HIV Life Cycle | HHMI BioInteractive Video

Ғылым және технология

Пікірлер: 230

  • @ethellochrose6531
    @ethellochrose65312 жыл бұрын

    Honestly, I have so much respect for animators. I'm a 2nd year medical student and this video has been so so helpful. Great job, guys!💫👏

  • @TalhaPenArt

    @TalhaPenArt

    2 жыл бұрын

    Damn you’re doing this in second year ??? I’m doing this in year 13, hopefully I get into medicine soon, still waiting on Uk offers :(

  • @huiioyasin1070

    @huiioyasin1070

    2 жыл бұрын

    1st year ma ap ky kitny marks hn

  • @luxxerpolman470

    @luxxerpolman470

    2 жыл бұрын

    @@TalhaPenArt ikr, I’m doing this in grade 11 and I’m just 15

  • @pdevine999

    @pdevine999

    2 жыл бұрын

    Its a good job students have animators to create viruses and then funded studies to create a backstory for the particles . Without that your simply studying something that never existed .

  • @SoLoGLidez

    @SoLoGLidez

    Жыл бұрын

    @@pdevine999 are you hinting that this is all bs? if so that’s funny

  • @debayan19
    @debayan192 жыл бұрын

    One of the best descriptive animated video in KZread for a viral infection cycle. A piece of advice cum request: Please make similar animated videos on different viruses like HBV, HSV, HCV, POLIOVIRUS, CORONAVIRUS, MYXOVIRUS, etc.

  • @mntonja
    @mntonja3 жыл бұрын

    I just wish I had KZread and the internet back in high school. It gets much easier to understand these concepts when you see them in action as opposed to reading about it.

  • @inuahead1218

    @inuahead1218

    6 ай бұрын

    How do u know this really happens. Virus being in a cell in a live host. How can this cycle be seen? In a live person? In this detail.?

  • @user-mo2sg8mf5k

    @user-mo2sg8mf5k

    2 ай бұрын

    @@inuahead1218microscopes probably

  • @sehoraneratau4375
    @sehoraneratau43752 жыл бұрын

    Cant express how helpful this video was,. Thank you so much, you are doing The Lords work for sure

  • @vanajasrimbbtc2769
    @vanajasrimbbtc27695 жыл бұрын

    such a great visualization...thank you so much for scientist for finding all these complex process....

  • @priyankasangasani6954
    @priyankasangasani69543 жыл бұрын

    Topic wise crystal clear visualisations 👌

  • @lavenderlouvesx_
    @lavenderlouvesx_ Жыл бұрын

    This video really made me understand the lifecycle of hiv

  • @abcmaniabcmani9361
    @abcmaniabcmani93612 жыл бұрын

    💯💯💯💯 I am pre medical student and get many help from this animation I am thankful of animators🥰🥰🥰🥰🥰

  • @Jindy2
    @Jindy24 жыл бұрын

    Excellent clip - very clear and well explained. Thanks!

  • @MrEthanhines
    @MrEthanhines4 жыл бұрын

    Now, can you make the same highly detailed video on Sars-Cov2? Showing the spike protein and ace2 receptor and conformational change in spike protein by TMPRSS2 and endocytosis along with the viral RNA dependant RNA polymerase, and the way the host ribosome sometimes frameshifts to read either ORFA/B and then proceeds to create negative strand subgenomic rnas, and how replication-transcription complexes are created and how they prevent interferon-α from being expressed and how non-structural proteins downregulate host immune responses. And finally how a low cost drug could prevent certain steps in viral replication

  • @Matthew-yc6nx

    @Matthew-yc6nx

    Жыл бұрын

    Such as adenosine nucleoside analogues and protease inhibitors?

  • @user-mo2sg8mf5k

    @user-mo2sg8mf5k

    2 ай бұрын

    No need. HIV is worse than Sars-Cov

  • @Sophia-gc5yz
    @Sophia-gc5yz4 жыл бұрын

    Thanks for this video! Helped me out with my genetics class.

  • @hulyagizemozkan184
    @hulyagizemozkan1846 жыл бұрын

    best intensive and clear explanation, thank you!

