sounds like something a cancer gene would say

@ToneyCrimson

4 жыл бұрын

lfmao

I figure, well before we get drugs that make us younger, we'll get those that keep us from getting older. Then, I'll just be stuck as an old geezer for an extended period of time. I can feel myself getting grumpier just thinking about it.

@gottagofastest

4 жыл бұрын

I would gladly wait however many years old as long as I avoid dying. Fixing aging means fixing cell division though so it would have to revert aging.

@bkingk8

4 жыл бұрын

Man I am waiting for a full cyborg conversion. Think robocop lol

@JesusChristDenton_7

4 жыл бұрын

@@gottagofastest Just become angry. It's worked wonders for me.

@JesusChristDenton_7

4 жыл бұрын

@@bkingk8 I prefer something like the Deus Ex series or Cyberpunk 2077.

@Natibe_

4 жыл бұрын

Don’t worry, it won’t happen in our lifetime. There aren’t enough funds to give any to aging research without having to buy less F-35s.

As a human biologist and researcher, I think that telomerase is one of the most fascinating enzymes in nature. As already mentioned in this video, telomerase is active in stem cells (stem cells are special cells in our bodies which divide and renew, for example, our skin, gut epithelium or the components of our blood). However, throughout our lives, stem cells stop dividing due to several reasons one of which is a decreased activity of telomerase - and this is one of the hallmarks of cellular aging. However, some studies have shown that our mental state influences telomerase activity: chronic stress can lead to less active telomerase while meditation can have positive impacts (among other lifestyle choices). As a result, we can actually influence aging on a cellular level (I made a video about this some weeks ago)! Feel free to ask me anything about that topic (or stem cells since I'm conducting research in this field)! Here are some sources: Epel, Elissa S., et al. "Accelerated telomere shortening in response to life stress." Proceedings of the National Academy of Sciences 101.49 (2004): 17312-17315. López-Otín, Carlos, et al. "The hallmarks of aging." Cell 153.6 (2013): 1194-1217. Ornish, Dean, et al. "Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study." The lancet oncology 14.11 (2013): 1112-1120.

@apeiron1700

4 жыл бұрын

I only liked this comment because it sounds smart.

@CyberiusT

4 жыл бұрын

@@apeiron1700 I liked it because cites. ;)

@brymac8904

4 жыл бұрын

Life Lab Learner - humble brag about being a human who’s a biologist and a researcher. Though to be fair, kudos and good info

@brymac8904

4 жыл бұрын

Apeiron1 - I only liked it because you responded to it

@cecilasen

4 жыл бұрын

So in that case, laughing does increase life.

Wish it was possible to volunteer for these life changing experiments

@IRosamelia

4 жыл бұрын

Why are you in a hurry to risk getting cancer?

@Vienna3080

4 жыл бұрын

@@IRosamelia If improving the human race would mean my certain death then I wouldnt mind volunteer

@JesusChristDenton_7

4 жыл бұрын

Careful. Umbrella might be watching.

@Axodus

4 жыл бұрын

@Ghastly That's what I was thinking.

@Sireamonncooperda3rd

4 жыл бұрын

Ghastly telomerase is often expressed by cancer cells in order to avoid entering scenescence and then apoptosis. By extending the telomeres the DNA can hide the large deletions that cause it to become cancerous this prevents the cellular checkpoints that search for DNA damage (by length) during cellular division allowing for the cell to continuously divide and grow allowing for further mutations.

Ahhh. The telomerase being released only when the cell thinks there is a chance for dna damageThat makes even more sense. It causes a set ageing process allowing for evolution giving the organism a better long term chance. And it makes a lot of sense for how cancer occurs! In general! I mean, why would damage cause cancer that happens to usually release telomerase? Thats oddly specific, unless its a response to the cell damage from the cell.

