🧠 CNS Pharmacology Course: www.medicosisperfectionalis.com/

My wife and I lost our just turned 2 year old son 7 months ago to Aml. He had MLL gene rearrangement or subtype KMT2A or 11q23. He had a translocation between chromosomes 6 and 11, t(6;11). He received cytarabine, daunorubicin, etoposide, gemtuzumab ozagamicin then mitoxNtrone and cytarabine. He relapsed after the second chemo which signified refractory Aml which had a poor prognosis. Decitabine with mylotarg was then used. He died shortly after from within 4 months of treatment. Some side effects he had were bloody nausea and diahrea. Horrible bloody mouth sores. He was in pain all over. His right eye was covered by a leukemia pool that ended up bleeding.He had a lot of liquid in his lungs which they thought was pnemonia. He ultimately died from a brain bleed within 24 hours caused we think by the chemo.

@alizaismailfunlife

Жыл бұрын

😢😢😢 may GOD u strength

Thank you so much, sir! It gives me courage to start reading my actual hematology book, which is kind of dull. I'm once again thanking you for making it easy and fun!

@MedicosisPerfectionalis

3 жыл бұрын

My pleasure 😇 Good luck to you!

📝 Download my handwritten notes: www.medicosisperfectionalis.com/

your voice is very soothing, it doesnt make m feel like i'm listening a lecture video, thank you for your work

Great info, my father in law was just diagnosed with aml and this was wonderful to find. For the record he is 84 so the age brackets you define might actually be a little looser.

I just received my pass result in NBDE part 1exam ...thank you medicosis .your channel helped me a lot in understanding the most hard subjects in pathology.

@MedicosisPerfectionalis

5 жыл бұрын

Yay 🎉🎈🎊

Never knew I would have so much fun learning patho... I bet it's my fav sub after this .... Thanks a ton

@MedicosisPerfectionalis

5 жыл бұрын

Best comment I’ve received in a while 😊😊😊

Your hematology oncology videos are perfect medicosis! Thank you. Truly, "medicosis perfectionalis, where medicine makes PERFECT sense".

@MedicosisPerfectionalis

Жыл бұрын

Thank you 😊

came here because of EMMAN NIMEDEZ ... get well soon lodi

Its a very simplified version of hematology. Thank you so much.

oh my god i cant believe i am finally able to understand these hematology and oncology topics!!! u are s uch a great teacher!!

I really loved your video! Thank you so much for teaching it in such a simplified and concise manner.

@MedicosisPerfectionalis

3 жыл бұрын

Thank you so much 😊

Now ,its very easy to understand because of simple and clear explanation. Thank you so much...!!!

Once again you hit it out of the ball park. I wish I'd found you years ago.

@MedicosisPerfectionalis

4 жыл бұрын

Thank you so much 😊

I have exam tmrw and thanks alot for helping me clear up ALL,CLL,AML,CML 👍

@MedicosisPerfectionalis

4 жыл бұрын

My pleasure 😇 Can you please help me by sharing my videos with your friends?

U r the saviour of medical students thank u so much

@MedicosisPerfectionalis

Жыл бұрын

Thank you 🙏

Great stuff brother, it was really helpful

@MedicosisPerfectionalis

5 жыл бұрын

Thank you 😊

Always very Good presentation, easy to learn and understand. Hats off to your Hard Work

@MedicosisPerfectionalis

4 жыл бұрын

Thank you so much 😊

I have no words. For last 3 months I was so damned about this Leukemia and tried several sources to understand it. This was the best ever possible video for it. Thankyou so much sir. In debt

@MedicosisPerfectionalis

5 жыл бұрын

My pleasure...I am happy to help! Thanks for your kind words...Keep it up!

@rovoB

5 жыл бұрын

@@MedicosisPerfectionalis Do you mind me asking which country are you from ?

@MedicosisPerfectionalis

5 жыл бұрын

Egypt

@rovoB

5 жыл бұрын

@@MedicosisPerfectionalis

@MedicosisPerfectionalis

5 жыл бұрын

😊

very good presentation as usual, very informative.

@MedicosisPerfectionalis

6 жыл бұрын

Appreciate it...This touches my heart...Thanks :)

7:46 a/c latest harrison mut. of FLT3 has good to moderate prognosis ,not bad

Thankyew medicosis I'm addicted to your teaching method..

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 😊

You are amazing! Really really amazing😍 thank you so much 💚

@MedicosisPerfectionalis

3 жыл бұрын

My pleasure 😇

Thank you so so much I've learnt a lot from this video especially with the question at the end of the video it really helped understand it better.

@MedicosisPerfectionalis

2 жыл бұрын

I am honored! Thank you so much!

Much easier that what's given in the book for multiple pages !

