I feel like im cheating on NileRed by watching this

@brooklynsoleil-iq7sk

10 күн бұрын

Underrated comment

@craigjonker7245

9 күн бұрын

Dont diss daddy red like that (jesus christ that sounds fucked)

@yung_megafone

9 күн бұрын

​@@craigjonker7245It's no homo because Nile is bro bro

@Alleroc

6 күн бұрын

Not your fault he doesn't make content like this much anymore. Much as I enjoy his content when it comes out, it's definitely not like this anymore.

@Cikeu1234

5 күн бұрын

If nile red posted more videos i wouldnt need to find these other channels

Hell yeah, government banned food additives are the bomb!

@chrisporter4286

8 ай бұрын

Make root beer with Chemiolis's cyclamates for the ultimate government banned collab 😎

@kylehurly6420

8 ай бұрын

@@chrisporter4286 we seriously need a collab between these two, they're probably the best new chemistry channels on youtube

@MandrakeFernflower

8 ай бұрын

Cyclamate and saffrole root beer

@SelectHawk

8 ай бұрын

Forbidden flavors

@donnymcgahan1158

8 ай бұрын

I was going to say do banned drugs next. Root beer is that drug

"I don't see the value in swallowing" Chemiolis, 2023

@MandrakeFernflower

8 ай бұрын

*click* noice

@williamkane

4 ай бұрын

I agree with him, it tastes bad, so just pump it into the cervix.

@Ignisan_66

3 ай бұрын

Fully agreed. It destroys the male gametes.

Definitely should make the sweetest known compound. What a great video idea!

@littlecook5960

8 ай бұрын

You could even say a sweet video idea

@antares8826

8 ай бұрын

Doesnt look too hard to synthesize as well, so let's go :D

@Coecoo

8 ай бұрын

Considering how many generations have been completely and utterly wrecked by the overabundance of sugar and high fructose corn syrup in everything essentially crippling 20% of the planet, we need solid safe sweeteners ASAP.

@Alsry1

8 ай бұрын

@@Coecoo or people could stop eating sweet things. though expecting self control from people is hard.

@Coecoo

8 ай бұрын

@@Alsry1 While self control is an aspect of it, i suggest you visit an average grocery store and look through all the products to see what DOESN'T have some form of sugar in it.

You should try to dissolve each into an unsweetened lemonade or something, in quantities normalized to their potencies, and compare the tastes...

@liar-888

8 ай бұрын

That would be a good video

I’m always amazed by how many artificial sweeteners were accidentally discovered due to poor lab hygiene practices.

@nothanks9503

8 ай бұрын

Oh no I mixed these 2 carcinogens Tastes it 🤑

@JohnSmith-ox3gy

8 ай бұрын

Yeah, by "accident". Right. You've never had the thought "I wonder what this new substance tastes like?".

@markiangooley

8 ай бұрын

Supposedly, sucralose was discovered to be a sweetener when a chemist was asked to test it but misheard that as “taste it” and did.

@pickleadaykeepsthedoctoraw5542

8 ай бұрын

Chemists in the earlier days used to taste test a lot of their products. It was actually a pretty normal thing to do. I do wonder how many chemists died from cancer/other diseases early in their life due to this.

@James-ly3rx

8 ай бұрын

Red Loctite is a sweetener. Ask me how I know.

just realized that chemistry is basically extreme baking

@Thegingerbreadm4n

24 күн бұрын

JESSE WE NEED TO COOK

@user-rj9pc9px8n

15 күн бұрын

Its the other way around. Cooking is chemistry.

@willbe3043

12 күн бұрын

@@user-rj9pc9px8n But cooking evolved first!

@HourRomanticist

11 күн бұрын

Baking is basically chemistry

@MintyArisato

6 күн бұрын

@@user-rj9pc9px8nthat’s baking - you can afford way more accidents in cooking but baking is unforgiving, just like chemistry

Banning an artificial sweetner that has dubious studies showing that it might be toxic, but keeping all of the obviously toxic things in other food, is the most USA thing that I have ever heard

@mpk6664

8 ай бұрын

*Laughs in saccharine*

@mpk6664

8 ай бұрын

I'm still pissed that sassafras is banned. My poor root beer.

