AlphaFold: The making of a scientific breakthrough

Ғылым және технология

The inside story of the DeepMind team of scientists and engineers who created AlphaFold, an AI system that is recognised as a solution to "protein folding", a grand scientific challenge for more than 50 years.
Find out more:
deepmind.com/alphafold
Protein references:
TBP = To be published
1BYI: Sandalova, T., et al. (1999) Structure of dethiobiotin synthetase at 0.97 A resolution. Acta Crystallographica Section D 55: 610-624.
3NPD: Das, D. et al. (2014) Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family. Proteins 82: 1086-1092.
5AOZ: Bule, P., et al. Structural Characterization of the Third Cohesin from Ruminococcus Flavefaciens Scaffoldin Protein, Scab. (TBP)
5ERE: Joachimiak, A. A novel extracellular ligand receptor. (TBP)
5L8E: Dharadhar, S., et al. (2016) A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme. Journal of Structural Biology 196: 437-447.
5M20: Liauw, P., et al. Structure of Thermosynechococcus elongatus Psb32 fused to sfGFP. (TBP)
5W9F: Buchko, G.W., et al. (2018) Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide-rich de novo designed peptides. Protein Science 27: 1611-1623.
6BTC: Mir-Sanchis, I., et al. (2018) Crystal Structure of an Unusual Single-Stranded DNA-Binding Protein Encoded by Staphylococcal Cassette Chromosome Elements. Structure 26: 1144.
6CL6: Buth, S.A., et al. (2018) Structure and Analysis of R1 and R2 Pyocin Receptor-Binding Fibers. Viruses 10.
6CP9: Gucinski, G.C., et al. (2019) Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins. Structure 27: 1660.
6CVZ: Loppnau, P., et al. Crystal structure of the WD40-repeat of RFWD3. (TBP)
6D2V: Clinger, J.A., et al. Structure and Function of Terfestatin Biosynthesis Enzymes TerB and TerC. (TBP)
6E4B: Tan, K., et al. The crystal structure of a putative alpha-ribazole-5'-P phosphatase from Escherichia coli str. K-12 substr. MG1655 (CASP target). (TBP)
6EK4: Brauning, B., et al. (2018) Structure and mechanism of the two-component alpha-helical pore-forming toxin YaxAB. Nature Communications 9: 1806-1806.
6F45: Dunne, M., et al. (2018) Salmonella Phage S16 Tail Fiber Adhesin Features a Rare Polyglycine Rich Domain for Host Recognition. Structure 26: 1573-1582.e4.
6M9T: Audet, M., et al. (2019) Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor. Nature Chemical Biology 15: 11-17.
6MSP: Koepnick, B., et al. (2019) De novo protein design by citizen scientists. Nature 570: 390-394.
6N64: Birkinshaw, R.W., et al. Structure of SMCHD1 hinge domain. (TBP)
6N9Y: Kerviel, A., et al. (2019) Atomic structure of the translation regulatory protein NS1 of bluetongue virus. Nature Microbiology 4: 837-845.
6ORI: Spiegelman, L., et al. Enterococcal surface protein, partial N-terminal region (CASP target). (TBP)
6PX4: Krieger, I.V., et al. (2020) The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition. Journal of Molecular Biology 432: 4623-4636.
6QVM: Osipov, E.M., et al. Crystal structure of native O-glycosylated multiheme cytochrome cf with S-layer binding domain. (TBP)
6T1Z: Debruycker, V., et al. (2020) An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity. Nature Structural & Molecular Biology 27: 829-835.
6TRI: Rasmussen, K.K., et al. (2020) Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage. PNAS 117: 20576-20585.
6U7L: Minasov, G., et al. 2.75 Angstrom Crystal Structure of Galactarate Dehydratase from Escherichia coli. (TBP)
6UBL: Kosgei, A.J., et al. Structure of DynF from the Dynemicin Biosynthesis Pathway of Micromonospora chersina. (TBP)
6UK5: Alvarado, S.K., et al. Structure of SAM bound CalS10, an amino pentose methyltransferase from Micromonospora echinaspora involved in calicheamicin biosynthesis. (TBP)
6VR4: Leiman, P.G., et al. Virion-packaged DNA-dependent RNA polymerase of crAss-like phage phi14:2 (CASP target). (TBP)
6X6O: Shi, K., et al. (2020) Crystal structure of bacteriophage T4 Spackle as determined by native SAD phasing. Acta Crystallographica Section D 76: 899-904.
6XBD: Coudray, N., et al. Structure of MlaFEDB lipid transporter reveals an ABC exporter fold and two bound phospholipids. (TBP)
6YA2: Bahat, Y., et al. First structure of a glycoprotein from enveloped plant virus. (TBP)
6YFN: Rumnieks, J., et al. Expansion of the structural diversity of single-stranded RNA bacteriophages. (TBP)
6YJ1: Sobieraj, A., et al. (CASP target) Crystal structure of the M23 peptidase domain of Staphylococcal phage 2638A endolysin. (TBP)
7JTL: Flower, T.G., et al. (2020) Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion. Biorxiv.

Пікірлер: 1 100

  • @cyberanup07
    @cyberanup073 жыл бұрын

    Request : Please also consider making an 30-40 min version documentary of this with some more details of protein folding and nuances. I have watched AlphaGo documentary over and over again(i'm sure many others would have) , and still gives me goosebumps.

