Heart Health: Fat Matters
Ғылым және технология
In this episode of The Metabolic Classroom, Dr. Ben Bikman challenges the traditional view that saturated fats are the primary cause of atherosclerotic plaques and heart disease. He asserts that while plaques, or atheromas, in coronary arteries are composed partly of fats and foam cells, the exact process of plaque formation remains speculative. Dr. Bikman emphasizes that anyone claiming to know the definitive cause of plaque formation is likely overstating their knowledge. Foam cells, which are fat-laden macrophages, play a critical role in plaque development and are consistently present at the sites of these plaques.
Dr. Bikman explains that inflammation is a significant factor in atherosclerosis, and C-reactive protein (CRP), a marker of inflammation, is a better predictor of heart disease than LDL cholesterol. He describes how macrophages engulf oxidized LDL cholesterol, turning into foam cells and secreting pro-inflammatory proteins like CRP. This process is driven by the presence of oxidized lipids, particularly those derived from omega-6 polyunsaturated fats such as linoleic acid, which are prevalent in modern diets due to the widespread use of vegetable oils.
Ben highlights several studies to support his argument. A notable study from 1979 by Brown and Goldstein showed that macrophages only consume LDL cholesterol when it is oxidized, not in its native form. Another study from 1998 found that oxidized LDL containing specific bioactive lipids, nine and 13 HODE, is particularly problematic. These oxidized lipids are derived from linoleic acid, not from saturated or monounsaturated fats. Moreover, historical dietary studies, such as the Minnesota Coronary Experiment and the Sydney Diet Heart Study, revealed that participants consuming more polyunsaturated fats had higher mortality rates than those consuming saturated fats.
To conclude, Dr. Bikman argues that the traditional belief that saturated fat causes heart disease is flawed. He points out that recent studies, including a correlational study published in the British Medical Journal, show that refined grains, not saturated fats, are more strongly linked to heart disease and overall mortality. He suggests that the real dietary culprit is the overconsumption of omega-6 polyunsaturated fats, particularly linoleic acid, found in processed foods. This shift in perspective underscores the importance of reevaluating dietary guidelines and focusing on the types of fats consumed.
00:18 - Challenging Traditional Views on Saturated Fats
01:26 - Uncertainty About Plaque Formation
02:22 - Inflammation and Heart Disease Predictors
03:23 - Foam Cells and Macrophages
04:37 - Brown and Goldstein's 1979 Study
06:51 - Role of Oxidized Lipids in Atherosclerosis
08:51 - 1998 Study on Hydroxy Fatty Acids
11:19 - Ramsden’s 2012 Study
13:23 - Reanalysis of Old Dietary Studies
15:27 - Correlation Studies and Refined Grains
16:25 - Rethinking Dietary Fats
#HeartHealth #SaturatedFat #Atherosclerosis #Inflammation #InsulinResistance #LDLCholesterol #OxidizedLDL #FoamCells #Macrophages #BenBikman #MetabolicHealth #CholesterolMyths #LinoleicAcid #PolyunsaturatedFats #DietaryFats #CardiovascularResearch
Studies referenced:
Binding Site on Macrophages that Mediates Uptake in Degradation by Brown and Goldstein (1979): academic.oup.com/clinchem/art...
Oxidized LDL Regulates Macrophage Gene Expression (1998): You can find more details on this study in resources like ScienceDirect and Cell Journal (you may need specific access or subscriptions to retrieve full texts).
Strong Increase in Hydroxy Fatty Acids Derived from Linoleic Acid in Human Low-Density Lipoproteins of Atherosclerotic Patients (1998): www.sciencegate.app/document/...
Learn more: www.insuliniq.com
Пікірлер: 128
Medical students with Dr Bikman as a professor are extremely fortunate. He is the best at explaining things and knows more about metabolism than probably anyone on the planet. To me, he represents hope for the future of medicine.