@brymac8904

4 жыл бұрын

Don donny - very good but I also know genetics... A squared + B squared = C squared... balls in your court

@buhbbl

4 жыл бұрын

Well you are assuming that only dysfunctional telomerase causes cancer, but thats just not true. Telomeres in general are like a clock on a time bomb, it just shows how long the cell has been alive for, and hence how much dna damage it could have incurred. Making the Telomeres longer is like resetting the clock on this time bomb, the bomb will still blast at the time it was programmed to, but you won't know when because you reset the timer

@wizardtim8573

4 жыл бұрын

@@buhbbl That doesn't follow. Telomeres shorten as the cells divide, causing aging. The shorter they are, the higher the chance of cellular decay and genetic damage. If telomerase are triggered by the cellular damage, they may not be related to the cause of cancer at all. Or rather, specific genetic problems occur that feed wrong instructions to the telomerase which causes them to basically immortalize the cancer cells. Either way, it seems the telomerase have one job, but sometimes do that job all too well.

@allhumansarejusthuman.5776

4 жыл бұрын

@@brymac8904 sounds like you can build a pyramid

@allhumansarejusthuman.5776

4 жыл бұрын

@@buhbbl First point of confusion, Telemerase is the enzyme that adds to the telmorones. All human cells produce telemerase when humans are growing. Second what this study has found it that the role of Telmorase is quite oppisite of what we thought. We thought it was a needed evil adding length to the telmorones during childhood growth, and adding cancer risk. But it is now known that adding length to telmorones can help prevent DNA damage! This is a huge development for both me and you, since like you, my last knowladge on telmorones comes from 1999, as studies questioning the nature of telmorones started in 2000.

Thought it would be cool to mention that in 1951 a woman named Henrietta Lacks was diagnosed with terminal cervical cancer. John Hopkins University were able to culture her cells and not only keep them alive but grow them infinitely due to the immortal behaviour of cancer cell lines discussed in this video. Her cells are still grown 60 close to 70 years later and are used in a number of cancer research experiments. Amazing how much contribution these cells have made to medical research!

this is extremely interesting but this would mean there are definitely more reasearch to be done

I am curious how long they can store the waves, and how stable it is, as well as how stable it could be. Then it might be able to work as a wave-battery.

@Zippyser

4 жыл бұрын

My first thoughts

I really like this channel. So full of great information and the presenters are so very good. One criticism -- There is no pause between sentences, and between important points. No time to digest them, with the pauses that naturally occur in conversations and talks. It makes for a very intense presentation. But it's hard to really learn, to really take in all this detailed info when there's no pauses.

I noticed a bunch of people in the comments complaining about Stefan's correct pronunciation of telomere and telomerase; the telo- prefix isn't pronounced the same in both words.

I'm interested. This is going to be a neat watch

Good information, hope future tell us more about it

What if this might be a way to help with space-caused cellular degradation?

@dejayrezme8617

4 жыл бұрын

I've thought this too. Anti-cancer meds would basically make us immune or resistant to radiation.

@dantoxism8538

4 жыл бұрын

@@dejayrezme8617 Immune?-no, with a sufficient enough level nothing can stop the ionization of your cells. Resistant?-possibly, that would be hella cool! Imagine walking on mars with just a protective coat and goggles, not having to worry about the radiation melting your lifespan away. (mask too of course, you don't want to be breathing in that Martian sand)

Everyone: Wow, amazing advances in cancer and aging research! Me: vibranium exists

Captive Wave Technology? PUNCH BATTERIES!? KINETIC STORAGE!? POWER GLOVES!

awesome episode today :D

3:53 This sounds like what was used on Discworld in _Soul Music._

I'm curious how this wave storing actually functions. It's not a wave anymore, it's not heat, and it's not reflected? So in what form is it stored?

@kantalot3797

4 жыл бұрын

Maaagic

my first thought when hearing about the sound capture was 'dupstep gun'

Isn't this old knowledge? It's been known for a long time that telomerase has slow aging effects. I learned about the 3 years back already?

@CuriousMike16

4 жыл бұрын

I thought this was why cancer was being studied more, to control that, than just being killed off the whole time

Friendly Cancer Gene was my favorite 90’s folk singer

Wait, so are you telling me the wave capture kept 100% of the energy? Since it didn't dissipate into heat? If so then that would have an enormous variety of uses... :O

I wonder if the "captive wave" tech could be used in the medical field. I work in ultrasound and im curious if you could somehow sent a resonant wave through a person to create an image.

