it's always a relief to look up an orgo reaction then find that Leah4sci has a video on it

@Leah4sci

2 жыл бұрын

Awww thanks so much! I'm honored!

You are one reliable guide for the new adventurers who are venturing into organic chemistry jungle, taking everyone step by step through complex mechanisms, thank you !

@Leah4sci

4 жыл бұрын

Thanks for your kind words, and you are very welcome!

@niru216

3 ай бұрын

Very true!

I spent so long trying to understand this mechanism and you made it so so easy! Thank you so much!!!!

@Leah4sci

5 жыл бұрын

awww! I'm glad the video helped! You are very much welcome :)

You're the greatest, your explanations are thorough and very easy to understand. Thanks for the great content!

@Leah4sci

6 жыл бұрын

Thank you for your kind words! You're very welcome!

@littlechemist

4 жыл бұрын

@@Leah4sci mam i am a little student of chemistry. I have a kindly request to u.i made a video. If u r free then plz see it and give some advice as a teacher.plz.i will waiting for you

Leah...ur awesome..... u make everything so easy.. that I'm in love with organic chemistry. thank you so much... and keep it up you are doing a gr8 job👍👌

@Leah4sci

6 ай бұрын

You're so welcome, happy to help and to hear that you fell in love with orgo!

if I pass organic chemistry this lady is the reason ,,thank you so much

@Leah4sci

2 жыл бұрын

You're very welcome!

@PunmasterSTP

Жыл бұрын

Hey I know it's been awhile, but I just came across your comment and was curious. Did you end up passing?

I just discovered this channel with this video. Amazing content! Thank you

@Leah4sci

2 жыл бұрын

You're very welcome, so glad you found my channel!

Thank you for your hardwork I wanted to ask something that when an aldehyde and ketone undergo aldol addition, is the product an aldol or a ketol?

@Leah4sci

11 ай бұрын

I'm sorry, but I don't offer tutoring over social media. If you ever find you need help with questions like this again, I recommend joining the organic chemistry study hall. Details: leah4sci.com/join or contact me through my website leah4sci.com/contact/

Thank you so much our teacher it was so useful , so i can use this video to synthesis chalcon molecule between acetophenone and benzen aldehyde in basic medium Na-OH

@Leah4sci

6 ай бұрын

you're very welcome!

Ur way is easy and simple to learn...thank u for the amazing video! :D But I've a doubt...what if we have 2 compounds in the left hand side...like how to find them . Shld we add them or keep one of them as constant? Pls solve my doubt 🙃

@Leah4sci

9 ай бұрын

Glad you found this video helpful. I don't understand your question, are you asking if you have two different starting molecules? If yes see the mixed condensation videos on my channel where I give you examples

Thank you for everything you do for us. I wish I could give you a big hug, so here I'm sending my virtual hugs.

@Leah4sci

Жыл бұрын

virtual hug accepted and returned ;)

U explained this very well .thank you ❣

@Leah4sci

4 жыл бұрын

You’re welcome 😊

9:46 Solomons describes intstead a proton shift and then condensation as well as removal of alpha-hydrogen to yield a,B-unsaturated product. Are both yours and Solomons’ mechanisms correct?

@Leah4sci

10 ай бұрын

I am unfamiliar with your textbook resource, but I still stand by the accuracy of the mechanism in this video. If you watch to the end of the video, you'll see how I form the a,B-unsaturated product.

You said in the beginning, 0:25 , that we'll be needing an aldehyde or a ketone, but wouldn't a ketone molecule, tautomerise in an acidic or basic solution ? So how do we differ K.E.T from aldol reaction ?

@Leah4sci

4 ай бұрын

There is an element of KET in aldol condensation reactions. Instead of forming and enol, the negative oxygen gives you an enolate which helps drive this aldol condensation reaction

Great explaination! Thank you

@Leah4sci

7 ай бұрын

You're so welcome!

