Burkitt’s Lymphoma - Aggressive B-Cell Neoplasm - Non-Hodgkin’s Lymphoma - Fastest Growing Cancer!!

Burkitt’s Lymphoma - Aggressive B-Cell Neoplasm - Non-Hodgkin’s Lymphoma - Fastest Growing Cancer!!
Hematological malignancies are subdivided into leukemias, lymphomas, and multiple myeloma.
Lymphoma can be Hodgkin or Non-Hodgin's (such as Burkitt's).
Burkitt's is associated with HIV/ AIDS as well as EBV virus.
It has an African subtype (jaw mass) and an American subtype (GI symptoms)...Burkitt's is the most rapidly progressive human tumor.
To diagnose, you need a core needle biopsy or an excisional biopsy of the lymph node (Starry-Sky appearance). Immunohistochemistry for CD19 + , CD20+, CD22+
Uric acid levels can be high---Give allopurinol (Xanthine oxidase inhibitor).
Staging of cancer is important (Ann-Arbor classification).
Treatment: Combination Chemotherapy (R-CHOP) regimen.
Tumor lysis syndrome can ensue.
PET scan is helpful.
The lymph node is a bean-shaped body (not a gland) that interrupts the flow of lymph through the lymphatic vessels.
Afferent lymphatics go towards the lymph node, while efferent exits the node. The lymph node has cortex (which contains the follicle, germinal center, mantle, and margin).
Lymphocyte activation and differentiation occur in the lymph node.
Lymph is a colorless fluid that floats in the lymphatic vessels (lymphatics) of your lymphatic systems.
Formed from the interstitial fluid (extracellular fluid) and returns back to the big veins (Superior vena cava) through the thoracic duct and Right lymphatic duct.
Lymph slows down when it passes in lymph nodes.
Lacteals are a special type of lymph, they are milky because they contain chylomicrons.
Lymph node enlargement can happen in cases of lymphoma (painless lymphadenopathy) or infection (painful).
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Пікірлер: 105

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis5 жыл бұрын

    50 hematology 💉 *cases*: www.medicosisperfectionalis.com/

  • @MEADOWMUFFIN
    @MEADOWMUFFIN3 жыл бұрын

    I'm a Berkitts survivor. Being an aggressive cancer is to your advantage, because it contains fast growing cancer cells , its is achilles heel . Chemo homes in on fast growing cancer cells. I had 3 months of daily chemo treatments , radiation, and spinal injections ( that was the worst) , they not only gave me chemo treatments through the IV but they also injected chemo into the base of my spine , really painful, apparently this type of Lymphoma has a tendency to travel up the spine and into your brain. . my treatment called for to have my bone marrow extracted, had to sit for 6 or 8 hours cant remember exactly how long but it was either or, they put a steel needle in my arm and had to keep my stationary for that length of time( was not allowed to move my arm ). One of the things that really bothered me was the food , the chemo changes the way you taste things ( everything tastes bad ). I highly recommend bring your own food , this is huge . I got to the point where even if i smelled the hospital food coming it would make me heave. Had to pee into a large jar that had measurements on it to record the amount of urine I was putting out . After a while even that was starting to make me ill , its gross after awhile. I was told that there was a 50/50 chance of survival. This was in 2007 so I have no idea of the advancements since then .

  • @scotttanner8043

    @scotttanner8043

    3 жыл бұрын

    I am inspired by your journey and am undergoing a similar treatment protocol. I hope to live. I have Burkitt's Light--- not sure what that means but I just spent a week in the hospital and go back in three weeks for another 5-day stay, then home to recoup, and so on...

  • @starrysky1588

    @starrysky1588

    3 жыл бұрын

    @@scotttanner8043 You will live! I wish you complete and speedy recovery...stay strong!!!

  • @starrysky1588

    @starrysky1588

    3 жыл бұрын

    Such an inspiring journey...what bravery you have displayed! I wish you a healthy life ahead...may no sickness even come near you!

  • @javismr1

    @javismr1

    3 жыл бұрын

    @@scotttanner8043 Just about to start my second cycle of DA-REPOCH. Keep it up!

  • @javismr1

    @javismr1

    3 жыл бұрын

    Undergoing treatment right now. My spinal cord injection wasn't bad at all. Also, Im having no problem with hospital food. At this point hospital food seems the smallest of my problems.

  • @leedamato1597
    @leedamato15974 жыл бұрын

    My brother died from this cancer last June, he finally passed away on my birthday after a long and horrible battle. Ty for putting up info on youtube.. it's hard to read on this but I am thankful.

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    4 жыл бұрын

    Sorry about your loss. Thank you so much for your kindness.

