Diuretics | Pharmacology | Dr Najeeb

#drnajeeb #medicines #pharmacology #diuretics
Diuretics | Pharmacology | Dr Najeeb
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Diuretics-Pharmacology
00:00:00
Diuretic and Natriuretic.
00:02:02
Relationship between Cardiac Output (CO) and Renal Blood Flow (RBF), Percentage of RBF ending up as Filtrate; Concept of Glomerular Filtration Rate (GFR) as a function of CO and RBF. Understanding the role of processes such as Filtration, Reabsorption and Secretion.
00:16:19
Percentage ending up as Final Urine Volume, Clinical co-relate: Oliguria, Polyuria; Nephron as the "Master Processor".
00:28:59
Diuretic and Natriuretic drugs' action on nephrons.
00:30:26
Outline: Mechanisms and sites of Reabsorption (Na+ primarily), 1-Proximal Convoluted Tubule (PCT) 2-Thick part of Ascending Loop of Henle (TALOH) 3-Distal Convoluted Tubule (DCT) 4-Collecting Tubule (CT)
00:33:42
1-Proximal Convoluted Tubule (PCT); Anatomy of PCT & mechanisms of Reabsorption, Secretion, Exchange (Na+, H+, HCO3-), Role of Na+H+-counter transporter and Na+K+ ATPases.
00:50:00
Carbonic Anhydrase (CA) enzyme, H2CO3 (Carbonic Acid); [HCO3- and H+] and the drugs that act through blocking CA enzyme (CA inhibitors); Increased Na+, HCO3- and H2O in urine: Acetazolamide.
01:00:29
4-Collecting Tubule (CT) : Principal cells, Mechanisms of K+ wasting (Kaliuretic); K+ Wasters = All Diuretics acting proximal to CT.
01:13:00
Descending LOH: Freely permeable to H2O [along with PCT]; Ascending parts of LOH + initial DCT fully impermeable to H2O, Role of ADH in CT's water permeability and excretion of dilute and concentrated urine, Osmolarities in various parts of tubule & its rationale.
01:35:56
2-Thick part of Ascending Limb of Loop of Henle (TALOH); Na+ K+ 2Cl- Co-transporter, K+ leaky channels on luminal side; electro positivity in lumen and its effect on Ca+, Mg+ reabsorption; Drugs blocking NaKCl co-transporter; Loop Diuretics [Furosemide etc.]; Kaliuretic + Calcinuria + Magnesiumurea
02:04:15
3-Distal Convoluted Tubule (DCT): Na+Cl- co-transporter, Na+Ca+ counter transporter, role of Parathyroid hormone (PTH), Thiazide Diuretics as Ca+ retaining drugs; Renal stones.
02:19:15
Comparing Thiazide Diuretics, Furosemide and their effect on Ca+ absorption & its clinical implications; Osteoporosis, Hyperuricemia. Interaction with NSAIDS.
02:26:35
Drugs acting distally to DCT; Antikaliuretic drugs: Importance of Principal cells in K+ balance, Na+ channel blocking drugs, Role of Aldosterone;
02:48:50
Effects of Diuretics on Principal Cells; Amiloride, Triamterene; K+ Sparing drugs. Aldosterone Receptor Blockers (ARBs): Spironolactone
02:54:54
Osmotic Diuresis; PCT: Mannitol; Increased Extracellular Fluid Volume (ECFV)
---------------------------------------------------------------------------------------------------------------------------
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  • @VivekYadav-bd1bt
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    Sir everytime u proove what u say always.......that is the crystal clear concepts....best teacher of medicine i have ever seen..

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    @DoctorNajeeb

    10 ай бұрын

    Thank you for all the love and support❤ Stay blessed ❤

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  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love, and happiness, always. ❤️❤️❤️❤️

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    6 ай бұрын

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    3 ай бұрын

    Best teacher in the world

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    @rajatpandurangi9209 Жыл бұрын

    Legends be this clear and still ask 'Am I clear?'. Love from India Sir

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    @DoctorNajeeb

    Жыл бұрын

    Thank you for your love and support ❤️

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    Ай бұрын

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  • @chiranjibidas1769
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    I haven't seen any teacher teaching like this very clear fundamental not only in pharma but also in physiology also 🔥🔥

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    Glad to hear that ❤ Keep supporting ❤

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    Жыл бұрын

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  • @DoctorNajeeb

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    Ай бұрын

    Thank you for your love and support. You can sign up to get premium video library access. www.drnajeeblectures.com/

