In this episode, we discuss: 0:00:35 - Defining the categories of “proven, promising, fuzzy, noise, and nonsense” 0:07:35 - Rapamycin 0:16:15 - Metformin 0:24:35 - NAD and its precursors 0:34:21 - Resveratrol 0:40:40 - The importance of VO2 max, muscle mass, and muscular strength for lifespan 0:47:02 - Blood flow restriction (BFR) training 0:55:11 - Using stem cells to treat osteoarthritis or injury 1:00:44 - Fasting as a tool for longevity (and why Peter stopped his fasting protocol) 1:12:55 - The energy balance theory 1:19:29 - The idea that sugar is poison 1:31:38 - The idea that sugar substitutes are dangerous 1:39:10 - The debate on red meat and cancer

@chokachu

11 күн бұрын

When it comes to nutrition, Attia said himself that large-scale, multi-decade, randomized human trial is practically impossible. Yet that is not a good reason to discredit all the animal research and association studies in nutrition, just because the conclusions might not fit his narratives or personal preference. WHO clearly classifies red meat as probably carcinogenic to humans (Group 2A), based on numerous multi-national scientific research. For an advocate who does not do his own research, but makes a living by combing through and summarizing the work by true scientists, to say that "the statement that red meat is carcinogenic is nonsensical", is rather, to say the least, nonsensical.

@chokachu

10 күн бұрын

As a long-term paid member of Peter Attia's podcast and Early Medical program, I've always noticed his evasive and dismissive attitude whenever it comes to nutrition. I came to this sudden realization today after watching this video - perhaps the reason why he's so famously frustrated with nutritional research is that most longevity studies in this field produce results that run against his dietary preferences (e.g., red meat consumption, high protein intake). That is just sad.

@denmark98

8 күн бұрын

Hey Peter maybe listened to all 300 episodes- when it comes to fasting, caloric restriction- I think as a “normal” person - a non scientific person, influencer or whatever there are no straight answers on nutrition. Other than calorie restriction regardless to lose weight. Just say it - outright without all the layered, “political” talk. I have listened to it all and tried it all. Just say caloric restriction/ energy balance is the only way to go.

Yes, we like this style of “summary synthesis.” 🙋🏻‍♀️

I am addicted to this show, but, it is very healthy addiction.

"..you see why I get animated, and phosphorylated when people are asking about resveratrol... [taking all these supplements] but not exercising!" I think phosphorylated is my new favorite adjective!

This podcast is just so helpful it's crazy. More people need to know about this

@sabine8419

12 күн бұрын

😂😂😂😂

@juicebox853

10 күн бұрын

He is a fraud.

@selaserafin3798

9 күн бұрын

@@juicebox853 Can you elaborate?

Excellent convo gentlemen !! 💯 On On

This is one of the best episodes! Please do more of this style 🙏

Appreciate when people are mentally flexible enough to change and base their decision-making off of the evidence, whether or not it agrees with what you thought or hoped to be true. THAT is why I trust this dude.

YES! Please do more of this style! This was a great episode! thank you!

I live for these podcasts! Cleaned my entire kitchen and did meal prep while listening to this, and I learn so much each time! I would love to have more of these overview podcasts! Here for as much as I can get.

Great conversation- I appreciate how differentiated the questions are answered! That’s Science !

I’m appreciative of all 300 episodes. I listen to many health podcasts. You are my favorite and by far, the most trusted. Thank you for your podcast and dedication to the health of humankind. 🥰

Yes please do more of these!

Love this concept. Keep'em coming.