  • @Daniman-nk2vj

    @Daniman-nk2vj

    4 жыл бұрын

    Nice pic

  • @shahmohshafi6103
    @shahmohshafi6103 Жыл бұрын

    This video is really awesome and a great way to clear the concepts

  • @vicente5942
    @vicente5942 Жыл бұрын

    Important to mention, is the fact that CD4 receptor is not exclusive to T helper cells. The CD4 receptor is in T helper cells, macrophage , dendritic cells, and others.

  • @Matthew-yc6nx

    @Matthew-yc6nx

    Жыл бұрын

    That's correct, however the main target cells of HIV-1/2 are CD4 expressing T-Helper leykocytes.

  • @Ciaran55
    @Ciaran554 жыл бұрын

    I started reading more and more about the immune system and these things we call viruses. But that only makes me want to ask more and more questions. For one thing, how does a strand of genetic material even know how to get into the nucleus? Do viruses need energy, and what are 'proteins' exactly? Rambling aside, thank you for the video! Life is incredibly complex

  • @kallashnykov

    @kallashnykov

    4 жыл бұрын

    Well a strand of genetic material is information. The virus has all the information necessary for it to get into the cell and multiply embedded in its dna. Proteins are biomolecules that carry functions inside a living being.

  • @bigpardner

    @bigpardner

    2 жыл бұрын

    @Unique Pros Sperm have motility

  • @bigpardner

    @bigpardner

    2 жыл бұрын

    Why would a virus need energy for if it is not a living thing? Nothing in this animation has ever been observed has it? Doesn't that make it all theoretical?

  • @pdevine999

    @pdevine999

    2 жыл бұрын

    @Abhiyanshu Chaudhary ribosomes probably don't even exist , I bet they never learned you about the work of Harold Hillman , they have turned something way too complicated for the human brain to understand or observe into simple materialistic blocks or repeatable information , the problem is is that its 99% wrong.

  • @biointeractive

    @biointeractive

    2 жыл бұрын

    Which 1% is right? Just asking

  • @eeltauy
    @eeltauy6 жыл бұрын

    I'm just speechless!

  • @nighteyes.5455
    @nighteyes.54552 жыл бұрын

    Leaving a comment for the algorithm. This was great, 10/10.

  • @JoaoVictor-dw2ci
    @JoaoVictor-dw2ciАй бұрын

    This video is magnificent to understand the whole process happening !!! amazing

  • @Thaofficialsensei
    @Thaofficialsensei9 ай бұрын

    It’s as if the viruses are computer coded they come with their own installation software and everything 😮

  • @Karan-wz7pt
    @Karan-wz7pt Жыл бұрын

    this is spooky and mind-boggling at the same time

  • @librarieskim8569
    @librarieskim8569 Жыл бұрын

    I subscribe a channel after a long time, can't miss your videos

  • @librarieskim8569
    @librarieskim8569 Жыл бұрын

    Finally, i finally understand this thing thanks to your amazing animated video and your explanation. Thanks a alot

  • @biointeractive

    @biointeractive

    Жыл бұрын

    Glad it helped!

  • @Folkmarev
    @Folkmarev4 ай бұрын

    Wow! Clear and amazing explanation, thank u so much

  • @Dr_SteveK
    @Dr_SteveK Жыл бұрын

    Brilliant, very brilliant depiction and quite concise. Thank you

  • @biointeractive

    @biointeractive

    Жыл бұрын

    You're very welcome!

  • @tayyabasehar1561
    @tayyabasehar15612 жыл бұрын

    Thank u so much for this kind of act

  • @kidspremieretv
    @kidspremieretv2 жыл бұрын

    Thank you 💗 sir, This video are really very helpful for me , in this video we are easily and clearly understand.

  • @mobinshafeian2711
    @mobinshafeian27118 ай бұрын

    incredible video, this video was super good for my school project

  • @thandolwethuntombela8691
    @thandolwethuntombela86912 жыл бұрын

    best video on the internet me thinks!

  • @buddy8998
    @buddy89982 жыл бұрын

    being A Neet Aspirant I have Watch This Video About 10 times...lol Before every test i Watch it Insted Of reading NCERT

  • @Matthew-yc6nx
    @Matthew-yc6nx Жыл бұрын

    1:27 This video is inaccurate. The capsid is not shed upon fusion into the cytoplasm. The capsid travels intact from the cytoplasm and is imported into the nucleus through nuclear pores by nuclear import proteins. Reverse transcriptase happens while the RNA is still inside the capsid, and the capsid does not uncoat until the reverse transcriptase process has complete (inside the nucleus) and the viral DNA is then ready to integrate itself into the host DNA.