@beaubolinger1521
28 күн бұрын
Totally agree from Australia 🥩🥚🥑🍤🦘🦌
@sharonlasper8999
28 күн бұрын
Agreed
@sanketchavan9456
22 күн бұрын
True
In 1999 my cardiologist told me emphatically that my vegan diet CAUSED my heart attack I had in front of him during a stress test . He was the smartest cardiologist I ever knew, he stopped my early death and made me stop being a "stupid vegan" and return to eating meat and fish. He was way ahead of his time in this regard.
@jandjhirst
25 күн бұрын
Were you still eating fried food and vegetable oils?
@andredaedone5
24 күн бұрын
Veganism is a disease.
I watched this episode with a smile on my face while eating fresh cut steak, seared in real butter and seasoned with fine keltic salt. (I'm a carnivore btw,) Thank you again Ben 👌🏻
@ArtLoverScotland
28 күн бұрын
Yep good on you! I am about half hour from cooking my ribeye then loading it with pure butter and pure mineral salt.
Ben is so clear and articulate, just fabulous, and his book 'Why we get sick' is phenomenal.
@doddsalfa
28 күн бұрын
Still has been debunked numerous times
@jameschesterton
27 күн бұрын
@@doddsalfa Can you point me to that please, I am interested.
@doddsalfa
27 күн бұрын
@@jameschesterton been debunked by Lane Norton phd and Chris MacAskill earth scientist in Plant Chomper for instance
@carrie2550
27 күн бұрын
@@doddsalfa I think you should follow up this statement with the actual proof.
@doddsalfa
27 күн бұрын
@@carrie2550 if you are not in a cult you should follow this up with a better education
I went HFLC a year ago and feel so much better. Dr. Bikman is a leader in health and research.
Well done sir!!! 20 years in commercial pharma speaking with science-types and you best them all in your clear discussions...thank you!
Avoid eating over-processed stuff from Bags, Boxes, & Barcodes! Love these talks so much!
Carnivore for 14 months, haven't felt this good since my 30's and my panels are now excellent. There are no "essential" carbs.
If you look up the side effects of eating just rabbit (it has no fat!) they call it Protein poisoning. Protein poisoning is when the body takes in too much protein with not enough fat and carbohydrates for a long period of time. Other names for this are “rabbit starvation” or “mal de caribou.” These terms came about to describe only consuming very lean proteins, such as rabbit, without consuming other nutrients. We need Fat!
@yoso585
27 күн бұрын
Don’t need much fat, carbohydrate, or fat. Won’t live for long on just one them either. Most may do well zero carbs. But certainly not all.
This is the first time I've heard this amount of depth on which specific inflamed molecules macrophages are consuming that eventually end up as plaque. Excellent video!
Thanks to all!
I’ve just finished reading Dr Bikman’s book ‘Why we get Sick’. Excellent book! Recommended reading. One of those books that you can read again and again!
@paulblijkers1549
20 күн бұрын
Yes, I like Dr Bikman's book too ("Why we get sick"). But he also describes atherosclerosis in Part 1 Chapter 2...is he speculating too...?
Between listening to Dr. Ben Bikman, Dr. Anthony Chaffee, Dr. Shawn Baker, and Dr. Ken Berry I have switched to a carnivore diet and feeling better than ever. I also do Mike Mentzer consolation workout routine once a week to stay strong for health span, because what's the point in increasing life span if you can't enjoy it up into that point.
I would love him to do a video on the Randle cycle.
Love it! And so glad the panel had such an integral part in the discussion.....
@jacquietarr7280
28 күн бұрын
He is the Prof. 😊
As always, a brilliant and informative presentation. Thank you Dr. Bikman.
Thank you! I love hearing your thoughts and discoveries!❤
This is really tough for the layman because there are brave doctors willing to buck the system and admit that the fat centric model of CVD is not accurate, yet all the medical licensing organizations still cling to it. So it gives the one the feeling that you are experimenting with fringe theories by not going by the established “guidelines.”