Dr. Attia, you can't convince me otherwise, you must have a photographic memory. Mechanical Engineering and MD! At least physical mechanics can be applied to the anatomy. Myself, electrical engineer only because I wasn't smart enough for med school. Now I'm glad I saved my money! Thank you for your continued curiosity and progress above and beyond. I know that personality. I was obsessed with work and continued learning. I was 24/7 with work and fitness. Now the boogie man caught me. So no vision, melanoma of the eye and of course skin cancer, (thanks to blond and blue eyed). I'm fine and planning to be a centurion. Thanks sharing all of your priceless knowledge!!❤

Regarding NMN. I have had a very good experience with it. My recovery has improved, most notably from injury, and I have improved stamina. I was a professional ballet dancer. I lived that life 24/7. I'm fifty-seven and have been working out hard, including weight training and cardio, for most of my adult life, so I know my body. Before I started taking NMN, I was dealing with chronic muscle injuries in my legs, which led to frequent physical therapy. I have not had that trouble since starting NMN two years ago. For example, in the spring, when transitioning from the treadmill to the outdoors, I was always sustaining an injury to my quads, leading to PT, but that's not happening now. I still get the initial injury of what feels like a very localized muscle strain, but instead of worsening, leading to PT, it goes away quickly. There's been no other changes to my routine in life, generally. Also, as I mentioned, I am running longer, and given the importance of VO2 max, I'm even more inclined to stick with it. I take it sublingually.

@handianus

12 күн бұрын

Ive done nmn 1-3G / d orally. Only subjective effect is less lethargy in the afternoon. To the point of increased insomnia

@TravelPhotoWriter

12 күн бұрын

Great input, thanks for taking the time to pay a detailed post.

@betsywestbrook7169

12 күн бұрын

I agree 100 percent none of these guys also discuss some of its mechanisms. It is a DHEA booster so helps your hormone profile also with reveritrol you receive as a woman phytoestrogen as well as a methyl group. I totally agree with you on recovery. Within 90 days I have been able to get to 10k rows from never rowing and I'm 60. Also use UMZU redwood and it's also a great product. Everyone is different but speaking as someone who does manual labour and has 5 yrs to go till I retire I will be using these products. Because they have worked for me.

@alan2102X

12 күн бұрын

Great results! Congratulations! You can get the same or very near same results from plain old niacin and niacinamide - at a small fraction of the cost.

@davidperfette1425

12 күн бұрын

@@alan2102X Thanks! But I get 100 grams of NMN powder from Renue by Science for $77. That's $23 per month, which is on the inexpensive side. I don't enjoy the blushing from Niacin. I don't know much about niacinamide. But that's interesting to know.

I like the "rating system", good to use that whenever appropriate and looking forward to the exercise for elderly podcasts.

I love this format. Thanks for all you do Peter!

Thank you, Dr. Attia and Colleagues for bringing this content each year.

You're a legend Petter. Thanks for all the great information

Thanks! Very nice episode style and very informative like always! One of the greatest podcasts ever!

Please do an episode on restless leg syndrome. Millions are affected by this including me. Disrupts sleep every night. I’m seeing a sleep medicine neurologist. She had me quit taking Pramopexole and replace with Horizant. Also, had an iron infusion. Neither have helped. I’m desperate for a solution to get uninterrupted sleep! 14:26

According to Brad Stanfield, David Sinclair has perpetrated a fraud on resveratrol. It's been clear almost from the beginning that there's no benefit, and there's actually harm, in that it diminishes the benefits of exercise. There's a similar pattern with Sinclair and NMN.

@betsywestbrook7169

12 күн бұрын

Reveritrol IS a Methyl donor and does help immensely post menopause for some women as pyto. If your system likes it it's a great addition.

NEVER stop with the deep dives 😂🙏🏼

Absolutely LOVE the summary style podcast.

Yes, please keep those coming! This was awesome, easy to understand and nice to get a quick recap on things. Thank you!

Your insights are always so informative and helpful. You're truly one of the best sources for science and daily health tips.

The mind of this man! All these complex, multi-layered concept just rolling of the mind and tongue! Thank you for helping us SO much! I have completely changed my health-span and likely my life-span based on your information. Have push my VO2Max up multiple points in the last year and can now dead hang for 2min

Thankyou for this episode ! I appreciate the review ! It confirms how much I have learned by listening to you Peter !

