People with XX chromosomes: have a higher chance of getting auto-immune diseases Doctors, somehow: it's just stress

@shakeyj4523

Ай бұрын

That's the worst part. And what they are saying really is that you are overly dramatic and emotional. That's why they add the "just".

@davidcia

Ай бұрын

​@@shakeyj4523 And you're giving them back up with the comments 😂

@skink84

Ай бұрын

Well Stress can be a killer and activate your genes. Cortisol can be a real bugger.

@outlawbillionairez9780

Ай бұрын

Doctor... "Autoimmune disease? Huh. Funny thing, Mrs Johnson... the one thing yer health plan doesn't cover." (Healthcare also sexist)

@jackabug2475

Ай бұрын

Also doctors: It's probably all in your head, but if you insist on making a fuss I _guess_ I can give you some anti-depressants...

Another problem with the gender imbalance of autoimmune diseases: It's quite hard for men to get diagnosed timely and correctly. Literally quoting a doctor here: "Well, that disease is so rare it practically doesn't exist. And you don't seem the type. Must be something else". It wasn't.

@kashiichan

Ай бұрын

I'm really sorry you experienced that. Our medical systems need to do better.

@PurpleNoir

Ай бұрын

That’s awful, I’m very sorry ❤ I hope you have had more caring doctors and received actually adequate medical care since then.

@lenabreijer1311

Ай бұрын

Welcome to women's World of medicine where it is all in our heads and we don't feel real pain and we can't possibly be experiencing that.

@damien991

Ай бұрын

@@lenabreijer1311 Not sure if this is just a US problem or if both my mum's and grandmother's situations are different but both their doctors are really good. They do listen the issue is just figuring out what the problem is, which is the case with my mum. If anyone is diagnosed with something with the word syndrome in it good luck, because that basically means medicine has little idea what is causing it and how to fix it.

@anyascelticcreations

Ай бұрын

I've been told that doctors are supposed to look for horses (common) not zebras (uncommon). Well, guess what. I have zebras.

I just got diagnosed with an autoimmune disorder (psoriatic arthritis). It took me years to get a diagnosis. Because I have a mental health history and am a woman, I was so often dismissed as "simply needing antidepressants".

@abbzeh137

Ай бұрын

It usually takes years to get diagnosed, especially if it's not life threatening! It took 10 years for me to get diagnosed with ibd

@abbzeh137

Ай бұрын

Now I need a stronger medication (with higher risks) because it caused scarring due to being untreated so long

@dreammaker9642

Ай бұрын

Antidepressants seems like the new medical equivalent of « have you tried turning it off and on? » which is kind of sad, I blame more big pharma pushing it than doctors being dumbs dumbs cause they people too but still

I swear I read it as “sexiest”, I was very confused for the first couple of minutes.😂

@JosephsDesign

Ай бұрын

That’s a fine looking autoimmune disease you have there. 😘

@mayaenglish5424

Ай бұрын

Lol, we're just so attractive! Fashion IS Suffering?

@jajajasputin8927

Ай бұрын

​@@mayaenglish5424 if beauty is pain I'm a goddamn primadonna

@charlessarver1637

Ай бұрын

I know my minds there too👍👍👍😆🥁😆

@karak962

28 күн бұрын

I have one,,,going to assume this as a compliment to me specifically,

I have Hashimoto’s and two former coworkers have lupus. This video helped me understand the mechanism of why we women experience autoimmune disorders more often than men. Now, if we could figure out how to make it stop.

Our son has 11 autoimmune diagnoses. Having all of these diagnoses, that primarily occur in females, makes me wonder why he ended up with these diseases. What does that mean for him? It’s difficult being a minority with medical conditions. And yes, I get the irony of that, but he’s an amazing child who deserves as much compassion as the next person. In case there are questions, I had an amniocentesis due to my age at pregnancy, and he has an XY chromosome.

@colddogs

Ай бұрын

i only ask this because i am going through it, and it's apparently can trigger them, but is there any chance your son experienced trauma? if so, look up ptsd and cpstd. also, i read once you have one autoimmune disease, it increases your chances of developing another. i have psoriasis and hashimoto's as a 42 year old man.

I have an extra X chromosome (trisomy x), no wonder I'm Autistic with multiple chronic illnesses, I have been told I seem like I have autoimmune diseases but whenever they try to test or scan me, nothing ever comes up. But very interesting!

