Immune System, Part 1: Crash Course Anatomy & Physiology #45
Our final episodes of Anatomy & Physiology explore the way your body keeps all that complex, intricate stuff alive and healthy -- your immune system. The immune system’s responses begin with physical barriers like skin and mucous membranes, and when they’re not enough, there are phagocytes -- the neutrophils and macrophages. It also features the awesomely named natural killer cells and the inflammatory response, and we'll explain how all of these elements work together to save the day if you happen to slip on a banana peel.
Pssst... we made flashcards to help you review the content in this episode! Find them on the free Crash Course App!
Download it here for Apple Devices: apple.co/3d4eyZo
Download it here for Android Devices: bit.ly/2SrDulJ
Chapters:
Introduction: Immune System 00:00
Skin as a Physical Barrier 1:47
Mucous Membranes 2:25
Phagocytes: Neutrophils and Macrophages 3:17
Natural Killer Cells 4:29
Inflammatory Response 5:16
Review 8:03
***
"Reformat" Kevin MacLeod (incompetech.com)
Licensed under Creative Commons: By Attribution 3.0 License
creativecommons.org/licenses/b...
***
Crash Course is on Patreon! You can support us directly by signing up at / crashcourse
Thanks to the following Patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:
Mark, Eric Kitchen, Jessica Wode, Jeffrey Thompson, Steve Marshall, Moritz Schmidt, Robert Kunz, Tim Curwick, Jason A Saslow, SR Foxley, Elliot Beter, Jacob Ash, Christian, Jan Schmid, Jirat, Christy Huddleston, Daniel Baulig, Chris Peters, Anna-Ester Volozh, Ian Dundore, Caleb Weeks
--
Want to find Crash Course elsewhere on the internet?
Facebook - / youtubecrashcourse
Twitter - / thecrashcourse
Tumblr - / thecrashcourse
Support Crash Course on Patreon: / crashcourse
CC Kids: / crashcoursekids
Пікірлер: 1 800
Pssst... we made flashcards to help you review the content in this episode! Find them on the free Crash Course App! Download it here for Apple Devices: apple.co/3d4eyZo Download it here for Android Devices: bit.ly/2SrDulJ
The animations were absolute quality.
@anti_MATT_er
8 жыл бұрын
+Scotticus25 The faces were so cute, haha.
@Lumamaster
8 жыл бұрын
+Scotticus25 best animation 11/10
@crashcourse
8 жыл бұрын
+Scotticus25 This was probably my favorite episode so far in terms of animations. There's some great stuff coming up too! +Thought Cafe is amazing. -Nicole
@TheChipmunk2008
8 жыл бұрын
+Scotticus25 Literally scrolled down to say 'the animations are awesome'. Saw this. +1 :D
@M_Chen333
8 жыл бұрын
+CrashCourse TOTALLY
You guys are amazing. Managing to pull off a cliffhanger on an educational video is quite the deed.
@kevinbutton4580
8 жыл бұрын
Right it's kinda scary
@Weston29406
8 жыл бұрын
+Tyrannosaurus Rex Didn't even think of it that way. It is impressive.
@minimooster7258
8 жыл бұрын
My Ancient Greek teacher did the same when talking about the Minoiens. He mentioned "in passing" that they could have been Atlantis and then said that the lesson was done!
@benaaronmusic
8 жыл бұрын
+Tyrannosaurus Rex - Very impressive, indeed!
@iggyg1370
7 жыл бұрын
If phagocytes can swallow invaders, like bacteria and viruses, then how can anyone be sure that vaccines that are made of inactive viruses really work? Inactive viruses do not reproduce, and do not cause infection, vaccines with weaken viruses may replicate, but also do not cause infection. Does the immune system really need to produce antibodies, for viruses that do not cause infection?
This guy: "Our immune system is very sophisticated." Immune system: "My solution to this problem is to BURN EVERYTHING TO THE GROUND!"