I really enjoyed this one. I think this format is great!

ABSOLUTELY FANTASTIC. Long term member. Enjoy the deep dives but this is my dessert and helps form my macro view.

🎉I love hearing your wisdom and knowledge. 🌟🌟🌟🌟🌟🌟🌟🌟🌟

I like the format, thank you 🙏🏻

I appreciate this podcast and having followed peter for so long it’s great to hear Peter make a definitive statement . My grandmother who was born in 1886 and died in 1984 used to walk daily down a hill to the shops and always said everything in moderation . Which would seem to be were Peter is at.

Great format. Hope to see more like this in the future. Also woukd love ballpark guidelines on what consistutes 'good' for things like strength and similar.

Love this style episode!

Loved this format! You should have more episodes like this, even if it comes at the expense of fewer deep dives.

Love the format

Another excellent podcast....

This is a really good format!

Love this summary style, sometimes it's hard to find the time to go super deep and so the TLDR approach becomes really helpful!

Love how you will change your mind on something according to most recent data. 👏🏼 Also, love this format to infinity and beyond. 👍🏼

good format--thank you

Thank you for sharing all of this with most of us here who are average “dummies”… some are many steps above for sure, but it’s just nice to have someone like Dr Attia sharing his honest opinions on things that can really affect the human lifespan.

I really liked this format.

really good stuff keep doing this

Yes, do more of this style but carry on with everything else you do too. It is rare to not learn someting from each video you post so please keep it up, it is much appreciated.

I like this format.

Thank you and congrats Peter and your team! Well done 🎉I bought your book in digital format, enjoy reading it but not yet finished, will resume in winter when it's too cold outside

Best episode ever.

Because of information from his podcasts, I have reduced my ldl & apo b to 70 and TG to 65.

I like this recap & rating method👍🏻

but this is lovely 👍🏼 and needed

The nerves in the body especially in the heart and brain ,are organs that always work nonstop. This organ has its own sensitivity and how we build communication and understand " them" and treat them as good Friends so that they care about us ( in the contex of the body as a whole ) as human beings or sosial humans.

This podcast is great! ❤ I would be really interested to learn Peter's opinion on red light and near infra-red light therapies.

Hello Peter et al, In response to your request for feedback, I enjoyed this podcast. The deployment of the ranking system, and the magazine style of multiple issues still with relevant depth. I was also vastly amused by your use of the verb phosphorylated to describe your emotional state. Following on from phosphorylation, perhaps you might consider producing a podcast exploring the longevity potential of AMPK activation, along with the potential of calorie restriction mimetics like salicylate, glucosamine and EGCG, maybe in a chronosynchronous fashion when fasted. As opposed to a subsequent mTORC1 activation by excellent quality food later in the day, potentially cycling AMPK activation then mTORC1 activation over a 24 hour period. Thank you for the very deep dives into health. Fascinating and appreciated. Cheers, Michael.

Resveritol benefits are wishful thinking by people who love their regular glass of wine and are desperate to find an excuse. Thanks for confirming what science has to say about this. I congratulate you for having the courage to change your mind when scientific evidence shows a new direction.

Brad Stanfield has raised the funding for a study on rapamycin. It will be interesting to see the results.

@Engrave.Danger

7 күн бұрын

Somebody else will have to let me know how that goes. I can't tolerate that guy.

I really enjoyed the summary format with Peter's rankings from "Proven" to nonsense. I hope they do repeat this format in the future.

Stem cell therapy is being done. Listening to you, I'm shocked. My friends son is going to bar stem cells harvest in Sacramento, UC system. I will update here in a few weeks

I think after 25 years of working with clients and talking about nutrition and being interested in it myself I’m where Peter is currently at 🤣

Yes, love this style. It helps me to know where to invest my time for further research. And scientists like Dr. Attia who change their minds as new evidence emerges have my respect. In strong contrast to those who sign onto a cause and whose videos become a waste of time because they will simply say the same thing forever, while ignoring any evidence to the contrary.

