In this episode, we discuss: 0:00:34 - Colleen’s background and current focus 0:03:08 - The basics of the microbiome 0:12:37 - The study of the human microbiome 0:17:42 - Categories of bacteria, and the implications on health of the rapid evolution of bacteria 0:27:51 - Methods for measuring and understanding the microbiome, and key indicators of microbiome health 0:39:52 - The important role of fiber for promoting gut health through the production of butyrate 0:47:21 - The case for manipulating gut bacteria via fecal microbiota transplant (FMT) 0:53:25 - Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome's diversity and function 0:59:16 - Factors that influence the vaginal microbiome 1:03:46 - The effect of gut microbes on obesity and challenges with fecal transplants in people 1:06:25 - Beneficial strains of gut bacteria and strains commonly found in probiotics 1:16:35 - The difference between a probiotic and prebiotic, and how CFUs are a measure of the “active ingredient” 1:21:47 - Considerations about how probiotic strains are produced, and more on the meaning of CFU 1:31:12 - Mitigating the effect of antibiotics on the microbiome 1:39:58 - What do we know about the effect of artificial sweeteners on the gut microbiome? 1:47:02 - Why Akkermansia is a keystone strain with implications for metabolic health and an individual’s response to dietary interventions 1:58:14 - The essential steps necessary to develop a robust probiotic for optimal health support 2:01:45 - How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more 2:22:46 - Pendulum Therapeutics’ commitment to rigorous product develop 2:29:54 - Details about the probiotic “Glucose Control” and other probiotics developed by Pendulum Therapeutics 2:38:43 - Further studies of Akkermansia that have been proposed or are underway

@SPIGON1000

5 ай бұрын

Por favor:Activen la transcripcion del video para poder descargar en escrito lo tratado en el video. Gracias ¡¡¡¡

@dancevids23

5 ай бұрын

How was your A1c after as a nondiabetic using glucose control?

@esgee3829

5 ай бұрын

14:25 phages in animal mucus protect against bacterial infection; hsv1 primes nk cells to recognize cancer cells, etc. so, i would say, yes, there are "good viruses" or viruses that do benefit animals and humans.

@Renatus_Eruditus

4 ай бұрын

​@@esgee3829sensing TWiV vibes here

@fBrunPeressin

Ай бұрын

thank you Peter!

It really surprises me how many people choose to complain while given free information.

@sharonphillips3700

5 ай бұрын

Right. And if someone is working for free and giving free advice, they have the right to share their products that would help people with the problems that those listening probably have!

@dawnhabeck6364

5 ай бұрын

I second that!!!! We are or are not receiving consolidated information from the world's finest and I choose to receive it and be quite grateful!!!

@MarshalGerman-sc6bc

2 ай бұрын

My theory is some people are professional complainers (complainitis) and are deficient in the mifrobiome that flips their switch to reduce or stop their chronic complainitis 😉

@Lise-ss8qw

Ай бұрын

Exackly ​@@dawnhabeck6364

@joevs-tb5iw

15 күн бұрын

The modern world is insane.

"E. coli" = the species "Escherichia coli", written with the genus name "Escherichia" abbreviated (to E.). Therefore "E. coli" is not a strain (serotype) name, but the species name (the majority of which are not pathogenic). The strains are classified into serogroups & serotypes by antigens (O (somatic) , H (flagellar), K (capsular), F (fimbrial)), eg E. coli strain O104:H4.

Ok Colleen is one of the clearest most precise most engaging biomedical science people I’ve ever heard. And the Hyena story at around 22:00 is a great story but serious Peter doesn’t even crack a smile 😂

@niranjanpaul2176

5 ай бұрын

Ha ha 😀 he's actually a nice stern guy

@anthonycho6344

5 ай бұрын

He probably found it funny but didn’t want to get sidetracked because he didn’t want to keep her for four hours.

@robertoisripped7455

5 ай бұрын

He said cool story bro ; next topic.

@Alphacentauri819

4 ай бұрын

@@robertoisripped7455not even close…if you are even at all aware of microbiome studies, enzymatic processes, epigenetics and more…you’d see the value in the story. Also, in regards to a “cool story bro”…Peter had that moment telling about his high school biology…the moment she basically was saying “what’s your point”…so, introspection and metacognition might be a good route for you to take

@Nona-jn3fg

Ай бұрын

I liked the story and I wondered if the hyena introduced a new microbiome to the subject and I wonder how he is now.