  • @maximgodzi2480

    @maximgodzi2480

    3 жыл бұрын

    Totally agree on this! Really would support both financially and with any other possible efforts and resources the documentary like that. This is a unique topic to be covered!

  • @jean-pierrecoffe6666

    @jean-pierrecoffe6666

    3 жыл бұрын

    I actually thought this was a teaser for something of this kind and was bitterly disappointed! The AlphaGo documentary is so damn good

  • @youngjin8300

    @youngjin8300

    3 жыл бұрын

    I second this. Even willing to chip in if you are going crowd-funding.

  • @nirajabcd

    @nirajabcd

    3 жыл бұрын

    Me too

  • @97kerala

    @97kerala

    3 жыл бұрын

    Seconded!!

  • @vineetgundecha7872
    @vineetgundecha78723 жыл бұрын

    I wish this was longer with all the details!

  • @1231legomaniac

    @1231legomaniac

    3 жыл бұрын

    I’m hoping they do a full documentary like they did with alpha go

  • @insomnia20422

    @insomnia20422

    3 жыл бұрын

    the paper isnt released yet, so they are prob waiting for that to happen

  • @aldwintanner1386

    @aldwintanner1386

    3 жыл бұрын

    @@1231legomaniac Same!

  • @Milanesium

    @Milanesium

    3 жыл бұрын

    I wish it had any details. It began with telling us that protein are important and never exceeded that low level of information.

  • @idkanymore6634

    @idkanymore6634

    2 жыл бұрын

    as a molecular biology major this is sick

  • @schneeekind
    @schneeekind3 жыл бұрын

    4:04 coder starts running... NOW IT'S GETTING SERIOUS 😱😱😱

  • @gregh7457

    @gregh7457

    3 жыл бұрын

    britches on fire. must find water

  • @davethepants

    @davethepants

    3 жыл бұрын

    He's gonna merge to master! After him!

  • @yomajo

    @yomajo

    3 жыл бұрын

    Bad food.

  • @sucim
    @sucim3 жыл бұрын

    "The only thing I find more amazing than the rate of progress in AI is the rate in which we get accustomed to it" - Ilya Sutskever

  • @kinngrimm

    @kinngrimm

    3 жыл бұрын

    Another aspect which to me, is worrying. If we can not see the incoming train as a threat how to avoid any dangers concerning it?

  • @lutZnrw

    @lutZnrw

    3 жыл бұрын

    not a good quote

  • @sucim

    @sucim

    3 жыл бұрын

    @@lutZnrw Not a good criticism ;) Tell us why and we can discuss it

  • @johndoesson

    @johndoesson

    3 жыл бұрын

    "the AI effect", look it up.

  • @siinxx7656

    @siinxx7656

    3 жыл бұрын

    "AI is technically an expantion of our capability to process and order information. So it would be unlikely that AI was unfamiliar to us." - Me (sorry forgot to mark the quote)

  • @neousagi
    @neousagi3 жыл бұрын

    As a protein chemist and structural biologist, I truly am impressed and congratulations to the DeepMind / Alpha Fold team. This is a major advancement and if you are taking requests, please present a solution structure for apolipoproteins. Their lipid-free state has defied analysis for over 50 years and it would be terrific to have a validated base structure to build upon.

  • @serenolopez-darwin1975

    @serenolopez-darwin1975

    2 жыл бұрын

    I don't understand the distinction between AlphaFold and Rosetta. I'm not a structural biologist but hasn't Rosetta already been doing computational protein structural prediction for years?

  • @neousagi

    @neousagi

    2 жыл бұрын

    @@serenolopez-darwin1975 Structural prediction software like Rosetta have been instrumental in identifying structural domains and conformational states that were not anticipated and led to re-evaluation of data and a more clear idea of the shapes proteins may be adopting and how they may be doing their jobs. But no insult intended to the Rosetta software team but the algorithm(s) used don't necessarily result in a model or set of models that conform to reality. Often the more likely answer is what shape a molecule can adopt, not what conformation it does adopt. What Alphafold does is increases the "accuracy" of the estimated shape tremendously, although I predict that proteins with multiple conformational states or that are highly adaptive will still be elusive targets. A good example are lipoproteins.

  • @serenolopez-darwin1975

    @serenolopez-darwin1975

    2 жыл бұрын

    @@neousagi Yes I assume that even with google's computing power, IDPs are just too intense to simulate unless MD gets really accurate really fast. Rosetta seems to work fairly well for de novo design though, if only of super-stable proteins. I know it has the issue of trending towards extreme energy favorability while natural proteins don't always, does AlphaFold predict less stable crystal structures accurately?

  • @neousagi

    @neousagi

    2 жыл бұрын

    @@serenolopez-darwin1975 To address your question, first there are three basic areas of protein structural analysis: X-ray crystallographers, computational predictive analysts, and wet lab empirical analysts. Consistently these approaches yield different results for proteins with multiple or dynamic structures. The primary reason is that x-ray crystallography identifies the ground state or unit structure that is most prevalent near ground state. Software algorithms are designed to reproduce x-ray structures (as reported here for AlphaFold) and empirical analysis generally evaluates the native fold, which is not necessarily ground state. Viral fusion proteins are another good example of molecules whose native fold is not the same as their ground state fold. So often empirical data will not match X-ray or predictive analysis and therein lies a core debate in the field. Because X-ray and predictive analysis can display a protein's structure down to atomic level resolution in beautiful ribbon structures, they present convincing impressions of how molecules might fold. So the breakthrough with AlphaFold is not so much that they solved all structures but that they have created ground state prediction that is accurate enough to match crystallographic data. To my knowledge, this does not solve the gap between X-Ray crystallography and empirical data analysis (chief amongst them are the NMR, EPR, and spectrographic scientists).