Great class . Thanks Ben
Thank you
Outstanding explanation of truth.
To this very day, the great majority of American primary care doctors and cardiologists, under the spell of the AHA, STILL warn against eating too much saturated fat. Wouldn't you think that our medical professionals would keep up with the latest developments in the world of metabolic and cardiovascular disease? It is therefore imperative that we patients follow "critical thinking" scientists like Dr. Ben Bikman, et al, to improve our health and prolong our lives!
@lonmccarley5072
28 күн бұрын
No
Brilliant conversarion and information. Thank-you so much.
Outstanding as always. Thank you :)
Thank you for explaining this, Dr. B!
Thank you for sharing your knowledge in such an interesting and concise manner. Your work is changing the way we understand metabolic health.
I have saved this video to reference for every conversation I have with my aging parents. Their denialism of the truth is so scary.
Thank you for this veritable treasure trove of information! Someday, the processed grains industry, read as cereals, will be held accountable for the decades of lying and disease they caused.
@sashak441
28 күн бұрын
how about a big fat lawsuit against them!
@cassieoz1702
28 күн бұрын
Not gonna happen. Way too much complicity from USDA, FDA, AHA etcetera. They haven't accepted any responsibility for all the folks they killed by actively pushing hydrogenated margarines for years.
I wish I could be Student of Prof. Dr. Benjamin Bikman
@jobrown8146
28 күн бұрын
We are ...
@ProductiveHealthPH
28 күн бұрын
@@jobrown8146 yeah, definitely. I mean in his institute.
Dr Ben Bikman thank you for everything you do for me and this community. Carnivore for life 💪🏼
Excellent presentation. Thanks.
I’m still waiting to hear the root cause of the initial insult to the artery wall. You mention inflammation, which if acute is a natural response to an injury. I appreciate the information you’re sharing with the public. Thanks
@Petunia-fl9lu
28 күн бұрын
read 'the clot thickens'
@sunrisetacticalgear2676
28 күн бұрын
@@Petunia-fl9lu thank you!
Love your information SIR keep up your great work!!!!!!
Incredible studies that come out after 60years ! Why have they been concealed?
@onlinemarketerpro
28 күн бұрын
Follow rhe money, the purpose of some studies is to create a pill to give to peple.
@annewimsey6952
22 күн бұрын
When Dr. ATKINS, about 50 years ago now, wrote his ground-breaking books the Sugar Industry used Congress to grill him ( I have the transcripts still!) with an eye to lifting his medical license, shameful! Of course they failed as he used Science!!!!! TheSugar I dustry have only grown in power since then, and allied with Big Pharma.
Brilliantly explained! 👍🏻
👍👍👍 Just had to gives this more than one thumbs up.
Read the Clot Thickens by Dr Malcolm Kendrick
Wow thank you So clearly explained
Excellent, clear and concise summary of the relevant facts about fat and its association with heart health
Fantastic ..
Dr Bikman great lesson. Can you cover the “Randle Cycle”?
Another great video, thank you! A bit confused though… In a study (Gertz et al 1991), the researchers discovered that the composition of “plaques” was as follows: fibrous tissue (87 ± 8%), calcific deposits (7 ± 6%), pultaceous debris (5 ± 4%) and foam cells (1 ± 1%). So, surprisingly, foam cells only a very small component of the atherosclerosis plaque. Also no mention of Lp(a)! Are we sure LDL found in foam cells isLDL or is it also Lp(a)? Another study (Rath et al 1989) mentioned: “High serum Lp(a) also led to a significant increase of apo B In the arterial wall. This Initial study showed that Lp(a) accumulates in the arterial wall, partly in the form of lipoprotein-like particles, therefore contributing to plaque formation and coronary heart disease.” What are your thoughts about this? (references from Malcom Kendrick's book “The clot thickens”)
Dejar dr Ben, ❤ I hope you can do a video about food sensitivities and insulin resistance. How they are connected.
