Each year, roughly 10 million people die from cancer, almost 20 million die from heart disease, obesity is at epidemic levels, and up to half a billion people are diagnosed with type 2 diabetes. In 1980 there were no cases of adolescent diabetes in America. Today there are hundreds of thousands. And although less lethal, 40% of men over 45 today suffer from complications of low testosterone and almost 10% of women experience menstrual irregularities and infertility. All of these disorders (and many others) have one thing in common... To varying degrees, each is caused or exacerbated by the inability of the hormone insulin to perform as it should-a condition, largely within our control, known as Insulin Resistance. And, you might have it. Start raising your insulin IQ and discover what you can do to start feeling better.
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Dear Dr Bikman, I have my insuline at 3.3, glucose is around 100. On my CGM the glucose is very unstable, and spikes a lot. How is it possible if I officially have low insuline. 😢 In my body I feel like I'm insuline resistant and my glucose is not under control.
Are the ceramides in meat and dairy also contributing to insulin resistance..or just the ceramides produced by liver because of insulin resistance ? (Sorry i don't have a background in biology)
Wow! I wonder if I should be taking ceramide supplements...My favorite beauty influencer recommend this: "Sports Research Phytoceramides". If anyone see this and knows if this is a factor in insulin resistance please tell me....I think I will quit just in case...
Can dietary ceramides cause apoptosis of the beta cells in the pancreas, when insulin levels are elevated?
First time watching one of your videos, I think you explained things very clear. I hope people are learning from this. Since I'm coming from brad Marshall @Fireinabottle courses, I was wondering what your thoughts are on the roll of BCAAs in keeping us insulin resistant.
I heard a alleged medical expert on fat metabolism on Dr. Berry's channel this week and was horrified at the incorrect information she spewed and that Dr. Berry would give her a voice. I'm so THANKFUL for your generosity in educating me so I know when I hear WRONG information, half truths and theories based on just a notion instead of the real hard researched science.
Is that the "Dark Calories." Video?
Yep saw that. I think she’s spot on about seed oil toxicity but nothing trumps chronic high insulin as a metabolism killer. However seed oil consumption and the inflammatory state it causes should not be overlooked.
You sure were able to teach me new insights! Thanks again for these wonderful explanations (although it is bedtime over-here right now I just had to watch the whole video because of it's content and your excellent way of explaining all this.Thanks the Lord for internet and the new technologies. Greetings from the low lands on the north seacoast (i.e. The Netherlands)
QUESTION TO YOU DR. BIKMAN: Here is my take away. You are saying in a nutshell that high insulin over long periods of time leads to insulin resistance. The inference is that insulin resistance IS ALSO a problem. But I am confused. Ultimately, it is high BLOOD GLUCOSE that defines a person as a diabetic and causes the body to, basically rot. In my understanding, insulin resistance is a FABULOUS PROTECTIVE MECHANISM for each cell - the bouncer so to speak. If the cell is keeping out a fuel source, be it glucose or fat, it is because the cell is either FULL and taking in more would be damaging, OR the cell is not yet ready to take in more fuel. Why a cell may keep out fuel even though it has room to store more stems from complications based on eating a mixed diet of carbs and fat together. As I understand that complication, it is that a cell needs to control the composition of the fuel source inside the cell. At one end of the spectrum, if there is only fat inside the cell, and a fat cell is knocking at the door wanting to get in, PLUS there is room in the cell for more fuel, the bouncer lets the fat in, no problem. If there is glucose in a cell and glucose is at the door knocking to get in, sure, plenty of room, the bouncer lets it in. NO INSULIN RESISTANCE in these examples. BUT if the cell is using fat and glucose is at the door, the bouncer will keep out the glucose until the cell is drained of fat, THEN it will let the glucose in. And the waiting game, all the time it takes to drain a cell of one fuel source before the other can enter, this leads to degeneration, fatigue, AND because there still exists the problem of high blood glucose, the body is basically slowly embalming itself as the sugar dehydrates everything it comes in contact with. I am a Korean Natural Farming - we make farming inputs by mixing equal parts brown sugar to plant material in order to extract the liquid from the plant material; this works based on the principle of osmotic pressure, and this is what diabetes is to my understanding. What artificial insulin injections do is arm all the glucose in the blood with a battering ram so glucose can FORCE its way into cells, REGARDLESS of whether or not the cell is full, REGARDLESS of what fuel source is already occupying the cell. For cells containing fat, the mixture of fat and glucose is like mixing diesel and ethanol fuel in the same fuel tank - it's very very bad - IT'S INFLAMATION (cell damage) - it's early cell death. Artificial insulin DOES keep down blood glucose but the tradeoff seems to be a slow degenerative death spiral. My conclusion is that a 100% carnivore diet IS our species specific diet. I am so novice to this subject. Please, if it is not too much trouble, correct me where I am misunderstanding.