I am astonished that no one has yet mentioned a Black Panther suit. Of course, I didn't go through all 300 comments, but I didn't see it, and think this could potentially be the real world basis for such awesome comic tech!

nice, they figured out how to make a kinetic battery (Capacitor), wonder how long it will take them to figure out swing theory.

3:19 Also Raymond Rife "Rife Ray" developed this Tec and methodology long ago.

As someone who has a background in biomedical engineering with the intent of one day doing cancer genetic research (before I ended up switching into computer science...), this is super interesting research! Given the "bursts" of telomerase expression during genetic damage, I'm guessing that the process is something like this: cells divide, telomeres get shorter. Eventually, the telomeres are gone and the next mitosis cuts into actual genes. This, in turn, doesn't cause apoptosis (cell death) immediately like we tend to assume; instead, it causes an upregulation of telomerase to put some of those telomeres back. This protects the DNA for more divisions, until the cycle starts over. Every go-around cuts a little more into the genes, finally leading to apoptosis, but much later than it would otherwise without this "telomerase boost". So if we could somehow trigger these telomerase boosts in cells that haven't been damaged yet, but have "overly short" telomeres left, that could drastically slow the aging process; and as long as we only do it with short telomeres rather than all the time, it shouldn't be much of a cancer risk. OOOOHHHHH, science ideas. Sometimes I wish I'd stayed on the biomed track...

@Axodus

4 жыл бұрын

that'd be great, I'm totally not thinking from a selfish perspective.

That wave mechanism can be used for a short stage battery or energy convert. The possibilities are endless!

How does the space ship work, Scotty? Well, we capture incoming gravity waves and then we re-create those waves and ride the waves by warping space time. "Faster than light," but we don't have to do that much to make them as nature keeps sending them. Fascinating.

Hey I love this channel thanks everyone

The Wave capture technology is interesting because it's theory-to-application development, but the minute control required is more energy intensive than letting the wave dissipate. As it stands, converting waves into electricity and storing the electricity is the better way to go about doing things like that.

Telomere: long "e" tee-low-mear Telomerase: -- same, long "e" -- tee-low-mer-ace not tell-om-er-ace The general rule in English is that the vowel is long unless the following consonant is doubled, then the vowel is shortened.

many studies have demonstrated that mouse senescence is governed quite differently than human senescence. it is important to note that this paper does not show expression of human telomerase protein (hTERT) or telomerase activity in the human primary fibroblasts that they use. the authors demonstrate mRNA levels of hTERT by RT-PCR only. I do not think that the dogma of telomerase expression in human somatic cells can really be challenged by this paper, and while the authors' findings are indeed very interesting, this article should be considered with some caution in regards to its implications in human cellular aging.

Everything is fun and games until you suffer a resonance cascade. Remember to stay free, man!

@horacegentleman3296

4 жыл бұрын

Do you smell ashes?

That's interesting!

Couple of questions you could answer: Why do dogs never appear to get common colds? Why does metal get very hot when you bend it really quickly? (Try it guys, grab an old spoon and bend it back and forth and then touch the centre of the bend)

Maybe we could potentially use this sound energy capture for a new power source.

So basically what you’re telling me is that I could become the Shocker in the future

Nobody has as much fun slangin merch than this guy

So this video had an ad for a tablet can anyone link me? Can't find it again

am I the only here that thought "Black Panther Suite" when he mentioned wave capture tech

Captured, stored energy from vibrations. Hmmm... Doesn’t the earth emit low vibrational waves around 8hz? That would be like free energy, if captured. A lot more than needed to wirelessly charge a few cell phones. You guys may be on to something, and you mention it not connected to the title, at all. Seems odd.

Zarya's bubbles also works as captive wave technology in overwatch game :-)

So interesting

Looks like the first component of shock rifle has been invented. Needs a lot of improvement, together with the invention of other components, but hey. Maybe we will have actually cool weapons (aside of minigun, of course), with one of them capable to put force of 200 t moving about 100 m/s in area ranging from 1 mm^2 to 1 m^2.

