"CHOPS OFF A BIG HUNK! and if that doesn't wake you up, I don't know what will." Funny thing is that I was laying in bed, all comfy, my eyes closed, just about to drift off into dreamland, and that woke me the heck up thank you very much

@hernicayt

6 жыл бұрын

i cracked up for this part

@qalishhashim

4 жыл бұрын

Lena Liu same i was wearing earphones and during that part it was so loud, i was so suprised and cracked later hahahah

@zekeriyamustafa9952

3 жыл бұрын

This exactly me rn😂😂

@Hahaha-px5ep

3 жыл бұрын

I like how Angiotensin I doesn't even look awake but just totally zoinked

Nursing student here, struggling in Pathophisiology and your videos are SO CRAZY HELPFUL!!! My peers love them too. Can't thank you enough!

For everyone wondering about ACE (Angiotensin Converting Enzym), its on the surface of the Endothlial cells which he describes at 7:20. Or you can kinda say that ACE is released by Endothelial cells but they are still attatched to the walls of the vessels.

You forgot to mention the enzymes found on endothelial cells that convert angiotensin 1 to angiotensin 2 are called angiotensin - converting enzymes - (ACE)

@wonderfullymade8690

Жыл бұрын

Your comment flicked a switch in my brain and now I understand the role of ACE inhibitor drugs in lowering BP. Thank you!

Angiotensin 2 is indeed a happy little fellow. =)

1. Yes, Going from A1 to A2 requires ACE 2. A2 has effects on the Prox. Conv. Tubule to reabsorb Na+ (this is not negligible) 3. Hypervolemia with Hyponatremia sounds like an SIADH type syndrome. In SIADH, GFR is high, so Renin levels are low. We will be doing an ANP video in the future to help describe its role.

One of the most organized, beautiful, color-coded, clear videos ever! If every video was like this. Learning would be so easy! lol (visual learner here) I only watched it once and I got it.

YOUR VOICE IS SO SOOTHING!

@KChow-nb1pz

5 жыл бұрын

6:33 : Am I a joke to you

@smallfung1994

3 жыл бұрын

His voice was all soothing and games until renin CHOPS OFF a big hunk of angiotensinogen

You are the BEST! You are helping me get through graduate school. You don't talk too fast, you break things down and make them fun, interesting and understandable. Also you have an amazingly great voice! Thank you so much for your videos

Again excellently explained! You are officially my favourite youtube channel to watch!!!

WOW! This is an outstanding video. RAAS, easy peezy.

I love the neighbor analogy! This was so helpful! Thank you for the great content!

I really enjoy your videos, actually I think out of all khanacademy videos, yours are the best. You really make a lot of sense of things and help consolidate the info in my head. You really gave me a chuckle with your angiotensinogen face in this video.

I find it strange that ACE was never mentioned in this vid (especially due to clinical significance), but still a great overview. Loving the khan academy medicine videos as introductions to topics/study motivators. Thank you 👍🏼

thank you it’s really helping me , i’m a medical student and now i’m on gastrourinary system topics 😃

Thank you for this creative video and thinking of angiotensinogen as a sleep walker with a resting face and angio I as active with a smile will help the info stick in my memory! Textbooks show ACE in the simplified RAAS charts and i think the reason it wasnt mentioned here is because the focus is on the badic pathways and there is probably more than one enzyme at work here. Although ACE is very important. This isnt our first exposure to RAAS so you are here with a basic understanding of physiology or anatomy. I was able to fill in the enzyme there and find it interesting that it is not only from lung endothelial cells but also from the endothelial cells in the blood vessels throughout the body. Most importantly thank you for showing the 4 targets of Angio 2 and explaining the difference between local and distant messengers.

thanks so much, you made that really clear :) bring on the exams!

Excellent explanation. Great videos, very clear, nice pace and use of graphics and voice. Thank-you!