So, if you are constantly in ketosis, it is a good sign that you are insulin sensitive (enough anyway) and do not have lipotoxicity. That is me, but my TG is always a little high like 120. A really insulin sensitive person has TG below 80. What goes on with me?
stress, fructose, snacking ...a little high is kind of euphemistic... normal human healthy levels are <50. above 80 it depends on your HDL whether you may count as metabolically healthy. Most likely you are not. check dr. paul mason about the ration TG/HDL
I’ve been on the carnivore diet for three months. It is working, absolute wonders, but now I want to understand why and that’s when I come to your channel.. thank you very much
Slight confusion here on my part: you mentioned fat released from fat cells that are then taken up downstream by muscle cells; however, if we are dealing here with insulin resistance, and therefore I am assuming hyperinsulinemia, how can lipolysis take place in a situation of elevated insulin levels? I am a layperson, not a student nor scientist.
as he said: fat cells are not listening, they are insulin resistant as well
So how do you block the ceramides? 25:34
When I saw the puc 4 this video I thought he would b talking about his experience with penis enlargement supplements.
Have you watched Dr Ken Berry. His wife has Hashimoto's disease. She hasn't cured her illness but she is no linger on thyroid medication. He has a lot of videos on the thyroid. with dietary advice, drugs. He covers Keto, Ketovore and Carnivore. If you are able to join his private group, I understand there are people who have different types of thyroid problems who will help you. I think it is $5.00 a month. Worth it at least for a few months for the support you will get not just when he lectures. You get 2 or 3 help lectures a week where you can ask questions of the doctor. Otherwise just look up his videos.
How does one "block the ceramides"? 😊
Stop eating carbs 24x7, eat non-inflammatory foods, take care of your leaky gut, reduce stress and stress hormones.
Why is it that I literally cannot fall asleep unless I have a full belly? If I’m hungry, I ain’t sleeping.
Is it okay to take exogenous ketones if you are diabetic and insulin resistant but not needing to take insulin shots? What to look out for if you do take exogenous ketones under theses conditions???
Can you comment on the studies Dr. Paul Saladino cites in a recent video on Keto diets not being optimal because of cortisol, epinephrine & glucagon? A friend sent me his video because they think I'm a lunatic for living a 94% carnivore lifestyle.
great job. Thank you. If able, why do you think my fasting sugar is going up 130 to 200 to 240 in the morning. I am on strict water, carnivore, salt. It seems as though my insulin levels have dropped to the point where even without any carbs, my sugar is remaining high per my CGM. I was hoping my sugar would have dropped, not increase. 50/50 protein fat ratio. For one month now, and little weight loss. BMI 38. Sending this info as an opportunity to review the carnivore diet for diabetics. Is there a way to restart my insulin resistance?
Also, MAF proponents claim the muscles burn fat during "maximum aerobic function". I take it the intramyocellular lipid droplets are used in the fatty acid oxidation cycle to provide immediate ATP after the glycogen has been consumed. So wouldn't high insulin levels prevent the lipolysis and use of these lipid droplets (as well as adipose tissue generally) and curtail aerobic endurance activity (even if you fat-loaded before an ultramarathon, as one study examined)?
Energy toxicity. Great concept! Your liver makes all the glucose you need. Any you eat is extra and presents a problem of storage and disposal for your body. Any glucose consumed must be burned or stored before any fat can be burned. So any fat you eat with your carbs just piles on. If you are going to eat bread, rice and potato, eat them with no fat. No butter, no gravy, no nothin. Enjoy!
Is anyone aware of any one on one coaching I could take advantage of in helping me reverse my insulin resistance? I've been eating essentially no carbs for 6 months now. My fasting insulin has come down from 40 to 15, which is a huge improvement, but my glucose is still between 200 and 250 and it just stays there. My doctor wants me to take long acting insulin, but I know that isn't going to help me reverse my insulin resistance. I really need some direction or one on one coaching, even if I have to pay for it. I can't figure this out on my own.
Thank you
Eat bread 🍞
This makes the idea of low carb style of eating all the more important. Thank you Dr. Bickman👍🏻
Thankyou teacher
23:33 whew! I thought you were going to say dairy and eggs were causing increased ceramides.
QUESTION: Do ceramides in topical skin cosmetics have any effect upon this info?
"Inflammation as a cause..." Question: What about the effects of chronic and intermittent systemic inflammation from Rheumatoid Arthritis?
I’ll need to listen 4-5 more times. This is dense 😊
"We *hypothesize* (my emphasis) that a dietary intervention focused on increasing the intake of fruit and vegetables, and reducing the consumption of refined carbohydrates or fat in free‐living subjects would lower serum ceramide concentrations in young adults." www.ncbi.nlm.nih.gov/pmc/articles/PMC5506522/ The paper also blames inadequate consumption of fruits and vegetables for metabolic syndrome and T2 diabetes, so there you are. Statins reduce ceramides, which tells me that ketosis is the natural way to reduce ceramides. Dr. Bikman, I wish you had elucidated how to reduce ceramides.
Just wonder:What autoimnun issue do you have? I can see that your imunsystem are little upset.
The only time the general public hears about ceramides is regarding cosmetics, that it softens and plumps up your skin.
