Cell Biology | Tay-Sachs, Fabry, Gaucher, Niemann-Pick Disease

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about the structure and function of lysosomes. We will begin by discussing the normal function of lysosomes and will conclude with lysosomal storage disorders in a USMLE step 1 review. These conditions include Tay-Sachs, Fabry, Gaucher, and Niemann-Pick Disease. We hope you enjoy this lecture and be sure to support us below!
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Пікірлер: 197

  • @alih6953
    @alih69533 жыл бұрын

    If everyone in the world were like Zach, the world would be heaven! Thank you for making 3 videos in 3 days!

  • @ZucchiZ

    @ZucchiZ

    2 жыл бұрын

    But... We can't have good things

  • @Fatima-kq6xg

    @Fatima-kq6xg

    Жыл бұрын

    I agree 🧘🏻‍♀️🤍

  • @arokan327
    @arokan3273 жыл бұрын

    I just started study medicine one week ago and already, I do nothing else. These videos are probably going to be the reason, I pass my exams properly and going to be a knowledgeable doctor. Thank you very much for all you've done and all the videos to come!

  • @hollythebreastcancerslayer
    @hollythebreastcancerslayer3 жыл бұрын

    This channel is changing my life, no joke. 🙏🏻 I would be SO HAPPY if you did a lecture all about the Lymphatic system - especially how it works in conjunction with blood vessels - because I have lymphoedema and there is NO good information about this disorder out there. Thank you just a million thanks for what you guys do. So excellent 🏆

  • @alih6953
    @alih69533 жыл бұрын

    Zach you are amazing! So close to 900K subs mate! Whenever I see your videos, I am so grateful. 3 Videos in 3 Days . In Soccer you would be Hat Trick Hero. In Basketball you would be MVP

  • @soco2020
    @soco20205 ай бұрын

    I would have never made it through my first year of med school without your help. Thank you for all of the great videos.

  • @biancab2231
    @biancab22312 жыл бұрын

    I clap after each video. Thank you so much for doing this, you're a blessing on this app! Virtual hugs

  • @jjjjj2706
    @jjjjj27063 жыл бұрын

    i can't believe this man is actually real!!! a genius indeed

  • @ayeshashabbir2324
    @ayeshashabbir23243 жыл бұрын

    Please make video on some tips for studying and How to make effective notes and how to keep maintain focus.. I know there is a lot on videos on KZread but you are deep explainer so it will be helpful.. Thanks in advance 😇

  • @granola1210

    @granola1210

    3 жыл бұрын

    Yessss please 🙏🙏

  • @drirfan72941

    @drirfan72941

    3 жыл бұрын

    Best thing is to make notes form videos lecture or you can do another thing you can also make notes form the different books material and also from google and makes different diagram and writes in your own words as it will be easy for your revision.

  • @granola1210

    @granola1210

    3 жыл бұрын

    @@drirfan72941 thanks you! 😊❤️

  • @alih6953

    @alih6953

    3 жыл бұрын

    he already did a studying video on his channel 2-3 weeks ago

  • @linhyybear143
    @linhyybear1433 жыл бұрын

    Making STEP 1 studying so much easier. Thank you so much!

  • @zman0894
    @zman08942 жыл бұрын

    I love all of your videos, Zach! So helpful in all my courses I’ve taken thus far and I’m just 2 semesters away from graduating, then onto graduate school 😃 you’ve made learning an enjoyable experience. Do you think you could make a video series of ways that YOU study? Since you clearly have retained so much information 😃 thank you!

  • @alih6953
    @alih69533 жыл бұрын

    Zach I want to say from the bottom of my heart you represent the best of humanity! You are giving so much and asking for so little. You are an angel mate! (Have tears in my eyes)

  • @Muhammad.1885
    @Muhammad.18853 жыл бұрын

    This is the first video I've seen on KZread without a dislike! Thanks Ninja!

  • @alishaakhani1016
    @alishaakhani1016 Жыл бұрын

    Such a simple, to the point, awesome video!!! You make learning fun. Keep going

  • @yashwantlonkar7074
    @yashwantlonkar7074 Жыл бұрын

    This man is a Angel for medical students. Thank you so much. Keep it up.

  • @user-yl5fl1fu1z
    @user-yl5fl1fu1z3 жыл бұрын

    Thank you so much You make my knowledge concrete! I have been studying biology with you. I hope you feel our happy 😊 Be safe from Covid19! Be always happy!