  • @serenolopez-darwin1975

    @serenolopez-darwin1975

    2 жыл бұрын

    @@neousagi Ah, I've revealed the depth of my ignorance here, I didn't realize that crystal structures are also always ground state (I'm a computational scientist specialized in genomics and so am entirely unfamiliar with the actual experimental methods of XRC). I always heard that conformation to crystal structure was the gold standard of structural prediction but didn't realize the high-stability problem extended even beyond computational analysis to XRC as well. Thanks for the clarification, maybe now I won't seem so dumb when I talk to the proteomics folks lol

  • @TimHuettner
    @TimHuettner3 жыл бұрын

    Please make the background music louder, I can still kind of hear what the people are saying.

  • @ginak1462

    @ginak1462

    3 жыл бұрын

    You would think that Google has the budget for good video editing, but I guess they spent it all on AI... :P

  • @AgingsAProblemFPS

    @AgingsAProblemFPS

    3 жыл бұрын

    Is this sarcasm?

  • @grandpaobvious

    @grandpaobvious

    3 жыл бұрын

    Maybe you have some high frequency hearing loss.

  • @joannot6706

    @joannot6706

    3 жыл бұрын

    @@AgingsAProblemFPS No sheldon, it's not.

  • @bloodaid

    @bloodaid

    3 жыл бұрын

    @@joannot6706 hey man, let the AI learn

  • @danielyum930
    @danielyum9303 жыл бұрын

    Absolutely huge... props to developers. Look forward to history in the making.

  • @theunofficialfordyfunclub1761

    @theunofficialfordyfunclub1761

    3 жыл бұрын

    Huge? That’s what she said

  • @Deez-Master
    @Deez-Master3 жыл бұрын

    I have been waiting on the next bombshell from deepmind and oooooh boy did they ever deliver!! Being on the life science field myself I can appreciate how absolutely monumental this achievement is

  • @ishtarcephei5054

    @ishtarcephei5054

    3 жыл бұрын

    Please, elaborate your answer as to possible utilization scenarios. If I may say it this way, if we have the biomedicine equivalent of a 3d printer and right materials, does this mean we can synthesize combative medicine on a need basis?

  • @bobbiebailey9067

    @bobbiebailey9067

    3 жыл бұрын

    04:01 Demis: "We need to double down and go as fast as possible from here" 04:04 Pushmeet: sprinting through the lobby, here I come bossss Jokes aside

  • @mehulgoel5875

    @mehulgoel5875

    3 жыл бұрын

    i question your being in the life science field @DeezMaster seeing what youtube channels you've subscribed to

  • @nick111138

    @nick111138

    3 жыл бұрын

    @@mehulgoel5875 Pretty idiotic comment btw. How does the selection of people he watches affect his career? The height of petty.

  • @vblaas246

    @vblaas246

    3 жыл бұрын

    @@nick111138 Agreed. Still.. his answer is so generic. On topic: would be useful for folding transmembrane proteins, that are hard to crystalize and solve the structure of by means of x-ray crystalography. If this can be used for that.

  • @10HW
    @10HW3 жыл бұрын

    you know we all want a 48min to 1h30 documentary with slow motions, drone shots and epic music

  • @tensevo

    @tensevo

    3 жыл бұрын

    No mate, I just want to know what they are talking about.

  • @10HW

    @10HW

    3 жыл бұрын

    ​@@tensevo 1- Go watch the AlphaGo documentary. 2- Educate yourself on Google's "Deepmind" department 3- Come back to watch this. You'll have a bit more context.

  • @Cabothedog14
    @Cabothedog143 жыл бұрын

    I'm 21 years old, and this is without a doubt one of the biggest scientific advancements in my lifetime

  • @thisismyalias

    @thisismyalias

    3 жыл бұрын

    It is and Im so happy to read a comment acknowledging this!

  • @NextFuckingLevel

    @NextFuckingLevel

    3 жыл бұрын

    I know right.. Yesterday GPT-3, now its AlphaFold2

  • @PulsatingShadow

    @PulsatingShadow

    3 жыл бұрын

    KEEP YOUR FOOT ON THE PEDAL

  • @hedf

    @hedf

    3 жыл бұрын

    In everyones. AI is the next big industrial revolution. First came fossil fuels, and steam engine, mass production, computing, automatization, internet, then ai

  • @aheinstein291

    @aheinstein291

    3 жыл бұрын

    @Billy Bob If you don't see any breakthrough here I highly recommend to read up on the impact of knowing protein structure and then to look into the CASP14 results of AlphaFold.

  • @LegionN7709
    @LegionN77093 жыл бұрын

    Congratulations and thank you to the DeepMind team for pushing science forward!

  • @everlearnercaveman3990
    @everlearnercaveman39903 жыл бұрын

    A paradigm shifting moment in our lifetime. Congratulations to all DeepMind team!