Peter is among top lists pod on health along with Huberman. I like his structured questions. Keep it up, sir. Thank you

Cancer survivor here (CDH1 mutation) and I recently started focusing on a diet high in butyrates. My ulcerative colitis flares have dramatically gone down in frequency and severity. I swear it has improved the quality of my life!

@MYOB2023

5 ай бұрын

@@Annzy99 I had ovarian and then lobular breast with a double mastectomy and lymph dissection last year. Did they rule out a genetic mutation for you? Supplements I take: garlic, cinnamon, tumeric, selenium, multi, ashweganda, artichoke, B and D, melatonin and CBD. I eat almonds, Greek yogurt, peanut butter, spinach, chickpeas and cheddar cheese for gut health! For the butyrate you have butter, peanut butter and whole wheat bread! Good luck and hope you see a difference in your gut! Edited to add that I also take a mushroom complex tablet!

@dinomiles7999

5 ай бұрын

Pro biotic, pre biotic s , digestive enzymes.

@Alphacentauri819

4 ай бұрын

Butyrate is absolutely so important…so happy it’s helping you!

@MYOB2023

4 ай бұрын

​@@Alphacentauri819 Between that and supplements added to my diet... Noticable difference! Highly recommend to anyone facing risk of recurrence!

@Anthonyinkz

4 ай бұрын

You mean butter?

This was awesome! I learned so much! Colleen was easy to listen to, she spoke clearly and intellectually. I especially loved learning how she built her company, the ups and downs one must go through for any kind of success. I wish her total success and I am going to her website right after this!

I listen everything that I can find about the gut health lately, I’m a lean person and people think that I’m so happy with myself but I struggle with overeating and bloating, basically with huge metabolism problems. I’m so shocked that we start learning things and researching actually only recently ! This shows us how undeveloped we are as society omg !

Inspiring! I struggled with gut issues for many years have been a fan of the BioGaia and Biotiquest products (with their history of research), and this Pendulum story is next level! It's incredibly exciting that the Microbiome is getting the mainstream attention it deserves.

@MoniqueElwell

5 ай бұрын

Hello!! I know Martha (biotquest) and her products really are top notch. Colleen validated a lot of what Martha taught me.

Loved, loved, loved the episode! Thanks for the collaboration!

The books, “Herbal Antivirals,”, and “Herbal Antibiotics“ , by Stephen Buhner, gave me a great understanding of how bacteria lives, and recreates itself according to its environment. Everyone should read it.

@MoniqueElwell

5 ай бұрын

Thank you! I will.

I improved my health in general since i started eating whole food. If I crave for sugar I eat fruits with respect to the variety.

Excellent information. Very well illuminated by colleen. Also like that she knows what she doesn't know and is confident in sharing what she does know

really, unbelievable information. a 4 year degree in 3 hours about gut health. 😉😉

@anthonycho6344

5 ай бұрын

I feel absolutely the same way. I freaking hated Bio AP in grade 12 because of bacteria. Now that hatred is transformed into obsession because of her. Now I’m going to raid Costco for some copious amount of fibre and eat like a cow.

Fantastic Pod!!! Wow.!!! So much to take in. Love Pendulum’s integrity and rigor.

@carolhemingway2793

5 ай бұрын

Remember, As Colleen herself reveals at the end of the podcast, and very briefly, with no discussion, that for80-85% of the participants, her product Did Not Colonize!!! Which means you have to always buy and consume her product to get any benefit

@fpypnts

3 ай бұрын

I think it’s also important to think about a further scientific question which would be: how long would you have to take it to colonize X amount of people. And like Peter suggested, what kind of diet/fiber intake might promote colonization

55:23 That is just f ing mindblowing...wow!....I dont think people is paying that much attention to that point. It really can be a turning point about everything we think we know regarding behaviour and human psychology...

@karthikesh37

4 ай бұрын

Indeed. This is what got me obsessed with the gut science. I'm more excited to hear about what the future research has got to say about this.

I have my doubts about the claims about the microbiome. Here's why: I went on the Australian CSIRO microbiome diet for 350 days (2016) in the hope it would help with autoimmune response. Had my gut microbiome (faeces) tested by the American Gut Project at the beginning and then at the end. There was almost no discernible difference in gut bacteria between start of diet and end of diet. I was eating "high prebiotic foods" containing fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS), and trans-galacto-oligosaccharides (TOS) such yogurt, kefir, kombucha, sauerkraut, pickles, miso, tempeh, houmous, kimchi and some cheeses. Very little change to gut bacteria but huge change to autoimmune response in that it got worse. Had my first full blown lupus attack since diagnosis 8 years before on this diet.