As both a medical student and artist, I find this blend of animation and science all sorts of awesome. 👍
This is, by far, the most adorable portrayal of the immune system I have ever seen. Props to Crash Course.
@alex_zetsu
4 жыл бұрын
It certainly was at that time. Japan made a longer portrayal. It's called Cells at Work (all but three episodes the immune system is featured prominently)
this is the best animation yet, oh my god.
@Thought-Cafe
8 жыл бұрын
+herpsenderpsen Thank you!
@Chaltaq
8 жыл бұрын
+Thought Café Your every animation is amazing :) Do you have a store we could buy products from?
@sydney3213
7 жыл бұрын
+
the fact that I watched this 10 minute video and understood everything astonishes me. It also amazes me how college professors literally elongate so much of their lectures, sometimes talking for 3 hours straight to tell us the same information in this video.
The Macrophages are so darn cute!!
@misss7096
7 жыл бұрын
And the neutrophils! ☺️
@JoseJimenez-sh1yi
5 жыл бұрын
Best waifu
@katiie7
4 жыл бұрын
My first thought ☺️
@HeIsAnAli
4 жыл бұрын
Careful, they're only 17. _(Oi, oi!)_
@belgiumball2308
4 жыл бұрын
Macrophage: WE ARE INFECTED WIH THE EBOLA VIRUS MA' AM CD4+ CELL: THEN GET TO WORK YOU FREAKING @#$%@$$#$
you there stop looking at the comments section and study
@tbsjgmyt
5 жыл бұрын
Got me
@sanaearthfire3833
5 жыл бұрын
@@tbsjgmyt N ME!))))
@ahahxx7068
5 жыл бұрын
😂😂 ok I will go now
@spacier2988
5 жыл бұрын
lol got me too xD
@zainabzubair1797
5 жыл бұрын
Likes comment to proceed scrolling
Literally the best animations yet. Absolutely flawless.
@thepikarivera7706
6 жыл бұрын
empCarnivore I agree
@WadcaWymiaru
5 жыл бұрын
*Kurzgesagt* is better...
@rachelfaith3578
5 жыл бұрын
@@WadcaWymiaru nope
@nandamulya3117
5 жыл бұрын
Is ur profile pic mugi from K-On?
@darrellsimon4462
5 жыл бұрын
Smiley face phagocytes
*you just explained 2 chapters of college micro in like 5 minutes*
@ronb7062
4 жыл бұрын
yes. haha.
@scabootie
4 жыл бұрын
but you learnt f'all
@davidcrawford4909
4 жыл бұрын
Its 9
@aloksrivastava7483
4 жыл бұрын
3:13 BAD BAD BAD.BAD!!! I AM NOT REALLY GONNA BEACOME A COOK
@keraris1639
4 жыл бұрын
Ave Hank!
For some reason, I lost it when the Hypothalamus used Fire Blast. XD I love this unit.
@tuke3541
7 жыл бұрын
Legend27?
@MistressVantablack
6 жыл бұрын
lol same
@midnight_gmr8562
4 жыл бұрын
It's not very effective...
@lukaswalker7230
4 жыл бұрын
@@midnight_gmr8562 haha
I need plushies of those little animated cells omg
@paytonvandy8140
8 жыл бұрын
Same! They're the cutest microscopic structures I've ever seen
@quintenfranks8024
8 жыл бұрын
+Jess Liu I want the plague doctor NK cell
@mythologiefan
8 жыл бұрын
they kinda exist already. check giant microbes. There are several blood cells too.
@plankton67js
8 жыл бұрын
+Jess Liu Indeed :)
@ChuPeach
8 жыл бұрын
+Jess Liu I remember that there is a company that makes custom plushie toys. I forget the name but you can look them up and send them this video saying you want a plushie of this cell at this time in the video.
I am a visual learner and let me just say this.......this FINALLY makes sense!! I love those animations!! Besides it being informative, it's really entertaining. Loved it!!
I don't know why people hit the dislike button... your videos are amazing keep doing what you are doing
@hamzaalali114
5 жыл бұрын
I think because he is really fast in talking
@thejoeare15
4 жыл бұрын
Well you can slow down the video...
