This is fascinating Dr Kruse, thank you. My father had Parkinsons in later life, he was a school teacher for most of his life, I dont know but I dont believe he was exposed to pesticides. he died before the symptoms became too severe but he was told eventually he would likely be in a wheelchair. Interestingly I have been diagnosed with ADHD. - The medication seems to help, but I am genuinely concerned about the long term effects. With that said I'm not sure I could function properly as an adult if I stopped the medication. Its a genuine concern for me that the treatment will make it more likely that I will have Parkinsons or it will hasten its effects if I'm genetically predisposed. I'm not sure what to do.

@therabbithat

Жыл бұрын

I gave up milk for a while because a huge study on over 70,000 people found it correlated with hip fractures. And that's how I learned what p-hacking is

Thank you for making this video. It turns out that Dutch Academic Professor (chairholder) Bas Bloem is certain that about 70% of the parkinsonism suffers have it caused by environmental factors such as crop protection chemicals such as the currently allowed glyphosate. However, I am interested in the following after reading your reply to someone else in the comments here. You’re stating that your clinical experience tell you that people who take adhd meds especially dexamphetamine, have had a higher probability of developing those bodily disorders (I suppose you mean with those neurodegenerative diseases e.g. parkinsonism). Why would you, with that information in mind, still prescribe dexamphetamine to ADHD clients e.g. 10mg 2x/day? You also seem to be supportive of bupropion in your other videos, would you say that that had a smaller probability of developing these neurodegenerative diseases? In such a case, I may be inclined to switch to medications with a lower probability of developing those neurodegenerative disorders, e.g. ritalin, bupropion (even though scared of the week of insomnia and tinnitus). Would you be willing to share your thoughts on this? I think even a video where you’d go through the most common adhd meds and the ones with partial workings e.g. busper and go over their likely long-time (adverse) effects would be interesting. Thanks and have a great day!

@DrJohnKruse

5 ай бұрын

Part of my answer has to do with statistics. Parkinson's is not a very common condition, affecting less than 1% of most populations. So even if you had another condition or a treatment that tripled the rate of getting Parkinson's, that would mean that 97% of those people did NOT develop Parkinson's. I work with many people who are severely disabled with ADHD, and many of them have felt that the benefit of being able to function socially and at work pretty much every day for decades is worth whatever end of life conditions they may have increased their risk of acquiring. I think informed consent is important, even if most people with ADHD may be biased to discount future negative outcomes. My impression is that buproprion probably has a lower risk, but almost no research compares the longterm effects of different medications on the same groups of patients. So the actual risks will be hard to sort out - is it the ADHD, or the stimulant (or another medication) that is really increasing the risk for a neurodegenerative condition.

I am a 62 year old woman, who has had lifelong severe inattentive ADHD (but not medicated), moderate to severe restless legs syndrome since a teenager, terrible benign muscle fasciculations, and general shakiness….. do all these things together make me “high risk” for Parkinson’s or dementia?

@DrJohnKruse

9 ай бұрын

There may be other pertinent facts about your history that I don't know, but it sounds like that your risk for Parkinson's is somewhat higher than the general population. That risk is close to 1%, so even with a substantial increase in risk, it is far more likely that you won't develop Parkinson's than that you will.

Then perhaps it could be a coincidence that my father, grandmother and uncle have Parkinson's and I have ADHD? I'm a bit scared to get Parkinson's as well.

@DrJohnKruse

2 жыл бұрын

It could be coincidence, or there might be some genetic predisposition to disruptions of dopamine systems which are showing up differently in different family members. Or the cluster of Parkinson's in the older generations of your family might have arisen from some common environmental exposure.

Hello Doctor. Thank you so much for your videos. I find them so helpful. Especially when you give the takeaway at the beginning. Such a thoughtful idea for those of us with ADHD who sometimes can’t make it through a whole video. Question 🙋🏻‍♀️ Can stimulant medication such as adderall long term cause Parkinson’s? Both my mom and I have ADHD and she got diagnosed with Parkinson’s around 78 years old. I’m very healthy at 47 and take adderall that helps my ADHD but I definitely don’t want to get Parkinson’s. What are your suggestions?

@DrJohnKruse

Жыл бұрын

For the vast majority of cases of Parkinsonism, we don't know what the causal factors are. The absolute risk for Parkinsonism is still quite low even in the studies that suggested that ADHD or stimulants may increase one's relative risk. Other than taking the lowest dose that seems effective for you, and minimizing potentially toxic chemical exposures, I don't know that we yet know how to reduce risks for Parkinson's.

@jen_counihan

Жыл бұрын

Thank you

@Truerealism747

10 ай бұрын

@@DrJohnKruse seams most have OCD who get Parkinson s I no over 12 in my life all had OCD or had it in remission when Parkinson's started nervous people get nervous conditions

I have a twitch in my lip I've been on stimulates medication for 2 years now could that be a sign of parkinsons

@therabbithat

Жыл бұрын

People with ADHD have higher rates of both tic disorders like Tourettes and subthreshold for diagnosis tics. Stimulant meds are known to accentuate existing tics, it could just be that?

@DrJohnKruse

11 ай бұрын

Somehow your question didn't pop up for me until just now, but as therabbithat points out, tics are much more strongly associated both with ADHD and with ADHD medication than Parkinsonism. A lip twitch would be a very unusual first symptom of Parkinsonism.

so very interesting..is there a difference between having tics (verbal and physical) and tardive dyskinesia? otherwise, with my frontal lobe trauma in concert with adult female adhd, i can't help but feel freaked out about getting older..also, have you ever spoke about stimulants not working ( i don't mean lack of euphoria) and what that might mean? thanks, Dr. Kruse!

@DrJohnKruse

2 жыл бұрын

Tics and tardive dyskinesia are separate and distinct movement disorders. At the most simple level, td tends to be pervasive, rhythmic, ongoing movements, while tics are spasmodic, occasional events.

Could ADHD meds help with schizophrenia? As both are caused by issues with dopamine.

@youtubeplaylist6374

11 ай бұрын

Oh you already kind of answered this when you started talking about the movement disorders.

@DrJohnKruse

11 ай бұрын

This is a big oversimplification, but for ADHD we use medications that tend to boost dopamine, whereas most of the antipsychotics are blocking dopamine. In fact, stimulants are associated with psychosis, here is my video on the topic: kzread.info/dash/bejne/nKJrmKWAeq69gco.html

LOL, "or if you want a red state example"

@heyybitchesss

2 жыл бұрын

@John Kruse Quitting my day job and doing stand up is sounding better and better everyday!

Can early signs of Parkinson's look like ADHD symptoms?

@DrJohnKruse

2 жыл бұрын

Not usually. Parkinsonism usually involves less spontaneous movement, flatter emotional expression, and the resting tremor that is part of it does not usually resemble the fidgeting or restlessness of hyperactivity.

@indyd9322

2 жыл бұрын

@@DrJohnKruse Thanks for your response!