@gifttanz

Ай бұрын

Hello extra X human

@maipai101

Ай бұрын

Yoooooo! You're a whole lotta woman! 🎉

@pigcatapult

21 күн бұрын

I’m autistic and have fibromyalgia, which was only recently confirmed to be autoimmune. It’s still a diagnosis of exclusion rn tho. No test, just you have the symptoms and they’ve ruled out everything else.

there's one more piece to the puzzle. women generally have a "more active/agressive" (that's the general idea, but ofc the picture is a lot more complicated) immune response to make up for the downregulation of the immune system necessary for pregnancy. over evolutionary time women have spent more time of their life pregnant than they do now, so that makes sense to get roughly equal function of the immune system for both. right now, women are therefore better equipped to fight off various infectious diseases like tuberculosis or amoeba hepatitis, but are disproportionally affected by autoimmune diseases.

You might want to add a correction, Hashimoto’s Thyroiditis is much more common than Lupus(SLE). It’s like 350/100,000 for women per year for HT vs 78.73/100,000 for women total with 3.04 million women affected worldwide. The total Lupus(SLE) diagnosis worldwide at 3.41 million people comes no where close to the estimated 2% of the world population effect by Hashimoto’s. Edit: Even if you count all forms of Lupus and not just SLE the total amount of people affected in the world is around 5 million.

@cfromnowhere

Ай бұрын

I have Hashimoto's thyroiditis and I am definitely confused by that wrong statement...Even by experience Hashimoto's thyroiditis seems more common than lupus.

@sini234

Ай бұрын

​@@cfromnowhere I have been tested for Hashimoto at least 4 times (my thyroid's fine), but when I state I belive I might have Lupus (my aunt and sister got that) that definitely isn't what I'm experiencing. I also do not believe Lupus is more common.

As someone with a notable amount of family with autoimmune things about them, I'm aware of the jist of this. Feels good to get more details about the 'hows' and 'whys'. Thanks! Also... the x-chromsome emiting XIST... it being tied to the feminine sex gene... seXist... gonna be a funky way of remembering this, ngl.

@user-xj8wy4uu1q

Ай бұрын

Lol

This stuff is why, as a non-intersex trans man, I still have F on my legal documents and when I change it, I want it to be X. There ARE medical differences between the different genomic sexes (and non-genomic influences, like hormones) and I want doctors to be able to tell at a glance that things may not be as they seem. I have too many medical issues to feel comfortable with doctors assuming I'm a cis man, especially if I end up in an emergency situation and they don't have my medical history or time to check.

@PlutosAsleep

Ай бұрын

And you 100% should have that right and it sucks that for a lot it’s just not an option

@Dx-Dm

Ай бұрын

Nonbinary doctor here. Even if you get it changed, we're still supposed to do an organ inventory. I wouldn't base my own legal gender listing on how I'm going to have my medical care addressed. Edit: and if a doctor doesn't do an organ inventory or ask you about your history in a culturally competent manner like they are supposed to, then the patient can bring it up.

@XSweetNSaucyX

Ай бұрын

SMART AND AUTHENTIC 💗🫶🏻💯

@fghsgh

Ай бұрын

@@Dx-Dm glad there are better practices out there in a lot of cases they really do just assume, from what ive heard and experienced (probably depends on the country) on the other hand there are also health issues that _are_ predominantly affected by hormones rather than genetic, which means trans people are affected in the same way as the gender they are presenting as, so being treated as your AGAB would actively be harmful, but that is exactly what misinformed doctors would do we need better education, and more research

@Dx-Dm

Ай бұрын

@@fghsgh I agree with all of your statements. Receiving gender-affirming hormone therapy or surgeries are very important things to discuss with your doctor. All the more reason to not change how you legally list your gender on the basis of your assumed medical treatment.

Solid presentation, Niba is rocking these 😊 It is interesting how much balance on the tightrope of DNA life is always dealing with and how too much or too little causes issues, but yet we maintain enough variation that DNA keeps cooking up new mutations… like any good chef, you will stick close to the good recipe but experiment to see if there is any room for improvement. Thanks to the whole team that makes these amazing vids 🎉

Well, Niba, its the second video ive seen you in! so i assume you are here to stay! Welcome to SciShow! I look forward to seeing more videos hosted by you.

Id love an episode on fibromyalgia, its so hard to find any information on it

@maipai101

Ай бұрын

This it seems to be linked to chronic fatigue syndrome

Me watching this while in an RA flare: 😨

@deedrole5296

Ай бұрын

solidarity!

@limalicious

Ай бұрын

@@deedrole5296 thanks, much needed right now!

Well now as a genetic XY with Crohn's and Ankylosing Spondylitis as well as the constellation of other side "benefits" linked to autoimmune issues like painful joints and recurrent uveitis I am feeling extra unlucky!