@MedicosisPerfectionalis

Жыл бұрын

Thank you 😊

earned my subscription and like! Really high quality stuff

@MedicosisPerfectionalis

Жыл бұрын

Thank you 🙏

Thank you so much!!!

Perfect explanation 💥💥💥🎊🎉🎉🎉🎊🎊🎉🎉🌃🌉💯💯💯👌👌👌👌

@MedicosisPerfectionalis

3 жыл бұрын

Thank you so much 😊

You are simply great!✌️

@MedicosisPerfectionalis

3 жыл бұрын

Thank you 🙏

Lovely explanation, thanks veryyy much ...this explantion very fantastic

@MedicosisPerfectionalis

3 жыл бұрын

Thank you so much 😊

Thank you and God bless you for your good explanation

@MedicosisPerfectionalis

Жыл бұрын

God bless you too!

Thank you soo much💙

Thank you

I understood now ❤ur skills

Thank you Very helpful

@MedicosisPerfectionalis

5 жыл бұрын

You’re very welcome, Sir!

These are great!!!

@MedicosisPerfectionalis

4 жыл бұрын

Thanks 🙏 Please help me by sharing!

Thank you for making hematology easier for me 😭😭😭

@MedicosisPerfectionalis

4 жыл бұрын

My pleasure 😇

@simi2469

3 жыл бұрын

Look who we have here 😁

I was diagnosed with AML last July. After months of arsenic trioxide chemo infusions, I'm almost done with my treatment!

@MedicosisPerfectionalis

5 жыл бұрын

And how is your health now?

@christy8693

3 жыл бұрын

update?

@MuhammadImran-ct6hb

2 ай бұрын

Are you living???

thank you you made it easier

@MedicosisPerfectionalis

2 жыл бұрын

My pleasure 😇

You are the best ,,your videos were helping me a lot in preparation to NBDE exam ..my exam is next week and I want to thank you for these amazing videos

@MedicosisPerfectionalis

5 жыл бұрын

My pleasure! I am so happy that my videos helped! When you pass your exam, please share my videos with others! Thanks!

@dr.nesreenibrahim499

5 жыл бұрын

Yes of course I already told everybody how your videos are the best :)

@MedicosisPerfectionalis

5 жыл бұрын

Thanks, dear! If you have any questions, please ask!

@dr.nesreenibrahim499

5 жыл бұрын

And I have a question about the most common leukemia in general ..? In First Aid it puts CLL as the most common one which I feel is not right ..

@MedicosisPerfectionalis

5 жыл бұрын

According to Harrison's: CLL is the most prevalent leukemia in Western countries.

Thank you thank you Dr Medicosis perfectionlis

@MedicosisPerfectionalis

2 жыл бұрын

My pleasure 😇

Hey! Thanks for your videos. I have one question that has bothered me for days and I can’t figure out… what are the pathophysiological mechanisms of splenomegaly, lymphadenopathy, etc.? Is it due to metastasis? If so, what’s the difference with myeloid sarcoma? And is lymphadenopathy a lymphoma stage of leukemia?

Thank you very much.

@MedicosisPerfectionalis

29 күн бұрын

My pleasure!

So helpful👍🏾👍🏾

Thank You , Sir

@MedicosisPerfectionalis

Жыл бұрын

My pleasure 😇

Your videos are awesome😍😍😍

@MedicosisPerfectionalis

4 жыл бұрын

Thank you so much 😊

this is really useful, thank you so much :)

@MedicosisPerfectionalis

3 жыл бұрын

My pleasure 😇

Thanku thanku thankuu.......U r great sir.....keep it up .👍👍👍👍👍👍👍

@MedicosisPerfectionalis

5 жыл бұрын

I sure will 👍👍

Thank you so muchhhhhh

Could your next video focus on Myeloid leukemia without maturation? Interesting video :)

Great video....and waiting for much more

@MedicosisPerfectionalis

5 жыл бұрын

Thanks...Sure...Can you give me examples, please?

@drimranabdullah2516

5 жыл бұрын

@@MedicosisPerfectionalis Thanks for your concern.... I am in the field of medical oncogy... and want videos related to my field.... Especially pharmacology.... Pathogenesis of different tumors... Modern recent developments in the Drug development in different tumors

@MedicosisPerfectionalis

5 жыл бұрын

Got it... Thanks

Thank u

@MedicosisPerfectionalis

5 жыл бұрын

You’re very welcome!

great thanks you👍👍

Thousands thanks ❤

@MedicosisPerfectionalis

5 ай бұрын

Thank you!