@joojoobss

Ай бұрын

Oh wow that's so interesting to hear. I'm also curious where you procured and how you ate these items as I think that makes a difference. Meaning, example most of the yogurt and sauerkraut purchased from big grocery stores are pasteurized. Or even heating kimchi up past 120 degrees kills most of the probiotics. But regardless it is still very interesting to hear all these food didn't make a difference for you 😢 bc I also have autoimmune issues

@mariemonn8912

Ай бұрын

Where did you get the fermented food? Research shows the stuff on the shelves don’t have what they say. .. no good bacteria on the food or in the probiotic…

@lmyers9999

29 күн бұрын

Vit D controls the immune system… some of the microbiome won’t change under a Vit D deficiency and most respond with just optimal Vit D of 80ng- 100ng and your immune system will settle down and be selective again

@lmyers9999

29 күн бұрын

You would need to also normalize B vitamins which will happen with optimal Vit D if you seed in with a b 50 complex - Vit d can be raised quickly with huge doses- no problem

I am definitely your number one fan!!! Listen to all “The Drive” podcasts all the time!!! Thank you Peter for doing all this with your brilliant guests too!!!

I was considering trying a probiotic called Seed but I could never get past the subscription part. You couldn't just get a one time purchase to try it. Her company Pendulum has that offered. I think I'm going to give it a try.

@whiskerske3218

5 ай бұрын

I tried Seed but it upset my stomach , made me very nauseous, so much I stopped.

@carolhemingway2793

5 ай бұрын

Remember, asColleen herself reveals, in the last few minutes, and very briefly with no discussion of the important fact, that for 80-85% of the participants, her product Did Not Colonize--which means that you have to take it consistently to get benefit--stop buying/taking it and the benefit soon leaves the room.

@prunepoo

5 ай бұрын

I’m 3 months on. Seed is good stuff.

@RLeeErmy

5 ай бұрын

@prunepoo I believe it. I just wasn't ready to commit to a subscription. Just got my first bottle of Akermansia. I feel like maybe I will lean into the idea that this stuff is great but its not going to provide the microbiome diversity that I am looking for. If that happens, I feel like Seed is probably one of the only ones I can trust.

Well, when I was a teenager, I ate pretty much only carbs when left to myself, which was mostly and I can say that since I was 15 years old, I’ve always been embarrassed by my big stomach until six years ago when I started low-carb and reversed my diabetes.

@lmyers9999

29 күн бұрын

And with no millions of dollars lol

@lmyers9999

29 күн бұрын

Congrats!!

What a fascinating episode and startup story. Thank you so much for doing this one!

I was fortunate to have ppl around me that ate a diverse variety of fruits vegetables and herbs. I value eating this way. This episode has highlighted many reasons to stay focused on my diet as well as medication effectiveness, stress, travel stress etc… knowledge is powerful and transformational. Thank u 🙏🏼💜✨

Eating polyphenol rich foods (colourful fruits & veggies, cocoa etc|), will help cultivate akkermansia, and also, provide lots of other beneficial health synergies. Will be buying the pendulum product once it is available in the UK.

@carolhemingway2793

5 ай бұрын

Remember, Colleen herself says, in the last few minutes, and very briefly, that for 80-85% of participants her product Did Not Colonize!!! Thus means you have to continue taking is as long as you hope to get any benefit.

@inthevortex-de1rh

4 ай бұрын

​Better change your bad eating habits and you can reverse type 2 diabetes 😮

I really enjoyed and loved this episode . Never miss an episode thank you Peter ❤

Fascinating podcast regarding the human microbiome! Now I have to narrow down which probiotic is the correct one for me to order. I am convinced that their company is legitimate based on her persona, educational background and honesty.

@incaseofamnesia6380

5 ай бұрын

Just make your kefir and sauerkraut. Boom, actually affordable and alive probiotics.

@paulevans2246

5 ай бұрын

What’s the easiest way to make it? Each time I look I ended up thinking it looks too difficult 🤔

@Vscustomprinting

5 ай бұрын

This is definitely a scam account. No one should be buy probiotics. At best you have a highly skilled gastroenterologists who can help in certain cases, but those instances are fairly rare.

