AKT/PKB Signaling Pathway | PI3k Signaling
This video will be encompass the AKT/PKB Signaling Pathway .
The Akt Pathway, or PI3K-Akt Pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (Protein Kinase B).
Initial stimulation by one of the growth factors causes activation of a cell surface receptor and phosphorylation of PI3K. Activated PI3K then phosphorylates lipids on the plasma membrane, forming second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Akt, a serine/threonine kinase, is recruited to the membrane by interaction with these phosphoinositide docking sites, so that it can be fully activated.[1] Activated Akt mediates downstream responses, including cell survival, growth, proliferation, cell migration and angiogenesis, by phosphorylating a range of intracellular proteins. The pathway is present in all cells of higher eukaryotes and is highly conserved.
There are multiple types of phosphoinositide 3-kinase but only class I are responsible for lipid phosphorylation in response to growth stimuli.
Akt resides in the cytosol in an inactive conformation, until the cell is stimulated and it translocates to the plasma membrane. The Akt PH domain has a high affinity for second messenger PI(3,4,5)P3, binding to it preferentially over other phosphoinositides.[11] Thus PI3K activity is essential for translocation of Akt to the membrane. Interaction with PI(3,4,5)P3 causes conformational changes and exposure of phosphorylation sites Thr308 in the kinase domain and Ser473 in the C-terminal domain. Akt is partially activated by phosphorylation of T308 by PDK1. Full activation requires phosphorylation of S473, which can be catalysed by multiple proteins, including phosphoinositide-dependent kinase 2 (PDK2), integrin-linked kinase (ILK)
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Very detailed explanation, it’s very helpful, many thanks🙏
Thank you so much, for the well explained concept
Thank you for this amazing lecture!
@carlgustafssonwold7861
3 жыл бұрын
From three very thankful swedish med students!
Mind-blowing, Excellent What an explanation 👍👍👍👍👍
@hussainbiology
4 жыл бұрын
thanks for appreciation..Glad to know that it helps ✌️
Thanks a lot!
Great! Thanks!!
This is rather good. Thank you.
@hussainbiology
22 күн бұрын
Thank you too!
Thank you sir g....
Thank you for making this video sir .
@hussainbiology
3 жыл бұрын
thanks Farheen for appreciation... Glad it helps
sir are these related to toll like receptors?
Amazing explained 😊😊😊😊thanku so. Much bro
@hussainbiology
3 жыл бұрын
thanks for appreciation..Glad it helps
Thank you for explaining it is very good video ❤
@hussainbiology
2 ай бұрын
Thanks for appreciation....Glad it helps
Thnku sir for making this video 🙏🙏it cleared my doubts....
@beinghuman4457
3 ай бұрын
tum yaha kya kr rhe ho.. ye toh madarasa chaap hai na ..
Very good explanation 🔥
@hussainbiology
4 жыл бұрын
thanks for appreciation..Glad to know that it helps ✌️
Thank you so much for this lecture! Which are the specific residues on p85 are phosphorylated?
@hussainbiology
9 ай бұрын
Tyrosine 688 residue of P85 are phosphorylated
thanks !
Thank you sir , 🙏
@hussainbiology
4 жыл бұрын
You are welcome ✌️
Ur the goat ❤
@hussainbiology
7 ай бұрын
thanks for appreciation....lots of love
You are amazing 🤩
@hussainbiology
Жыл бұрын
Thanks for appreciation
👌
Thanks sir ji
@hussainbiology
3 жыл бұрын
You are welcome ✌️
Best videos...sir
👍
@hussainbiology
4 жыл бұрын
boi...
Kindly tell me plz this pathway is used in non Hodgkin's cancer plzzz bcz tomorrow is my ppt
@hussainbiology
2 жыл бұрын
Yes.. this signalling pathway is deregulated in non-Hodgkin’s lymphoma
nice video sir plzzzzzz complete eukaryotic tranlation
@hussainbiology
4 жыл бұрын
Have completed it...Now only Processing is pending
@biology_mcqs3037
4 жыл бұрын
U should do little bit by yourself
@hussainbiology
4 жыл бұрын
boi che kale...em enus be waleth
@biology_mcqs3037
4 жыл бұрын
Wun hasa aes be panie emis jawab wana.....
where are the information for this video?
@hussainbiology
3 жыл бұрын
?????
@DreadedCup
3 жыл бұрын
I guess he's asking for the resources you used. The books.
ıt is great
@hussainbiology
2 жыл бұрын
thanks for appreciation..Glad it helps ✌️
Sir I need your help from where I can get these pathways any book for this
@hussainbiology
3 жыл бұрын
hello sir.... U can't get all pathways from a single book..
@hussainbiology
3 жыл бұрын
Alberts Cell Biology Lodish Cell Biology Development Biology by Gilbert
@shbangash437
3 жыл бұрын
@@hussainbiology ok sir I am going to download these books
@shbangash437
3 жыл бұрын
@@hussainbiology Sir can I get these chapters from where you have covered all these pathways
@hussainbiology
3 жыл бұрын
@@shbangash437 these are books dear.. U can download them from Internet easily
what is a monomore? or does he just have a bad accent ?
@peyman2965
7 ай бұрын
Monomer
Hello sir
Rrre
It would be better to understand if you speak in hindi it will be like a story