in this video we go over four deadly poisons to reveal the cellular mechanisms of how they kill, their medicinal or molecular biology uses, and list the animals that are somehow immune.
Patrick Kelly's channel: / patrickkellymedicalhis...
written, narrated and edited by April
info sources:
RELATIVE TOXICITY:
+I. Keller. (October 31, 2016). ‘Here's how much Halloween candy you can eat before it kills you’ USA Today www.usatoday.com/story/news/n...
+C. Whelan. (October 21, 2015). ‘Can you drink too much water?’ Science in Our World sites.psu.edu/siowfa15/2015/1...
COLCHICINE:
+B. Dasgeb et al. (2017). Colchicine: an ancient drug with novel applications, British Journal of Dermatology dx.doi.org/10.1111%2Fbjd.15896
+M. R. Lee. (1999). Colchicum Autumnale and the Gout, Proceedings of the Royal College of Physicians of Edinburgh www.rcpe.ac.uk/sites/default/...
+Y. Finkelstein et al. (2010). Colchicine poisoning: the dark side of an ancient drug, Clinical Toxicology doi.org/10.3109/15563650.2010...
STRYCHNINE:
+J. Otter & J. L. D’Orazio (2021). Strychnine Toxicity, StatPearls Publishing www.ncbi.nlm.nih.gov/books/NB...
+‘Strychnine’ National Institute for Occupational Safety and Health www.cdc.gov/niosh/ershdb/emer...
+D. Blum. (January 30, 2012). ‘The Science of Mysteries: An Overdose of Strychnine’ Wired www.wired.com/2012/01/the-sci...
+C. Drahl. (August 19, 2016). ‘What You Need To Know About Strychnine, The Poison That Cost A Rio Weightlifter His Medal For Doping’ Forbes www.forbes.com/sites/carmendr...
ALPHA-AMANITIN:
+C. Childs. (February 1, 2019). ‘Death-Cap Mushrooms are Spreading Across North America’ The Atlantic www.theatlantic.com/science/a...
+K. Matinkhoo et al. (2018). Synthesis of the Death-Cap Mushroom Toxin α-Amanitin, Journal of the American Chemical Society doi.org/10.1021/jacs.7b12698
+K. T. Vo et al. (2016). Amanita phalloides Mushroom Poisonings - Northern California, Morbidity & Mortality Weekly Report www.cdc.gov/mmwr/volumes/66/w...
+ 'Mushrooms Foraging' The Washington Poison Center (WAPC) www.wapc.org/media/seasonal-a...
TETANOSPASMIN:
+S.P. Tejpratap et al. ‘Tetanus’, CDC Pink Book www.cdc.gov/vaccines/pubs/pin...
+C, Bae & D. Bourget. (2021). ‘Tetanus’, StatPearls Publishing www.ncbi.nlm.nih.gov/books/NB...
image sources:
+neuron video animation by XVIVO Scientific Animation 'Glutamate Modulation' • Glutamate Modulation |...
+'Organelles of a human cell (2014) by wehi.tv' by Drew Berry and Etsuko Uno, wehi.tv • Organelles of a human ...
+Squirrel consuming “poisonous” mushrooms by Kenji Suetsugu & Koichi Gomi doi.org/10.1002/fee.2443
+cell migration video from Mitin N et al. (2013). The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility', PLOS ONE. doi.org/10.1371/journal.pone.... retrieved from wikipedia: commons.wikimedia.org/wiki/Fi...
+mitosis gif en.wikipedia.org/wiki/Mitosis...
+upload.wikimedia.org/wikipedi...
+Strychnine medicine bottle from Museum of Health Care at Kingston mhc.andornot.com/en/permalink...
+mushroom image from wikipedia user Danny_S commons.wikimedia.org/wiki/Fi...
+mushroom image from Holger Krisp commons.wikimedia.org/wiki/Fi...
+structure of RNA pol I www.rcsb.org/3d-view/ngl/4c3j
+structure of RNA pol II www.rcsb.org/3d-view/ngl/5c4x
+structure of RNA pol III www.rcsb.org/3d-view/ngl/5fj8
Funded by: UPMC Hillman Academy & NCI R25 YES
#poison #science #chemistry
Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation, National Institutes of Health or UPMC.