@CarnivoreDMD

5 ай бұрын

Agree, and IF you are convinced, buy fresh refrigerated in dark glass ($50+)....but a reset diet would be easier @@Vscustomprinting

@carrievanderhoff

5 ай бұрын

@@Vscustomprinting Wow! I give my honest conclusion and you accuse me of having a scam account! You are completely clueless.

Merci Ashok d'être là pour nous🙏💜

Great episode and big fan of the podcast. Would have loved to hear more about evidence re: whether a probiotic will have a clinically meaningful impact on someone who is healthy, has a low A1C/blood glucose, consumes a healthy diet with plenty of fiber, and consumes probiotic-rich foods (e.g., yogurt, pickled vegetables, etc.)

Does gut biome sharing due to proximity explain why family members often present together as obese?

Thank you, I also really appreciate you asking about their supplement's falloff.

What a great discussion. Thank you for sharing all of this information.

As a survivor of a widowmaker heart attack I would be interested in the microbiome's role in cardiovascular and heart health. A recent published study found that Oscillibacter consumed cholesterol in the gut but didn't make any claims on its long-term impact on keeping the arteries clean or overall health outcomes. Dietary changes for people with heart attack risk already essentially point to a high fiber diet, so I wonder if part of what is going on is improving the gut health to in turn improve heart health? It would be better to manage gut health for heart health if possible than have to soley rely on the buffet of prescription pills you get when you have a ticking time bomb in your chest. Maybe it could act as another layer of protection as opposed to a replacement therapy? Interesting guest. I appreciate the information. TY

Super interesting, thanks guys!

I stumbled on this unprepared for such an informative lesson. I got just enough to scrape the wound open. Learning new things is often like this, it prepares one to be keen to know more.

I worked for a surgeon/genius in 1989 and told me he in the past saved a man's life from this deadly lack of biome by serving him a stool shake to drink. It worked, and he acted as if he even came up with this idea of stool reintroduced to the entire gut. Crazy we have so much still to learn...

@Sidandemily5423

5 ай бұрын

Implanted into the rectum not drink?

@babyboltbark

4 ай бұрын

Wtf

I can't help wondering given the sensitivity of Akkermansia to oxygen, do people who use hyperbaric oxygen therapy lose a ton of their Akkermansia? How much does this impact the gut microbiome?

I always enjoy your vlogs. I’m definitely looking into the app. I didn’t know how help it can be.

Excellent show Colleen please do more appearances and put this information about the differences in your products on your website. I didn’t ever understand that your glucose control product was meant for people that weren’t consuming sugar and I’ve been a customer of yours for years

I studied molecular biology..Spectacular, Cutting edge.

Loving the podcasts, thanks

I love this kind research and the success with her due diligence is so hopeful for srnsiors. She has a really good product website. Also excellent reviews for the various supplements.

Great to se Peter connecting with the web of life . . . with a great guest.

Loved this episode--learned of and started metabolic daily (husband and I both did) after listening!

Great information, very interesting and insightful.

This was great, thank you! Colleen is a wealth of relevant knowledge.

A topic that all the OBs I talk to are going crazy about is how the microbiome forms in c-section babies. Plenty of studies finding correlation to psychiatric illness, but unfortunately they're waiting for 5-10 year followups on infant nutrition, what swabbing vaginal fluids on c-section babies does, and if their microbiomes are more of a 'blank slate' than normal deliveries which might leave them more vulnerable to unfavorable environmental exposures.

@bardsamok9221

4 ай бұрын

Great comment.

@healthyteddy

4 ай бұрын

Years ago I read the blog of a lady called Wellness Mama. She had 5 kids. First few deliveries were vaginal then had to have a c-section. She described how she soaked a small piece of cloth in her vagina and wiped her baby all over, including the face with it. If I remember correctly, it was done behind the back of the doctor for fear of being stopped. She was very knowledgeable what I would call a citizen scientist.

@marinasmith4772

17 күн бұрын

My son was delivered by c-section then bottle fed. He has never had GI issues. I on the other hand was delivered naturally and breast fed. I have had a horrible GI since the age of 12. It has gotten worse in my 50s. I think it is the onslaught of antibiotics we are getting that gradually wear our of GI.

Omg she has beautiful skin. Do they discuss eczema or allergies? Skin microbiome?