  • @mbbslovers9572
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    If we call Dr Najeeb as Father of Modern medicine ,we will not do any crime , ,,let’s call him By this name on wards ,, Thanks a lot sir ,,, you deserve more but I don’t have words to explain 💝💝💝💝 Love from Kashmir

  • @DoctorNajeeb

    @DoctorNajeeb

    4 жыл бұрын

    Dear Doctor imran Hussain, Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love and happiness, always. We wish you success and happiness in every walk of life and good luck in your future endeavors. Regards, Dr. Najeeb Team

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    4 жыл бұрын

    Dr. Najeeb Lectures Ameen You too dear sir ♥️♥️

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    3 жыл бұрын

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    @@veeradivyasingiri1029 It is working perfectly okay, if you are still unable to use the APP, please contact support@drnajeeblectures.com

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    2 жыл бұрын

    3

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    @pilliprabakar6864 жыл бұрын

    May be god has come on to this earth in your soul to make us best doctors ... iam really surprized sir with your Art of teaching..... million thanks to you sir...for every sentence i understand wholeheartedly...i convey my heartful thanks to you again and again really sir... truly indebted to you sir...really thankyou so much for enlighting us sir....tqsm!! Dr. Najeeb sir....... from: your student, Sravanthi ..M.B,B.S Final year.

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  • @aisharasool4598
    @aisharasool45983 жыл бұрын

    I saw this lecture couple of days back and now I was revising for my upcoming exams ,I just felt the beauty of crystal clear concept and just came back to video to thank you sir.. Thank you so much sir .... I pray to Almighty to keep you always charming and blessed ...once again thank you sir

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    2 жыл бұрын

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    @papaibiswas7993

    2 жыл бұрын

    O ok

  • @beingkashmiri145
    @beingkashmiri1454 жыл бұрын

    Thank sir for giving beautiful explanation 🥰🥰😍

  • @yassinouasti625
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    Respect from 🇲🇦 You are the best Dr. Najib

  • @muslimrenaissance
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    @mohitsharma2529 Жыл бұрын

    Turn on Mono Audio in your device settings to balance the sound on left and right channels. Thank me later.

  • @navaneeth_us
    @navaneeth_us2 жыл бұрын

    26:50 56:00 1:11:20 (Recap of why some diuretics ppt keleuresis/pot. wasting) 1:34:19 - action of ADH on Collecting tubule and the deciding factor if the urine which is excreted is concentrated or diluted. 1:49:50 - How the diuretics are differentiated into high ceiling /low ceiling diuretics. 1:54:30 Management of hypercalcemia - 1:56:50 2:02:00 - 2:02:33 - Recap of furosemide 2:21:28 - furosemide v/s thiazide diuretics 2:27:30 - Principle cells 2:28:48 **- sodium handling proteins in Diff parts of nephron Beauty of electrochemical gradient - 2:36:06 Aldosterone - 2:44:30 2:49:00 - pot sparring diuretics

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    2 жыл бұрын

    9

  • @misbah2905
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    Thanks a lot, sir !!!

  • @abhameedkhanday8381
    @abhameedkhanday83813 жыл бұрын

    Extraordinary contribution.

  • @rashik3829
    @rashik38293 жыл бұрын

    So easy to understand , thanks a ton ❤️

  • @arghyabiswas8987
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    Thank u sir for explaining so easily....

  • @pranisharaut1406
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    Thank you for being with us ❤️ I have never seen such tutor , clearing all the concept❤️

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    Glad to hear that

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    Жыл бұрын

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  • @Gabagooch
    @Gabagooch Жыл бұрын

    This is a fantastic lecture

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    @suedolma77685 ай бұрын

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  • @DoctorNajeeb

    @DoctorNajeeb

    5 ай бұрын

    So nice of you

  • @Malineiscool
    @Malineiscool7 жыл бұрын

    thanks a lot sir

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    @docstale32174 жыл бұрын

    Excellent lecture sir

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    @abdelgadireshagabdelraheem80014 жыл бұрын

    Thank you doctor..

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    @mannykamra80703 жыл бұрын

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    2 жыл бұрын

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  • @71krish
    @71krish3 жыл бұрын

    superb Dr. I just came across this video as my mother often loses the levels of sodium and pottassium.. excellent lecture...god bless you ...for a common man like me with little knowledge of science..you have made to understand the concepts. ..though not familiar with tech. words you use... hats off....