@K5E4VX7YY2I9N
4 жыл бұрын
The dislikes are viruses that escaped the immune system.
@ccmkoho
4 жыл бұрын
Jose Arellano , yup at 75% he sounds normal
@yarakharam5343
4 жыл бұрын
Simplified bait video, useless graphics (but good, gotta give em that!), narration is "overacted" to the fullest.
hes gesturing so hard the fluid on the table in the flask is jiggling wildly
I work in medicine and i approve of this video, everything is spot on, amazing presentation and an absolutely hilarious barrage of jokes and puns. Well done Hank, well done. I will be referring to this video anytime a friend of mine asks about immune systems in the future.
NEXT TIME ON IMMUNEBALL-Z
@K_i_t_t_y84
8 жыл бұрын
+ling Su LOL!
@moshikon44
8 жыл бұрын
+ling Su This has to become a thing!
@flyingzambie1201
8 жыл бұрын
What will dendritic cells do with an overwhelming attack on the body? TUNE IN Next time, for "THE ADAPTATION". PS. the mitochondria is the powerhouse of the cell
@ferret813
8 жыл бұрын
+ling Su lmaoo gold
@user-mw4il7hx2h
8 жыл бұрын
+Paul Ferrell MBC播.M(沒開口) 沒 :😶😀😑😀😐😉😀 😃
“The pathogens are flooding in like orcs from helms deep” that had me dying 😂
@theresageiger584
4 жыл бұрын
Are you better
I just wanna give a HUGE thank you to this entire series of videos (but especially the immune system ones!!) I took the MCAT last May after many months of studying and watching this series over and over and over (by the end I was literally playing them while I slept). I got an amazing score and I've now been accepted to a couple of great schools, and I literally could not have done it without these fantastic videos that present the topics in such an engaging and informative way! Seriously, THANK YOU!
BURN EVERYTHING. Awesome Seriously the immune system is so freaking cool
"You can also call them NK cells, but, like, why would you do that?" > **calls them NK cells**
our own immune systems are more intelligent and work harder than most humans do...
@shaunowyang2841
7 жыл бұрын
lol very true
@alejandrovallejos4454
5 жыл бұрын
but actually your immune cells are human too.... pero en realidad tus células inmunes son humanas también... xd
@izjerker
5 жыл бұрын
Your scope of domain gets larger.
@IvanMatyushov
5 жыл бұрын
but if it's a part of us along with many other organ systems then doesn't that mean that humans actually work far harder than the immune system itself?
@Cheka__
5 жыл бұрын
I wish my I.S. would go to work for my brain cells. They're doing the jobs that Americans just don't want to do.
The cells are so cute
If everything fails... BURN EVERYTHING :D
@adamlatosinski5475
8 жыл бұрын
+fatherdoctor "Burn them all" - Aerys II Targaryen
@creepernerd101
8 жыл бұрын
That's called cytokinesis xD
@ConradJD777
8 жыл бұрын
+fatherdoctor IMMA FIRN' MA LAZER!!! BBWWAAAAAAA!!!!!!
@abikochin2462
8 жыл бұрын
+Conrad JD 777 i love your minecraft skin xD
@ConradJD777
8 жыл бұрын
gamer mega elite Thanks m8! ;)
I didn't know bananas came from factories so glad I learnt something from this vid
"and it can do it over and over again, like a boss" OMG
so basically the immune system is the custom and border protection, your Innate is the office of border patrol, adaptive defense system is the Office of Field Operations
Amazing episode. Very funny and very informative.
those macrophages are absolutely adorable, i would buy a plushie.
neutrophils: we can destroy bacteria ! macrophages and monocytes: hold my proteins
@therightflyer7806
4 жыл бұрын
yeet
"Just because it's simple doesn't mean it can't be elegant." A perfect example of that would be Kirby.
AAAAHHHGG CLIFFHANGERS!
