Diuretics | Pharmacology | Dr Najeeb
#drnajeeb #medicines #pharmacology #diuretics
Diuretics | Pharmacology | Dr Najeeb
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Diuretics-Pharmacology
00:00:00
Diuretic and Natriuretic.
00:02:02
Relationship between Cardiac Output (CO) and Renal Blood Flow (RBF), Percentage of RBF ending up as Filtrate; Concept of Glomerular Filtration Rate (GFR) as a function of CO and RBF. Understanding the role of processes such as Filtration, Reabsorption and Secretion.
00:16:19
Percentage ending up as Final Urine Volume, Clinical co-relate: Oliguria, Polyuria; Nephron as the "Master Processor".
00:28:59
Diuretic and Natriuretic drugs' action on nephrons.
00:30:26
Outline: Mechanisms and sites of Reabsorption (Na+ primarily), 1-Proximal Convoluted Tubule (PCT) 2-Thick part of Ascending Loop of Henle (TALOH) 3-Distal Convoluted Tubule (DCT) 4-Collecting Tubule (CT)
00:33:42
1-Proximal Convoluted Tubule (PCT); Anatomy of PCT & mechanisms of Reabsorption, Secretion, Exchange (Na+, H+, HCO3-), Role of Na+H+-counter transporter and Na+K+ ATPases.
00:50:00
Carbonic Anhydrase (CA) enzyme, H2CO3 (Carbonic Acid); [HCO3- and H+] and the drugs that act through blocking CA enzyme (CA inhibitors); Increased Na+, HCO3- and H2O in urine: Acetazolamide.
01:00:29
4-Collecting Tubule (CT) : Principal cells, Mechanisms of K+ wasting (Kaliuretic); K+ Wasters = All Diuretics acting proximal to CT.
01:13:00
Descending LOH: Freely permeable to H2O [along with PCT]; Ascending parts of LOH + initial DCT fully impermeable to H2O, Role of ADH in CT's water permeability and excretion of dilute and concentrated urine, Osmolarities in various parts of tubule & its rationale.
01:35:56
2-Thick part of Ascending Limb of Loop of Henle (TALOH); Na+ K+ 2Cl- Co-transporter, K+ leaky channels on luminal side; electro positivity in lumen and its effect on Ca+, Mg+ reabsorption; Drugs blocking NaKCl co-transporter; Loop Diuretics [Furosemide etc.]; Kaliuretic + Calcinuria + Magnesiumurea
02:04:15
3-Distal Convoluted Tubule (DCT): Na+Cl- co-transporter, Na+Ca+ counter transporter, role of Parathyroid hormone (PTH), Thiazide Diuretics as Ca+ retaining drugs; Renal stones.
02:19:15
Comparing Thiazide Diuretics, Furosemide and their effect on Ca+ absorption & its clinical implications; Osteoporosis, Hyperuricemia. Interaction with NSAIDS.
02:26:35
Drugs acting distally to DCT; Antikaliuretic drugs: Importance of Principal cells in K+ balance, Na+ channel blocking drugs, Role of Aldosterone;
02:48:50
Effects of Diuretics on Principal Cells; Amiloride, Triamterene; K+ Sparing drugs. Aldosterone Receptor Blockers (ARBs): Spironolactone
02:54:54
Osmotic Diuresis; PCT: Mannitol; Increased Extracellular Fluid Volume (ECFV)
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Sir everytime u proove what u say always.......that is the crystal clear concepts....best teacher of medicine i have ever seen..
@DoctorNajeeb
10 ай бұрын
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It's such a strange thing... I have spent MANY MANY hours (probably days if you add it all up, hey maybe even weeks) reading and studying my own health and body. Once you start watching this Dr. and his gift of being able to explain things, the pennies just constantly drop. Also, he also makes you feel better about yourself and your own health because of the fact you understand it all MUCH MUCH more. Thank you Dr. Najeeb. Medical science has a gift in you.
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2 жыл бұрын
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After 5 years you are still liking every comment Great
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999
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6 ай бұрын
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@nimishymasamvu9870
3 ай бұрын
Best teacher in the world
Legends be this clear and still ask 'Am I clear?'. Love from India Sir
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Жыл бұрын
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Ай бұрын
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I missed a teacher like you during my graduation. Thanks for making the mechanism clear and simple. With prayers.
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I haven't seen any teacher teaching like this very clear fundamental not only in pharma but also in physiology also 🔥🔥
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Жыл бұрын
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Жыл бұрын
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4 жыл бұрын
Dear Doctor imran Hussain, Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love and happiness, always. We wish you success and happiness in every walk of life and good luck in your future endeavors. Regards, Dr. Najeeb Team
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4 жыл бұрын
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3 жыл бұрын
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2 жыл бұрын
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May be god has come on to this earth in your soul to make us best doctors ... iam really surprized sir with your Art of teaching..... million thanks to you sir...for every sentence i understand wholeheartedly...i convey my heartful thanks to you again and again really sir... truly indebted to you sir...really thankyou so much for enlighting us sir....tqsm!! Dr. Najeeb sir....... from: your student, Sravanthi ..M.B,B.S Final year.