@sharonphillips3700

5 ай бұрын

Skin and everything else, comes from the gut microbiome

Amazing Doctors thank you so much beautifully said and a service to humanity ❤️

Finally, an intelligent, non-gimmicky discussion of the micro biome.

Loved her! Learned so much! Thank you

That was awesome, definitely worth a replay in my book!

Great interview!

I’m glad you mentioned the point about green powdered drinks. My dad had colon cancer. He was a meat and potatoes guy but not other vegetables. I tried to buy him a green powdered drink mix. Weeks went by and it just sat on that countertop. I never thought to check the fiber content. Those green powders are processed to be liquified but fiber is thick so those drinks don’t have a lot of fiber.

@Engrave.Danger

4 ай бұрын

Probably because fiber is an anti-nutrient and there are enough of those preventing absorption of vitamins and minerals in those drinks.

@anitahernandez1207

4 ай бұрын

@@Engrave.Danger many of those powdered nutrition drinks are a placebo, unless they are freeze dried or minimally processed. If they are processed with heat, most of the nutrition is gone, which is why they add synthetic vitamins. 💊 So, it’s mostly a mind game with the consumer, thinking they’re getting their nutrition through greens or phytonutrients/enzymes/chlorophyll, etc. but what they’re mostly consuming is an expensive synthetic multivitamin. Humans were created through microbes or bacteria/dirt. There are microbes in plant foods as well as the animals that eat the plant foods. That’s how our body functions and even creates its own vitamins in the micro biome. So, consuming a green powder, drink that omits those microbes through its processing, can create antibodies and other types of zombie cells, which is why there are so many new types of diseases in the last 100 years compared to thousands of years in the past. There is not enough of the other nutrients to make much of an impact because there’s no way they can put those nutrients such as milk thistle, coenzyme Q10, etc, along with the green nutrients in that one scoop of powder. Fiber makes butyrate in the body and that is very important. Protein or meat can also create butyrate, but some people need a little bit more nutrition.

@Engrave.Danger

4 ай бұрын

@@anitahernandez1207 yeah, processed plant products caused the chronic health issues and now people are looking for more processed plants to resolve it. 🤦‍♂️ I'm not buying into the butyrate thing. All of the things it's said to be good for have improved since I cut out fiber. The push to go plant based just keeps coming up with more B.S. propaganda every time something doesn't hold water.

@anitahernandez1207

4 ай бұрын

@@Engrave.Danger who said anything about a plant-based agenda? I’m omnivore. Some individuals have different metabolic conditions and require certain types of temporary diets. I don’t know what was going on with your system, which required you to cut back on fiber. Your system may change again in a few years. An interesting point in that discussion was that the experiments on humans with transporting feces (yuck) 💩 didn’t work the way they hoped because peoples Microbiome can be like their fingerprint.

Mind blowing!!! Great one!!

So fascinating!! Smart questions too :)

This is a really great video, especially useful to me after receiving the results of a microbiome test and seeing that my levels are significantly disturbed... subscribing to Pendulum Glucose Control and will retest after 6 months to see if it has positive effect.

I think Frodo’s journey to return the ring to the fires of Mount Doom in Mordor was less arduous than the journey Pendulum endured. They definitely believed in their hypothesis and dream. That is enough to convince me to buy their product. Excellent podcast - informative, funny, compelling.

@carolhemingway2793

5 ай бұрын

NB: As Colleen herself reveals at the end of the podcast, and very briefly, with no discussion , that for 80-85% of the participants, her product Did Not Colonize!! So plan to buy and consume it forever if you want the benefits.

@anthonycho6344

5 ай бұрын

@@carolhemingway2793 To clarify Carol’s comment, every participant colonized all five strands. After the 90-day fall out period, 15-20% of the people who maintained Akkermancia in their gut were the ones who kept high fiber diet. So fascinating!

@lmyers9999

29 күн бұрын

Or just eat low carb for free… better results.., blood sugar down immediately… a1 down after 90 days…. Both for life

Excellent talk.

I learned something but little disappointing that she does not know more about established probiotics, other than Akkermansia. Although, I have been impressed by importance of Akkermansia. First, Lactobacillus and Bifidobacterium are genus, Lactobacillus (new Lactiplantibacillus) rhamnosus is a species. Strains are individual unique and have alphanumeric designation by which you can search PubMed. Examples: L.rhamnosus LGG, L.acidophilus DDS-1, Bifidobacterium BB12, L.paracasei strain Shirota (in Yakult). These are clinically documented strains. Double blind placebo controlled studies. Effective dose (CFU) is a good measure (not just marketing) based on results of clinical studies. It can be 1 Billion, 5 Billions, 10 Billions. The episode with Michael Gershon is hard to match.

