your a life saver wow i thought this topic was difficult until i found your videos.

@kristeenbarker

Жыл бұрын

Aw Mohamed thank you so much for watching. You have no idea how much it means to me, knowing that this helped your studies :) my best wishes Kristeen

i absolutely love this video. Thank you so much

this is amazingly in-depth! although as a teenager it's hard to take in all this, this process is far more complicated than I imagined!

@kristeenbarker

2 жыл бұрын

Isn't the human body incredible! thanks so much for stopping by. :)

Wonderful thanks very much

Great video! Thanks

Excellent synopsis

The best video yet

@kristeenbarker

3 ай бұрын

Yay so excited u enjoyed it!!!

Your enthusiasm is infectious (pun so intended)! Fantastic videos! :)

@kristeenbarker

2 жыл бұрын

Thank you so much Melissa, I'm so excited you are enjoying the series. This made my day! :)

@melissabereti6144

2 жыл бұрын

@@kristeenbarker After 4 years of med school, 3 years of IM residency, and now nearly 2 years of Rheum fellowship, I've FINALLY been able to wrap my head around immunology concepts because of you and your videos!😍 I don't just 'get' the concepts, I *UNDERSTAND* them, and can apply them (which you know, is just a bit important 😅). The way you explain and visualize things works so well for my neurodivergent brain - I'm beyond excited. I'm so happy to have made your day, because for real, you've made my fuckin' month (and very likely more)!! I look so forward to whatever other videos you make! :)

@elizabethnewell3133

2 жыл бұрын

Thanks for this video, as. B-cell depleated patient, this was super helpful.

@kristeenbarker

2 жыл бұрын

@@elizabethnewell3133 I'm so pleased you found it helpful. My best wishes for your health and wellbeing

what is the function of plasma cell during an immune response

That is Epic

@kristeenbarker

2 жыл бұрын

Thank you so much Ameen, I'm so glad you enjoyed it :)

Are the HLA class 2 antigens present on HLA class 2 presenting cells heterogeneous for the possible combinations of each inherited allele within the same cell, or does each HLA class 2 presenting cell only present one variant ( ie: allelic exclusion or clonal expression for a given clone of B cells or a given histiocyte or dendritic cell) ?? My question is the same for HLA class 1 cells (?).

Amazing explanation! Hence, in chronic autoimmune diseases, are the autoantibodies produced by plasma cells or memory B cells? Does this depends on the type of disease?

@kristeenbarker

2 жыл бұрын

Niccolo, this is such a fascinating question. As i was researching this, i understood the B cells (at last) then I started to question how rituximab even works because it doesn't target plasma cells after all - and so there's something more to this - I'm hoping to get to the bottom of this question at some stage but please let me know if you find clarity before i do! :) Immunology = a journey!

@niccolowrld

2 жыл бұрын

@@kristeenbarker Kristeen what a wonderful reply! I will definitely let you know and I thought about the same thing given that, as you said, Rituximab does not work on plasma cells. I am on an impossible mission of curing my own multisistemic autoimmune (in part) diseases (MECFS, POTS and Autonomic SFN). I am sure there is a lot of work to be advanced in research. 😊May I ask you, given my ignorance, do B cells become eventually plasma cell? And if so, how long does the whole process take? I am sure the answer will be not straightforward. 😅 Thanks again!

@kristeenbarker

2 жыл бұрын

@@niccolowrld they say patients are experts in their own condition, and i very much hope your journey leads you to cure. So some b cells become plasma cells, some remain as memory cells and can become plasma cells later. in terms of timeline, i'm not sure exactly - will be slower the first time the B cell sees the foreign particle, and it will switch from IgM antibodies to IgG antibodies along the way, so it's sort of days-weeks initially. Memory B cell can spring into action much faster (the rationale for vaccination) - hope that helps and again my best wishes for your health. Kristeen

Then iga2 or iga6 are produced by B1 or B2?

@kristeenbarker

9 ай бұрын

oooofffft waht a question! =Admittedly i have never done a deep a dive into the different classes of IgA - defintely let me know if you solve this mystery!

@il3mendo

7 ай бұрын

@@kristeenbarker Can the innate immune system, throgh the NK Cell, iverpowering the immoglobin class switching? Which chronic infection can interfere with the cd19 production ?