@damonroberts7372

8 ай бұрын

@@mpk6664: 100%. The ban on real root beer is outrageous.

@FlyByWire1

8 ай бұрын

Europe is the KING of banning ingredients that have very little evidence of harm. Lmao

@trippyvortex

6 ай бұрын

​@@mpk6664since when? Wtf!?

"You know it's gonna be good because it has a funny color". If you ever wonder why there are so many warning labels on cleaning supplies, this is it.

That 1.2GHz NMR is just hot 🥵 🥵 🥵

@TheBackyardChemist

8 ай бұрын

Hopefully not the magnet itself, that is a *bad* day when it happens

Testing for cancer in rats is maybe the worst way since rats are tiny cancer factories. Lab rat populations genetic diversity is also tiny which has caused poor reproducibility in humans and other animals.

@Thaumius

8 ай бұрын

GL finding brave humans to risk their lives to be tested on chemicals

@Natediggetydog

8 ай бұрын

It wouldn’t matter what kind of lab animals were used, they would’ve found a way to make those artificial sweeteners illegal since the studies were funded by the sugar industry

@mnxs

5 ай бұрын

​@@ThaumiusI doubt that's the point; rather that it would be beneficial to introduce more genetic diversity into rat models

@user-rj9pc9px8n

15 күн бұрын

​​@@mnxsThats like saying our measuring instrument is too sensitive, we need a less sensitive one. I mean there are mole rats that never get cancer. Why not use them and prove that nothing is cancerous?

The most potent one you made here, according to the German Wikipedia Article has a slight local anesthetic effect. So that raw feeling you had in your mouth afterwards was definetly that stuff. It literally knocked-out your tastebuds 😬

I love when he’s trying to explain how these reactions work “I like your funny words magic man”

@kawaiiintelligenceagency3889

4 ай бұрын

Yeah I'm like Oh nice I know the markovnikov addition. Then this guy pulls up with the most complex reactions I ever seen

I was expecting lead sugar. Man didnt even entertain the idea of low hanging fruit and went for the beakers as fast as possible.

@pickleadaykeepsthedoctoraw5542

8 ай бұрын

Fun fact: Lead paint chips taste sweet. So if the paint is sweet, it's probably lead X_X.

@Patrick-857

6 ай бұрын

Mmmm lead acitate. Yummy.

@user-su5uf5yv1w

5 ай бұрын

Coconut milk.

damn, i’ve always wondered what the worlds strongest sweetener would taste like. apparently you’ll be able to taste it for weeks

@user-su5uf5yv1w

5 ай бұрын

Ethelyne Glycol is like Red bull energy drink gives you wing's literally never had to use it Thank God. Coffee should only be slightly carcinogenic pumpkin flavor pumpkin spice.

The FDA bans items that are proven to not be carcinogens and approves items that are proven carcinogens. Sickening

@nee3029

8 ай бұрын

I love my three meals a day that consist only of glucose syrup

@WhereToby

8 ай бұрын

It’s messed up, not enough people know about it

@Oroborus710

8 ай бұрын

It really shows you where their true agenda lies... Like almost all other government sects, the focus is mainly on profit and control.

@Dial8Transmition

8 ай бұрын

Shut up and eat your grains

@keelo-byte

8 ай бұрын

Defund the fda and just let the drug companies decide what's best for everyone.

11:10, man thats how i know youre the real deal. showing the most likely transition state just based on the electron withdrawling nature of the two competing groups... since they can both technically donate electrons but the alkyl moiety on the para posistion would win over the withdrawling carbonyl moiety inside the amid. I wonder how much of these mechanisms is just you yoloing your sage ochem intuition... papers never get specific enough about every transition state in every theoretical reaction scheme. its been a long time since ochem for me, but i remember when i used to have a sliver of this ochem intuition. hopefully by watching your really well made videos i can get some of that back. keep them coming. youre more giften than the average viewer knows to gives you credit. thanks for uploading man

The way you describe in minute detail what happens on the molecular level is fascinating and I'm googling my ass off to understand it and that's how you learn new things!