Useful again. Thanks

My best friend and I are 75 yesrs old. He has been drinking diet Dr Pepper since it was introduced in 1962. He has also been giving himself an enema every third day to be able to got to the bathroom since he can remember. He finally stopped drinking the diet Dr Pepper and now he goes to the bathroom EVERYDAY.

@mjgrant1515

5 ай бұрын

interesting!

Thank you for this info

Thank you Peter Attia for this Amazing interview 🙏🏽 i have been watching Colleen's interviews for about 6 months and finally decided to purchase her Glucose Control Akkermansia supplement and have been taking it for almost a month now. You definitely had new questions that other interviewers hadn't asked! So informative from start to finish. Thank you for this 🙏🏽 ❤️

@EffectivePickyEatersSolutions

5 ай бұрын

Can you report any difference? Do you feel better or anything else?

@goutfromfriedokra3936

5 ай бұрын

any good changes to glucose control supplement?

@aquisces9532

5 ай бұрын

I have only been taking it for a month, she mentions to give it at least 3 months to feel the benifits. In this short time frame that I have taken them I do feel better with my overall health my energy levels are stable. I ate a pastry and hot chocolate (on my cheat day) and my glucose only spiked to 140 vs other times it would be closer to 180. Also a huge change I have noticed is how stable and consistent my bowl movement are (I'm sorry if it's TMI), I use to go 2 times a day now I go 3 times sometimes 4 depending on how much I eat. They are normal BMs, not too soft just normal. I will report back on month 2 and month 3 if your interested to know how it's going. Sending out positive and healing energy to all 💓🙏🏽

@aquisces9532

5 ай бұрын

Also as an FYI in a different podcast she mentions that we don't have to keep taking the akkermansia muciniphila supplement so long as we keep feeding them polyphenol rich foods to keep them alive in our gut. (She did say her investors may not like that comment 😅) I feel since she was honest and upfront that made me move forward with my purchase. I do plan to keep taking them after the 3 months but maybe take them every other month or every 3rd month. I do also take a polyphenol supplement and try to eat a lot of berries and Pomegranates as well as matcha green tea 🍵 . Hope this helped 💛

@goutfromfriedokra3936

5 ай бұрын

Awesome keep sending your updates. @@aquisces9532

It would be extremely valuable for a show like this to deep dive on the interaction between cytokines and the microbiome. This is massive. Ideally someone who's taken a very wide ranging cytokine dataset (not just tye usual suspects) during a microbiome study that uses a higher standard of genetic sequencing on the biota than the weaker studies. This is potentially one of the greatest avenues in biology as it affects the entire body and brain. Those studies are out there and the information from the better methodological studies (,newer the better usually,) is excellent and groundbreaking. Has to be experienced with wider cytokine datasets than the older microbiome studies, and also the higher standard of sequencing microbiota (old ones are poor quality).

I definitely learned a bit from this, so thank you Peter and Colleen for doing this podcast. I appreciated the focus on microbiome function instead of just strain or number. Just a few things I thought may be helpful to note: 1) Fecal transplants- success is not quite 99% like Colleen said, but 80-90% in most published literature. I know her takeway was that it has a high succeess rate. 2) Yogurts- Besides Lactobacillus and Bifidobacteria, Streoptococcus thermophilus is also commonly used. 3) Gut Microbiome- besides viruses, bacteria, and fungi, there are also Archaea that we have much to learn about. We at least know Arachea can contribute to a type of SIBO.

@JacquesTreehorn

6 күн бұрын

Consider Kefir. Luckily it is easy to find for me in the UAE. I take my evening stack with it right out of the jug.

Thank you very much doctors for this very informative discussion. I'm currently working my way through Dr. Wm. Davis' Super Gut protocol and have been thinking about which way to go next if I don't acheive my goal of diabetes remission. Wheat Belly Total Health saved my heart and carnivore barely moved the scale on diabetes. I will do more research into the Glucose Control product. Really appreciate such a frank discussion. Thank you.

@evaanthony6729

5 ай бұрын

You need to join dr.Davis's Inner Circle and following his entire program...to overcome diabetes.