  • @Obama1111

    @Obama1111

    3 жыл бұрын

    Did he find out about his cancer very late? I heard the survival rates are rly high Made me kinda scared hearing this since i got diagnosed with burkitts lymphoma 2 months ago but so far everything went well

  • @anthraxxxxxx

    @anthraxxxxxx

    Жыл бұрын

    My brother was diagnosed 10 months ago, and there are high chances that he is going to die bc chemo and radio did not respond well, probably with car-t he has one last chance. It's hard.

  • @aliceducornet9422

    @aliceducornet9422

    Жыл бұрын

    My brother died in 2001 after 10 months of treatments. In France. He was 18. So sudden, so violent. Awful.

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis2 жыл бұрын

    ♥️ Cardiac Pharmacology: www.medicosisperfectionalis.com/ 📝 Download Notes: www.medicosisperfectionalis.com/

  • @adigunmorilewa6573
    @adigunmorilewa65732 жыл бұрын

    I really really appreciate this your lecture when the doctor said my child has Burkett lymphoma I was what is this, but now leave everything for God we have started the chemo for 6wks now, my trust is in God.

  • @palusakarthik1524
    @palusakarthik15244 жыл бұрын

    Why I didn't watch your videos 1 year back. Your explanation is just 💥💥💥

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    4 жыл бұрын

    Thanks 🙏 Welcome to Medicosis

  • @shaleen25
    @shaleen254 жыл бұрын

    Absolutely well put information. These are very helpful. Thank You Medicosis Perfectionalis !

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    4 жыл бұрын

    My pleasure 😇

  • @fadeskywards1245
    @fadeskywards12455 жыл бұрын

    Once again, very informative. Thank you! 😃

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    5 жыл бұрын

    My pleasure 😇😊😊

  • @iconkahmei9399
    @iconkahmei93994 жыл бұрын

    Thank you so much. So easy to understand from ur videos, m going to watch all of ur videos and m your new subscriber🙏🙏

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    4 жыл бұрын

    Thank you so much 😊

  • @sukantadey9276
    @sukantadey92763 жыл бұрын

    Really nice and informative. Found very useful and interesting this topic in a short time interval.Thank u ,😊

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    3 жыл бұрын

    My pleasure 😇

  • @shivanipatel3975
    @shivanipatel39753 жыл бұрын

    explanation, wow,...i love watching your videos!!!!

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    3 жыл бұрын

    Thank you so much 😊

  • @priyasharma1110
    @priyasharma11104 жыл бұрын

    Love ur all lectures 😍

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    4 жыл бұрын

    Thanks 🙏

  • @nflugrad
    @nflugrad5 жыл бұрын

    I want the Mnemonic now! Lol I never quite 100% understood why its stary sky but now I will remember the pac-man looking macrophages eatting :D

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    5 жыл бұрын

    Haha! That’s so funny! I am so happy you liked the macrophage :)

  • @evans873
    @evans8732 жыл бұрын

    I beat Burkitt’s Lymphoma 1 of the worst and rare ones, Put up one hell of a fight!! 4 surgery and round after rounds of chemo!

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    2 жыл бұрын

    Good fight! I am happy for you!

  • @percussionpeople528
    @percussionpeople5283 жыл бұрын

    Watching this 3 months after one of my best friends died to this disease. :(

  • @victoriasaidi5494
    @victoriasaidi5494Ай бұрын

    Hey, why hypercalcemia yet you said there's a high phosphate level after cell destruction and the phosphate reacts with the calcium leading to hypocalcemia?

  • @berkesolak9985
    @berkesolak99852 жыл бұрын

    you are awesome

  • @wusongg
    @wusongg2 жыл бұрын

    so the calcium is high or low?

  • @WorldwideRealityVideos
    @WorldwideRealityVideos3 жыл бұрын

    My brother has it... first chemo today

  • @hq2t554

    @hq2t554

    3 жыл бұрын

    how’s he doing?

  • @hq2t554

    @hq2t554

    3 жыл бұрын

    wishing him the absolute best

  • @WorldwideRealityVideos

    @WorldwideRealityVideos

    3 жыл бұрын

    @@hq2t554 looking good!

  • @christdiedforoursins5756
    @christdiedforoursins57565 жыл бұрын

    "pathologists are romantic people: )".i have a family member with a type of cancer,i know about cancer as a unwelcome common friend,"genesis in gene",you teach well i love language so your explination of terms is very good .your videos explains well what doctors are doing next and why.and what happening in the body.if it can be fixed or not,and treatments.

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    5 жыл бұрын

    Thanks a million!

  • @noorzozo2220
    @noorzozo22205 жыл бұрын

    amazing👌👌👌 keep up my dude but I have a question at 2:19 u said there is low ca due to high uric acid but also there is hypercalcemia below it I am confused now 🤦‍♀️ is there low or high ca?

