genus of nine species of plants belonging to the nightshade family

@allx7912

2 ай бұрын

@@thecavesys107 my mistake I was misinformed. You're absolutely correct.

@thecavesys107

2 ай бұрын

​@@allx7912no worries :)

How the hell do you have access to all of this??

Bros literally the most chill super villain to ever exsist

Hi Chemiolis, great video. However I noticed that you labelled your bottle of 2-bromopentane ‘2-bromopentanol’! I hope you don’t end up using the wrong reagent in a future synthesis! Thanks again for great chemistry content

Does your diethyl malonate have an odor at all?

@bromisovalum8417

2 ай бұрын

it should, it's used in perfumery, smells like apples and grapes

I love your creativity you have for these videos and bravery to get yourself certain attention from "some" organization. 😅😂

please make a follow up video testing it

Blue screen, nice analogy

Great video! My Grandma had brain tumors. She used barbiturates after surgery or before? I'm not sure, I was just a kid. After she died, we found a 20 year old rx bottle of a barbiturate. It had 1 pill left.

@Quinazolineking

2 ай бұрын

Which

@side3672

2 ай бұрын

@@Quinazolinekingludes

i know its unlikely, but id love to see some examples from Pihkal or Tihkal i think theres a divine moments of truth molecule in there too!

You said it right

Slay girllllll 💅

@kebabchlorate

2 ай бұрын

Slay

Technically any gaba a agonist could be used as truth serum including alcohol. Xanax, clonazapam, diazapam, etc. Could all be used as truth serum. Pretty much most barbituates could be used as truth serum as well. Gaba agonist have tendency to lower inhibitions, making it easier to say/do things you normally wouldn't say or do. The issue Is your intoxicating an individual will means your altering there mind state. They may be telling the truth, or they may not because there so intoxicated. So there not really a good way to see if the person is truelly telling the truth

Love that this vid showed up a soon as I took my barbies

Found it. Thanks