  • @xxacidusxx2
    @xxacidusxx22 жыл бұрын

    I memorized a chart for this section because I didn't understand the purpose of these enzymes in lysosomes. So basically what I think I'm getting from this video is that all the sphingolipidoses are due to defects in lipid metabolism. These lipids are all derivatives of sphingosine and are part of the cell membrane whether they are sphingomylelins, ceramides, cerebrosides, or gangliosides. They are not the same as TG that undergo beta oxidation, they are broken down in lysosomes and are either released in the cytoplasm or ECM via secondary lysosomes. They are used in the liver for LDL degradation, in all cells that undergo autophagocytoses, and in the WBC for pathogen degradation. Fabry is the only XR disease the rest is AR, Fabry and Gaucher usually present in adulthood whereas the other diseases present during childhood. Only gaucher disease may present with increased risk of infection due to pancytopenia, differentiating Tay Sach from Niemann Pick via hyperreflexia vs hyptonia and no hepatosplenomegaly vs hepatosplenomegaly.

  • @jelenajovanov4149
    @jelenajovanov41493 жыл бұрын

    20 years after biology semester, recapitulation with Zach.Thank you Ninja Nerd🙏

  • @drirfan72941
    @drirfan729413 жыл бұрын

    I will say only one sentence "you are amazing zach"❤️❤️❤️

  • @shelbyschwarz7901
    @shelbyschwarz79012 жыл бұрын

    I’m a third year phd student at Notre dame working on npc disease. Loved the video, and it was really impressive.

  • @duhaali03
    @duhaali03 Жыл бұрын

    This is wonderful. Everything I wanted to know and understand about the lysosome, I found it here. Thank you very much😊

  • @gsudheerreddy1954
    @gsudheerreddy19543 жыл бұрын

    Congrats zach bro you are near to 1million

  • @noorjahanjaganath2582
    @noorjahanjaganath2582 Жыл бұрын

    you saved my many hours of reading God Bless you Zach

  • @bobwilliams2679
    @bobwilliams26793 жыл бұрын

    I’m currently taking a paramedic class thank you for your videos. Tremendous help! For a future video topic can you do a video on med math . We were learning about IV piggybacks with dopamine drips of different Concentrations. Some of your clear explanation would really be helpful!

  • @williamowen7152
    @williamowen71529 ай бұрын

    Don't often see anything on LSDs like this. Thanks for raising the profile. Woild like to see something on lysosomal membrane proteins especially NPC1 (Niemann-Pick 1 protein. Amazing small writing!

  • @sonamdhondup5426
    @sonamdhondup542611 ай бұрын

    stunning!! Love all the lectures. Bless you all.

  • @thokomasango2294
    @thokomasango229410 ай бұрын

    Thank you for making it easy for me to understand 🙏🏾💞

  • @janislechner3523
    @janislechner3523 Жыл бұрын

    you are so awesome to watch!! Thank you for making and sharing your super personality with us!! love ur videos!!

  • @rodneyklinger5811
    @rodneyklinger58113 жыл бұрын

    Dude, you are a hero! We all love you! Thanks to you and your team!

  • @megha111
    @megha1113 ай бұрын

    Thank you so much for this wonderful video❤

  • @titusnelson1024
    @titusnelson10243 жыл бұрын

    As an old engineer I had a brain freeze about 1:00 in. Then about 10:00 when you talk about Receptor Mediated Endocytosis a few brain cells came out of hibernation connecting stress analysis and vibrations and I nearly had a stroke. I couldn’t even relate to nonlinear optics. Holey-Moley I guess I better start with basic biology. However, after a third go of it some synapses are forming.

  • @pushpashakya3051
    @pushpashakya30512 жыл бұрын

    Thank you so much for this knowledge🙂

  • @amalsingha1894
    @amalsingha18948 ай бұрын

    You make the lesson very easy.

  • @albuanastasya
    @albuanastasya3 жыл бұрын

    Loved it! Thank you, Zach, appreciate your contribution!

  • @user-db3xb5lt5s
    @user-db3xb5lt5s3 жыл бұрын

    The best lecture I've ever seen! Thank you so much!

  • @ramonfontes9025
    @ramonfontes90253 жыл бұрын

    U are just AMAZING Professor !

  • @antoniogomez-rguez1038
    @antoniogomez-rguez10382 жыл бұрын

    OMG you are simply amazing, i enjoyed the full lecture. Thank you very much for this!

  • @franzcalipusan3367
    @franzcalipusan33678 ай бұрын

    This helped a lot sir.... Thank you so much...