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    5 жыл бұрын

    Great question...I think it could be either one...Hypercalcemia due to the malignancy, and hypocalcemia due to the tumor lysis syndrome.

  • @noorzozo2220

    @noorzozo2220

    5 жыл бұрын

    Perfectionalis it is clear now. thx for your answer😀

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    5 жыл бұрын

    My pleasure!

  • @aliahmedqasem1502
    @aliahmedqasem15023 жыл бұрын

    Here is the intro yay

  • @dianewristen
    @dianewristen8 ай бұрын

    THANK YOU

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    8 ай бұрын

    My pleasure!

  • @jsl8461
    @jsl84614 жыл бұрын

    I know this is an aggressive lymphoma, but isn't the cure rate also quite high (like 60-90%)?

  • @hq2t554

    @hq2t554

    3 жыл бұрын

    correct! just quicker growing

  • @topshorts9864

    @topshorts9864

    3 жыл бұрын

    It is 80-90%

  • @starrysky1588
    @starrysky15883 жыл бұрын

    2:18 I have a question...you are saying that since phosphate is binding calcium, it will be low. And also you have written hypercalcemia. So I am very confused. Maybe I am missing something. Please help!!

  • @ThatsWhy-

    @ThatsWhy-

    3 жыл бұрын

    Maybe this results into hypocalcium after that

  • @emmanuelbanda1380

    @emmanuelbanda1380

    3 жыл бұрын

    He meant in a case of tumor lysis syndrome; the electrolyte imbalance would occur but mainly the hypocalcemia noted in tumor lysis syndrome is as a result of the phosphate binding to calcium leading to a reduction in free Ca++

  • @delusionboy
    @delusionboy7 ай бұрын

    the holly grail of intro

  • @martmj
    @martmj2 жыл бұрын

    My skin burns so bad

  • @rathodnehal2869
    @rathodnehal28693 жыл бұрын

    hey doctor you write , abnormal labs in NHL hypercalcemia why ??

  • @ethiooldmusic1913

    @ethiooldmusic1913

    3 жыл бұрын

    it is wrong must be hypocalcemia

  • @IsaacOnyait
    @IsaacOnyait2 жыл бұрын

    Where are you rushing bro 😂

  • @chrizstele5922
    @chrizstele59222 жыл бұрын

    I watched all these lymphoma lukemia videos,i understood them pretty well...now im confused and scared on how to just memorize all these on my fingertips and forever...someone plz suggest me...😭😭😭

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    2 жыл бұрын

    Repetition and taking your own notes are crucial.

  • @joebudi5136
    @joebudi51364 жыл бұрын

    What CAUSES this Cancer? Did it exist 300 years ago? What can be done to spit it in the future?

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    4 жыл бұрын

    300 years ago, we didn’t know that microorganisms existed.

  • @norahhakami3647
    @norahhakami36473 жыл бұрын

    At 2:47

  • @sofiaahmed3872
    @sofiaahmed38723 жыл бұрын

    Done

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    3 жыл бұрын

    Ok

  • @sowmya5675
    @sowmya5675 Жыл бұрын

    Can anyone say that is lymphoblasticlymphoma a cancer

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    Жыл бұрын

    Yes, it is!

  • @sowmya5675

    @sowmya5675

    Жыл бұрын

    @@MedicosisPerfectionalis is it curable

  • @sowmya5675

    @sowmya5675

    Жыл бұрын

    @@MedicosisPerfectionalis but some doctors were saying that it is not a cancer

  • @toot4935-2
    @toot4935-2 Жыл бұрын

    عاشت ايدك🥲😩♥🥲😂

  • @alex_theperson7064
    @alex_theperson70642 жыл бұрын

    Doesn’t this cancer double in size every 16-24 hours

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    2 жыл бұрын

    If that were true, the cancer size would be bigger than the patient in less than a month. This is not true.

  • @alex_theperson7064

    @alex_theperson7064

    2 жыл бұрын

    @@MedicosisPerfectionalis oh I heard somewhere that it did

  • @hardicbhattacharya929
    @hardicbhattacharya9292 жыл бұрын

    Came here from House M.D!

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    2 жыл бұрын

    Welcome!

  • @Idowu_Balogun
    @Idowu_Balogun3 жыл бұрын

    Study hard... 😶😶😶

  • @MedicosisPerfectionalis

    @MedicosisPerfectionalis

    3 жыл бұрын

    😊😊

  • @SherienElBehery
    @SherienElBeheryАй бұрын

    👏👍

  • @donquenick9863
    @donquenick98632 жыл бұрын

    #giveusourharvest

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