Wow! Your voice a is so cool and you teach incredibly well! ✨ I'm so happy that this amazing channel is free and I can't thank you enough for being here and helping students like me who can't afford even low membership fees. Please don't forget people like me and continue to make FREE contents as you are amazing at explaining things and making the most informative short videos! ✨❤🙏

Thank you so much for illustrating the mechanism!

Really incredible....thankful to u

you are the best! Thanks a lot! thanks Khan Academy!

Wow!! Very well explained. Thank you. Nice summary

Awsm video.. Vry clear nd lucid explanation.. it's amazing.. thank u so much!!!!!!

its not juzt helpful for nursing students but also helped alot to cover basics for medical students too...i was confused through books but got clearity here ❤️❤️❤️

Okay so that adrenal (add+renal) thing completely blew my mind. Great video, btw.

@snaggybeans

6 жыл бұрын

me too! I don't think I'll forget where it is ever again!

Really helpful -- thank you so much!

Absolutely brilliant at explaining, thank you !

Thank you and congratulations on this lecture. Plus my 5month old daughter loves your voice! So everybody is happy!!

@ski.7

3 жыл бұрын

Plus angiotensin 2 too

thank you soooo much... this one video made everything so easy!

Thanks professor for opening my brain

Great explanation. I love your little analogies

thank you so much!! very well explained.

you are the best. I finally understood. I felt hopeless for unable to understand these processes by reading books or watching other videos. Thank you so much. Can you please be my lecturer haha

Great videos! Keep making more!

Excellent video ....Thank you

Thank you, it's amazing!

It is very nice and easy to understand

Thank you so much for such a beautiful explanation

great voice..video..and explanation...keep videos coming

So so so so so helpful.

Great video and explanation, thank you!

I love these videos. They are super helpful!!! It’s like if Bob Ross went to med school.

Thanks for the great teaching. I'm not sure why the last three people who commented were on an education site. Keep up the great work!

Love ur way of teaching

Thank You very much, This really helped

Thank you very much I had an exam today and this really helped

wt a perfect video!

You are an amazing teacher!

this is so good!!!!

Sir v good style of teaching. Thanks alot

Haha it woke me up! :D good video thanks

It's amazing , thank you

amazing video thank you so much

An excellent tutorial.

Thanks for the information. This was a great refresher. Not only did it brush me up on my knowledge of the RASS, it also touched on the action of ACE Inhibitors and Vasopressin. Great job

@bhavanapatel4357

5 жыл бұрын

Sarcastic bro

I am literally crying because finally now i understand this literally the night before my exam :,)

wow thank you for that!

nice presentation! thankyou

amazing)) thank you;)

Thank you!

Great video, thanks! But what about ACE?

@changolord93

5 жыл бұрын

I did and he didn't mention ACE

that was awesome

love the lectures

Thank you soooooooooooooo much!!

Great video ! What software is this ? It's awesome !

can someone explain to me why macula densa cells use prostaglandins? Prostaglandins are pro-inflammatory, and also, especially the PGE2 increase sensitivity to bradykinin, which would then just cause hypotension. It's really confusing.

Angiotensinogen: I sleep Angiotensin 1: REAL SHIT

גdo you use a graphic tablet? what program do you use? thanks for the lectures, they are great

Thankyou!!!😭😭💛💛

Thank you g

thank you

such a soothing voice you could read to me by my bedside...#prohomo

THANKS YOU SO MUCH!!! 14 minutes well spent!

Thank you

Thank you. Oskar

Thanks

Well explain

what about ace in the lung ?

thank you sooo much! So easy now!

@philw3953

7 жыл бұрын

I know, wasn't that wonderful?

Great explanation, but I think you missed out angiotensin-converting enzymes.

The sympathetic nerve cells are from pelvic nerve?

Your video's really helped me! One thing I would like to ask is... could you sometimes write bigger letters please?:) Your " smooth muscle" was a challenge to read :) Thank a lot!

there other things that control bp ,ANP that is activated when bp is rised and there is hypernatemia/elivation of Na ion and then the ANP on right atria is activated and acts on the collactnig tube of the kidney and leads excration of Na and retenssion of Ka,2 the prostaglandin ,nitric oxid and so on

is it the enzyme ACE released by the endothelial cells that convert Angiotensin I into Angiotensin II?