@gemmydoadance1593

Ай бұрын

The genetic lottery is more like landing on a Bowser space in Mario Party and just hoping that you don't get outright punted into the sun, LMAO

@overlordfemto7523

19 күн бұрын

Lmfaooo DEFECT

My maternal great grandmother, grandmother, aunt, and mother all had/have autoimmune issues. I and my two sisters have always had strong immune systems, but I got bit by a tick with Lyme's when I was in my late teens. Two decades on, I have four diagnosed autoimmune disorders and CRPS. So, I was genetically primed to get chronically ill, and the tick bite was the match to the fuse.

@poultryinmotion5721

Ай бұрын

People with an autoimmune disease often have aggressively strong immune systems.

@deedrole5296

Ай бұрын

You have an aggressive immune system. It's not weak. We take immune system modulators to help treat our illnesses.

@yvonnetruelove2270

Ай бұрын

I’m so sorry. CRPS sucks and autoimmune diseases suck. 🙁

@IzDiaries

Ай бұрын

@@yvonnetruelove2270 Yep, they do. Thank you.

I‘m sorry, but Hashimoto‘s thyreoiditis is way more common than lupus!

@SquashyPan

Ай бұрын

Yeah lupus is something like 1-2 over 10.000 incidence while hashimoto is more like 5-10 over 100

@jackabug2475

Ай бұрын

Maybe they meant better-known -- I'd heard of lupus long before Hashimoto's thyroiditis.

@KrisRyanStallard

Ай бұрын

I didn't gather that they said Lupus was more common.

@shellym79

Ай бұрын

​@@KrisRyanStallardshe very clearly says "in the far less common hashimotos thyroiditis" immediately after discussing Lupus.

@solarmoth4628

Ай бұрын

@@KrisRyanStallard They did say in the video “far less common Hashimoto’s thyroiditis” according to the subtitles.

I was diagnosed with hashimotos at 7 and its difficult. Always nice to hear people talking about it.

Howdy hi hi, Thanks for doing this episode. I'd always wondered why autoimmune disorders were so much more prevalent in women. I am male, genetically and in every other way. However I've developed not just one but two autoimmune disorders. I have a family history of Lupus, but I am thankful to report that hasn't manifested and I hope it never does. What is do have however is primary antiphospholipid syndrome positive for anticardiolipin auto antibodies, anti beta 2 glycoprotein 1 auto antibodies, the lupus anticoagulant (again, not lupus YAY) and something called polygonal phase that I still have no idea what it means. As well as factor V Leiden with activated protein C resistance. And to top off that quaint little cocktail let's toss in ocular migraines for good measure. Yeah migraine, another disorder far more prevalent in women. While I've not heard any estimates as to how many people might have this spectrum of disorders. I have to imagine that it's pretty rare overall. I lived with this, let's see...this is my 25th year surviving this stuff. Too stubborn to let it get the better of me. Next month I'll hit 53 years young and (hopefully), still kicking. If there is one thing I'd like to share is that if you know someone who is dealing with an autoimmune disorder of any type. Be kind to them. Understand that it's not a matter of learning and living within your limits. The rules can change from year to year, month to month, day to day, or even hour to hour. I might have extreme difficulty doing the easiest of tasks in the morning. Only to breeze through it later in the day. Or vice versa. So when they cancel on plans, or just can't keep up. Maybe sit with them for a while, or include them in ways that work for them. For those who suffer through these things. It really makes a world of difference when we see others making an effort to do what they can. Even if that means just leaving them alone to rest for a while. Anyways, thanks for reading this. I hope your day treats you well.

@yvonnetruelove2270

Ай бұрын

Thank you for your post. ❤

Given how often most women are ignored when they complain of symptoms, I would guess that the extra stress is a real factor!

@wombat.6652

Ай бұрын

The problem is we get " you're stressed (that solves the problem) would you like to try a yoga class I know". or....x tablet in the Valium group.

Fyi: I'm a man with psoriasis and psoriatic arthritis, and I've had women doctors completely disregard me over it.

@gemmydoadance1593

Ай бұрын

I'm sure they have, it's really not fair. I've also been disregarded by doctors for my issues, male and female alike; it took me 2 years to get diagnosed with hashimotos, and 2 more before they got me with endometriosis. The medical establishment has a habit of saying "when you hear hoofbeats, think horses, not zebras". Sometimes, it is a zebra. And those mf's are nasty.

@scarletpathcat

Ай бұрын

And psoriasis is one of the few that affect both genders! I'm sorry you go through that, it's not fair...