I found this interesting.

If someone went from a balanced 3000 calorie diet to a keto 3000 calorie diet, there are are at least a couple of reasons they may lose fat on keto. 1 being that the initial process of fat adaptation is extremely inefficient. Consider the urinary ketone strips for example. When someone starts a keto diet, they're producing way more ketones than they're using and some of that is being excreted, so there's a period where they're basically peeing out fat. 2 our fat absorption is limited to bile and enzyme production, as well as undiluted stomach acid, so excess fat per meal has the potential to pass right through.

Love these update episodes. I understand that resveratrol is nonsense for longevity but what about for keeping us healthier during a normal lifespan? In light of the 2006 study could it prevent or delay progression of NAFLD in the context of a high saturated fat diet?

. I understand Peter's change of mind on fasting and muscle loss. But what about short fasts (24-48 hours) a few times per month ?

this format is great! I wanted to compare but episode 200 is not in your video-feed

1:02:12 I agree with u wholeheartedly and I think it’s such a pain spot for u is because the lack of understanding nutrition in general and the grossly inaccurate things people say about various diets and fads that makes anyone with some remote knowledge recoil 😅

Would really like to hear a podcast on sugar and carbs ...they literally control my life,mood and behavior...I struggled for years until I realized in my late 40's that I'm not depressed...that it was my sugar and carbs intake..but I'm still trying to figure it all out...

@Engrave.Danger

7 күн бұрын

You'd be better off looking into Dr Georgia Ede and Chris Palmer imo.

One thought/request, can you talk about rahbdyomyosis. I find a lot of athletes joke about it. I've gotten it. 7k creatinine! Always been an athlete and always get crazy sore. I know it can be very dangerous. Personally, I'm not sure what is too much and does 1 rahbdo mean more, or does it mean I've had it most of my life?? I honestly wonder how careful I need to be. I don't know ways to avoid it... Anything?? Electrolytes, magnesium, or just back off the workouts?? How common is it? Is this just normal for athletes? I remember as a kid thinking high performance athletes are definitely masochistic. This is a lifetime of sports for many years personally. Can you touch on if soreness is dangerous or just the norm for decades of exercise???? I can't remember not having weekly soreness since I've been a child. What's up with that???

@PeterAttiaMD would you consider adding close captions of your videos? Adding Chinese would be great so I can share your videos with my parents. Thanks for considering.

Let's hurry and get Peter to 667k subs! 😅

@kepdani

12 күн бұрын

hehe

In regards to the opening statement of this video- What does this curve look like? When does it plateau for each of these biomarkers?

@FlatToRentUK

11 күн бұрын

The benefits of high VO2 Max are seen at the elite level - top 2.5%. Strength benefits are seen at least in the top 10%. For the vast majority of us we don't have the time or capability to reach either of those groups so instead of worrying about where we plateau concentrate more on the best use of your time and maximising what you can do.

Can someone tell me the protocol for building muscle mass for older folks? How do you do? Thank you.

@Engrave.Danger

7 күн бұрын

I would suggest picking up a copy of Dr Gabrielle Lyon's book Forever Strong: A New, Science-Based Strategy for Aging Well Focus on animal protein (about 1 gram per pound of ideal body weight) and resistance training. You might also consider a digestive enzyme for better absorption of said protein. Spend some time with a personal trainer and go kick some butt. 😉

Doesnt the % of mortality go down with remission of TYPE 2?

How does someone that is APOE4/4 play out?

Statins -> no statins Fasting -> no fasting 6 hours exercise per day -> 1 hour exercise Low carb -> regular food People expect everything in Outlive to be contradicted in 5 years.

❤🔥🙏

I don't agree. With" the more mass the better. "... I think there's a limit to that. But I do agree with overall muscle tone and strengths along with detailed cardio.