  • @zubaireditz5900
    @zubaireditz59002 жыл бұрын

    The best of best video

  • @minahalriazbutt121
    @minahalriazbutt1213 жыл бұрын

    thank u so much sir for such a best video.......it is really helpful in understanding the whole process which would otherwise be very difficult to learn

  • @biointeractive

    @biointeractive

    3 жыл бұрын

    You are most welcome

  • @InfinixHotPlay-vn6cv
    @InfinixHotPlay-vn6cv2 жыл бұрын

    Animation is the best way of learning.

  • @shafiulismam5334
    @shafiulismam53344 жыл бұрын

    make more technical videos like this pls

  • @t.r.4496
    @t.r.44964 жыл бұрын

    Somebody figured all this out with a microscope, all I can say is bravo.

  • @gerontodon

    @gerontodon

    3 жыл бұрын

    Did they? I doubt it, because that's not how it was 'isolated'.

  • @coneyworks8791

    @coneyworks8791

    3 жыл бұрын

    Most viruses are too small to be seen with a typical light microscope however can be seen with a electron microscope. But I quite agree, still bravo :)

  • @yangjiansir
    @yangjiansir7 жыл бұрын

    So complex how do the scientist find such process?

  • @williamcahyadi

    @williamcahyadi

    5 жыл бұрын

    Curiosity

  • @thundaga4005

    @thundaga4005

    4 жыл бұрын

    By forming hypotheses and testing them against laboratory experiments, repeated over and over again.

  • @kotsaris87

    @kotsaris87

    4 жыл бұрын

    By doing science.

  • @razvanboasca1146

    @razvanboasca1146

    4 жыл бұрын

    Because they made it.

  • @shafiulismam5334

    @shafiulismam5334

    4 жыл бұрын

    Biochemistry X Genetics

  • @warriork4802
    @warriork48024 жыл бұрын

    The best one 👏👏😊

  • @user-hi3je8jx1o
    @user-hi3je8jx1o3 жыл бұрын

    thank you so much for that amazing video

  • @biointeractive

    @biointeractive

    3 жыл бұрын

    Glad you liked it!

  • @Alasr27
    @Alasr272 жыл бұрын

    Thanks so much.. Alot of work has been accomplished for me

  • @biointeractive

    @biointeractive

    2 жыл бұрын

    You are so welcome

  • @jaethegoddexx
    @jaethegoddexx2 жыл бұрын

    This was great to follow along

  • @rudygarcia2567
    @rudygarcia25675 жыл бұрын

    Agree 100 percent. Nice video. I only have 1 question why can't the body detect Hiv during the early phase or upon entry? I have a theory which could be extremely wrong- because Hiv is so unique- the body of course can detect Hiv. However during early immune response Hiv can easily elude this by giving up its receptor sites( gp 120). The immune system would stop attacking the virus because it only attacks virus with antennas or gp 120. In the absence of gp 120 it would shut down. Then Hiv would grow back its gp 120 if threatened again it would give it up again. The process would go on and on until it reaches its target tcells. By then it's checkmate.anyway it's just a theory which is probably wrong anyway. I just wish people with Hiv aids will be healed soonest.

  • @puteripelangi3388

    @puteripelangi3388

    2 жыл бұрын

    @Unique Pros yup

  • @shafiulismam5334
    @shafiulismam53344 жыл бұрын

    Hi Biointeractive, make one like this for corona virus

  • @natalierobinson177
    @natalierobinson1775 ай бұрын

    I would have done so much better in highschool if the internet was around. It’s hard for me to grasp these concepts without a visual ❤❤❤ really helping me in college

  • @Static_Symphony
    @Static_Symphony3 жыл бұрын

    Really interesting video. Thanks for posting! :)

  • @biointeractive

    @biointeractive

    3 жыл бұрын

    Glad you enjoyed it!