@dinomiles7999

5 ай бұрын

Berberine . Your welcome . Any questions?

is it effective to colonize yogurt or sauerkraut with the contents of probiotic capsules to increase to quality & number of species? i’ve been doing this & I’m. wondering if i’m wasting my time (& possibly money)

Loved it, thank you.

The microbiome is one of the most fascinating things. Its such an influence in what and how we are. N it looks like in more ways than we imagine.

One of the best videos I've ever heard on the gut/microbiome. Thank you

In my opinion, this seem like a very in depth info. Thank you

@Engrave.Danger

4 ай бұрын

I used to feel the same way when I'd watch an infomercial as a kid. Way more in depth than the average commercial.

How does the cleansing for a Colonoscopy affect the microbiome? What are the best steps for post Colonoscopy for restoring microbiome?

I love Peter’s interviews.

Very minor gripe, but E. coli and C. difficile are the species, not the strain. Escherichia and Clostridioides are the genera.

Yogurt contains lactic acid bacteria but not all yogurts are probiotics. Some are. They label the probiotic strain identity. Examples: Stonyfield YoBaby & quarts, Activia, DanActive, Nancy's yogurt. If the product (yogurt) has labeled strain identity (well documented, reputable strain), it corresponds to effective dose, at the end of shelf life. It is delivered in one serving, or state number of servings needed to deliver effective dose. Some of the mentioned are available in yogurt and supplements. There are other well documented probiotic strains available only as supplements, such as L.reuteri SD2112 (Biogaia) B.infantis 35624 (Align).

You mention step exercise and grip strength in another video. Can we use the bottom 2 stairs and what is best for grip strength?

Wow ! Didn`t think I would be able to watch the whole episode, but I did ! I learned a lot and more important, I liked it ! I`m going to order the Akkermansia. I don`t have diabetes and I am metabolically healthy. However, I am 69. So, let`s try it !...:)))

0:17:45 There is something morbidly poetic about the fact that mice drove pestilence for millennia and they now serve as one of our biggest levers in working against those forces.

44:53 If “E. coli” is a strain name, what kind of name is “E. coli MG1655”?

@gocsa

5 ай бұрын

She was absolutely wrong. E. coli IS the species. And it has different strains. And same thing with Clostridioides difficile. Clostridioides is the genus (just like Escherichia is the genus), Clostridioides difficile is the species. Strains are always a bunch of letters and numbers.

@mirjanacuric-bawden8557

5 ай бұрын

Alpha-numeric designation is the strain. This one is isolated by Mark Guyer, hence MG.

What’s a time window between when an episode drops here and on Spotify?

My grandmother who was a doctor gave me probiotics when I had to take an antibiotic . She was born in paris in 1889

@YOSOYLADISCO

5 ай бұрын

She must have been also the first woman doctor of her time if thats the year she was born...

@mirjanacuric-bawden8557

5 ай бұрын

Did she know Isaak and Daniel Carasso?

Wondering about COVID affect on gut microbiome? I researched and found science that did support the idea that COVID damages gut microbiome. The reason I was looking- mine changed substantially after succumbing to COVID (trip to Ireland).Fixing it with Dr. Will Bulsiewicz's Fiber Fuel 28 day regime and seems to be working. Do you know of this effect of COVID? Are there other recommended protocols? Thank you.

@Engrave.Danger

4 ай бұрын

A trip to Ireland and exposure to the food and environment would have altered your microbiome within a couple of days, so that may have been part of it.

@sophiamogere7828

4 ай бұрын

We have a gut-lung axis similar to the gut-brain axis, so that could be one of the reasons COVID affects one's gut microbiome.

Thanks!

Excellent! Colleen is so righteous. Humble, frank,knowledgeable, brilliant. One comment, at 1:38:24, Peter talks about what he would do now after antibiotics which is load up on fiber by eating lots of salad and fruit. That’s not going to cut it. The highest fiber plant foods are white beans with 19 g per cup Followed by most other kinds of beans and lentils, avocados have 13 g per hundred grams and then seeds such as Chia and flax, then acorn squash and green peas. Most fruits and salad have too high a water content to contain much fiber per 100gms. So after antibiotic… eat beans! Probably best to start with small quantities and build up.

@juderickman8275

Ай бұрын

Thanks. I had major dental surgery five days ago and am in the middle of a course of antibiotics but have to be on a soft diet. So refried beans it is.

Is it not soluble fiber, rather than insoluble, that the gut microbes convert to short chain fatty acids like buterate?