@sharronhankins7722

Ай бұрын

Truth😱😱😭😭​@@gemmydoadance1593

@VizzyInks

25 күн бұрын

Women reproduce medical gaslighting too, even if not based on gender.

I didn’t realize how rare it is for men to get this disorder. I actually got lupus when I was younger where my body started attacking my kidneys. Considering I didn’t realize though that it mostly occurred in women.

i am a man living with psoriasis and hashimoto's thyroiditis. my mother and sister also have hashimoto's.

@cexilady3333

Ай бұрын

How does it feel to be part of the 5%? /lh

@Finkeldinken

Ай бұрын

Dang, that's some tough luck! Did you have any issues getting it diagnosed correctly because of your sex (I can imagine unconscious bias on a doctor's part) or did things go alright? I hope your conditions are well managed - all the best!

@blazer9547

Ай бұрын

@@cexilady3333 what's with mocking a person who has a serious disease Next time have empathy.

@shakeyj4523

Ай бұрын

@@blazer9547 You aren't edgy sweetheart.

@deedrole5296

Ай бұрын

@@blazer9547 the /lh at the end of the statement indicates that what they said was light hearted...if you don't know something, look it up before berating others for your lack of context. Please read this as a neutral tone and good advice.

Early detection? I’d settle for doctors believing us when we come in with all the symptoms and a family history asking specifically about the disease we have!

Not all autoimmune diseases are more common in people with XX chromosomes though - ALS for example is more common in XY men. Granted that one we don't really understand as far as I know.

@katbairwell

Ай бұрын

I thought the evidence for Motor Neurone Disease being autoimmune was a bit sketchy, circumstantial only at the current time. Have I missed something important? We lost my husband's mum to MND, and I tend to try and keep an eye on the research, but I've had my eye off the ball the last 12 months or so. If I've missed something important, I'd really appreciate any heads up you can give. Thanks.

@danriddick914

Ай бұрын

@@katbairwell So sorry to hear that. I lost my mom to ALS so I only really keep up with that specific MND, but you're right - it's still debated whether it's an autoimmune disease. Saying that, sometime last year there was a study that suggested that ALS patients may benefit from a therapy that targets autoimmune inflammation. Either way, it's wild how little we know about such devastating diseases.

@katbairwell

Ай бұрын

@@danriddick914 I'm sorry, my friend, you put it precisely when you say it's a devastating disease. It's telling that almost everyone we've talked too, that has lost a loved one to it, has become a keen watcher of the science, hoping that other families will get better outcomes one day soon. Much love

@dreammaker9642

Ай бұрын

Idk why I first interpreted the « that one we don’t really understand » as referring to males and not ALS to which I was gonna say Amen 😭 I do have lots of questions to take up with my Y chromosome like why can’t I just sit around in peace and think of nothing 😂 why am I preparing in my head for a scenario where I may or may not have to fight a bear? I’ve never even lived in bear country before wtf

@katbairwell

Ай бұрын

@@dreammaker9642 Until I was adult diagnosed with ADHD, I had no idea that when most people talk about letting their brain go "silent", they meant they could actually think of nothing, just, like, empty peaceful quietude. Mine has always squealed and screamed at me like a sugar-overdosed child at a theme park!

Just a woman here, grateful not to suffer from an autoimmune disorder

@Swaythru

Ай бұрын

Lucky you

This video makes a lot of sense. Woman who have babies go through drastic immune system responses while bring pregnant. Just look into how chaotic pregnancy is on the human body.

@thehomeschoolinglibrarian

Ай бұрын

Not to mention breastfeeding. Growing and feeding a small human does some interesting stuff to the female body.

@deedrole5296

Ай бұрын

also interesting that autoimmune symptoms will often be suppressed during pregnancy and then come roaring back after delivery.

@gemmydoadance1593

Ай бұрын

My hashimotos is directly related to the birth of my son, there's apparently a correlation.