@kid_missive

8 ай бұрын

You will probably need a book if you want to make much progress there. I've taken a degree worth of chemistry and organic synthesis is devilishly hard for me (and most people, including chemists). I've had to re-teach myself basic organic chemistry twice since then working in industry. But some people have a knack for it and it's just so beautiful so it's rewarding at the same time.

@kid_missive

8 ай бұрын

@Daniel_Meyers Well, as with a lot of math and science, you need to do problems in order to really get a handle on them. Clayden is the definitive O-chem bible and super fundamental. Handles concepts super systematically and organizes everything properly, but I probably would not recommend it to someone learning it for the first time. Way too dense and challenging.

@prathyushareddy9404

8 ай бұрын

​@Daniel_Meyershow about organic chemistry by Solomon's And Fryhle?

You should do a similar video about making banned food dyes! I find it very interesting that Canada and The USA still allow a lot of dyes that are banned in many other countries and it would be very interesting to learn more and get a better understanding of what we are putting into our bodies!

@dogbot55

7 ай бұрын

Titanium is good for you, keep eating skittles, don't even worrrrry about it

Amazing, thanks for putting your taste buds on the line for us!

I like how you mixed in some funny words here and there 🤣

i came for the chemistry.. i stayed for the fancy stir bars.. only ever seen the pill shaped ones.. so this was interesting in many ways.. happy brain :)

greaaat pls do the sweetest sweetener. would be sweet ig. maybe even synthesise the most bitter and hot compound to have the squad together

@Zelbozo

8 ай бұрын

Combine and consume them all for an achievement

@Auroral_Anomaly

8 ай бұрын

@@ZelbozoAchievement get: how did we get here?

@Qmeister044

8 ай бұрын

​​​@@Auroral_Anomaly* wakes up in Explosions&Fire's shed *

@pickleadaykeepsthedoctoraw5542

8 ай бұрын

The super bitter compounds are usually extremely toxic. Even the ones we use to this day are still VERY toxic, it's just you don't need very much.

Absolutely yes, make the most potant sweetener known 😁😁😁

@headphoneguy9086

8 ай бұрын

I would really want to see a synthesis of lugduname

Could team up with nile red and make forbidden diet grape soda

@user-su5uf5yv1w

5 ай бұрын

Lead acetate or ethelyne glycol terrifying sweet dangerous deadly Suicide soda would be good name.

Here's something interesting about overloading tastebuds. I once got an especially strong stalk of rhubarb and lost my taste for a week. It was... different.

You should synthesize L-Glucose, or even L-Sucrose (β-L-Fructofuranosyl α-L-glucopyranoside) if possible. They're supposed to taste the same as the D isomers but no biological caloric value. Plus the Sinistrose would be cool trade name 🙂. I don't think they're *banned* per se, but they're probably not certified for use either, since they're so much more expensive than the D isomers which you can find everywhere. I personally hate artificial sweeteners since they linger so much longer than normal sugars. I think L isomers of the same molecules would not have that problem.

I’ve never been as confused as I was just now when listening to you explain the chemical process of these sweeteners. But it sounds very scientific and smart so I really enjoyed listening to it

Babe wake up!!! Chemiolis just uploaded!

Man you're amazing! Really helps when it comes to understanding why people use some reagents in organic synthesis and understanding some mechanisms too. Thx man, for real, learned a lot from this video!

They all look nice and clean! Good work.

I want to commend you on your technique. I especially like the addition of ice directly in the first rx's dilution. I really appreciate all the effort you put into this video. I'm a Biochemist myself, and I know how difficult finding good synthesis pathways can be. Especially when working with food additives (and pharmaceuticals). Also, let's hear it for that thick-ass stir bar!

I need to try forbidden orange nitro sugar

You definitelly should make the supersweet nitrile compound. It looks beautiful.

Amazing how many reactions can be accomplished with Nucleophilic Replacement. I only took Ochem 1 but I’m amazed at how well I could follow the Ochem here. Cheers!

So cool going through the organic chemistry sequence and all of this starting to make sense.