  • @fatamajolly6012
    @fatamajolly60124 ай бұрын

    Excellent video

  • @user-nm1rh3ih5x
    @user-nm1rh3ih5x4 ай бұрын

    I subscribed your channel bcz of this beautiful video, thanks! If you add more detail like from how it enters our body + for macrophage i.e. CXCR4 …… its budding off and destroying the cell membrane. Again Thanks for you👍

  • @marcayalde1953
    @marcayalde19532 жыл бұрын

    10/10 animation, W

  • @mortadhaqasim959
    @mortadhaqasim9592 жыл бұрын

    Well done 👏🏻

  • @gjzztrrettmmggrrertzhgyena4950
    @gjzztrrettmmggrrertzhgyena49504 жыл бұрын

    Thanks Sir🖐💖💖💖💖

  • @maniblue707
    @maniblue7077 жыл бұрын

    very usefull

  • @vladimirvondracek7570
    @vladimirvondracek75702 жыл бұрын

    Excelent video, thank you

  • @biointeractive

    @biointeractive

    2 жыл бұрын

    You are welcome!

  • @andrashajdu
    @andrashajdu4 жыл бұрын

    Its amazing that we are able to understand this

  • @junepadi4362

    @junepadi4362

    3 жыл бұрын

    Now that we understand it, how do we neutralize it, permanently.

  • @Matthew-yc6nx

    @Matthew-yc6nx

    Жыл бұрын

    ​@@junepadi4362bNAB's? Latency reversal agents?

  • @mcdonnell-douglasdc-1087
    @mcdonnell-douglasdc-10875 жыл бұрын

    EXCELLENT.

  • @noorain_fathima
    @noorain_fathima3 жыл бұрын

    Superbbb

  • @Hareemqureshi991
    @Hareemqureshi99110 ай бұрын

    Thank u so much Sir❤❤❤

  • @moulya.s5066
    @moulya.s50663 жыл бұрын

    Tq fr d information

  • @rawandahhan8866
    @rawandahhan88665 жыл бұрын

    Perfect!!

  • @sugarbrownies8080
    @sugarbrownies80804 жыл бұрын

    what happens to the other rna asit is double rna

  • @sharafallmai8140
    @sharafallmai81404 ай бұрын

    Thank you

  • @yaranady9860
    @yaranady98603 жыл бұрын

    Perfect ❤️

  • @vishnujwalapuram1415
    @vishnujwalapuram14154 жыл бұрын

    Excellent Video with good Voice description !! it is shocking to see how many activities inside our body happens with such high precision. what direct Virus to do all these ? the whole ego of any organism is reflected in the form of multiplication of itself. Is Virus doing the same ?

  • @Cleeon

    @Cleeon

    4 жыл бұрын

    Chemical reaction, by the natural law, all creature programmed to keep their existence, they just want to stay "immortal" or exist

  • @bigpardner

    @bigpardner

    2 жыл бұрын

    If virus is not alive it is not an "organism" is it?

  • @yersinia3510
    @yersinia35102 жыл бұрын

    I thought CCR5 coreceptor is required for HIV to enter macrophages? Based on my source, it is CXCR4 that is required for HIV to enter T-lymphocytes particularly T-helper cells. Can you please enlighten me?

  • @Matthew-yc6nx

    @Matthew-yc6nx

    Жыл бұрын

    Some strains of HIV utilise the CCR5 corepector, some use the CXCR4 coreceptor, and some use both. This is called HIV-tropism. Some people are co-infected with both CCR5 and CXCR4 trophic viruses. This is known as HIV superinfection.

  • @Dr.Iftekharbaloch
    @Dr.Iftekharbaloch4 жыл бұрын

    Very informative. What happens to 2nd RNA strand?

  • @sina8398

    @sina8398

    4 жыл бұрын

    when HIV enters the cell both of RNA's form a double stranded viral DNA , and that DNA will go and stick to the host DNA. so that will cause a long-life infection because scientist are not able to remove that viral DNA from the host DNA

  • @ilyasyo6079
    @ilyasyo607910 ай бұрын

    thnk you very mutch

  • @user-hl3uv3ki5c
    @user-hl3uv3ki5c Жыл бұрын

    Very helpful, thanks

  • @biointeractive

    @biointeractive

    Жыл бұрын

    Glad it was helpful!

  • @tinabrahim7085
    @tinabrahim70852 жыл бұрын

    Great video!