I love SciShow but I must admit I'm a little confused now. Here they talk about a new study telling us that telomerase is used by healthy cells to slow down aging and not only stem cells and cancer cells as previously thought. Well, in my own biology studies I was taught exactly that in 2013 by my molecular biology teacher. Was he from the future?

Distracted by that truck backing up

Listened to this and found out that all these years, I've supported myself as a guitar plucker. Sounds kind of plucked up to me!

Can't find the links for the pins.

Where did I hear this before?

So could this sound wave capturing be used for sound dampening in studios?

Didn't Tesla have an earthquake device concept just like that captive wave deal?

It probably means that there's an ideal amount of telomerase to allow apoptois to happen before the telomeres are fully decayed and active genes start to get damaged

Okay, official "pronunciation of telomere" research: In American English it's typically pronounced "teh-lə-meer", while British english prefers "tee-lə-meer". A far less common variation is "til-ə-meer", though this one is still valid. In the original Greek form τέλος (telos), the e is much higher, sounding like the Canadianism "eh". Considering the original Greek, a person could be a hipster about it and pronounce it "tay-lə-mare", which is obviously the preferable way to do it on the internet.

3:11 so like when T'Chaka kicked his suit? 🐱

I've always said that cancer holds the secret to extending our lives, and maybe even immortality. The closer we get to understanding cancer, the closer we get to drastically extending life expectancy.

how much energy could be stored maximaly?

Wat, I thought this was already well known, lobsters and such have lots of telomerase and stuff I thought? That's how they manage to live forever (in terms of age, being eaten is still kills). Then again what do I know I only read the wikipedia page on it years ago.

It looks like we're heading towards storing wind!

I must say I was surprised that telomerase was seen as something that could be unhealthy and create cancer. My view understanding the function of telomerase would have the opposite effect. Of course I do not know if really helps in high dosage. Just that it seem important function to keep you healthy. But I do know that some senescence research are interesting in using it for anti-ageing. It will likely not cure ageing but could possibly help people live longer more healthy lives. (And is not pretty much all curative medical science really about extending lifespans in the long run?)

WTF!! I was just leaving that exact moment O.o

Have the telomerase activate before devision.

I recall it being mentioned when I watched From The New World. Of course, It is a fictitious story so who knows if we could actually live that long.

This seems so complex! How do doctors and scientists keep it all straight?

@ricefloppa2800

4 жыл бұрын

Documentation. Maybe...

@Zippyser

4 жыл бұрын

The same way anyone keeps their job straight, they don't remember absolutely everything they keep notes. They practice it every day so it's always in their heads.

@ricefloppa2800

4 жыл бұрын

@@Zippyser Yea.

can u post ur intro somewhere so we can DL n listen to it?

The journal PNAS. Best..name..ever!

What other way can a cell become immortal (without telomerase)? Did the researchers put forth a possible explanation for this backwards sounding concept?

So captive wave technology means we can finally build those weird spinning force sticks from Minority Report?

RIP the poor fools who had Telomere-lengthening treatments. Higher cancer rates and stronger aging effects could ruin their plans of eternal life.

@jerotoro2021

4 жыл бұрын

Not if you could end up as an undying, walking mass of tumors. Has anyone made a zombie variation like this yet?

@CookieCutVids

4 жыл бұрын

@@jerotoro2021 deadpool lol and alex Mercer in prototype the game

Wait, is that how telomerase is pronounced?

@lordgarion514

4 жыл бұрын

mkatseal Yes. Telomerase is pronounced with the long "E" sound, but telomeres is correctly pronounced with either the long or short "E" sound.

I look at this new wave technology and I think of the Weirding Modules in Dune.

Captive wave tech seems like sci fi 😄

Or captive wave technology could be used to cause catastrophic earthquakes. Instead of germ warfare, it'd be wave warfare.

And thus the inertia dampeners of Star Trek were invented.

"Pseudo-Immortality" is not something I ever expected to hear.

@Axodus

4 жыл бұрын

gimme gimme, I'll gladly live an extra 100 years even if I eventually get cancer around the end.

