Introduction to Cancer Biology (Part 2): Loss of Apoptosis

Apoptosis or "programmed cell death" is a mechanism by which organisms limit the growth and replication of cells. Loss of apoptosis is one of the key mechanisms behind cancer.
This animation is the second part of the series "An Introduction to Cancer Biology", and reveals the faulty apoptotic pathways that tumor cells often have.
REFERENCES:
1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000 Jan 7;100(1):57-70.
2. Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys. 2004;59(2 Suppl):21-6.
3. Gerharz CD, Ramp U, Reinecke P, et al. Analysis of growth factor-dependent signalling in human epithelioid sarcoma cell lines. Clues to the role of autocrine, juxtacrine and paracrine interactions in epithelioid sarcoma. Eur J Cancer. 2000 Jun;36(9):1171-9.
4. Potapova O, Fakhrai H, Mercola D. Growth factor PDGF-B/v-sis confers a tumorigenic phenotype to human tumor cells bearing PDGF receptors but not to cells devoid of receptors: evidence for an autocrine, but not a paracrine, mechanism. Int J Cancer. 1996 May 29;66(5):669-77.
5. Andl CD, Mizushima T, Nakagawa H, et al. Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. J Biol Chem. 2003 Jan 17;278(3):1824-30.
6. Di Fiore PP, Pierce JH, Kraus MH, Segatto O, King CR, Aaronson SA. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science. 1987 Jul 10;237(4811):178-82.
7. Batra SK, Castelino-Prabhu S, Wikstrand CJ, et al. Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene. Cell Growth Differ. 1995 Oct;6(10):1251-9.
8. Egeblad M, Mortensen OH, Jaattela M. Truncated ErbB2 receptor enhances ErbB1 signaling and induces reversible, ERK-independent loss of epithelial morphology. Int J Cancer. 2001 Oct 15;94(2):185-91.
9. Lage A, Crombet T, González G. Targeting epidermal growth factor receptor signaling: early results and future trends in oncology. Ann Med. 2003; 35(5):327-36.
10. Adjei AA, Hidalgo M. Intracellular signal transduction pathway proteins as targets for cancer therapy. J Clin Oncol. 2005 Aug 10;23(23):5386-403.
11. Beeram M, Patnaik A, Rowinsky EK. Raf: a strategic target for therapeutic development against cancer. J Clin Oncol. 2005 Sep 20;23(27):6771-90.
12. Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000 Oct 13;103(2):253-62.
13. Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001 Feb;2(2):127-37.
14. Igney FH, Krammer PH. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer. 2002 Apr; 2(4):277-88.
15. Delhalle S, Duvoix A, Schnekenburger M, Morceau F, Dicato M, Diederich M. An introduction to the molecular mechanisms of apoptosis. Ann N Y Acad Sci. 2003 Dec;1010:1-8.
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Пікірлер: 14

  • @NatVN88
    @NatVN8811 жыл бұрын

    Studying for my defense. You guys are doing such a great job! Thank you very much :)

  • @nitrohide1991
    @nitrohide199110 жыл бұрын

    all your videos are great ! everytime they help me realize processes in the body better !!!

  • @alz123alz
    @alz123alz8 жыл бұрын

    FINALLY, INFORMATION THAT UNDERSTAND EXFOLIATIVE CYTOLOGY

  • @ayaanejj3482
    @ayaanejj34826 жыл бұрын

    short and clear .......good animation.

  • @aprilhicks3474
    @aprilhicks34743 жыл бұрын

    sounds promising and was educational, thanks!

  • @fatimahayssam120
    @fatimahayssam1205 жыл бұрын

    Thanks for your effort ♥️

  • @abdelrahmanahmed8133
    @abdelrahmanahmed81337 жыл бұрын

    Helpful Thanks

  • @juliechao1074
    @juliechao10748 жыл бұрын

    Thanks for the upload!! It's really concise and clear

  • @harithhusam
    @harithhusam9 жыл бұрын

    Nice

  • @zainabalradi2306
    @zainabalradi23066 жыл бұрын

    is It possible that we loss apoptosis due to mutations in death receptor genes for example? or this is the only way found in humans regarding loss of apoptosis?

  • @Tinky1rs

    @Tinky1rs

    6 жыл бұрын

    There are many many pathways that eventually induce or inhibit apoptosis. One example: tumours can have a Fas receptor mutation, so that they are resistant to FasL (ligand) secreted by cytotoxic T-cells, reducing or even preventing T-cell mediated killing. This can even be taken one step further: tumours start producing lots of FasL while having no Fas Receptor, thereby killing nearby T-cells trying to destroy the tumour.

  • @mariannebest6796
    @mariannebest67967 жыл бұрын

    could you give an example of what you mean by an NFkB inhibitor? Thanks

  • @davidcunningham2984

    @davidcunningham2984

    6 жыл бұрын

    try the internet. a new search engine called google might help.

  • @Josh350

    @Josh350

    5 жыл бұрын

    Protine inhibitor.