@dawsie

Ай бұрын

Yep, I was placed on a drug used in transplant patients because my body treated my pregnancy as a virus, but even that did not work. I have only gotten to 8 months on 3 of my many pregnancies and they ended in being stillborn I won’t say how many pregnancies that never got past the first trimester it’s just to heartbreaking. The Drs at the IVF programme never could work out why my body kept treating each pregnancy as a virus. In many cases I never made it past the first 6 weeks of my pregnancy. I never told family if and when I was pregnant anymore simply because I knew that by the time the family were told I had already lost my baby. I use to give blood every month in my 20’s early 30’s and because of an oddity in my blood each time I went in to donate extra blood was taken and sent to the UNI for their special tests and experiments they were running. After my 2nd blood transfusion I was no longer allowed to donate blood which I was only doing because I was on the bone marrow donor listing. I am 61 now, but they never could find the answers as to why my body did what it did. I have no idea if there are other women out there who have never been able to go full term with the same issues as me. The Drs never said if they had other patients like me. During those years of disaster I only had one Dr no matter where I moved around the Sydney Bowl I always went to my family GP since I was 16 years of age, before that I use to live in the UK. lol I just worked it, from the time I was born to my present day I have only ever had 6 family Dr’s in my 61 years, and only one of them I have ever refused to see again because he’s a jerk. The 2 best Drs I have ever had in my life were old school Drs, the first one was my last Dr in the UK, he was 92 when we left and he was still practicing Dr he was also one of the Drs who was training the next generation of Drs. The 2nd Dr is my current GP he is 84 and was one of the Drs who created the “Flying Drs” service in Australia he now only works Mornings and he said as long as he still sharp he will keep working. Funny how the best Drs are also our oldest Drs.

@tru7hhimself

Ай бұрын

@@deedrole5296 broadly speaking, estrogen ramps up the immune system while progesterone dampens immune response.

Really informative video for how short the watch time was, thank you SciShow for keeping my brain occupied, and interested. Thank you Niba for another awesome video

Thank you SciShow. Welcome to SciShow Niba - you are a very skilled communicator - my Internet-weakened attention span allowed me to watch the entire video! This information about the genetic sex chromosome component of autoimmune diseases is also part of the explanation for the large variety of hetero, homo, trans and every other human sexual behaviour. I wish those of us humans who think anything other than hetero sexual desire is a sin or somehow wrong could instead try to learn and understand their fellow humans before condemning them. I am optimistic, but won't live to see it.

@nerdywolverine8640

Ай бұрын

i think you might've misspoke a bit, trans isn't a sexual behavior

@WingedAsarath

Ай бұрын

​@@nerdywolverine8640 he's a little confused, but he's got the spirit 😂

I'm a 32 years old man who got diagnosed with MS at 18, an age where it's pretty uncommon for men to be diagnosed and way more common for women. I absolutely can't argue with this video. When it comes to MS women get diagnosed more often than men and, on average, at a starkly younger age

"Xist" sounds like the name of some sort of health-focused tech start-up lol.

@JerehmiaBoaz

28 күн бұрын

Sounds like a gamer name.

It should be noted that males and those with Turner’s syndrome also have a waning immune strength against pathogens as we age. This difference in higher rates of autoimmunity in females vs age-associated waning pathogen resistance in males fits into the paradigm of the immune system having to strike a balance between being strong enough to be protective but not so strong as to attack the self.

"...y is much smaller than x..." 784+ dislikes: "and i took that personally."

Welcome to SciShow Niba, I love your expressive presentation style. With autoimmune diseases, the complexities of our genetics and the immune system combine into mindboggling complexity squared. Fascinating!

OMG, you mentioned Hashimoto's Thyroiditis! That's my autoimmune disease!

Great video as always

Very good reporting here, you gave a great sense of the research!!!

Thank you for this. Yes part of the problem for women is that our pain (and other symptoms) are just not treated seriously. I'm post menopause now. I love it!!!! Kind of wish I had been diagnosed with endometriosis. At least they would stop fobbing me off with "you'll be fine once you've had a baby / past menopause. "

I remember another video on autoimmune disorders here and how it was noted that the trend even occurs among trans women, which wouldn’t normally be expected. Which does make me think Estrogen is likely involved too tbh. (Yes, one can be trans without HRT but I believe the study cited did look only at trans women on HRT so yeah. :V)

Ive always found it fascinating how each sex is disproportionately affected by different kinds of genetically based illnesses. It really goes to show that despite how amazing the capabilities of our genes are, there are still massive flaws to be found in them as well.

@shakeyj4523

Ай бұрын

Especially ones on sex based chromosomes.

@blazer9547

Ай бұрын

Evolution don't care.

@TV-xm4ps

Ай бұрын

They are not inherently flaws per se. Your genes make sense for the environment they have developed for. If we do not live in that environment any longer - which most of us don't, in "the modern" world - then the interaction of your genes with the new conditions can go awry.

@vidal9747

Ай бұрын

​@@TV-xm4psThey are actually flaws. You can't justify being born blind or missing your hearing. Our bodies are not perfect. They are far from it. They are as bad as evolution could get away with. Genetic issues are totally useless and mostly don't have a "hidden meaning".