  • @bxlawless100
    @bxlawless1003 жыл бұрын

    I love great scientific achievements. The few people who recognize them in this world applauded your life long efforts!

  • @0Amaretto0

    @0Amaretto0

    2 жыл бұрын

    :-D That comment makes you even more stupid than the people in this movie!

  • @user-ol5bj4dm2v

    @user-ol5bj4dm2v

    2 жыл бұрын

    @@0Amaretto0 I bet you wouldn't say that to their face now, would you, coward?

  • @0Amaretto0

    @0Amaretto0

    2 жыл бұрын

    @@user-ol5bj4dm2v Hm? Why wouldnt i? Its the truth. I am known for spitting the truth.

  • @EngineeringArchiTECHure
    @EngineeringArchiTECHure3 жыл бұрын

    This video gave me goosebumps. Kudos to amazing work, documentation of the journey and music. I wish they make a full documentary like AlphaGo.

  • @Shapedef
    @Shapedef3 жыл бұрын

    Congratulations to the Deep Mind team for solving this previously unresolved problem! Fantastic work.

  • @scottwarren4998

    @scottwarren4998

    8 ай бұрын

    I wish they could try to improve alpha zero-chess so it can defeat stockfish 16-chess in a 1000 game match

  • @nathanlaird
    @nathanlaird Жыл бұрын

    Indeed, "What will be the next surprise?" is the chief motivator of life. Curiosity and discovery. Excellent work.

  • @ApexMark2002
    @ApexMark20023 жыл бұрын

    What a triumph! Congratulations to everyone involved, and humanity thanks you for your efforts.

  • @gomideadriano
    @gomideadriano3 жыл бұрын

    Congratulations! Your achievement really brought me to tears of deep joy!

  • @danielelkadi3499
    @danielelkadi34993 жыл бұрын

    Fantastic and inspiring work. There are handful of people who are genuinely changing the world for the better and I believe you guys are one of them!

  • @pacman7959
    @pacman79593 жыл бұрын

    I haven't a clue what these geeks are talking about but the music sounds like they've are solving a massive problem. Good luck geeks.

  • @furiousfajitaa2367

    @furiousfajitaa2367

    3 жыл бұрын

    Good luck pac man

  • @PascalKeys

    @PascalKeys

    3 жыл бұрын

    These are nerds, not geeks.

  • @lorenzweb
    @lorenzweb3 жыл бұрын

    Those crescendo cellos in the background hit me. Almost shed a tear. Then the Email response happend at 6:50

  • @zaidsal5438
    @zaidsal54383 жыл бұрын

    Thank you for your service guys. The world appreciates it

  • @folarinosibodu
    @folarinosibodu3 жыл бұрын

    Congrats to the team for doing really complex and difficult work.

  • @scrawnymcknucklehead
    @scrawnymcknucklehead3 жыл бұрын

    Incredible work, congratulations! Hoping for a full documentation like AlphaGo!

  • @taiebshahalizade9115
    @taiebshahalizade91153 жыл бұрын

    Deepmind: Humanity, we discovered how the proteins fold up! Humanity: 240K views .

  • @herauthon

    @herauthon

    3 жыл бұрын

    pull, vibrate...virbrate.. bend..bend.. automode..hmm..ok, it's spaghetti . .

  • @herauthon

    @herauthon

    3 жыл бұрын

    @@8joeb219 i installed foldit a few times also with the corona viral protein code but.. it was .. limited partly locked .. why?

  • @BoulderConnoisseur

    @BoulderConnoisseur

    3 жыл бұрын

    @@taiebshahalizade9115 I agree, this company has clearly worked tirelessly over the past year to establish this revolutionary software. Making it open source straight away is a bit of a kick in the nuts, let them get their due share.

  • @danielbuckland4329

    @danielbuckland4329

    3 жыл бұрын

    @@8joeb219 Yeah, Imagine pushing this to github

  • @richhobo1216

    @richhobo1216

    3 жыл бұрын

    @@8joeb219 I imagine they're still refining it and once they're satisfied with its reliability and accuracy they'll commercialize it in some way. I doubt they'll release it for free after dumping so many resources into it. And if I'm being honest, I think they would be completely justified in charging a fee

  • @GodfatherRush
    @GodfatherRush3 жыл бұрын

    I don't know why but i feel so happy for them.

  • @sinkler123
    @sinkler1233 жыл бұрын

    Congratulation ! Looking forward to a longer video/blog/talk with some more details for us non casuals. ;) Thanks !

  • @Ixions
    @Ixions3 жыл бұрын

    This is both incredibly amazing and unnerving. Deep learning has now demonstrated specialized super intelligence beyond rudimentary game theory... The box is being opened and who knows what applications will be developed/ are being developed outside of the public eye.

  • @aurealacerdacancado1512
    @aurealacerdacancado15122 жыл бұрын

    Maravilha. Estou amando poder acompanhar a pesquisa de vocês. Muito obrigada! 😀👍🏻

  • @Dendus90
    @Dendus903 жыл бұрын

    @DeepMind are you going to publish a second video to give a more detailed explanation of how the model is implemented and what kind of improvement did you implement to solve the protein fold problem?