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Thank you for your feedback. Keep supporting the hard work. ❤️🔥

  • @mohammadsufyan5715

    @mohammadsufyan5715

    2 жыл бұрын

    Mool

  • @mohammadsufyan5715

    @mohammadsufyan5715

    2 жыл бұрын

    Mool

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    @ZafarKhan-eb7fl10 ай бұрын

    Dr. Saab you are the best doctor in the world

  • @iamwhatiam7272
    @iamwhatiam72728 ай бұрын

    I never listen to any online classes like this. Thank you sir for the brilliant class

  • @DoctorNajeeb

    @DoctorNajeeb

    8 ай бұрын

    You are very welcome❤

  • @zawamlttnetnet
    @zawamlttnetnet4 жыл бұрын

    Thnkyou doctor شكرا دكتور

  • @saimahusain9630
    @saimahusain96309 ай бұрын

    After 6 years i m watching this lecture superb sir g

  • @ritade1529
    @ritade15292 ай бұрын

    Thank you sir for your hard work. We will be forever grateful😊

  • @DoctorNajeeb

    @DoctorNajeeb

    2 ай бұрын

    It's my pleasure❤

  • @vaishnavidahalkar7969
    @vaishnavidahalkar7969 Жыл бұрын

    Mind blowing lecture

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    @vijayadurgaakula16423 жыл бұрын

    Lovely class😍😍😍

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    @aqoonkorodhsi Жыл бұрын

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  • @tessblog3384
    @tessblog33842 жыл бұрын

    fantastic job great content good luck

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you dear❤️ Keep supporting❤️

  • @tanujamhetre2879
    @tanujamhetre28794 жыл бұрын

    Thanking u sir..

  • @shivathmikaanumulapuri5429
    @shivathmikaanumulapuri542911 ай бұрын

    Your lectures are amazing sir🎉❤

  • @hstudy8406
    @hstudy84064 жыл бұрын

    Thank u sir

  • @bandrusowjanya9584
    @bandrusowjanya95843 жыл бұрын

    Thanq sir for your wonderful lectures 🙏🙏

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Thank you so much.❤️

  • @hafizurrahman2959
    @hafizurrahman29594 жыл бұрын

    Awesome.... thank you sir ❤️

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Thank you so much :)

  • @DavidJones-ie1qp
    @DavidJones-ie1qp4 жыл бұрын

    You Sir, are a true master. Respect, and thank you very much for your lecture. God bless...

  • @salonirapelliwar9285
    @salonirapelliwar9285 Жыл бұрын

    Sir u explained it so easily,u r awesome sir thank u so much 💫💯

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    You can access full lectures at www.DrNajeebLectures.com

  • @rudrapatel813
    @rudrapatel8138 ай бұрын

    Thank you so much sir 😊🙏🏻 God bless you 😇💐

  • @DoctorNajeeb

    @DoctorNajeeb

    8 ай бұрын

    Thank you for your Love and support

  • @25-anishaherala83
    @25-anishaherala832 жыл бұрын

    Every word spoken by your mouth is pure gold sir thank you so much!!!!!

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    So sweet of you! ❤️

  • @alimohsin4281
    @alimohsin4281Ай бұрын

    Learned this four years ago Lost my register Came back Learnt again Thankyou sir❤

  • @DoctorNajeeb

    @DoctorNajeeb

    Ай бұрын

    So nice of you 💓

  • @sabaansari6320
    @sabaansari63208 ай бұрын

    Best teacher ever❤

  • @mrabhi1672
    @mrabhi1672Ай бұрын

    Sir you are great ❤ i can't describe feeling with any word your teaching way are very very very understanding ❤😊

  • @DoctorNajeeb

    @DoctorNajeeb

    Ай бұрын

    Glad to hear that❤ Keep supporting ❤

  • @drahsanarain856
    @drahsanarain856 Жыл бұрын

    A big thanks Sir

  • @khadramohamed8367
    @khadramohamed83673 жыл бұрын

    After recently discovering your videos by random chance I went from frustrating c to an A. Thank you for a superb teaching style. You help me comprehend basics so the abstract and complicated become easy

  • @user-fc1yi5dx6f
    @user-fc1yi5dx6f Жыл бұрын

    Thank you...u r the best teacher

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    It's my pleasure❤️ Keep supporting❤️

  • @bereketzerihun8000
    @bereketzerihun8000 Жыл бұрын

    Thanks Dr for deep explanation

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    My pleasure❤ Stay blessed ❤

  • @monikachawla6811
    @monikachawla68112 жыл бұрын

    Very nicely explained Sir.