@FinalFanatsylover

3 ай бұрын

Fr

great chemistry with mechanism keep it up bro

I love substitued nitroanilines, i had to make some for my Msc thesis and they all have such a nice color (usually yellow-orange), they are the best.

Great video as always thanks for sharing

I made and tasted Lead Acetate before. It is far too good for how toxic it is.

@user-su5uf5yv1w

5 ай бұрын

Ethelyne Glycol also far too sweet unfortunately. Sugar of lead dangerous. Corn syrup. Sorghum. Sugarcane.

I had no idea you could dissolve sodium metal in ethanol. Does the dissolved sodium still react violently with water? If yes: that would make for a pretty gnarly weapon, imagine getting "maced" with liquid sodium ☠️

@ejkozan

8 ай бұрын

it is not dissolving, you react it with alcohol. In case of water addition it just reforms alcohol and sodium hydroxide, no hydrogen production, as you do not have sodium in this solution

@ashe1.070

8 ай бұрын

Not really. It’s forms sodium ethoxide with is like sodium hydroxide, but stronger. When mixed with water it is still exothermic though

Super! Thank you very much!

Or you could try going the opposite direction and make denatonium benzoate and maybe some other super bitter compounds.

7:30 slight correction, the bromine-carbon bond is not easily attacked due to the polarization. In that line of thought, a C-F bond should be even more reactive, which would be bad news for all of our PTFE-lined pans. In the end it comes down to orbital energy levels and overlap, the latter of which is particularly low in a C-Br bond

@ams8399

8 ай бұрын

Okay genius bet you did this experiment yourself

@ams8399

8 ай бұрын

Sorry i just tried understanding what you said and used my 12th grade chemistry book to understand it.. And somehow it does make a bit sense.. I didn't understand it completely.. Hopefully someone teaches me more about it

If the strongest sweetener is neotame, you should totally make it. Neotame is cool!

@diablominero

8 ай бұрын

@Daniel_Meyers that's epic! I didn't know they'd made an even better one.

@damonroberts7372

8 ай бұрын

Lugduname, developed by researchers at the University of Lyon, is claimed to be 220,000-300,000 times as sweet as sucrose. But unlike Neotame and Advantame, no word on whether it's ever likely to be approved as a food additive.

@damonroberts7372

8 ай бұрын

@Daniel_Meyers could be a range of reasons... maybe safety concerns, maybe _too_ sweet to be of practical use as a food additive. A PubMed search only retrieves a single article, which isn't particularly helpful.

What an awesome NMR Machine that was!

The way you talk about the history of certain chemicals is very entertaining

Absolutely the sweetest known compound!!!

I really need a video about your stir bar collection

Absolutely make the strongest one. I am very curious! And thank you for this video!

I just synthesized Dulcin last semester in organic chemistry lab

That was very interesting. Would you by any chance consider making lugduname or sucronic acid some time in the future?

The similarity between dulcin and Tylenol Can explain the mild sweetness that tylenol has.

Thank you for this great video! I would be interested to see if you used proportional amounts (based on the sweetness) in a liquid (like water, tea or coffee) if you could notice a difference maybe using a fixed amount of sugar as a control. I would imagine you could swish and spit them to minimize any potential harm too.

Geweldige video's maak je man👍 door jouw uitleg met reactie vergelijkingen erbij snap ik echt wat er gebeurt. Hoop nog veel video's van je te zien in de toekomst😊

"But now I want to install something else there, so it has to fuck off." - Absolutely love the humour of this guy, and how straight-forward he is with all his synthesis steps, no bullshit, no clickbait, just content - this channel reminds me of early 2010's KZread, where swearing wouldn't get you demonetized instantly, where gender debates weren't a thing yet, where we didn't have all this drama - a much better time for sure. Stay the same, Chemiolis, unless it's positive changes - you earned a new subscriber for sure. Much love from Germany❤

I've always wondered how you deal with all the used solvents and failed reactions, i think it would be a great video!

@sotetsotetsotetsotetsotet2379

7 ай бұрын

You dilute them to an extreme degree

@smoothbraindetainer

7 ай бұрын

​@@sotetsotetsotetsotetsotet2379no you drink them

I know every step was explained, but this is just magic

"Three banned that all tasted sweet, amazing". - Chemiolis, 2023

You give people who work harder more credit to causally encourage hard work in the future.