  • @Deez-Master

    @Deez-Master

    3 жыл бұрын

    The still have yet to publish their paper on it, give them some time I guess

  • @Dendus90

    @Dendus90

    3 жыл бұрын

    @@Deez-Master, I am fully aware of that. I just wanted to emphasize that it would be great to see a proper paper review given by the authors (it would be like Einstein explaining general relativity). Obviously, I can do it by myself or wait for some KZreadrs to prepare one. Still, it would be much more interesting to see the authors describing their project emphasizing all the moments when they struggled and how they figured out the solution.

  • @asifdomo500

    @asifdomo500

    3 жыл бұрын

    @Adam Dendek kzread.info/dash/bejne/dG2ErsGYl7nefKw.html this is from Yannic Kilcher, he explains paper and many research in this area. Who explained quite in details the abstract from Alpha Fold. Fun fact one of the woman engineer u saw in the video, was an intern under him :P

  • @adityapatil325

    @adityapatil325

    3 жыл бұрын

    I think it is a graph nn based transformer

  • @thert.hon.thelordnicholson7261

    @thert.hon.thelordnicholson7261

    3 жыл бұрын

    @@asifdomo500 fun fact: "woman engineers" are called engineers

  • @Enchantaire
    @Enchantaire3 жыл бұрын

    Congratulations to everyone in the team, that's a significant milestone

  • @donovangumbo388
    @donovangumbo3883 жыл бұрын

    Congratulations. I can imagine the feeling of success after 14 years. All the best

  • @dionbridger5944
    @dionbridger59443 жыл бұрын

    Hop - Deep Learning Skip - Nanotechnology Jump - Singularity

  • @philosophyman

    @philosophyman

    3 жыл бұрын

    then we will find another problem to bound after. unless the singularity kills us.

  • @B2359

    @B2359

    3 жыл бұрын

    But all of these techniques are symbiotic : you can’t have quantum computers without jumps in nano fabrication techniques etc

  • @dionbridger5944

    @dionbridger5944

    3 жыл бұрын

    @@philosophyman Singularity doesn't mean we have no challenges left. But it does mean we can have more and better choices.

  • @shinseiki2015

    @shinseiki2015

    2 жыл бұрын

    let's goooooooooooooooooooooooooooooooooooo

  • @rangergun
    @rangergun3 жыл бұрын

    FOLDING AT HOME TEAMS HAVE LEFT CHAT

  • @default2826

    @default2826

    3 жыл бұрын

    Folding at home will work even better now, they will hopefully create an AlphaFold package that you can run on your gpu for increased accuracy and speed compared to traditional methods.

  • @Amipotsophspond

    @Amipotsophspond

    3 жыл бұрын

    they also likely help make the training data for this Ai's formula is basically (training data) + GPU = Magic.

  • @octavianc.2569

    @octavianc.2569

    3 жыл бұрын

    @@default2826 hopefully!

  • @sofia.eris.bauhaus

    @sofia.eris.bauhaus

    3 жыл бұрын

    @@default2826 that would be amazing.

  • @prescod

    @prescod

    3 жыл бұрын

    @@default2826 If the price drops sufficiently, the complexity of Folding@home may not be worth it.

  • @oscar6082
    @oscar60822 жыл бұрын

    I studied Biochemistry in 2000, and macromolecules structure was one of the hardest subjects. Glad for this breakthrough finally arrived and looking forward to seeing real-life applicaitons and industry applied technologies soon.

  • @dinoanastasopoulos8511
    @dinoanastasopoulos85112 жыл бұрын

    This is absolutely incredible, well done to everyone involved!!

  • @clarkh3314
    @clarkh33143 жыл бұрын

    You guys are so amazing and inspiring, thank you so much for the work you do for humanity. I really hope I can use AlphaFold to model different maternal transcription factors binding together on a segment of DNA for my research.

  • @basedandchristpilled
    @basedandchristpilled3 жыл бұрын

    as someone who has a deficiency which causes protein misfolding in the liver, i greatly appreciate contributions in science like this. and hope there will be more studies like this in the future to prevent diseases...unfortunately things like treatments and "cures" are really expensive but these are still incredible strides anyway!

  • @gauravbhokare
    @gauravbhokare2 жыл бұрын

    This is mind-blowing, inspiring! What a time to be alive.

  • @MikeKleinsteuber
    @MikeKleinsteuber3 жыл бұрын

    Really nicely made piece covering an extremely complex subject.

  • @TheAIEpiphany
    @TheAIEpiphany3 жыл бұрын

    04:01 Demis: "We need to double down and go as fast as possible from here" 04:04 Pushmeet: sprinting through the lobby, here I come bossss Jokes aside

  • @user-sm2fz1zh5h

    @user-sm2fz1zh5h

    3 жыл бұрын

    FOLDING AT HOME TEAMS HAVE LEFT CHAT

  • @egor.okhterov
    @egor.okhterov3 жыл бұрын

    "the DeepMind team presents its approach on 1 December"

  • @zeronothinghere9334

    @zeronothinghere9334

    3 жыл бұрын

    Where did you find this o.o

  • @egor.okhterov

    @egor.okhterov

    3 жыл бұрын

    @@zeronothinghere9334 From the nature article

  • @LKRaider

    @LKRaider

    3 жыл бұрын

    It is today where is it !!! Hype

  • @paulb1953

    @paulb1953

    3 жыл бұрын

    www.nature.com/articles/d41586-020-03348-4

  • @rushgear6614

    @rushgear6614

    3 жыл бұрын

    i think I've seen you on cf?!