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you dear💖 Stay blessed💖

  • @nabeelmudassir3437
    @nabeelmudassir3437 Жыл бұрын

    Amazing, now diuretics are on my finger tips

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    Glad to hear that. Keep supporting❤️

  • @zahidkhanzahidkhan5705
    @zahidkhanzahidkhan57054 ай бұрын

    Great u are very great and the best Dr ❤❤

  • @DoctorNajeeb

    @DoctorNajeeb

    4 ай бұрын

    Thank you so much for your love. Keep supporting!

  • @zehniii_
    @zehniii_ Жыл бұрын

    Mind blowing lecture 🙈❤️

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    Thanks a lot 😊

  • @munnahossain2704
    @munnahossain27042 жыл бұрын

    Really!! You are a bless in the field of medical science ❤️

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thanks A lot. Stay blessed ❤️❤️❤️

  • @sundusomar1960
    @sundusomar1960 Жыл бұрын

    Thnks dr najeeb

  • @co2_os
    @co2_os7 жыл бұрын

    You deserve more than what I paid for my university tuition fee

  • @shafiqurrehman1095

    @shafiqurrehman1095

    4 жыл бұрын

    in my entire career of mbbs i always felt frustrated not undertanding the things easily..but dr najeeb video makes miracle feel like genius and core concept of a topic which enable u solve any releavant mcq

  • @safayethossen7569
    @safayethossen75692 жыл бұрын

    Thank you sir for your good lecture

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Most welcome❤️ Stay blessed ❤️

  • @gudlikeplan182
    @gudlikeplan1823 жыл бұрын

    Before wathing this lecture one must understand the physiology of kidney. See the counter current multipilication video of Dr. Najeeb, then you'll understand this lecture very well. Thank you sir for making the concepts crystal clear.

  • @BharatBhushan-vm1oq
    @BharatBhushan-vm1oq2 жыл бұрын

    Nice and supereb explanation in easy way. 🙏🙏

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you so much for the appreciation! ❤️

  • @doctor.hemantyadav4558
    @doctor.hemantyadav45584 жыл бұрын

    I'm greatly thankful to you sir,

  • @subhangikumar5930
    @subhangikumar59303 жыл бұрын

    Sir your contribution is priceless! You are a true blessing!😊

  • @vimleshwarprasad9357

    @vimleshwarprasad9357

    2 жыл бұрын

    Ji ok k oo ooooo hi I oo oo o or oo oooo kya hua h n isliye the h kya or

  • @lifeisbeautiful2443
    @lifeisbeautiful24434 жыл бұрын

    Respect sir

  • @Shimbhudayalsaini270
    @Shimbhudayalsaini2707 ай бұрын

    Love from India ❤❤great man 🎉

  • @saimahusain9630
    @saimahusain96309 ай бұрын

    So clear and so informative

  • @DoctorNajeeb

    @DoctorNajeeb

    9 ай бұрын

    Glad it was helpful❤ Stay blessed ❤

  • @R3dlineArts
    @R3dlineArts Жыл бұрын

    Amazing lecture sir❤

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    Glad to hear that❤ Stay blessed ❤

  • @gutemamitiku3985
    @gutemamitiku39852 жыл бұрын

    what influential person.Really,I want to express my great appreciation for your indispensable good deed

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Many many thanks. Stay blessed ❤️

  • @Dr.Shikha-rl7on
    @Dr.Shikha-rl7onАй бұрын

    Thank you sir for such beautiful explanation

  • @DoctorNajeeb

    @DoctorNajeeb

    Ай бұрын

    Most welcome 🤗

  • @Dr.Shikha-rl7on

    @Dr.Shikha-rl7on

    Ай бұрын

    @@DoctorNajeeb Thank you Sir..... You are really great Sir.Feel really blessed to have studied from your lectures although I knew very late about it

  • @friday2993
    @friday29934 жыл бұрын

    You are the best Sir! ❤️❤️❤️ thank you 🙏

  • @acksonmunshya2696
    @acksonmunshya26962 жыл бұрын

    Thank you Doc

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    You are very welcome❤️

  • @SagarSingh-st9fu
    @SagarSingh-st9fu2 жыл бұрын

    Very good sir

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you💖 Keep watching💖

  • @user-hi5bl3yn3w
    @user-hi5bl3yn3w2 ай бұрын

    Very nice

  • @saimahusain9630
    @saimahusain96309 ай бұрын

    I m answering your question like I m taking this class live

  • @googlyvlogers
    @googlyvlogers5 ай бұрын

    Stay happy and blessed sir 🎉🎉❤❤

  • @DoctorNajeeb

    @DoctorNajeeb

    5 ай бұрын

    Thank you

  • @sadiafarzana3929
    @sadiafarzana3929 Жыл бұрын

    U r the best teacher ❤️

  • @DoctorNajeeb

    @DoctorNajeeb

    Жыл бұрын

    Thank you dear ❤️

  • @maiksmith4185
    @maiksmith41854 жыл бұрын

    This is a good bedtime story Thankyou.