  • @ahmadbhaiyat3015

    @ahmadbhaiyat3015

    2 жыл бұрын

    Agreed

  • @biointeractive

    @biointeractive

    2 жыл бұрын

    Thanks!

  • @shivamghosh7019
    @shivamghosh701911 ай бұрын

    Can multiple hiv virus enter same cd4 cell ?

  • @Dr.Iftekharbaloch
    @Dr.Iftekharbaloch4 жыл бұрын

    2:06 Single stranded DNA is again reverse transcribed? Since the single stranded DNA is used as a template for synthesis of 2nd strand of DNA so can we call it reverse transcription?

  • @biointeractive

    @biointeractive

    4 жыл бұрын

    Good point, that shouldn't be considered reverse transcription I don't think. Many of these animations will be re-narrated so we will check that. Thanks!

  • @Dr.Iftekharbaloch

    @Dr.Iftekharbaloch

    4 жыл бұрын

    @@biointeractive It would be better to narrate the polymerase and nuclease activity of reverse transcriptase..

  • @thokling361

    @thokling361

    4 жыл бұрын

    The process is described by the narration (and subsequently the video) as a single operation and by the incorrect enzyme. It appears that DNA polymerase synthesises two single DNA strands from one, and DNA ligase joins two single DNA strands into one by joining DNA sugars on each strand together.

  • @Dr.Iftekharbaloch

    @Dr.Iftekharbaloch

    Жыл бұрын

    @@biointeractive Still not re narrated...

  • @biointeractive

    @biointeractive

    Жыл бұрын

    Thanks for bumping this. Turns out that reverse transcriptase does indeed make a double-stranded DNA molecule out of the single-stranded DNA. Using the phrase "reverse transcribed" is misleading, I agree, but reverse transcriptase is indeed the enzyme that does it. If we ever re-record this narration (the current one was taken from a live lecture) we will keep this in mind. "Reverse transcriptase (RT), also known as RNA-dependent DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into DNA. This enzyme is able to synthesize a double helix DNA once the RNA has been reverse transcribed in a first step into a single-strand DNA." From: www.sciencedirect.com/topics/neuroscience/reverse-transcriptase

  • @basisTermium
    @basisTermium4 жыл бұрын

    i dont get how the virus know when too bud off?

  • @jetrogutierrez1356

    @jetrogutierrez1356

    4 жыл бұрын

    The virus budds out once it has all the correct protiens to mature into an infectious hiv virus. Then it will mature outside of the cells after peotease does its job.

  • @sandrodream5418
    @sandrodream54183 жыл бұрын

    This is incredible only got the cold create this perfection

  • @omarsantiago2826
    @omarsantiago28262 жыл бұрын

    excelente

  • @TheWa4er
    @TheWa4er5 жыл бұрын

    It would be great to see a similar video about how modern HIV medicines works

  • @antonioacevedo5200

    @antonioacevedo5200

    5 жыл бұрын

    I am no expert by any means, but I just watched another video where it explained that medications specialize in preventing one or more of the sequences that occur during the replication processes of HIV. What I wonder is if these retroviruses eventually die of old age.

  • @roo6784

    @roo6784

    4 жыл бұрын

    Antonio Acevedo Unfortunately no, viruses cannot be killed. Viruses are non living microorganisms that contain genetic coding (DNA, RNA, etc). However, a virus can only thrive if it invades a host, they cannot live independently. Once a virus binds its receptors to cells, they hijack the genetic instructions and multiply in vast numbers, unless a medication is taken to prevent the receptors from binding. But it would be difficult to predict a viral invasion because symptoms will not start until after the damage has already been done (Which in this case, would be the virus hijacking the genetic coding of an individual and multiplying).

  • @bigpardner

    @bigpardner

    2 жыл бұрын

    @@roo6784 In one sentence you say "viruses are non living microorganisms ". If non living they are not microorganisms are they? Organisms and microorganisms are living things. How can a virus invade a host if it is not living? How can it can or cannot "live independently" if it is not a living thing, an organism? How can something have a reproductive cycle if it is not alive?