Love your cardigan!! 😊❤ I definitely believe this... all of the women in my family have at least 1 autoimmune disorder, but most have 2 or more; I have 3.

here for the guys who didn't realize the title is a joke

"It's never lupus"

Ahh so informative video! Thanks! 👍

I know exactly what you're talking about, yet still curious

Y'all, the title isn't clickbait - it's a pun. "Sexist" is actually a play on the issue being related to X chromosomes (aka the long-standing idea that this is an issue in "women") and Xist (the stuff that wraps around the extra X and silences it). "Autoimmune disorders are Xist. Here's why."

@blazer9547

Ай бұрын

I don't think so.

@justaregularguy115

Ай бұрын

Ikr, NPC is reaching hard.

@kashiichan

Ай бұрын

​@@blazer9547I hope you experience joy one day! Good luck!

@PurpleNoir

Ай бұрын

@@justaregularguy115 do you have a counter argument based on facts and data? I have already stated this a few times already but the title of the video is clearly tongue-in-cheek, think of the headlines from a few years ago the “Covid-19 is homophobic” article titles were clearly not meant to be taken literally and are just using a jokey description of the actual problem.

@WrottJackson

Ай бұрын

No, by definition it’s still clickbait. Clickbait is everywhere, not all of it is bad. If this video was titled “Why women get autoimmune diseases more” less people would click. There’s also nothing related to sexism in this video, if they wanted it to be less clickbait-y, they should’ve called it “Why Autoimmune Diseases are SeXIST” Or something. This is still very much clickbait.

I read that trans women (who are XY) sometimes develop autoimmune diseases when they start on oestrogen. Maybe there's a hormonal component to the sex discrepancy as well. Unfortunately I can't remember where I read this

@gatordays1538

11 күн бұрын

schishow actually did another video on autoimmune disorders that discusses this, a few years ago i believe

New presenter is great! 👏 👏

@adamwishneusky

Ай бұрын

Still not sure about the recent use of multiple camera angles 😛

I recently started suspecting I have systemic lupus (tons of symptoms + family history), so this is right on time 💀

Trisomy 21 is fatal in utero in about 50% of affected fetuses. A few more die during the early newborn period. Life expectancy is reduced even with optimal supportive care.

Hi Niba!!❤❤

I have lupus and always thought it was induced by hormones, since triggers are puberty, UV rays, and other stress.

Gotta love the sexism from the people who very obviously posted without watching the video. 🙄 When it's over 7 mins long, 4 mins old, and you posted your factually incorrect comment 30 seconds ago...

@blazer9547

Ай бұрын

Title is inappropriate. nature don't discriminate

@scalpingsnake

Ай бұрын

@@blazer9547 It's obviously just fun word play... calm down

@Screeno1993

Ай бұрын

Bots I assume

@moorbene5104

Ай бұрын

Where would that be "factually incorrect" tell me please

@therealking6202

Ай бұрын

​​@@scalpingsnakeNo, it's not "obviously word play." That's the mistake. Assuming everyone is "in on the joke." They're not. Normalizing terms like sexist is the real problem.

If Autoimmune Disease are more prevelant in animals that have two or sets of Sex-Chromosomes, does that mean the disease in animals where the males have the two sets, like with birds, are mire prevelant to the males?

@doraspoljar697

Ай бұрын

That would be a very interesting question and could help people learn a lot about autoimmune disease!

Good stuff

As a sufferer of Hashimoto's I'm thrilled you're talking about autoimmune disease and I think you should do so as often as possible. However, maybe refrain from the (perfectly comprehensible) puns because people are media illiterate and the sexist culture war weirdos who hate women come out of the woodwork. (They'll do that anyway.)

@mayaenglish5424

Ай бұрын

Eh, we can't let the no fun, media illiterate weirdos win. If you can't tell it's a silly joke you're doing something wrong. (Unless English isn't your first language or you have some sort of learning disorder obviously).

I am a man and I get hemiplegic migraines, which are FAR more common in women. Is that why I love when my daughters paint my nails?

I have Grave's disease just like my father. Thankfully mine went into remission before having to have my thyroid removed.

My family have a bunch autoimmune disorders that are expressed differently among us. We all have primary clubbed fingers, my grandmother had AIED, and my mother has psoriasis and rheumatoid arthritis. I myself, a male, have vitiligo and HSP. There is still much research to be done on why autoimmune disorders are expressed differently among the global population.

It's overbearing, a verital verbal assault - does she breathe through her ears?