  • @FalguniDasShuvo
    @FalguniDasShuvo3 жыл бұрын

    Congratulations to the team! Great work!

  • @driziiD
    @driziiD3 жыл бұрын

    it's amazing how many consistent breakthroughs deepmind is making!

  • @Artaxerxes.

    @Artaxerxes.

    3 жыл бұрын

    How exactly does Google brain fit into all of this. What do they do

  • @jishnuchatterjee6517
    @jishnuchatterjee65173 жыл бұрын

    Never has a group of people looked more like how I'd imagined they would, if I'd only been given their job descriptions.

  • @ABLuna712

    @ABLuna712

    3 жыл бұрын

    LMAO so trueee

  • @sapitron

    @sapitron

    3 жыл бұрын

    I hope they are not incels

  • @CastaneaMa

    @CastaneaMa

    3 жыл бұрын

    @@sapitron some of them might sadly be

  • @mythrin

    @mythrin

    3 жыл бұрын

    @@CastaneaMa Even if they are they shouldn't be grouped together with people like twitch mods because they're actually geniuses who are contributing much to humanity.

  • @tommyhagberg5261

    @tommyhagberg5261

    3 жыл бұрын

    So what??? You should be very grateful that such people exist...so we all can have a better life!

  • @joseortiz_io
    @joseortiz_io3 жыл бұрын

    1:03 That Marriages band shirt!🤘

  • @markoliver6189
    @markoliver61893 жыл бұрын

    It's ALL about the chart at 7:26. Amazing!

  • @peters972
    @peters9723 жыл бұрын

    Where is that other bloke we saw during the go movie that was interviewed by Lex? I’m confused about the deep mind team. Definitely all amazing! Well done guys and girls.

  • @scatteredvideos1
    @scatteredvideos13 жыл бұрын

    Based off their actual data the folding problem isn't solved yet but they are damn close. If they keep on finding tricks (like they did with epistatitic data) to better teach the ML algorithms they will have this solved within a couple years. Keep up the good work.

  • @zack_120

    @zack_120

    Жыл бұрын

    make sense

  • @squamish4244

    @squamish4244

    10 ай бұрын

    Since then, a number of other protein-folding programs have made their debut. They are all faster. AlphaFold 2.3.2 is currently the most up-to-date.

  • @santiagoespada7533
    @santiagoespada75333 жыл бұрын

    What a time to be alive!

  • @alphacore4332

    @alphacore4332

    3 жыл бұрын

    *two minute paper intensifies*

  • @onsemiro7988
    @onsemiro79883 жыл бұрын

    Awsome! Deepmind, you did a really incredible job ever! I respect you, and look forward the next steps of you!

  • @esragbilir
    @esragbilir2 жыл бұрын

    Outstanding! Excited about the future of treatments I can offer to my patients

  • @BardCanning
    @BardCanning3 жыл бұрын

    The machine of the world runs to power endeavours such as this. I hope you all know how important you are to humanity as a whole.

  • @markwilliams5654
    @markwilliams56543 жыл бұрын

    When we all work together amazing things happen

  • @luisperdigao6204
    @luisperdigao62043 жыл бұрын

    Congratulations. You solved the static problem. Now we need to find out how the proteins work and move, the dynamics.

  • @lkocevar
    @lkocevar3 жыл бұрын

    I was weeping while I heard the news. This IS a game changer!

  • @soggychip6302
    @soggychip63022 жыл бұрын

    I use AlphaFold for my biochemistry research! Amazing stuff, I used it to predict whether a mutation on a specific amino acid site would be possible on a beta-glucosidase enzyme and after weeks of work - the mutation actually expressed!

  • @darx7852

    @darx7852

    2 жыл бұрын

    Really?? How did you get access to alphafold? I want to deduce a structure, where do I submit?

  • @beholdthechris
    @beholdthechris3 жыл бұрын

    Congratulations to the whole team at DeepMind. This is an incredible achievement. If you could also create an ai to predict the interactions between different structures, that would open up even more possibilities for custom protein design.

  • @0Amaretto0

    @0Amaretto0

    2 жыл бұрын

    Archievment??? :-D IS that a joke? They made up a an idea and needed 50 years to solve their OWN IDEA!!! This couldnt be more funny stupidity... :-D

  • @aedaldaniel

    @aedaldaniel

    Жыл бұрын

    @@0Amaretto0 what have you achieved in your life little man? What knowledge did you give to humankind?

  • @aedaldaniel

    @aedaldaniel

    Жыл бұрын

    @@0Amaretto0 you know you’re being a piece of hot fuming garbage who thinks he’s a genius.

  • @0Amaretto0

    @0Amaretto0

    Жыл бұрын

    @@aedaldaniel I AM life. And i give the highest knowledge that could ever be recieved. But what has it to do with the topic?

  • @aedaldaniel

    @aedaldaniel

    Жыл бұрын

    @@0Amaretto0 that explains it your knowledge can be received and understood by worms because you produce worm knowledge. Congrats 🎉

  • @gbpferrao
    @gbpferrao2 жыл бұрын

    the level of these animations is outstanding

  • @oguzhancakar1194
    @oguzhancakar11943 жыл бұрын

    You are so inspiring. Excellent work.