I agree and sent Dr. Bikman a question regarding this. Especially the relationship between topically applying this and their effects on the body's production of ceramides since the skin is the largest organ and toxins are absorbed through our skin.
I'm curious about the lesser hormones that have an influence on insulin resistance and energy toxicity. Do we have influence on these?
Then what does this mean for GLP1 agonists like Ozempic and Wegovy? You have over-production of insulin due to the GLP inhibition, and you have a fasting state, due to the enduring over-production of insulin. It sounds like the perfect scenario for lipid toxicity.
He has done sessions on those - I think in this series. Seek and ye shall find. 😊
I left a comment or question for Dr Bikman about TG and was hoping to hear his take on TG. Also expressed my observation about some people that burn fat or lose fat mass very well but deal with high or very high TG. And here it makes more sense when Dr Bikman explains what could be going wrong. My history is 30 year very high stress job, 5’ 11 200 lb for years, steady weight but drop pounds quick with food restriction, TG 350 to 450 with meds, today its 85 with only Vasepa and no statin or fenofibrate. I stoped all sugar, limit carbs greatly to 20 or 50g maybe, time restricted 16:8 with random extended fast 1 to 3 days in duration. The random fasts are just that, whenever i feel well enough to handle, no plan just dive into it. Never compensate in food mass just out of a fast and eat high protein first and then a little carbs.
Have to add, lost 30 lb however at 200 lb you would wonder where i put it since i carried the weight very well.
yep, stress, snacking carbs, too much fructose ingestion, where the first two result in endogenous fructose production, then leading to high TG.
When are you going to talk about the toxic of the 💉 dangers injuries...take a stand- your wrong it’s all about glucagon/ what’s keeping insulin from signaling-it’s stress/glucagon/fatty acid/cortisol/adrenaline noradrenaline. Under “eating” not energy surplus/body is not getting [signal] stuck-inflammation. Low car from the start caused under-eating (Minnesota starvation experiment only 24 weeks major dame to liver heart loss of muscle,shrinking of brain)Insulin youth/anabolic youth hormone stimulates glutathione....prevents ACEs -glycation masterjohn did his PHD v6.examinecdn.com/erd/chrismasterjohn2.pdf
I appreciate your videos, very helpful. Thanks
Thank you Professor Ben Bikman!! Love your content and I’ve learned so much from you 🎉
Dr. Bikman, please explain, why is there zero ketonuria after a 20-hour fast in a fast-adapted and well-exercised middle aged person with a fasting insulin of less than 5( quest diagnostics units) ?
Beautiful talk! I have CLARITY now! Thank you so much!
So…. How to block ceramides??
preventing the fat in the muscles getting old: keeping energy balance, fasted exercise, TRF
Thanks Ben
02:30 How about "glucotoxicity"? After all, glucose is the molecule that the body will do anything to get out of the blood stream, and even when it has entered a cell, as I understand it, it more or less immediately gets phosphorylated to glucose 6-phosphate.
first, not anything. he body keeps producing glucose, even if i is in small amounts.The brain likes to run on at leas10..20% of its energy consumption on glucose. Second, glucose is weakly toxic, as it causes glycation, mainly of proteins. I s reflected in the hbA1c. It cause stiff connective tissue, from eyes, to arteries, and tendons. These processes are extracellular, hence it is not a classic toxin in the more narrow sense. Those are working intracellular, causing the death of cells
These are sooo good and informative. Thank you!
I believe we go to hard on the saturated fats and starches as the source of disease when I think we are looking at the wrong thing. I'm beginning to think that anti-nutrients, malnourishment and autoimmune should be the focus. What if it's not starch or saturated fats, maybe there desired by humans. What is the driving factor is an impairment to our immune system that effects the lipid metabolism, the glucose metabolism and much more! What drive the the immune system to act this way? Is it excessive sugar, fat? Or is it just malnourishment and anti-nutrients that trigger an immune response. What if polyphenols were actually stressing the digestive system when we consume too much? I believe there is flvalue to both starch sugar and fats especially saturated fats.
When you look in the dictionary for the word CLARITY you will find Dr. B's picture next to it. Well done, ooooh soooo well done. Thank you
Thank you so much, Doctor. Yes this is very deep. As a complete layperson, I can grasp most of it if I really pay attention and listen a second time on another day. I appreciate this information so much. Myself, my family and even three generations back have struggled with obesity. It is good to understand the mechanisms. I have completely reversed pre diabetes, fatty liver, high BP, but the excess 50 lbs of fat defy me at every turn. 63 yr old female, 5'3". I would love to eliminate the excess fat. I am working at increasing insulin sensitivity.
Is it possible to use diagrams, pictures and slides in these clips? I am sure they would help clarify a lot of things.
OK, you opened another rabbit hole for me, one that sounds near and dear to you. Ceramides and sphingolipid family. I want to know more details as it this appears to be a primary key holder! Pathway interactions, how and where they fit! Sounds like you would be the perfect one to lead the way in informing us.