I wonder how this affects the few XX males with an SRY on one of their X chromosomes.

autoimmune disorders run in my family, for us both men & women get them pretty equally since almost everybody has something. though i've noticed that specifically crohn's & ankylosing spondylitis are most common in my male relatives vs lupus, hashimoto's, & sjogren's which only affect my female relatives (as far as i know)

From my wife: "I KNEW IT!! I knew it!! Dammit! Life is unfair!" Then she said some unmentionable things along these same lines.

My brother has Hashimoto's thyreoiditis, my second cousin (a female) has lupus. My brother also thinks her daughter has lupus.

I have health problems that got worse the last couple years, especially since COVID. My gynecologist said to me I should get checked by my GP, because my symptoms sound like an immune issue. I don't like that... 😅

As a woman who has hoshomitos, this was very interesting

My husband has MS and we know a lady with MS. Lupus runs in my husband's biological family on his father's side.

@rookregent5623

Ай бұрын

One set of experiences does not offset statistical facts.

Where’s Hank

That second camera angle in the intro was super unexpected

Cancel autoimmune diseases!

@Gaetano.94

Ай бұрын

Tell that to my Crohn's who has taken most of my bowels from me.

@poultryinmotion5721

Ай бұрын

Yes, please!

@mayaenglish5424

Ай бұрын

Yes lets do that please and thank you lol.

I have 5 autoimmune diseases. Possibly a 6th which I am being tested for, all related to the Type 1 Diabetes I was diagnosed with in my teen years. I am now in my 70's. This is a very interesting video and would like to find out more.about this theory.

I inherited Hashimoto's from my mom, but I guess I'll take that over inheritance of her schizophrenia and epilepsy. I really wasted a significant amount of time in my teens wondering if I was under a counter waiting for my mental capacity to decline. The Hashimoto's wasnt on my radar at all.

It's never Lupus.

Can you do a video on Mallen streaks or poliosis?

Women health is actually well established for years. It’s men’s health which has been largely ignored.

I have a unspecific arthritic diagnosis including the genetic testing for HLA-B27, which was positive. I thought it was also related to sex, but I just read on wikipedia that HLA-B27 is coded on chromosome 6 though... it still associated with sex or was that a misunderstanding on my part?

Narator "People born with two or more x chromosomes" Me: "OR MORE HERE TO REPRESENT!!!" also got extra autoimmune shenanigans for added spice.

I expected this to discuss Polyvagal theory

WE LOVE DIANA aka PHYSICS GIRL!! ❤

i like her style very mych thanks for the videooooooooooooooooooooooooooooooo

I tested positive for autoimmune disease, specifically what type not known yet

I have lupus and now i wanna get my genome sequenced

I have the hlab27 type that is linked to ankylosing spondylitis in more men, but I keep stumping the rheumatologists because I only have eye issues and no spinal problems. For some reason it seems being female is protecting me from the worst of this specific disease.

As a man with an autoimmune disease I concur.

OK, the first 2.5m of this video leads me to posit that, because of Barr Bodies, where cells turn off one of the X chromosomes, and it's basically never ALL one parent's that gets turned off (most notably visible in Calico cats where they are a patchwork of both parents colorations)... if there is some minor conflict between this where the Mother's X chromosomes are entirely in charge of the Immune system's detection apparatus and it sees another cell with the father's X expressing, it triggers an overactive defense response. It would also seem that certain systems are more susceptible to these issues... now to unpause and see if I'm in the general vicinity. Hrm, right path, slightly different path... but the compound that turns off the chromosome getting loose and messing with other genes seems like a good, plausible theory that I hadn't thought of.

Can we test for this? I want to be tested! I have multiple autoimmune diseases and want to know if my chromosomes are faulty!

TL;DR - Excesses of Xs's cause a lot of messes

@gifttanz

Ай бұрын

Living a life full of messes caused by my excess x's (and exes) xD I love this rhyme

Great explanation, for those who are trying to deviate chromosomes with sexuality are completely wrong. There is only X and Y and no moroe. Pay attention or replay the video.

I'm a type 1 diabetic and a cisgender woman. How common is that compared with other autoimmune disorders? I've met several type 1 diabetic men and I wonder what the statistic is for xy vs xx in diabetes. Also wondering how common is it to have more than 1 autoimmune disorder since I also have Hashimotos.

@fghsgh

Ай бұрын

i know the reason T2 is more common in men is because estrogen increases insulin sensitivity... but of course that's a very different thing from T1 looking it up, it seems the ratio for T1 is slightly under 2:1, and, considering it usually develops in childhood, is probably caused by genetic differences rather than hormonal ones, so trans people would be affected similarly to their AGAB (although maybe it is still partially hormonal? so specifically trans men going on hormones could be more likely to develop it in adulthood, which does also happen for cis people but is relatively rare)

@heyna1185

18 күн бұрын

It‘s very common to have more than one autoimmune disease sadly.