You just gotta Love the title

24:40 Ok, so would the amine + urea -> N-substituted urea reaction work with thiourea as well? Or just with thiocyanate directly. I'd love to turn taurine into the thiourea and try if it works as a copper plating brightener.

Cool video!

Any intresting smells during the synthesis or from the products?

Monatin, commonly known as arruva, is a naturally occurring, high intensity sweetener isolated from the plant Sclerochiton ilicifolius, found in the Transvaal region of South Africa. Monatin contains no carbohydrate or sugar, and nearly no food energy, unlike sucrose or other nutritive sweeteners.[1] The name "monatin" is derived from the indigenous word for it, "molomo monate," which literally means "mouth nice."[2] Monatin is an indole derivative and, upon degradation, smells like feces.[3] It is 3000 times sweeter than sugar.[4]

1:54 well depends on if you want to be pedantic about allulose and various sugar alcohols, since they are produced artificially but at least most are also naturally occurring.

Dude is more worried about the stuff not being food grade than the possibility it could be lethal 💀

Awesome video! Sweetener chemistry really is quite fascinating. Ive always wanted to try a few grains of pure neotame, although I'm sure it wouldn't be very pleasant. Definitely try making some, Id love to hear your comparison of it to the sweeteners you made here. As a side note, if you're exploring food chemistry, making pure vanillin (from vanilla) could make for an interesting tasting! Of course there's tons of other simple aroma compounds you could also make.

@chemistryofquestionablequa6252

8 ай бұрын

Vanillin from lignin extracted from wood would be cool.

@sync_loss

8 ай бұрын

I've tried neotame, and it tastes surprisingly good, better than pure aspartame. It's very potent, the tiny amount of neotame dust from opening a ziplock is enough to make your kitchen smell sweet for a few hours. Give it a try, don't let your dreams be dreams :)

@CDCI3

8 ай бұрын

Neotame is no longer the sweetest known compound. Advantame now holds that claim.

Next time please put them in a Tier-list! Maybe add normal sugar as a calibration baseline as well 😊

Gotta say 5-nitro-2-propoxyaniline sounds like it could be shortened to something like "nitropox", which for a super potent but also toxic artificial sweetener is kind of awesome.

Sodium cyclamate is banned? Oh, banned in the USA. I was going to say, I use it in my tea every day!

@Natediggetydog

8 ай бұрын

Lots of artificial sweeteners and flavors are banned in the US for their “toxicity” even though they are less harmful than actual sugar. This is because the sugar industry paid the government to ban them

I mean..... A lot of problems could be solved, by just boiling the cause of the problem in HCl....

Where are you getting the septa that you use on your flasks?

"No bitter aftertaste" which literally every single sweetener on the market has in spades, and never registers as being nearly as sweet as regular sugar despite allegedly being '200x as sweet as sugar'

For how much the term is used in the video, I'd have liked a definition of what you meant by "potency" and "strength" for something subjective like sweetness. I could presume it's something like the mass of sugar that produces similar reported sweetness according to some group of human tasters as a standardised mass of sweetener, but I don't know that.

"This is handy because it prevented side-reactions in the first reaction, but now, I want to install something else there, so it has to fuck off."

22:50 is so funny lmao

dude i miss your full videos

Strongest sweetener on the planet sounds like a very good video

Can you perhaps make a perfume that smells like mdp2p or whatever gives off that sweet lovely smell in the production of MDMA? I love that scent

What's the name of the stir bar you were using during the synthesis?

what if you just react tve tylenol with ethanol and H+ directly and afterwards add a base to form the freebase amine again? would this work or fuck up the amine? so just doing the etherformation and deprotection of the amine at the same time

What is the active ingredient in monk fruit extract? Even the crude material is auite sweet.

Maybe a dumb question, but wont the oxygen also be acetylated in the beginning by the acetic anhydride? Or is it cause some phenyl resonance shit i must admit forgot way too much from

@That_Chemist

8 ай бұрын

when the phenol is protonated, the aniline is a much better nucleophile - if the phenol was deprotonated then it becomes a super potent nucleophile

A lot of compounds in this video need to be deprotected from amine-acetylation. You should try using dishwash soap, which contains substiline, or washing powder, which contain lipases, to see if you can do it in less harsh condition and cheaper.