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I saw this lecture couple of days back and now I was revising for my upcoming exams ,I just felt the beauty of crystal clear concept and just came back to video to thank you sir.. Thank you so much sir .... I pray to Almighty to keep you always charming and blessed ...once again thank you sir
@papaibiswas7993
2 жыл бұрын
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@papaibiswas7993
2 жыл бұрын
O ok
Thank sir for giving beautiful explanation 🥰🥰😍
Respect from 🇲🇦 You are the best Dr. Najib
Who can create millions of master processors within 5 inch of kidneys other than Allah? Glory be to Allah❤️
Turn on Mono Audio in your device settings to balance the sound on left and right channels. Thank me later.
26:50 56:00 1:11:20 (Recap of why some diuretics ppt keleuresis/pot. wasting) 1:34:19 - action of ADH on Collecting tubule and the deciding factor if the urine which is excreted is concentrated or diluted. 1:49:50 - How the diuretics are differentiated into high ceiling /low ceiling diuretics. 1:54:30 Management of hypercalcemia - 1:56:50 2:02:00 - 2:02:33 - Recap of furosemide 2:21:28 - furosemide v/s thiazide diuretics 2:27:30 - Principle cells 2:28:48 **- sodium handling proteins in Diff parts of nephron Beauty of electrochemical gradient - 2:36:06 Aldosterone - 2:44:30 2:49:00 - pot sparring diuretics
@bhojpurisingerofficialchan2885
2 жыл бұрын
9
@bhojpurisingerofficialchan2885
2 жыл бұрын
9 oo
@bhojpurisingerofficialchan2885
2 жыл бұрын
Oo N
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The fact that you made me believe that even pharmacology can be understood and need not be crammed is itself praise worthy .. thank you so much sir ... Extremely grateful 🙏
@ismetkarabyk2040
2 жыл бұрын
9
Thanks a lot, sir !!!
Extraordinary contribution.
So easy to understand , thanks a ton ❤️
Thank u sir for explaining so easily....
Thank you for being with us ❤️ I have never seen such tutor , clearing all the concept❤️
@DoctorNajeeb
Жыл бұрын
Glad to hear that
@suryaprasantnaram5141
Жыл бұрын
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This is a fantastic lecture
Dr. Najeeb, i normally tell my husband that, he is the GOAT. but you sir, are the GOAT of teaching and explaining. God bless you
@DoctorNajeeb
5 ай бұрын
So nice of you
thanks a lot sir
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Thank you doctor..
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2 жыл бұрын
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superb Dr. I just came across this video as my mother often loses the levels of sodium and pottassium.. excellent lecture...god bless you ...for a common man like me with little knowledge of science..you have made to understand the concepts. ..though not familiar with tech. words you use... hats off....
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3 жыл бұрын
Thank you for your feedback. Keep supporting the hard work. ❤️🔥
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2 жыл бұрын
Mool
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2 жыл бұрын
Mool
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8 ай бұрын
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Thnkyou doctor شكرا دكتور
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2 ай бұрын
It's my pleasure❤
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2 жыл бұрын
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Thanking u sir..
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3 жыл бұрын
Thank you so much.❤️
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3 жыл бұрын
Thank you so much :)
You Sir, are a true master. Respect, and thank you very much for your lecture. God bless...
Sir u explained it so easily,u r awesome sir thank u so much 💫💯
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Жыл бұрын
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8 ай бұрын
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2 жыл бұрын
So sweet of you! ❤️
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Ай бұрын
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Ай бұрын
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A big thanks Sir
After recently discovering your videos by random chance I went from frustrating c to an A. Thank you for a superb teaching style. You help me comprehend basics so the abstract and complicated become easy
Thank you...u r the best teacher
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Жыл бұрын
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Thanks Dr for deep explanation
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Жыл бұрын
My pleasure❤ Stay blessed ❤
Very nicely explained Sir.
@DoctorNajeeb
2 жыл бұрын
Thank you dear💖 Stay blessed💖
Amazing, now diuretics are on my finger tips
@DoctorNajeeb
Жыл бұрын
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4 ай бұрын
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Mind blowing lecture 🙈❤️
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Жыл бұрын
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2 жыл бұрын
Thanks A lot. Stay blessed ❤️❤️❤️
Thnks dr najeeb
You deserve more than what I paid for my university tuition fee
@shafiqurrehman1095
4 жыл бұрын
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Thank you sir for your good lecture
@DoctorNajeeb
2 жыл бұрын
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Before wathing this lecture one must understand the physiology of kidney. See the counter current multipilication video of Dr. Najeeb, then you'll understand this lecture very well. Thank you sir for making the concepts crystal clear.