@connorgray2896

5 ай бұрын

i thought it was soluble

@gocsa

5 ай бұрын

Yeah, she's all over the place. She also mentions inulin which is again, soluble. And yes, insoluble fiber is poorly fermented by gut microbiome. So the whole basis of that section was a mistake.

Colleen was actually wrong about the bacteria taxonomy. She said Clostridium was the species, and difficile is the strain, but Clostridium is actually the genus, difficile is the species, and the strain is usually some identifier. Examples: E. Coli O157:H7 and Lactobacillus Rhamnosus GG

Surprised they both mixed up soluble and insoluble fibers as far as which feed the microbiome

@neuroguy-cf1jl

5 ай бұрын

I feel like she must have just gone along with his mistake. She mentions inulin, which she must know is soluble.

Amazing!

Such a great video.

I’m 10 in to this discussion and it’s clearly apparent that Dr. Cutcliffe has a big brain.

Fermented foods ! Please so easy. Don't complicate it ! Your welcome . Any questions?

@jonessss

5 ай бұрын

Carcinogenic

@dinomiles7999

5 ай бұрын

@@jonessss wrong , but good luck to you .

@jonessss

5 ай бұрын

@@dinomiles7999 Well I've looked at the studies so I don't need a random comment on youtube to tell me what's right or wrong

@dinomiles7999

5 ай бұрын

@@jonessss fermented foods . Gut biome repair .

Antibiotics can seriously damage gut microbiome, but does not wipe all out. There is a population in deep crypts of gut lining that cannot be easily disturbed. Appendix is also a reservoir. But it takes time to re-establish, and this could be influenced by food. Takes up to 18 months after a course of broad spectrum antibiotics.

@IdeoDLaw

Ай бұрын

I think it depends, certain Antibiotika like fluorchonolone can even mess These up I guess. Just specuöagions

The influence of Akkermansia is based upon the ratios of the rest of the bacterial composition of the gut not just the diet ( vegan vs carnivore) yet the diet influences the ratio of different bacteria and impacts amounts of akkermansia in the gut. That’s why both vegans and carnivores can have higher levels of Akkermansia regardless of their preferred diets and why individuals have lower levels.

Love the information, hate how people are always trying to sell something.

I am curious about rebuilding one's microbiome with l. Reuteri fermented yogurt, as promoted by Dr. David Willis? Thank you!

1:13:25 I may have misunderstood this, but I thought the guest had stated earlier that the more important excretion products of microbiome organisms were produced by multiple organisms or strains maybe. If correct, is there not this "back up system" for the acromancia(sp?)?

Como puedo obtener la ttranscripcion escrita del video ?

There are several gut microbiome testing sites. Any way to choose the best? Has anyone done testing on changes to microbiome of people on Ozempic type drugs?

@XmanGoogler

5 ай бұрын

Ya, I was thinking that I’d want to do before/after microbiome tests around taking Pendulum.

Couple questions... first, if it is so sensitive to oxygen how does it originally get into the human body or in the case of post-antibiotic treatment how would it ever return to the body without a carefully packaged supplement? second, what effect does a routine colonoscopy have on the gut microbiome specifically all anaerobic organisms considering that during the colonoscopy they pump the colon full of air to move around with their camera? My father died of colon cancer so I have had to endure colonoscopies every 5 years since i turned 40. My Akkermansia level according to Thorne Gut Health test is basically zero... result shows my level is about 19% of what is considered normal. Incidentally Akkermansia is the only of the 5 strains I am deficient in according to my gut health analysis. Would be interested in transitioning to the single strain once it comes back in stock. I'm pre-diabetic, not diabetic.

A month ago I randomly picked up the book ''Super Gut'' by Dr William Davis. Quarter way in I was thinking to myself - why doesn't Peter have a podcast about it.

@netty062

5 ай бұрын

My husband is reading it now and can't stop talking about it. I already have vegetables fermenting in jars!!

@Ruudwardt

5 ай бұрын

To be fair many of the claims are over the top there - nevertheless, the topic appears to be a massive blind spot in science and health care@@netty062

@mirjanacuric-bawden8557

5 ай бұрын

Check the episode with Micheal Gershon. He wrote "The Second Brain"

To answer Peter's question around 7:00, the microbiome can weigh so little in spite of its large number of cells because human cells are massive, perhaps 1000 larger in volume than bacteria (it varies a lot from cell to cell of course). That's roughly the difference between a cat and an elefant.