  • @ayomkuot5580

    @ayomkuot5580

    3 жыл бұрын

    Very excellent sir. I always enjoy your videos because I am learning in French 🙏🙏

  • @naziaumar3169
    @naziaumar31692 жыл бұрын

    Nice information👍👍👍👍👍

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you❤️ Stay blessed❤️

  • @vaishnavikamble1185
    @vaishnavikamble11852 жыл бұрын

    Very nice lecture👌🙏

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thanks for liking. Stay blessed ❤️

  • @nesrinemly1538
    @nesrinemly15382 жыл бұрын

    thnk you so much

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Most welcome❤️

  • @progressisimminentjasbir8564
    @progressisimminentjasbir85642 жыл бұрын

    Thanks sir, you are just Greatttt. In Diploma in pharma its a concept to just pass so frankly no one is there to teach properly but you have made me so much interested in pharmacology, i just cant thank you in words but THANKS Sir.

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Glad you loved my lectures. Stay tuned! ❤️

  • @suzanwanjiru3989
    @suzanwanjiru39893 жыл бұрын

    👌👍💪excellent quality job 👏 Doctor. Blessings again 🙏.

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    So nice of you. Stay Blessed

  • @arshisiddiqui7657
    @arshisiddiqui76572 жыл бұрын

    Gratefull that we have teachers like u....u r awesome ✌️🙌🙌

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Glad you found this lecture easy to understand and meaningful! Stay tuned 💗

  • @dr_sinha
    @dr_sinha7 ай бұрын

    thankyou sir❤

  • @DoctorNajeeb

    @DoctorNajeeb

    7 ай бұрын

    You are welcome❤

  • @medicoanu7210
    @medicoanu72102 жыл бұрын

    Thankyou so much Sir 🙏🙏🙏🙏

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Most welcome 💖💖

  • @mdmahmudulhasan2303
    @mdmahmudulhasan23032 жыл бұрын

    Very good explanation sir, please create more and more videos

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you, I will. Keep supporting ❤️

  • @sanjeev4061
    @sanjeev40614 жыл бұрын

    Thanku sir.. your video clear all my doubts and your video is very helpfull..

  • @sandeepsingla153
    @sandeepsingla1532 жыл бұрын

    Excellent 👌👌👌

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thanks a lot ❤️

  • @AmitThakur-nk4sg
    @AmitThakur-nk4sg4 жыл бұрын

    Awesome lecture.

  • @DoctorNajeeb

    @DoctorNajeeb

    4 жыл бұрын

    Thank you. :)

  • @muhammadishrat9607
    @muhammadishrat96072 жыл бұрын

    Mashaallah Very nice lecture

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you💖 Keep supporting 💖

  • @AnjaliSingh-jv9mr
    @AnjaliSingh-jv9mr3 жыл бұрын

    Sir you are just amazing, God bless you 🙏❤

  • @DoctorNajeeb

    @DoctorNajeeb

    3 жыл бұрын

    Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love and happiness, always. We wish you success and happiness in every walk of life and good luck in your future endeavors. Regards, Dr. Najeeb Team

  • @somnathwagh9063

    @somnathwagh9063

    2 жыл бұрын

    @@DoctorNajeeb ओोओओओओओओ

  • @somnathwagh9063

    @somnathwagh9063

    2 жыл бұрын

    @@DoctorNajeeb ओओओओओओओओओओओ

  • @somnathwagh9063

    @somnathwagh9063

    2 жыл бұрын

  • @somnathwagh9063

    @somnathwagh9063

    2 жыл бұрын

    ओओओ

  • @msairavitejanaga7426
    @msairavitejanaga74262 жыл бұрын

    One word to say this video... Simply superb ...

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    Thank you so much ❤️

  • @mnb7947
    @mnb79474 жыл бұрын

    Awesome lecture . Before this for me the renal was the most difficult to understand . Thanks sir now it is not so.😊😊😊😊

  • @reasoning89
    @reasoning892 жыл бұрын

    I use to watch ur videos like in 2010- 2011 , time flies but i have so clear concepts since then . Thank u so much sir

  • @DoctorNajeeb

    @DoctorNajeeb

    2 жыл бұрын

    You are most welcome! ❤️ Stay blessed ❤️