  • @biointeractive

    @biointeractive

    2 жыл бұрын

    www.sciencenews.org/article/viruses-alive-coronavirus-definition

  • @sarwatfatima4946
    @sarwatfatima49463 ай бұрын

    well explained

  • @luislanga
    @luislanga9 ай бұрын

    How does all that stuff move into the right place to do all that

  • @ZKhan782
    @ZKhan782 Жыл бұрын

    From where other glycoprotein of virus com from on cell surface

  • @jaylxxxi1908
    @jaylxxxi19083 ай бұрын

    Its like cells are biological computer machines.

  • @80sbrunnette
    @80sbrunnette3 жыл бұрын

    crazy, its as if it has a mind of its own!!

  • @syntacticcave9514
    @syntacticcave95142 жыл бұрын

    Very interesting

  • @jonathanmwanzia1804
    @jonathanmwanzia1804 Жыл бұрын

    wonderful one

  • @biointeractive

    @biointeractive

    Жыл бұрын

    Many thanks

  • @ozdevil4564
    @ozdevil45642 жыл бұрын

    How does Prep works?

  • @alfmerck6262

    @alfmerck6262

    3 ай бұрын

    It creates chemicals that disrupt the virus's reproduction at all of the various stages described in the video.....1) it prevents the HIV entering the cell.....2) those that do enter the cell are then stopped from reverse-transcriptions....3) those that manage RT then get prevented from cleaving the DNA....and so on.

  • @LOZtwilit
    @LOZtwilit5 жыл бұрын

    Would it be possible to destroy those receptors somehow? If the virus can't replicate wouldn't it expire past the incubation period? I'm asking in all seriousness.

  • @NotoriousPyro

    @NotoriousPyro

    4 жыл бұрын

    You'd die if you destroyed those receptors. They're used in immune response.

  • @jamesjohnson1050

    @jamesjohnson1050

    4 жыл бұрын

    Some HIV medication work by blocking the receptors on the virus.

  • @Matthew-yc6nx

    @Matthew-yc6nx

    Жыл бұрын

    ​@@jamesjohnson1050Like Maraviroc, Enfurvitide and Ibalizumab?

  • @matman7691
    @matman76912 жыл бұрын

    Can anyone explain like I'm five? How would reverse transcriptase be able to read the single strand of DNA? I have it in my head that reverse transcriptase only interacts with RNA. Am I simply incorrect in thinking this?

  • @biointeractive

    @biointeractive

    2 жыл бұрын

    Transcription is making RNA from a DNA sequence. That's why this is reverse transcriptase: it makes DNA from an RNA sequence.

  • @ZKhan782

    @ZKhan782

    Жыл бұрын

    What? You are only five and studying this 😨

  • @wolfpackflt670
    @wolfpackflt6704 жыл бұрын

    Soo.....why not just use crisper to change the "keys" on the helper-t cells so that the virus can't enter?

  • @biointeractive

    @biointeractive

    4 жыл бұрын

    Main issue is changing the receptor enough to make it unrecognizable to the virus but still maintaining its regular function. (And that's assuming we get CRISPR working in humans)

  • @KunglawAdy

    @KunglawAdy

    3 жыл бұрын

    @@biointeractive man.... looking at this is like human body is just complex functional super computer with doing complex computation

  • @knightshade6232
    @knightshade62324 жыл бұрын

    do viruses move on their own do they have some mechanism to fly around or swim like bacteria??? if they do move this can require energy so they must eat but they do not eat?????????? can someone answer....

  • @happyrick-c1327

    @happyrick-c1327

    4 жыл бұрын

    Yes

  • @bigpardner

    @bigpardner

    2 жыл бұрын

    Aren't viruses not alive, not a living thing, not an organism? If that is the case how could they move? How can something not alive have a reproductive cycle?

  • @alfmerck6262

    @alfmerck6262

    3 ай бұрын

    It's all chemical rection. Remember, there are millions/billions of HIV roaming around the body, and about 1-4% of them get the job done (against about 1500 immune cells per cubic mm). So its not about 'eating' its about chemical reactions.

  • @dr.archanamane

    @dr.archanamane

    24 күн бұрын

    ​@@alfmerck6262explained well.. Can you further elaborate what happens to remaining 99-94% viruses if only 1-6% get the job done..

  • @hiturbo1918
    @hiturbo19182 жыл бұрын

    Why can't the body detect all of this happening inside?