2:34 "for the 9th time" 😂😂 thank you for making me laugh when I least expect to

@MedicosisPerfectionalis

2 жыл бұрын

Haha 😂

Great videos! Short and clear. I'm not doubting you or anything but please may I know the source of your knowledge. Thank you

@MedicosisPerfectionalis

5 жыл бұрын

I use Harrison’s, Davidson’s, Goldman-Cecil and Goljan

Nice presentation

@MedicosisPerfectionalis

4 жыл бұрын

Thanks 🙏

Good bro thanku alot 100000000

@MedicosisPerfectionalis

5 жыл бұрын

My pleasure 😇

plz make a playlist on Cardiology as well.....plzzzzz.....loads of love from India.....

@MedicosisPerfectionalis

4 жыл бұрын

Thanks 🙏 Have you seen my last videos? They were about Cardiology!

@payalnayak2176

4 жыл бұрын

@@MedicosisPerfectionalis Yaa but I need videos about all the disease conditions in Cardiology....plz its a request...plz.....🙏🙏🙏🙏

The age estimate is not correct. Maybe read this article: Shallis, R. M., Wang, R., Davidoff, A., Ma, X., & Zeidan, A. M. (2019). Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges. Blood reviews, 36, 70-87. It is really good.

Great videos. I am learning a lot. Thank you very much. As a person who is in cytogenetic, I noticed some things. It's cytovenetic not cytogenic. And t(15;17), t(8;21), not t(15:17), t(8:21). It should be semicolon between different chromosome numbers. Sorry to pick those up. Thank you for great videos. I will keep studying hard!

@MedicosisPerfectionalis

4 жыл бұрын

You’re absolutely correct! Thanks a lot! Please let me know if you see any other mistakes.

Perfect👌👌TNX

Thank youuu!

@MedicosisPerfectionalis

2 жыл бұрын

My pleasure 😇

Love u doctor , love u❤️😅

I think u have to give minimum of two case sheets (like which u have given in this video) in every video . Good luck🤝👍

@MedicosisPerfectionalis

4 жыл бұрын

That’s a good idea 💡

I love the video❤

@MedicosisPerfectionalis

Жыл бұрын

Thank you 🙏

how can we tell the difference between AML and ALL with just clinical presentation and CBC?

I was diagnosed with aml at 74. I have been in remission for almost five years and most recent bloodwork was good. If the expectation is I will not live beyond five years should I be concerned?

@MA-yt4xf

2 жыл бұрын

Unless it comes back I would not be concerned. And even if it comes back there are always treatment options. Wishing you the best.

@marionvanstaalduinen8562

2 жыл бұрын

@@MA-yt4xf not for someone my age. I had to leave my province for 7 months to get the original treatment.

beautiful

@MedicosisPerfectionalis

2 жыл бұрын

Thank you 🙏

U r ammmmmmmazing .. i ve got it quickly ❤

@MedicosisPerfectionalis

4 жыл бұрын

Thanks 🙏

My sister in law diagnosed AML last Dec.4,2021 and she died Dec.5 at the age of 31😭

@warhog1337

2 жыл бұрын

very sorry to hear this. be strong for the family.

@ffardoun7544

Жыл бұрын

@@warhog1337 how and why did uo arrive very late

My father has pancytopenia with 8-9 normoblast / 100 wbc, bone marrow aspirate test indicated fair number megaloblasts and normoblastic normoblasis, does he have leaukemia ? Please answer !

❤ medicosis perfectionalis ❤

U sh'd be having billions of subscribers uptil now,

@MedicosisPerfectionalis

4 жыл бұрын

Thank you so much 😊 Can you please help me by sharing?

why does wbc count increase in labs shouldnt it be reduced due to the invasion of the myeloid neoplasm? or the labs count the blasts in blood as wbcs too?

Don't worry y'all ...we'll get through it😞

I couldn't watch the entire video... My friend has recently been diagnosed with this. Could you tell me if there is a cure?

@michaellam2622

3 жыл бұрын

feed your friend chicken nuggets

Acute lukemia means precursor cells(myeloblasts) are seen not that patients are younger. Am i wrong?

Younger patients ?? ALM most commonly affects people around 60 years old !! It’s ALL which occurs in children

Thank u so much, u came like god to me😭😩😩💕💕💕💕

@MedicosisPerfectionalis

3 жыл бұрын

My pleasure 😇

To my mkm and dad , Thank you for not believing but geez , even my fake friends bullyung me iam still fighting !! My last chemo i think in 2 week it is home chemo so .. to my ADOPTED brother thanks !!

@MedicosisPerfectionalis

3 жыл бұрын

Best of luck to you! Stay strong and don’t give up!

@majinvegeta3284

3 жыл бұрын

What were your symptoms?

Is there 19:11 or 9:11 ????? In the book there is 9:11 for intermediate.