What is the compund at 1:10?

Why does the sodium ethoxide not react with the propyl bromide, but deprotonate the hydroxy group? I assume the equilibrium is leaning towards the deprotonation of the hydroxy group of the compound on the left? (Ether synthesis in the first product)

@1:33, I'm pretty sure the structure you've shown is a Family B GPCR (either CLR or CTR) in complex with a RAMP (1, 2, or 3). Taste receptors are also GPCRs, but for sweet receptors, they're Family C (Larger N-terminus that also functions as the ligand binding domain; family B GPCRs also have a large N-terminus but both the N-terminus and intrahelical domain are important for ligand binding) and typically form dimers, think GABA B or metabotropic glutamate receptors. Please correct me if I'm wrong.

@10:45 GAH I should have just watched. I paused the video the second I saw Sulfuric, Acetic, AND Nitic acid going in at the same time. I wasted about 10 minutes trying to work through this coordination chemistry sorcery. I was counting bonds, checking electronegativity values, trying to figure out where the AcOH fit into the picture... only to find out 15 seconds of video later, "I just used it to dissolve the phenylaniline." TL;DR Thank you for your experimental completeness.

Cyclamate is only banned in the US and South Korea. They ran a monkey study for 24 years to see if it caused cancer. It did not.

so which one did you like the best?

That's cool and all, but how sweet is Cubane?

0:03 even today the best artificial sweetener is sucralose, which has a chlorine aftertaste (to me at least), and cannot be heated to more than ~110 °C So yeah a new sweetener without aftertaste, that would be cool.

@pickleadaykeepsthedoctoraw5542

8 ай бұрын

It really is too bad that sugar alcohols are such strong laxatives. Taste great, very similar in taste to sugar. The laxative effects put mildly are profound. TMI: It feels like you're peeing from your butt. Doesn't seem to cause much gastro distress though, so that's nice I guess... Except you'll be gassy and suddenly one of those releases aren't going to be just gas.

@Drinksfromtap

8 ай бұрын

Yeah man, and that aftertaste can linger for a day! Eurgh.

I noticed at 12:40 that you display a different isomer from the original step when you created the 5-Nitro-2-propoxyacetanilide, is there any significance in that change or it doesn't matter because the product is likely racemic?

@ashe1.070

8 ай бұрын

The C-N bond is an sp3 bond, so it’s free to rotate. In other words, those two structures are the same compound not isomers

@adrianpip2000

8 ай бұрын

@@ashe1.070 Just to be nitpicky, they kinda are isomers, but they're conformational isomers or even more specifically rotamers. Amide C-N bonds have significant double bond character, so rotation is actually quite far from free. Rotamers can actually (somewhat) often be observed by NMR (although I've never been (un)fortunate enough to experience it myself). But in practice, for this compound, they are the same. It just depends on which time scale you're considering.

@ashe1.070

7 ай бұрын

@@adrianpip2000 That's really interesting. Especially them being detected by NMR. I've never really thought of them being isomers because the conformations are rapidly interchanging depending on the compound, and the stability of the conformations. I've always seen them being called conformations, and not conformational isomers. You learn something new everyday. Thanks

you should for sure try to make the most soured and most spiciest and world most sweetener all in one video kind of like a 1v1v1 kind of deal

Last video's Chemiolis: Nilered left out the yield, f you! Also Chemiolis 5:30: I assume my yield is 100% 🤣

I’m taking organic chemistry right now, and it’s kind of crazy that I can actually somewhat understand what is going on within the video

Triggers me how you pour ether straight, I always use a beaker 😂

Did you show, that you really got 2-acetamidophenol? Did you run a test for the phenolic hydroxy group? Did you take FTIR and NMR spectra? Did you show, that this stage of the synthesis is pure enough via TLC? Even an MS would show, that you did not just isolate the starting material.

Why would you need to use ethoxide to deprotonate a phenol? isn't that a bit overkill?