@spindash64

4 жыл бұрын

Aging is just passive damage build up over time. True immortality would require infinitely effective regeneration, pseudo only needs to be able to counter aging

It almost seems like someone with the right kind of cancer could be immortalized if the body didn't react and the cancer only wanted to join with us endlessly and help sustain our form. Thus only dying disease or physical loss of homeostasis

Real life dubstep gun

A Telomere acts like a paladin of some sort, i guess. Redirecting some or all of the damage to itself through its own means.

Or can be used to charge weapons and power space ships. The possibilities are endless

Maybe we can use this to eventually "cure" the aging process. It will be a game changer and have huge implications on society and the environment, but if we approach it wisely we as a species Dave advance greatly

Telomere and telomerase. I say both with “teh” sound. I guess this is different across regions. People who say “tee”lomere, do you also say “mee”thane? Or “meh”thane?

New jackhammer anyone? This can lead to some very scary products, like rail guns.

Isn't the reason for cells turning cancerous because it's genetic material is too different from its surrounding, normal, human cells? So an enzyme that increases the length of the DNA protecting cap reducing cancer rates is expected since that would mean less genetic deterioration for the cell.

Who ever named Telomerase was a jerk. 'Hmm what should be call this... Lets just mess with everyone and make it sound like Telomeres. Hee hee.'

“And speaking of ways to get things to stick around for an unusually long time...” I’m embarrassed to admit how long it took me to realize that _wasn’t_ a setup for a dirty joke.

Sounds like they just invented Vibranium.

A few years to immortality.

@gottagofastest

4 жыл бұрын

A few years after I die of aging I bet

@myeyesaredrymylove

4 жыл бұрын

@@gottagofastest Don't be pessimistic about it. What if it happens the next decade?

@gottagofastest

4 жыл бұрын

@@myeyesaredrymylove People have said that about lots of things, the future is coming but takes a lot longer than we like to think. People in the past would be certain we'd have a moon base by now.

@myeyesaredrymylove

4 жыл бұрын

@@gottagofastest Think positive, friend. No one can accurately predict that but we can hope for a better future.

@chesterplemany

4 жыл бұрын

@@myeyesaredrymylove There's optimistic, and then there's delusional.

interesting

"monitor bridge safety" meh "make better speakers" YES

Why can't they use this technology to produce energy from bridges?

@Axodus

4 жыл бұрын

good idea

@jkg6211

4 жыл бұрын

@Herbal Shaman You didn't watch the whole video, did you? Start at 2:43 ... try to keep up with the topic when you jump into a conversation. lol

So the begining of creating Deadpool has started.

Meh. Even if a treatment for ageing was discovered, I highly doubt it would ever be available to the general public. But hey, who knows...

@Axodus

4 жыл бұрын

If it happens procreation would need to be outlawed for those who take the treatment.

@spindash64

4 жыл бұрын

Axodus Not really. Life spans go up, birth rates go down. It’s a well established pattern

@Axodus

4 жыл бұрын

@@spindash64 I've seen the studies.

I thought he said tamales lol

So maybe it’s not such a dumb idea to use telomerase to artificially combat senescence... I was thinking about this very idea just a few minutes before I saw the video.

i like it

Funny how i said something about this just the other day then *plop* this video came

Captive wave tech You guys stole wakanda tech?

@VioletEnds

4 жыл бұрын

I've been looking for this comment. I was like, "Surely I'm not the only one that noticed that this seems to fit the exact behavior of Vibranium?" Seriously though, a material that stores mechanical energy indefinitely as if was fully absorbed, and then can release it on command later? It's like an exact description of Vibranium.

Just so you're aware, there's something seriously wrong with the captions in this video, making them nearly unusable.

Am I the only one looking at the captured waves and thinking of Black Panther's suit?

By the time im 30 or 40 we will get the key to immortality... or at least expand our life time a heck of a lot more... cool... great time to be alive amiright?

@gottagofastest

4 жыл бұрын

People in the 80s thought that too

@dinkledankle

4 жыл бұрын

@@gottagofastest Everything is inevitable.

@gottagofastest

4 жыл бұрын

@@dinkledankle Yeah but it happening in 2200 isn't much help

@dantoxism8538

4 жыл бұрын

I'VE GIVEN UP MY HUMANITY JOJO, NOW I'M IMMORTAL