Nice and supereb explanation in easy way. 🙏🙏
@DoctorNajeeb
2 жыл бұрын
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I'm greatly thankful to you sir,
Sir your contribution is priceless! You are a true blessing!😊
@vimleshwarprasad9357
2 жыл бұрын
Ji ok k oo ooooo hi I oo oo o or oo oooo kya hua h n isliye the h kya or
Respect sir
Love from India ❤❤great man 🎉
So clear and so informative
@DoctorNajeeb
9 ай бұрын
Glad it was helpful❤ Stay blessed ❤
Amazing lecture sir❤
@DoctorNajeeb
Жыл бұрын
Glad to hear that❤ Stay blessed ❤
what influential person.Really,I want to express my great appreciation for your indispensable good deed
@DoctorNajeeb
2 жыл бұрын
Many many thanks. Stay blessed ❤️
Thank you sir for such beautiful explanation
@DoctorNajeeb
Ай бұрын
Most welcome 🤗
@Dr.Shikha-rl7on
Ай бұрын
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Thank you Doc
@DoctorNajeeb
2 жыл бұрын
You are very welcome❤️
Very good sir
@DoctorNajeeb
2 жыл бұрын
Thank you💖 Keep watching💖
Very nice
I m answering your question like I m taking this class live
Stay happy and blessed sir 🎉🎉❤❤
@DoctorNajeeb
5 ай бұрын
Thank you
U r the best teacher ❤️
@DoctorNajeeb
Жыл бұрын
Thank you dear ❤️
This is a good bedtime story Thankyou.
@ayomkuot5580
3 жыл бұрын
Very excellent sir. I always enjoy your videos because I am learning in French 🙏🙏
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@DoctorNajeeb
2 жыл бұрын
Thank you❤️ Stay blessed❤️
Very nice lecture👌🙏
@DoctorNajeeb
2 жыл бұрын
Thanks for liking. Stay blessed ❤️
thnk you so much
@DoctorNajeeb
2 жыл бұрын
Most welcome❤️
Thanks sir, you are just Greatttt. In Diploma in pharma its a concept to just pass so frankly no one is there to teach properly but you have made me so much interested in pharmacology, i just cant thank you in words but THANKS Sir.
@DoctorNajeeb
2 жыл бұрын
Glad you loved my lectures. Stay tuned! ❤️
👌👍💪excellent quality job 👏 Doctor. Blessings again 🙏.
@DoctorNajeeb
3 жыл бұрын
So nice of you. Stay Blessed
Gratefull that we have teachers like u....u r awesome ✌️🙌🙌
@DoctorNajeeb
2 жыл бұрын
Glad you found this lecture easy to understand and meaningful! Stay tuned 💗
thankyou sir❤
@DoctorNajeeb
7 ай бұрын
You are welcome❤
Thankyou so much Sir 🙏🙏🙏🙏
@DoctorNajeeb
2 жыл бұрын
Most welcome 💖💖
Very good explanation sir, please create more and more videos
@DoctorNajeeb
2 жыл бұрын
Thank you, I will. Keep supporting ❤️
Thanku sir.. your video clear all my doubts and your video is very helpfull..
Excellent 👌👌👌
@DoctorNajeeb
2 жыл бұрын
Thanks a lot ❤️
Awesome lecture.
@DoctorNajeeb
4 жыл бұрын
Thank you. :)
Mashaallah Very nice lecture
@DoctorNajeeb
2 жыл бұрын
Thank you💖 Keep supporting 💖
Sir you are just amazing, God bless you 🙏❤
@DoctorNajeeb
3 жыл бұрын
Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love and happiness, always. We wish you success and happiness in every walk of life and good luck in your future endeavors. Regards, Dr. Najeeb Team
@somnathwagh9063
2 жыл бұрын
@@DoctorNajeeb ओोओओओओओओ
@somnathwagh9063
2 жыл бұрын
@@DoctorNajeeb ओओओओओओओओओओओ
@somnathwagh9063
2 жыл бұрын
ओ
@somnathwagh9063
2 жыл бұрын
ओओओ
One word to say this video... Simply superb ...
@DoctorNajeeb
2 жыл бұрын
Thank you so much ❤️
Awesome lecture . Before this for me the renal was the most difficult to understand . Thanks sir now it is not so.😊😊😊😊
I use to watch ur videos like in 2010- 2011 , time flies but i have so clear concepts since then . Thank u so much sir
@DoctorNajeeb
2 жыл бұрын
You are most welcome! ❤️ Stay blessed ❤️