A good explanation,we like your way

@Leah4sci

6 жыл бұрын

Glad you like it :)

Thank you so much for this video!

@Leah4sci

7 ай бұрын

You're welcome!

Thanks for all

@Leah4sci

Жыл бұрын

you are welcome

So the difference between aldol addition and aldol condensation are related to each other like nucleophillic substitution is to nucleophillic elimination ? 1:24

@Leah4sci

9 ай бұрын

You can think of it as more of a step-wise process. After aldol addition, at high temperatures, you can have a dehydration reaction in which water is eliminated. So the aldol condensation is an addition followed by a dehydration (removal of a water molecule).

@Shreyaraman2005

9 ай бұрын

@@Leah4sci Ohh.......thank you☺

nice video and helpful

@Leah4sci

6 ай бұрын

Happy to help!

why couldn't the oxygen with 3 lone pairs on the enolate ion act as a nuclepohile? Why did it have to be the carbon atom?

@Leah4sci

7 ай бұрын

While the oxygen is reactive with 3 lone pairs and a negative charge, it's negativity is pulled towards the carbon atom and will resonate towards carbon for the ultimate attack

Thank you so much for this nice video

@Leah4sci

5 жыл бұрын

You are very much welcome

6:04 isn’t OH a bad leaving group? It won’t be able to leave like that without protonation right?

@Leah4sci

Жыл бұрын

In a highly basic solution, it is definitely possible to leave like that. Remember our starting reagent was NaOH, so there's already tons of OH- floating in solution.

@cool_youtube

Жыл бұрын

@@Leah4sci oh ok great, thank you!

Nice one thxs

@Leah4sci

7 жыл бұрын

You're welcome!

why can't we kick out OH with heat under acidic condition??? at 10:08

@Leah4sci

3 ай бұрын

Acidic solutions are very positive which means an OH- would not be allowed to form. Instead the most 'negative' in an acidic solution would be the lone pair of electrons on a neutral oxygen (think water or alcohol)

Technically during a base-catalysed aldol, the base deprotonates the aldol addition product and the electrons DO actually go to the carbonyl to form an enolate, and then the (-) goes to form a pi bond on the other side to kick out the -OH. This is because -OH isn't a good leaving group under basic conditions, yet in this case the mechanism is an E1cB, hence it will work.

@traxxasbro5604

6 жыл бұрын

Guy de Fauxpassant what she drew was not incorrect...she just didn’t show the other resonance form which is what you’re describing. The E1cB elimination will proceed regardless of which resonance form is drawn, and either form would be considered correct on an exam for mechanistic purposes, unless the professor instructed to draw all possible resonance forms of reaction intermediates.

@Leah4sci

3 ай бұрын

You are correct about resonance, I teach the enolate resonance in the introductory video and then skipped to simplify in the rest hoping that students remember the resonance can and does take place

I was worried about this mechanism, but with ur videos i think it is safe to say organic chem will be breeze

@Leah4sci

6 ай бұрын

That's my goal! Glad it's helping

Aldol addition? More like "Amazing videos (making them) seems to be your mission!"

@Leah4sci

Жыл бұрын

Thanks so much!!

i did not understand

@Leah4sci

2 жыл бұрын

I'm sorry to hear that! Reach out to me at leah4sci.com/contact with further questions

you're missing a aldehyde hydrogen

@Leah4sci

2 жыл бұрын

At which point in the video? I believe that I drew it in, at all points in the mechanism. However, even if I didn't, it would not be incorrect. By convention, drawing the aldehyde hydrogen is not necessary, just as you are not required to draw hydrogens in a line structure.

@torresthemonster

2 жыл бұрын

​@@Leah4sci Ah you're correct. For this unit, I have been drawing the hydrogens to make sure I connect the bonds correctly. You are correct, sorry for the confusion. Do you by chance have a video on how to ace the ACS final? On your website, you only posted tips and reviews, but I did not see a whole review video to sum it up. But I did buy the ACS final ORGO which you recommend.