@Exotiicfruiit

9 жыл бұрын

It has to be. I got confused too because i´ve learned that it´s ACE that convert Angiotensin I into Angiotensin II. But then I remembered that i happens in the endothelial cells.

Wouldn't low salt in the distal tubulus (urine) measured by the macula densa cells mean that there is are high levels of salt blood, i.e. high blood pressure instead of low blood pressure?

There are actually several ACE-independant pathways.

doesn't your SV decrease when the kidney holds more water, which doesn't get absorbed by the capillaries, which also doesn't increase blood volume?

could you please explain to me,how sympathetic nerves can increase renin secretion?could you please give me the link or reference for more clarification?

@arielsmith5246

9 жыл бұрын

Nazmulur Rahman nazmul Sympathetic nerves innervate the afferent and efferent arterioles and receive signals from baroreceptors in the cardiovascular system (in the carotid sinus, aortic arch, etc) when extra cellular volume is low to secrete renin.

@azifahahmed4462

8 жыл бұрын

+Ariel Smith love it

thanks for the tutorial it was very helpful, does this mean Hypertension is also responsible for the urine output of a person?

@MsElizard

3 жыл бұрын

My skin is very dry and I have incredibly high B.P when upset I Lost my brother due to him having Kidney cancer and am trying to avoid medication.Is that a good idea ?

4:06 ... how does less BP lead to less movement of fluid ? does filtration rate increase or decrease ? how ?

@ANonyMouse627

5 жыл бұрын

When there's less pressure, there's a less flow. Think of a faucet

@evantansimore7634

4 жыл бұрын

And less pressure means less “squeezing out” of materials in the Bowman’s capsule

is it just me or the dude kinda sounds suuuuper high ... great video though ;)

@victoriasandsphillips8140

6 жыл бұрын

it's just you

You sounded like Chien-Po from Mulan in the beginning..

@inomniaparatus3326

5 жыл бұрын

Lol

I laughed so hard!

Renin is enzyme not hormone?

Can sleep apnea trigger this?

NICE! But what about ACE?

@RCTWorks

5 жыл бұрын

Yes. ACE is the Angiotension-converting-enzyme correct? And it comes from the lungs?

@guit-art6666

5 жыл бұрын

@@RCTWorks yeah most of it, indeed you can find it in vascular endothelium, brain and kidney

So what is the point in Aldosterone if Angiotensin 2 has the same effect on the kidney?

@CuppaChai11

9 жыл бұрын

i think it DOUBLES the effect...

I'm a little confused about what actually induces renin secretion. Other than sympathetic innervation, you also mention a drop in blood pressure as well as a drop in Sodium concentration (in tubule fluid or in blood? Not necessarily the same thing). I have read that the decrease in blood pressure is actually detected by baroreceptors in the afferent arteriols in the kidney, not by the JG cells. Does anyone know? Also, I have read that the macula densa detects a decrease in sodium as you say, but also a decrease in blood perfusion to the kidney. Both of these factors will induce Renin-secretion. Does anyone know about this blood perfusion to the macula densa thing? Or is it just misinterpreted to the drop in blood pressure?

@emilyjw19

7 жыл бұрын

Not sure if this is right but surely if there was a decrease in blood perfusion it would cause a decrease in blood pressure? So the macula dense is picking up the decrease in blood perfusion and realising that there is a drop in blood pressure because of that. Could be wrong though.

@hamedbedar4671

7 жыл бұрын

erik wennberg actually when the bp gets high initially the gfr increases causing more nacl to to be filtered so if the GFR is high fluid goes through tubules faster and there is less time for nacl to be reabsorbed from the PCT into the peritubular capillaries and when this high nacl reaches the macula dense it causes vasoconstriction of the afferent arterioles through vaso active substances thus decreasing GFR

what about ANP and BNP