@matiaselizalde7051
8 жыл бұрын
+Caer Ibormeith Game of Thrones style D:!
@RBLXbranefreez
8 жыл бұрын
+Caer Ibormeith You have to admit, though, that this particular cliffhanger was quite masterfully presented.
@Itaju
8 жыл бұрын
+Caer Ibormeith spoiler alert: watch Crash Course Biology #32: Immune System
@saomaitran65
7 жыл бұрын
Itaju pp
@chattapolchawantanpipat9156
6 жыл бұрын
Yep IKR
DO MICROBIOLOGY!
@0123biteme
8 жыл бұрын
PLEASEEEEEE
@chloroplast8611
6 жыл бұрын
THIS IS MICROBIOLOGY!!!!!! YOU JUST DONT NOTICE YOU ARE LEARNING YET
@douglasw1545
6 жыл бұрын
And kinesiology!
@chloroplast8611
6 жыл бұрын
This is letterally the same things as a chapter in my microbiology textbook
@SkopeeProductions
5 жыл бұрын
Yup, I'm watching the immune system series for my Microbiology final!
The professionalism of this channel is incredible. So informative and yet even I can almost understand what's going on.
"You can also call them NK, but I mean, why would you?" Hahaha. Hank, cracks me up!
@SkopeeProductions
5 жыл бұрын
"Banana factories are very dirty places!" That's the quote that got me from this video :D
@spartanhead8131
4 жыл бұрын
@@SkopeeProductions Wounderful quote! Wasn't it?
I love the Pokemon reference 😁
@musent_
7 жыл бұрын
When?
@mistersquirtlegamingandtut5936
7 жыл бұрын
Musent! Hey other me!
@mistersquirtlegamingandtut5936
7 жыл бұрын
Btw it's the fire blast
@zoroearc2582
6 жыл бұрын
But Fire Blast used the sound effect for hyper beam
@ainsoff_6663
6 жыл бұрын
Totally! I keep rewatching 😂
Man!!! I can't say enough how awesome!! you are... I got an A on my bio.... I love you!!! ;-))))thank you very much!!
Whos here after the coronavirus outbreak
@memalang94
4 жыл бұрын
Better be ready
@pikaszablak7933
4 жыл бұрын
That and after watching Cell at Work.
@chandlerancar1080
4 жыл бұрын
Im here because of cells at work also.
@edmind47
4 жыл бұрын
Children:*sighs of relief*
@thebelyahvlog7059
4 жыл бұрын
me
Gotta love learning about the immune system while in self isolation from a spreading virus
"The pathogens are just flooding in like orcs through Helm's Deep". Best lotr reference ever!!!! hahah he's so awesome :)
As a struggling A-Level Biology student, thank you Hank Green and the Crash Course team, you rock!
I can't tell you how helpful this episode has been to me. I have an immune system quiz a couple days from now and being the visual learner that I am, decided to watch this episode in order to better understand the process. My Biology AP grade and I thank you for your thorough explanations and great analogies and examples.
I actually found the CrashCourse Biology version of the Immune System more helpful although the animations are better here yet it was more easy to comprehense in that video. Is it just me or anyone else too?
I can't explain just how much your videos are helping me! I'm also 62 but just getting into this education lark (I hated school when I was a kid, now I'm a big kid I don't think I'll ever really grow up) If only this sort of thing was available then! I am training yes at a late stage to be a reflexologist and need to understand anatomy and physiology you have made this all possible as I was struggling just reading books. Thank you, thank you, thank you.
Just happens I'm doing this in biology, my absolute favourite topic when it come to biology, so grateful to be able to watch these videos to enforce everything i learned in class(while teaching me more) thanks again!
This reminds me how amazing the human body is that it can all of this without me thinking about it
They've really outdone themselves this time, haven't they? Thoroughly enjoyed it. Good work CrashCourse team!!!
Don't get me STARTED on the dangers of bagel cutting!
"Natural Killer Cells" would make a great Quentin Tarantino film.