  • @Matthew-yc6nx

    @Matthew-yc6nx

    Жыл бұрын

    It can. Sometimes CD4 cells compromised by HIV can self-destruct, either by apoptosis or pyroptosis. This self-destruction mechanism is one of the major causes of CD4 cell depletion where HIV infection progresses into AIDS (CD4 count of less than 200 per uL of blood).

  • @joaosayeg
    @joaosayegАй бұрын

    The RNA is not converted in DNA, it's used as a mold to create DNA. Is that right?

  • @intelligentmind5028
    @intelligentmind50283 жыл бұрын

    🙌

  • @inuahead1218
    @inuahead12186 ай бұрын

    How do u know this really happens? How can u study life cycle of virus which are within a cell in a live human. ?

  • @dr.k.nandhakumar
    @dr.k.nandhakumar Жыл бұрын

    How to create similar animation video

  • @taniaratobilskaja-obreiter4616
    @taniaratobilskaja-obreiter46164 жыл бұрын

    Классные видео! Сделайте pleas субтитры на русском oder auf Deutsch.

  • @gscreations8680
    @gscreations86802 жыл бұрын

    Man, God Is Incredible! How He Programmed All These Functions In Our Body. Stay Blessed Everyone.

  • @Matthew-yc6nx

    @Matthew-yc6nx

    Жыл бұрын

    No this is just how we evolved.

  • @justforyou3371
    @justforyou3371 Жыл бұрын

    Macrophage???

  • @Letseewhat
    @Letseewhat4 жыл бұрын

    sneaky creatures!

  • @joeyng1282
    @joeyng12823 жыл бұрын

    One question why HIV virus only targeting the T Helper cells but not other types of cells?

  • @scrullybrully751

    @scrullybrully751

    3 жыл бұрын

    Because the virus binds to a protein (CD4) that is only present in T helper cells. The HIV only has the "key" for a kind of "door" exclusive of T helper cells, while other cells have other kinds of "doors".

  • @dr.archanamane

    @dr.archanamane

    24 күн бұрын

    ​Does it sound that hiv won't be present in tissues where cd4 receptors are absent...

  • @hadianawaz7621
    @hadianawaz7621 Жыл бұрын

  • @leonak7654
    @leonak76542 жыл бұрын

    Smart virus and scary !

  • @Matthew-yc6nx

    @Matthew-yc6nx

    Жыл бұрын

    Not smarts, just evolution and selection

  • @josephsimon4580
    @josephsimon45802 жыл бұрын

    It seems like to me that this virus has some kind of intelligence to know exactly which host cell to attack and which is DNA to Infect.

  • @biointeractive

    @biointeractive

    2 жыл бұрын

    No intelligence, just selection for viruses that can attach most efficiently to a particular type of host cell, based on a specific receptor only found on that cell type.

  • @josephsimon4580
    @josephsimon45802 жыл бұрын

    Why can't they stop the intergrase from happening I kid you not I think I know what the cure for hiv antibodies I will bring this information to bear once I have time to do research.

  • @Matthew-yc6nx

    @Matthew-yc6nx

    Жыл бұрын

    They can. Molecules called integrase strand transfer inhibitors block the integrase enzyme from splicing the viral DNA into the host cell DNA. But, once integration occurs, the cell is compromised permanently, and no medication currently exists that can undo that. Because current HIV medications are designed to target steps in the HIV life cycle, they are only effective when the virus is actively reproducing. Another barrier is the fact that HIV-infected cells can remain dormant, and dormant HIV- infected CD4 cells aren't distinguishable by the immune system from non-infected CD4 cells, and there are no approved drugs or treatments that can reverse HIV latency. Therefore, in an HIV-positive individual, there will always be a reservoir of dormant, HIV-infected cells; hence, no cure for HIV currently exists. But scientists around the world are working to one day develop a cure, as well as potentially even a vaccine for HIV.

  • @ai7783
    @ai7783 Жыл бұрын

    Still no cure?

  • @Matthew-yc6nx

    @Matthew-yc6nx

    Жыл бұрын

    The issues with developing a cure is viral latency and the highly mutagenic nature of the virus

  • @shafiulismam5334
    @shafiulismam53344 жыл бұрын

    mmhmm this is the stuff

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