  • @arian105
    @arian1053 жыл бұрын

    Congratulations to the whole team, Shoutout to Sardarji, Love and respects from India.

  • @crystalrowe800
    @crystalrowe8003 жыл бұрын

    As an aspiring Biochemist I am excited to see the final result!!!!!.... It just makes science even more exciting

  • @JJs_playground
    @JJs_playground3 жыл бұрын

    I wish this was longer. Like explaining the point of protein folding and what this means to future science and medications.

  • @zeinfahrozi7828
    @zeinfahrozi78283 жыл бұрын

    Imagine they can make 2D Waifu based on Virtual Protein.

  • @jackriver1999

    @jackriver1999

    3 жыл бұрын

    The important questions in life

  • @cromeaxe

    @cromeaxe

    3 жыл бұрын

    I need 10's of these

  • @asterlofts1565

    @asterlofts1565

    3 жыл бұрын

    Maybe in 50 or 60 years in the future.

  • @jambalaya201
    @jambalaya2013 жыл бұрын

    I swear this group of people emits intelligence. I would give everything to spend one week with them and just listen and observe.

  • @user-fhdiro6
    @user-fhdiro63 жыл бұрын

    Hats off again from a long time StarCraft fan. This time you’re saving the world!

  • @Myrslokstok
    @Myrslokstok3 жыл бұрын

    Amazing stuff, we know when Demis say we have gone AGI we are in a knew world in the making.

  • @nathanvanderriet209
    @nathanvanderriet2093 жыл бұрын

    Remember learning about protein structures in school and asking exactly if we couldn't just figure it out from the base sequence since it was deterministic. Of course my teacher told me that would never be possible due to the complexity. Glad "never" just means a few decades in the scientific fields

  • @alaeifR
    @alaeifR3 жыл бұрын

    The "next surprise" is the Paperclip Accumulator scenario.

  • @kimtaylor6149
    @kimtaylor61493 жыл бұрын

    Thanks simply amazing and thank you, all of you!

  • @stylersimon1
    @stylersimon13 жыл бұрын

    I hope y'all be joining my "How to make Simon rich af" science competition this year?

  • @stylersimon1

    @stylersimon1

    3 жыл бұрын

    @Grandfather_Din_Racket Yeah i am quite a stochsatic benchmark but that‘s where the fun starts

  • @tylerknight99

    @tylerknight99

    3 жыл бұрын

    This is actually the true story of how Google was founded

  • @rRobertSmith

    @rRobertSmith

    3 жыл бұрын

    an open source AI that is a stock traders best friend is right around the corner (within 2 years)

  • @pjacobsen1000
    @pjacobsen10003 жыл бұрын

    Towards the end of this event, the competing teams just completely folded.

  • @ClayMann

    @ClayMann

    3 жыл бұрын

    you could say they were pro team folding. I'll get my coat.

  • @pjacobsen1000

    @pjacobsen1000

    3 жыл бұрын

    @@ClayMann That kind of humor works for me. :-)

  • @thert.hon.thelordnicholson7261

    @thert.hon.thelordnicholson7261

    3 жыл бұрын

    i guess you've got to know when to hold em, and when to fold em

  • @themagic8310
    @themagic83103 жыл бұрын

    That's great work... congratulations Team AlphaFold.

  • @subhrodeepsaha9245
    @subhrodeepsaha92453 жыл бұрын

    Amazing stuff. Just starting out in the field of structural biology this year.

  • @arian105
    @arian1053 жыл бұрын

    Hyy Deep Mind.. Great going But just wanted to let you know that ur logo looks like Doordarshan 😆😍

  • @dprophecyguy
    @dprophecyguy3 жыл бұрын

    Why does it sound like Interstellar Docking Scene ?

  • @egor.okhterov

    @egor.okhterov

    3 жыл бұрын

    Because it is on that level

  • @mak5386

    @mak5386

    3 жыл бұрын

    Y do I hear boss music?

  • @iori7370

    @iori7370

    3 жыл бұрын

    7:30 peep the dudes background reminds me of the bookshelf scene from interstellar, as if someone going to give him a morse code to asi through small movements of the books from other dimensions.

  • @ConnoisseurOfExistence
    @ConnoisseurOfExistence3 жыл бұрын

    Superb! Sharing this here and there...

  • @Adeshgrg
    @Adeshgrg14 күн бұрын

    More please, a documentary like the AlphaGo one, it was amazing

  • @sebbecht
    @sebbecht3 жыл бұрын

    Awe inspiring! Thank you for working so hard for man kind. A little more fuel to finish writing my PhD...

  • @NextFuckingLevel
    @NextFuckingLevel3 жыл бұрын

    Waiting for the chinese version of CASP14, Because it would be a sign that the Chinese gov and academia are pursuing AGI too

  • @hammond1994
    @hammond19943 жыл бұрын

    Such very important and significant work.

  • @robshift
    @robshift3 жыл бұрын

    Congratulations. Absolutely amazing achievement.