  • @nyananguei1928
    @nyananguei19283 жыл бұрын

    Thanks you ninja nerd for the best you have done.

  • @mohammadnawaz4450
    @mohammadnawaz4450 Жыл бұрын

    Brilliant video

  • @basharalzohily7017
    @basharalzohily7017 Жыл бұрын

    Many thanks. It was really helpful.

  • @Mari-qo4dh
    @Mari-qo4dh3 жыл бұрын

    great video! I like you explained end to end process

  • @kingka9489
    @kingka9489 Жыл бұрын

    Best up and coming rapper!!!

  • @vernelloydcalunsag3763
    @vernelloydcalunsag37633 жыл бұрын

    Thank you for making this video.. you make things simplier.

  • @gargsiblings6230
    @gargsiblings62303 жыл бұрын

    Thank you so much for being just the way u r

  • @jelwzhoodgirl6169
    @jelwzhoodgirl61692 жыл бұрын

    I love how you are repeating facts with having these little breaks, so one has a change to suggest frist

  • @abdisamadahmedyasinshcali8927
    @abdisamadahmedyasinshcali89273 жыл бұрын

    only 100k away from the million lets do this ninja nerds!

  • @ikka5314
    @ikka53148 ай бұрын

    Thank you for this amazing video

  • @alfredovictoriagonzalez7462
    @alfredovictoriagonzalez74622 жыл бұрын

    YOU ALL ROCK THANK YOU

  • @yusufali5812
    @yusufali58123 жыл бұрын

    Excellent Lecture! Please provide me with the links for all of your biochemistry and molecular biology lectures

  • @dorcasb2194
    @dorcasb21943 жыл бұрын

    Kindly do a video series on how to read and interpret X-rays and other radiographs. Thanks

  • @aloksanidhya6476
    @aloksanidhya64763 жыл бұрын

    Loves your teaching style...❤️❤️🙏🙏

  • @MEZ4RCI
    @MEZ4RCI3 жыл бұрын

    it was an awesome lecture but I wished that you explained other sphingolipidoses. like krabbe farber etc. still was a nice roundup video. loved it.

  • @lilouvincent8407
    @lilouvincent84072 жыл бұрын

    Je parle pas anglais et j'ai quand même trouver son cours super

  • @rusudankurua6705
    @rusudankurua67053 жыл бұрын

    Thank you Zach

  • @user-tp7xc9fz9c
    @user-tp7xc9fz9c2 жыл бұрын

    You are a good teacher, thank you.

  • @EllenSweden
    @EllenSweden Жыл бұрын

    Hi Zach, Thank you so much for the amazing explanation, I have a question to share with you regarding the NPC disease (Niemann pick type c)! Out of this explanation, what is the possible consequences of following a low carb & high fat diet and Intermittent fasting on NPC cells and how consuming different kind of fat can increase or slow down the process of the disease in the cell level?

  • @aind1272
    @aind12722 жыл бұрын

    bro your energy while explaining is different!

  • @khalil_4924
    @khalil_49243 жыл бұрын

    Wow Zach you are explaining stuff that we used to think that they are non-doable in medschool and never understand 😂 lysosomal storage diseases are 💀💀

  • @salaheddinehouache1015
    @salaheddinehouache10153 жыл бұрын

    Great as usual... good job !

  • @luancarvalho1250
    @luancarvalho12502 жыл бұрын

    god damn i love you guys so, so, so much

  • @thirmizidiallo6729
    @thirmizidiallo6729 Жыл бұрын

    can never thank you enough for this !

  • @naveenajyothi1244
    @naveenajyothi12443 жыл бұрын

    Wow extraordinary it's makes me feel better understanding thankyou so much sir

  • @idrissayusuf6561
    @idrissayusuf65613 жыл бұрын

    Amazing explanation as always

  • @skiteflies3
    @skiteflies3 Жыл бұрын

    Thank you so much for the video, such a clear concise explanation. However, does anyone know why Tay Sachs and Nieman Picks present so similarly besides the hepatomegaly while Gaucher and Fabry dont. Also why does gaucher seem to affect the bone (is it because the enzyme that its deficient in is only found in that bone?)? What is the reason behind Fabry causing Angiokeratomas while the others are less likely? These might all be moot points, but Im just curious to know if there is an actual answer or if its just by experience that these are the most common presentations?