@BosonCollider
5 жыл бұрын
Natural Killer cells are basically like the inquisition. Because you didn't expect that comparison.
@augustusaurelius2628
5 жыл бұрын
Well they made them ss like soldiers in an anime. That's something
@enikisser
5 жыл бұрын
hahahaha..
@themightykyuss
5 жыл бұрын
I'm assuming you already know that he wrote the screenplay to the movie *Natural Born Killers*. Such a great movie.
@avocadothecat
5 жыл бұрын
no but they made a great anime
love your videos so much! I'm in grad school to be a family nurse practitioner and these videos are great ways to refresh information and make it easier and fun for patients to learn :) thank you!!!
Why are all these white blood cells the most adorable things I have ever seen?? Oh my gosh, they are so cute!
Amazing job again guys! Just wanted to add that fever also makes it harder for the invading bacteria to replicate as our usual body temperature is their optimum and a lot of bacteria are rather sensitive to temperature changes (at least that's what I learned in my immunology lectures)
This was so amazing and interesting and I especially LOVED the "Final Fantasy" style "cell fight" animations!!
@Thought-Cafe
8 жыл бұрын
+Megan Rivera :-)
@K_i_t_t_y84
8 жыл бұрын
Thought Café I subscribed to your channel!
@JDraks
8 жыл бұрын
+Megan Rivera It was Pokemon. Fire Blast is ripped directly from Pokemon.
@K_i_t_t_y84
8 жыл бұрын
JDraks Final Fantasy came out before pokemon did, Final Fantasy was released in 1987 and Pokemon came out in 1996. And I understood the Fire Blast Pokemon reference but the fight was in the style of Final Fantasy. I've been a video game geek for 31 years, you don't have to question my knowledge.
@JDraks
8 жыл бұрын
Megan Rivera The health bars and text box at the bottom are pretty much perfect matches for Pokemon. Really, the only difference between this and Pokemon is that Pokemon text boxes would be on bottom right for left and top left for right.
Whoever did the animations needs a pay raise
OUR BODY WILL BUILD A WALL (Skin), AND BACTERIA WILL PAY FOR IT 2:20
@WadcaWymiaru
5 жыл бұрын
Mexicans = germs? I was thought it is only about germans XD
Sounds like my ex, immediately engage with anything/anyone suspicious.
@elenorcorano5014
8 жыл бұрын
LOL
@HALOUNSC2552
8 жыл бұрын
Same here
@angeldude101
8 жыл бұрын
+Caleb Limb Is your ex a serial killer? Because in this context "engage" pretty much means "eliminate".
@SomeSmallFish
8 жыл бұрын
+angeldude101 funny story
@I_am_milan
8 жыл бұрын
lol
I totally lost it, during the Monocyte evolving + 6bit music
@anber4129
4 жыл бұрын
😂😂
Never saw a more interesting biology video.
these example are insane: "cut myself when opening a bagel" "slipped in a banana factory and grazed my knee"
Soooo... My biology final was this morning. And my professor specializes in the immune system. Thanks for nothing, Crash Course. But seriously, I actually appreciated these videos a lot while studying for this class. They made it a lot more interesting and manageable.
@nicktk1
8 жыл бұрын
+Kelsey Gertje May the curve be in your favor
@lougert
8 жыл бұрын
Funny you say that... my professor also doesn't curve.....
@nicktk1
8 жыл бұрын
:
@Syverson1979
8 жыл бұрын
Shut up, average person.
@nicktk1
8 жыл бұрын
+Syverson1979 okay then....
What I learned: PHAGOCYTES ARE BADASS!
thank you for doing such quick and effective videos! love watching you guys before starting a chapter just to get a quick overview before digging deeper!!! 20/10 recommend!
Thank you so much for making this video! I just started an immunology course and felt a little lost connecting the dots between all the concepts I've learned. This video was super helpful to me and I really liked all the visuals you used! They were funny, cute, and very informative! Thank you again for making this video!
Best episode ever? Can't wait for part 2.