@nichtsistkostenlos6565

12 күн бұрын

Maybe he should have been explicit, but obviously there's limits and he would 100% agree. Peter's never advocated that body builders are the pinnacle of longevity.

@scratchandwinner

12 күн бұрын

@@nichtsistkostenlos6565 he is not clear about that.... He has stated on numerous occasions that the more the better.

Peter, what's your opinion on Michael Greger's "How Not to Age" book?

@Engrave.Danger

7 күн бұрын

Take anything Michael Gregor says with a grain of salt and meat. 😂

Kudos to Peter for being so on point about resveratrol. Surely it's time for you to have an intensive discussion with Charles Brenner? There is so much misinformation still being amplified out there. You interviewed Sinclair, I think Brenner deserves a fair and intensive hearing on this. He has largely been ignored and blacklisted. I don't buy his claims about truniagen but you are well placed to grill him and have an informative episode that could have major benefits for the wider public on this. Thanks for all you do.

Where does candida imbalance fall into the sugar conclusion?

@Engrave.Danger

7 күн бұрын

If you wanna see some nasty stuff, throw some sugar syrup in a petri dish and leave it open to the elements. If candida were fire, sugar would be gasoline.

I hate the fact that I have to do the glucose tolerance test at 24 weeks gestation. Why do they have to dump 50 g of glucose in me and my baby. There’s gotta be a better way to dx GD or prevent it.

Is this sped up?

Ka-atsu. Katsu is cutlets.

Perhaps you can answer the question of why do women live longer than men?

@sabine8419

12 күн бұрын

They have more fat.😂

@KasKade7

11 күн бұрын

Multiple factors. Slower metabolism, estrogen protection effects on organs, smaller bodies age slower because fewer cells. Women eat much less total calories in a lifetime. Generally women also have better health practises than men and take less health risks.

The answer to the questions, could’ve been longer, but I’m not sure how. Lol.

Peter makes a living off of being an influencer to the naïve.

Sadly the discussant partner was not introduced a link to his credentials etc would be not only a courtesy, but be informative!

I don't know why you wouldn't take NMN when is clearly gives you more energy. Perhaps too pessimistic?

One of the reasons people like myself are so interested in resveratrol is because there are other reputable people who promote it quite vigorously. For example, David Sinclair, someone I believe you have had on your podcast in the past, swears by it. Another person who recently mentioned resveratrol is David Brecka. It would be interesting to understand why these individuals give it such weight if it's such nonsense.

@AlphaHealthYT

6 күн бұрын

He is a charlatan

The real question regarding fasting, were you actually strength training in conjunction? So let’s say you are fasting Monday-Friday, you would do a full body workout on Sunday morning with plenty of protein the rest of the day. Then on Wednesday (middle of the fast) you’ll do a very low volume with high intensity strength session using compound movements, then Saturday you will do another full body session but at the end of the day. I highly highly doubt a significant amount of muscle would be lost.

@Engrave.Danger

7 күн бұрын

He's an exercise addict.

What about Dr Robert Lustig's trial on kids with NAFLD and it's reversal by cutting out fructose from the diet and replacing it with glucose so that they wouldn't lose weight....how can Peter not know about that?

Truth is that everyone has a different DNA, even twins, and this entire video is just explanations of these differences. Common sense is being explained and all humans have additions of food and the only way to better your health is by exercising, eating healthy has no shortcuts but has many people wanting to believe in shortcuts. The world is not manufacturing any food good for you, period! Every study is skewed to favor money profit. Mental health is affected by whatever you put in your body. It's sad that Peter is just explaining common sense, the truth that no 2 people are the same and people should concentrate on doing the best things for your body and exercising, no matter how much, is better than no exercise. Move, keep moving and prepare your own food to control what's in it..

How long until Joe Rogan?