Can somebody clear something up for me please? This is obviously leukaemia. So how can we have both pancytopenia and WBC of >100000? Or did I misunderstand the case at the end?

@MedicosisPerfectionalis

Жыл бұрын

Some patients will have low WBC, some will have normal WBC count, and many patients will have high WBC count.

Doesnt gum hypertrophy occurs in M4?

@MedicosisPerfectionalis

4 жыл бұрын

It’s possible

Is there a way to differentiate between whether a person's bone marrow stem cells are creating bad blast cells over and over and over.. vs one blast cell that didn't mature and started replicating blast cells resulting in the blood being filled with blasts?... Or is Aml definite that the person's bone marrow is no longer functioning properly and there has to be a bone marrow transplant to stop the leukemia

@MedicosisPerfectionalis

4 жыл бұрын

Your question is how to differentiate between polyclonal and monoclonal. If a diagnosis with AML is confirmed, there is an extremely high chance that this is monoclonal (one cell “blast” or one cell line started the whole process). For practical purposes, most of the time, there is no need to perform expensive tests to establish whether it’s polyclonal or monoclonal, because this is not going to affect the management/therapy. Theoretically, there are some tests to differentiate between monoclonal vs polyclonal...They use some immunohistochemichal techniques to calculate the ratio between different antibodies...If the ratio is preserved, it’s polyclonal. If the ratio is altered, it’s monoclonal. This was discussed in my video titled: “leukemia vs lymphoma introduction...Distinctions in oncology” I wish you the best of luck!

@DPH1301

4 жыл бұрын

@@MedicosisPerfectionalis Thank you very much, I'm going to watch that video right now!!

@MedicosisPerfectionalis

4 жыл бұрын

My pleasure 😇

Hi, I have a question, even if I'm awake or I don't always get enough sleep, can I have leukemia?

@MedicosisPerfectionalis

2 жыл бұрын

What does this have to do with that?

What is acute myeloid leukemia without maturation, is there a video I can watch to learn the details?

@MedicosisPerfectionalis

4 жыл бұрын

It’s the exact same disease. It basically means that the cells are immature (i.e. blasts). Same diseases, just more severe.

@DPH1301

4 жыл бұрын

@@MedicosisPerfectionalis Ok I was thinking it was it's own sub-type of aml, thank you

@MedicosisPerfectionalis

4 жыл бұрын

It’s just a specifier

@DPH1301

4 жыл бұрын

@@MedicosisPerfectionalis Can fermented food like Kimchi cause leukemia?

The patient is older in AML

7:04 Is there a video on aml inversion 3?

@MedicosisPerfectionalis

3 жыл бұрын

Unfortunately not

@DPH1301

3 жыл бұрын

@@MedicosisPerfectionalis Ok, was looking to analyze that one in detail...

But what's denovo AML??

@onignednerb1482

3 жыл бұрын

I think it’s when you’re DX stage 4 right away

15-17

Does auer rods always mean cancer?

@MedicosisPerfectionalis

4 жыл бұрын

We can’t diagnose cancer based in Auer rods alone.

30 Jan

My mom's sister just died from AML . It appeared all of a sudden in the reports and she died before she even reach a month of the treatment . What could have caused that so quick ?

@MedicosisPerfectionalis

5 жыл бұрын

I don’t know, and I am sorry about your loss.

sir plz i have a confusion ...is it affecting all the process from myeloid forming erythrocytes, monocytes,wbc....or it just affect in processs of making wbc and monocytes....or if just affect wbc and monocytes forming cell then y erythocytes count is reduced.......sir plz make me clear ....

@mbulelombali3856

5 жыл бұрын

All myeloid cell lineages are affected...

n some videos says it affects myeloid cells and cant b differenciation of it...then how it could affect rbc wbc and monocytes cells when it is nt differenciated from myeloid.

@MedicosisPerfectionalis

5 жыл бұрын

Can you reinstate your question more clearly, please?

you saved my ass dude!!! tnx

@MedicosisPerfectionalis

3 жыл бұрын

My pleasure!

A few points for those studying from this: - Not really "40-60" as described. Median age is 65, with incidence increasing with age due to accumulated haematopoietic cell damage - AML rarely presents with lymphadenopathy unlike ALL - Bone pain in AML is rare. Bone tenderness in the sternum and long bones due to leukaemic myeloblastic expansion is, however, common (tenderness =/= pain)

lol I have CML right now:(

@MedicosisPerfectionalis

4 жыл бұрын

I am so sorry to hear that! Keep fighting the good fight! CML is very treatable...Please talk to your doctor! Good luck 🍀

@ysuzumiya6324

4 жыл бұрын

Medicosis Perfectionalis thx

@MedicosisPerfectionalis

4 жыл бұрын

My pleasure 😇