Thank you so much for these videos! Very informative, love the animation. Makes it so much clearer to understand. I love that they used Pokemon as an example. It makes a better understanding how the body works.
I have used your presentation so often as it explains the immune response magically THANK YOU
Anytime I hear about all the awesome ways my body is protecting myself from the outside world-which I hear mostly from you and Kurtzgesat-I get all giggity inside. Like, my body is freaking awesome! Good job bod!
4:30 macrophages "LIKE A BOSS"
Awesome. Thank you for this. loved the images and the explanation, I feel more in touch with my immune system. Great work.
Que didática ótima. Parabéns, continue postando 😀
wow that was the best description of the immune system i've came across yet. So cool! thank you so much
The immune system videos are among the best in the whole A & P series. Phagocytes and natural killer cells are described and illustrated in such a clear way. Thank you and God bless.
i love how you guys make the information engaging and explain things so well. it makes it easy to understand and interesting to listen to.
how perfect and amazing the human body is
can you please do a detailed video on IBS i.e Irritable Bowel Syndrome . How it effects the body and any prevention ways.
@sarahtelford9601
5 жыл бұрын
Abdullah Waseem omg yes
1 2 3 4, we are Cells at Work!
@Chris14_
4 жыл бұрын
?
@emmanuelbenitez3049
4 жыл бұрын
Ahhh, I see, a man of cultural
Doing my Diploma in Nursing at the moment and our tutors use your videos as they are great!
i was genuinely excited to do the next section. Well done as always
Coolest Nerd Eva! Who all agree?!?!?!?!
@lachlanmc2335
7 жыл бұрын
I DO
@akashalihazarika4690
4 жыл бұрын
@Aarushi Grover Are you a forensic student ?
absolutely love these
Thank you so much. I read a book about the immune system and it was somehow complicated but you just explained everything clearly and I just understand easily. You're awesome
These videos are amazing....... you have to make more of them
Now I can't stop imagining white blood cells sounding like Link from OoT. Thanks, ThoughtBubble.
@angeldude101
8 жыл бұрын
+Jake Mauger Hyah!!!!!!!!!!!!!!
@Thought-Cafe
8 жыл бұрын
+Jake Mauger ;-)
@JDraks
8 жыл бұрын
+Jake Mauger HYAHHH!!
@plankton67js
8 жыл бұрын
+Thought Café Sweet Job xD
holy crap the epicness of this episode is over 9000!
@7.08 best part of the video. How Uni's and lecturers still think 20-40 white slides with black text and a mundane robotic voice is the way to learn/teach is beyond me. This one video summed up a painful 40 min lecture in 9 minutes. That is how learning should be. Quick, fun, to the point.
This has to be my absolute FAVORITE crash course episode! This was so enjoyable to watch (in addition to being very educational! (:
I gave a lecture on antihistamines and inflammation just last week... next semester I'm using this video instead. The animations were amazing! PS: Rubor, tumor, calor and dolor. Oh yeah, you know what I'm talking about...
At minute 4:58 its not exactly true, MHC1 is presented on the cell that are infected by a virus, cancel cells etc, its not true that all the cell have MHC1, but whatever, i love your videos
this is the cutest video on immune system EVER!
What a convenient time for my a & p class to go over the immune system
"your outer fortress has been breached, and the pathogens are just flooding in like orcs through helm's deep" I love you 😂❤
Cells at Work!
This. Was. AWESOME! Man you guys do a great job. I'm 30 years old and you guys are fantastic at relaying complex topics into ideas I can digest.
Very fast and clear teaching on immune system..thanks
"Cells at work" reallife edition XD
I am watching this for school and it's too funny:) LOL.
@faithmitchell3870
7 жыл бұрын
This made immune system way more fun!
@K5E4VX7YY2I9N
4 жыл бұрын
Agreed
Favorite episode of all time including part 2
That was so cool and fun and easy to understand! l loved it! He talks so fast I'll watch it again but next time I'll also pause it so I can read the little notes that pop up here and there. THANK YOU for a fun and excellent job!