I just hate that I have to put it between 1.25x or 1.5x because they talk so slow....especially the guy with the blue hoodie, cmon mate i haven't got all day

When it comes to nutrition, Attia said himself that large-scale, multi-decade, randomized human trial is practically impossible. Yet that is not a good reason to discredit all the animal research and association studies in nutrition, just because the conclusions might not fit his narratives or personal preference. WHO clearly classifies red meat as probably carcinogenic to humans (Group 2A), based on numerous multi-national scientific research. For an advocate who does not do his own research, but makes a living by combing through and summarizing the work by true scientists, to say that "the statement that red meat is carcinogenic is nonsensical", is rather, to say the least, nonsensical.

@zaybx

10 күн бұрын

Yay, ad hominem attacks.

@chokachu

10 күн бұрын

@@zaybx Was just pointing out the fact. His double standard is simply appalling, as exhibited by consistent trashing of any research against, say red meat consumption or high protein intake; and wholehearted embrace of anything promoting muscle mass and exercise benefits, btw, there were plenty of ad hominem attacks in the former.

@Engrave.Danger

7 күн бұрын

I'm gonna direct you towards this video. You really might wanna sift through the WHO's supporting evidence (or lack there of) on red meat and cancer. Best of luck. kzread.info/dash/bejne/qnib3Ml9g6zUpJM.htmlsi=Q5VF1PrjoAgUV-9b

After someone has built their tolerance up for prolonged fasting, a 72-hour fasting should be done every 15 days. This will give the body and mind a break from food and the toxins that they put in our foods.

Monk fruit or GTFO.

This guy changes his mind like most people change their underwear. Just two years ago he was fast, fast, fast, load rapamycin and metformin. Now he’s eat high protein, don’t fast, take some bcaa’s and maximize protein synthesis. Let me make this entirely simple and succinct for all the non-biohacking people listening. It has been proven over and over in almost all animal species, if you restrict total calories and most importantly protein and leucine you extend lifespan. But at the same time it’s difficult to perform athleticly and recover from workouts with limited protein synthesis and limited leucine which is the most potent anabolic amino acid, found in milk and red meat in abundance. I’m not here to tell you which is right way to live, but the science is simple: you either maximize short term health and muscle mass or you maximize long term health and sacrifice some muscle mass, you can fall anywhere on that spectrum depending on how you choose to live and how far you restrict protein and calories. You can’t do both, especially simultaneously. Your body is either recycling (autophagy pathways) or growing (anabolic/Mtor pathways). They won’t tell you simple facts because then you’ll stop tuning in to hear the same thing told 100 different ways. They’ve got to keep you confused.

@Cass-gi4kk

12 күн бұрын

That’s a good scientist.

@joeschmidhofer2674

12 күн бұрын

Let’s all eat my companies highly processed deer jerky every hour on the hour to maximize lifespan!

@Cass-gi4kk

12 күн бұрын

@@joeschmidhofer2674 he never has said that.

@jakubchrobry3701

12 күн бұрын

How much protein do you believe it takes to grow muscle and increase strength? Or at least maintain? Do you believe 1.6 g/kg is the bare minimum and 2.2 g/kg is optimal as Dr. Attia does? I'm 6' 2" and Dr. Attia makes it sound like I need to be 220 lbs and all muscle at age 60 to live long. I haven't found where he's specific on strength and muscle mass goals. He's seems to imply that muscle must be maximized at all costs. Why else the extreme protein? Personally, I'm increasing strength with less than 1.6 g/kg.

@barnowl64

12 күн бұрын

@smoore8 that’s a really interesting duality of options that appear in tension. I’m curious, do you think the benefits of a low protein-low leucine diet outweigh the benefits of a lifestyle prioritizing muscle content and VO2 max? Surely it is possible to have a low protein diet and sufficient contractile tissue & VO2 max, but as far as an intuitive lifestyle I can see prioritizing recovering from exercises that increase longevity to be more important. Also he addresses the point of changing his mind around 1:17 PS I never comment on youtube, just thought your comment was very intriguing, respectfully.