Interesting stuff - however the business about XXX and XXY is given a little too much priority - that is much less than one per cent of the population and would not account for the huge female/male "perference".

@fghsgh

Ай бұрын

it's special cases like these that help us determine the specific causes of these issues, though similarly, trans people taking cross-sex hormones are invaluable to research about the effects of those hormones, even in cis people, and could further our understanding towards treating/curing diseases that affect them, just like how people with weird chromosomal makeups can further our understanding of certain genetic diseases and give us a pointer for how we could treat those for example, do you think we would have found out about the specific mechanism by which Xist deactivates X chromosomes, and how that protein is being attacked by the immune system? maybe, but it would have taken a lot longer to figure out, and we would be so much further from developing a treatment

@gifttanz

Ай бұрын

I am XXX and have always been told its 1 in 1000 live female births, (in my country anyway) presume its similar across the world, which is still signifigant number of people living with the condition.

@marksteers3424

Ай бұрын

@@fghsgh I did not mean to say that the overall number is insignificant and I agree wholeheartedly with looking at the "outliers" for want of a better term. I was simply saying that if XXX is one in a thousand it would not account for the female bad bias of the conditions - unless of course almost all of the auto-immune suffers were of this one in a thousand type. It sucks of course - just like the males with haemophilia carried by their mothers X chromosome.

Also this video should include autoimmune disease due to michrochimerism

I may just be more tired than usual, but I had a hard time following this video. I did listen to it at a slower speed, which helped some, but the concepts are multi-faceted and I needed the facets laid out one at a time and more of the connections between them explained a bit more. But fascinating topic. I'll keep an eye out for more information on it.

@marmar90000

Ай бұрын

I found it hard to follow because there were no pauses in the script. It seems that @SciShow *deliberately* edited out the pauses between sentences, which just made everything feel chaotic! We need the natural speech pauses to give our brains a break!

@Judymontel

Ай бұрын

@@marmar90000 Maybe that was the problem. Because when I slowed it down, there were still no pauses. Interesting how important that can be!

For anyone browsing the comments and wondering wtf is happening, the video title is not clickbait. Its similar to other clickbait memes, such as, "DOCTORS HATE HER!! 5 Secrets to Lobster Immortality" or "blank? In MY PC? It's more likely than you think" It's a tongue-in-cheek meme. The prevalence of auto immune conditions in women (specifically on the second x chromosome) is higher. That's the joke. Please, fam. Apply critical thinking instead of just diving headlong into reactivity. I say this as a cis woman with three autoimmune conditions (one of which I inherited from my father!).

@jackabug2475

Ай бұрын

Uh oh, you used the word 'cis'... the brains of half the people you were trying to reach just shut down when they saw that...

@deedrole5296

Ай бұрын

They cannot, they will not.

@laerwen

Ай бұрын

Media illiteracy is everywhere, unfortunately. I have Hashimoto's, so I got what they meant immediately.

@mayaenglish5424

Ай бұрын

Don't you know that jokes are illegal in science communication?! For Shame!

@brapamaldi7666

Ай бұрын

as a trans woman I am offended that you seem to think that being cis adds any weight to your argument.

If auto-immune diseases are related to trauma suffered under our gender based society then it makes sense women suffer more. Being AMAB myself, and receiving a butt load of trauma around not being heard and having my autonomy taken away from me, I suffer from a lot of auto-immune issues. Seems almost like a broken record now, "this conditions usually affects women", and me... POTS is a big one that seems indicative of underlying problems. 💜

I didn’t see a mention of what I’ve read quite a bit, the link between auto immune diseases and CPTSD. Off to read my life away… 🤣

@AndersWatches

Ай бұрын

… the what now? 🙃🙃🥲

I’m the only female in my family with ITP (body destroying my own platelets)

I read the title as "Automotive disasters" and was ready to type the ultimate joke in the comments.

Now I want to get genetic testing 🤔

I'm seriously confused. What are people upset with? Did I miss something?

@blazer9547

Ай бұрын

Diseases can't be sexist. Anti science title

@EbonyPope

Ай бұрын

Nobody is upset. The title is just very clickbaity.

@shakeyj4523

Ай бұрын

@@EbonyPope It is also accurate.

@SPACEDOUT19

Ай бұрын

women projecting "sexism" on diseases now, thats the thing

@deedrole5296

Ай бұрын

@@SPACEDOUT19 Oh look babyboi has a butthurt! Boo and hoo.