  • @abdussamad644
    @abdussamad6443 жыл бұрын

    Sir also deliver lectures on remaining cytology such as details description on nucleus . Cell membrane. And so on👍👍👍👍👍👍👍

  • @claudiaciciotti9973
    @claudiaciciotti99733 жыл бұрын

    Great video!! As always

  • @akhtarparas3238
    @akhtarparas32383 жыл бұрын

    Amazing sir keep making videos on cell biology lots of love from Pakistan ❤❤

  • @mnhlhmo7967
    @mnhlhmo79673 жыл бұрын

    thanks Zach

  • @Zetsuke4
    @Zetsuke43 жыл бұрын

    can’t wait to watch this!

  • @heydazzling
    @heydazzling Жыл бұрын

    thank you so much !!

  • @abdussamad644
    @abdussamad6443 жыл бұрын

    Thank you sir for making amazing lactures

  • @tamalmaity7037
    @tamalmaity70373 жыл бұрын

    Please make a video on Tuberculosis...Thanks

  • @kferdous5994
    @kferdous59943 жыл бұрын

    We want more video on organells of cell I mean on ribosome on golgi aperatus etc

  • @niyadeo7970
    @niyadeo79709 ай бұрын

    Amazing!

  • @moonsevinci88
    @moonsevinci88 Жыл бұрын

    Thank you very much

  • @gsudheerreddy1954
    @gsudheerreddy19543 жыл бұрын

    Thank you zach bro!! 😊

  • @hosaymamozay8773
    @hosaymamozay87739 ай бұрын

    You are a blessing

  • @johnh6093
    @johnh60933 жыл бұрын

    Thank you so much

  • @karthikarumugam1512
    @karthikarumugam15123 жыл бұрын

    Sir pls post more videos on pathology , pharmacology and microbiology.... We r waiting....🙏🙏❤️

  • @abdussamad644
    @abdussamad6443 жыл бұрын

    Sir wating for cell membrane details lacture

  • @roro13chavez74
    @roro13chavez743 жыл бұрын

    Wey neta que te amo, explicas super bien todo

  • @shabihusain3901
    @shabihusain39013 жыл бұрын

    His liiitttlle bit deeper is very deep😌

  • @jasminflower9762
    @jasminflower97623 жыл бұрын

    You r amazing.. plaease can explain the hormone and its role on immunity

  • @arizonablossom8635
    @arizonablossom86353 жыл бұрын

    Thanks a lot for your hard work👍🙏

  • @ferricyanide8112
    @ferricyanide81123 жыл бұрын

    Thank you, Sensei

  • @anushyabeulah2854
    @anushyabeulah28543 жыл бұрын

    Very good explanation..

  • @peacefromtheashesofwar4181
    @peacefromtheashesofwar41813 жыл бұрын

    I hope you be successful in your entire life and you worth it for all your dedication and your perseverance. I know you're work is not so easy but it worth.

  • @guna7558
    @guna75583 жыл бұрын

    Really,u r awesome n your videos r also awesome n very much helpful....thank you so much zach....lots of love (India)😍😍😍....please upload videos of all the cell organelles🙏

  • @sudhirgairola4889
    @sudhirgairola48892 жыл бұрын

    Nice information

  • @atulsinghtech52
    @atulsinghtech522 жыл бұрын

    Very nice content.

  • @owenosteocyte7455
    @owenosteocyte74552 жыл бұрын

    Thank you

  • @bobbiesal61
    @bobbiesal61 Жыл бұрын

    It's absolutely not true that Fabry disease is only seen in men. We are learning more and more about x-linked diseases and women are no longer considered "carriers," but often develop symptoms, typically less severe than their male counterparts. Fabry disease, untreated is every bit as fatal if not treated in women - very dependent on level of x-inactivation. Please update your slides :)

  • @earnwithbasam5541
    @earnwithbasam55412 жыл бұрын

    Excellent informative vedio

  • @karmen8873
    @karmen88732 жыл бұрын

    thank you so much

  • @abirmohammadkhan6742
    @abirmohammadkhan67423 жыл бұрын

    You are amazing...Love your videos...

  • @ahmedal_azzawi7292
    @ahmedal_azzawi72923 жыл бұрын

    Thanks zack sensi

  • @sunielkc
    @sunielkc7 ай бұрын

    thank you

  • @riturajsahoo3628
    @riturajsahoo36283 жыл бұрын

    Why not start to make videos on microbiology? You are doing great.

  • @MubashraZahoor
    @MubashraZahoor2 жыл бұрын

    Please tell me the name of the book from where you took this content

  • @yasirmohammedali
    @yasirmohammedali3 жыл бұрын

    Hi ... Thanks a lot for the videos