  • @numspacsym
    @numspacsym3 жыл бұрын

    Great job 👏🏼👏🏼👏🏼👏🏼 and congratulations to the Deep Mind team! Could y’all please please please make a full-length documentary feature on this epic saga like you did with AlphaGo? That would be bloody awesome! People please like this comment if you agree! 🙏🏼

  • @jossebrussels
    @jossebrussels3 жыл бұрын

    Hi there, I work at the MailOnline, can we use your video in our player with a credit back to you? many thanks, Phil

  • @Google_DeepMind

    @Google_DeepMind

    3 жыл бұрын

    Hi Philip - sure, usage with credit is fine! Thanks

  • @forcanadaru
    @forcanadaru3 жыл бұрын

    Pls, nominate for the Noble Prize, this work deserves it!

  • @azmodanpc
    @azmodanpc3 жыл бұрын

    Syndicate videogame picture behind Demis back @7:10 : My man! Played that game on the Amiga for a long time. Guy's a friggin genius.

  • @Shadowbladekokotil
    @Shadowbladekokotil3 жыл бұрын

    Damn, this made me emotional and proud for our kind...

  • @subhrodeepsaha9245

    @subhrodeepsaha9245

    3 жыл бұрын

    Structural biologists, computational biologists or computer scientists?

  • @Shadowbladekokotil

    @Shadowbladekokotil

    3 жыл бұрын

    @@subhrodeepsaha9245 Humankind.

  • @subhrodeepsaha9245

    @subhrodeepsaha9245

    3 жыл бұрын

    @@Shadowbladekokotil Was so caught up in the science that I didn't realize something so obviouse 😅😅😅 How stupid of me 😂

  • @scubasteve273
    @scubasteve2733 жыл бұрын

    Please, a round of applause for the 46 people that believe coronavirus isn't real. Great work, PLEASE keep working on this😍

  • @antronx7
    @antronx7 Жыл бұрын

    The music is really well done in this video.

  • @TheComicChild
    @TheComicChild3 жыл бұрын

    The way the video is spliced together makes everything rather exciting; running around, standing in circles for group meetings, etc. In this group of seemingly very clever people, I find it remarkable to see 26-27 years of work crunched into 8 minutes.

  • @TheComicChild

    @TheComicChild

    3 жыл бұрын

    I also still have very little idea what CASP is and how AI relates to protein folding.

  • @jordan-ho7gt

    @jordan-ho7gt

    3 жыл бұрын

    @@TheComicChild by statically manipulating we can predict through patterns, how they move, why they move etc.

  • @nano7586
    @nano75863 жыл бұрын

    Making DeepMind open-source will be revolutionary for us biologists/biotechnologists.. so please do so.

  • @StevenKger

    @StevenKger

    3 жыл бұрын

    They surely dumped millions and millions of $$$, time and dedication into this. You can't expect them to just give it away for free. This is not how the world works and they should reap the fruits of their labor.

  • @nano7586

    @nano7586

    3 жыл бұрын

    @@StevenKger I'm sorry. In that case I hope that everybody profits from it as well as possible.

  • @aaronvr_
    @aaronvr_3 жыл бұрын

    I think I've discovered enough seeing you wear those crocs at home

  • @neurophilosophers994
    @neurophilosophers9943 жыл бұрын

    I once asked Deep Mind hypothetically about using their algorithms for Gene sequencing. But I forget they replied something like they couldn’t work with data they didn’t have access to and other good reasons. Had no idea they were working on this biology breakthrough... amazing

  • @joey1772
    @joey17723 жыл бұрын

    This is epic!! I'm very excited to see what becomes possible with this technology.

  • @davidchavez657
    @davidchavez6573 жыл бұрын

    Me in CptS 121 writes an algorithm to reverse a string: This

  • @MrOvergryph
    @MrOvergryph3 жыл бұрын

    The fact that this video doesn't have 7 billion views is the reason why I cry myself to sleep at night.

  • @mallikarjunpatil7816
    @mallikarjunpatil78163 жыл бұрын

    Only yesterday I was reading a book about nanotechnology and authour has stated that predicting the protein folding is major problem and then today I saw this video.Solving this problem is going to open lot of opportunities in nanotechnology.

  • @andrefalcao3015
    @andrefalcao30153 жыл бұрын

    This is huge on so many levels, that I have no words. It is a total game changer. Many people will be desperate as Kodak was when digital photography became mainstream

  • @LionheartBeatz
    @LionheartBeatz3 жыл бұрын

    And they thought it was just about chess & go :)

  • @Alexander-dt2eq

    @Alexander-dt2eq

    3 жыл бұрын

    and they have seen nothing... this is just the very start.. imagine AI solving math problems by "playing" around with formula and structure. Lets do AlphaMath

  • @lolerie

    @lolerie

    2 жыл бұрын

    @@Alexander-dt2eq you do not need an AI for this...

  • @aminromero8599
    @aminromero85993 жыл бұрын

    37 structural biologists disliked the video 😂

  • @somilsharma3249

    @somilsharma3249

    3 жыл бұрын

    🤣🤣🤣

  • @airman122469

    @airman122469

    3 жыл бұрын

    And a software engineer that also understands how useless this actually is. It sounds cool, but it’s not actually useful given there’s a ton of effects fully ignored.

  • @asterlofts1565

    @asterlofts1565

    3 жыл бұрын

    @@airman122469 Well it's just the beginning... let's wait until 2022 and 2024 to see how all this progresses.

  • @JohelSouza

    @JohelSouza

    12 күн бұрын

    And here we are at 2024 and it’s great!

Келесі