Dr. Bikman please comment on a well-exercised healthy adult who produces low or no ketonuria at a 24 hour fast and who also has a fasting insulin of 5 or less.
Excellent classroom as usual. Could you do a topic about alpha linoleic acid and the best way to bring it as it is a essential w3 fatty acid. In France we recommand to take canola oil ! Maybe it is not the best idea as it is also full of linoleic acid
Is there any news on plant fats containing phytosterols mimicking animal cholesterol causing lesions?
@stevenmcc6052
28 күн бұрын
Main issues seem to be elevated glucose causing damage to glycocalix. Also glycating ldl making pattern B. Small ldl can get in where u have damaged glycocalix. Also oxidising omega 6. Akso fructose aging good tissue 7x faster than glucose.
@mystrength5640
28 күн бұрын
@@stevenmcc6052 Thank you, Difficult to hear and realise that Fructose from Fruit can do so damage! 😟
Has the mechanistic data on uptake of oxidised LDL by macrophages been verified in mice (in vivo) as well?
Thank you Dr. Bikman! Has the jury reached its verdict!?!?!?
Awesome description of the process.. is there a test to see how much oxidized ldl you have in your system?
@paulblijkers1549
20 күн бұрын
LDL ox (quite expensive, I think...)
How do you respond to the claims that saturated fats decrease cell membrane fluidity and make it rigid or stiff ? Many thanks
Ancient human diets would have included nuts, poultry,, and pork which have significant amounts of Omega-6 Linoleic acid. It may be that consumption of Omega-6 has increased and the Omega-6 found in processed foods has been oxidized through industrial processing.
@JasonBuckman
28 күн бұрын
Whole foods, real food.
@prunelle19
28 күн бұрын
Lard has less than 9% of Omega 6. This is less than olive oil. Animal sourced Omega 6 is not oxydized and can be used for energy
Just had an "aha moment". Now I understand *why* some people are saying that it is the seed oils. The pieces of the puzzle (from what I've been listening to over the last 2.5 years) are starting to make a lot of sense.
Where should we get our essential linoleic acid and how much of it ?
Whats the 90 day plan to reduce insulin resistance?
I've eliminated all processed foods from my regular diet, and feel great. But it's quite obvious that the animals today have a much higher fat content than the animals a few decades ago, which has to be a contributor to the increase in fat. Obviously frying food in oil is the worst, but what is the consequences of modern animal agriculture and higher fat ratios?
Hmm...where to get the large streaky bacon the size of Einstein's head in the background? 🙂
Are there any healthy Linoleic acids? I thought eggs were healthy, but they are high in linoleic acid.
But Omega 6 and Omega 3 fats are the only essential fats which we need to consume, we cannot make them. We do not require mono or saturated fats at all in out diet, but out metabolism does require Omega 6 and Omega 3 fats. It's not the polyunsaturated fats which are the problem, it's the industrial processing of them. They become technically rancid (spoiled), and this causes metabolic damage.
Insulin Spikes Artery-Clogging Plaque: NEW Study kzread.info/dash/bejne/kYSej8Rqe7K_gaQ.html
Im munching on a stick of kerrygold butter.
where do these oxidized LDL molecules come from?
@danacamp5437
28 күн бұрын
Inflammation
@hektor6766
24 күн бұрын
LDL produced in the body in which the apolipoproteins are attacked by Reactive Oxygen Species (ROS) introduced by an abundance of oxygen-rich carbohydrates.
👍
👏👏
Shockingly info...about omega 6 who's causing almost any disease!
I am a Lion so I only eat fatty beef and fatty lamb. Water and salt. I have no fear of getting any issue with my way of eating because it is the healthiest way.to.eat.
Dr Malcolm Kendrick has put forward his thrombogenic hypothesis for causing atherosclerosis. It seems like you're suggesting people such as him are speaking from a false sense of authority? I'm currently of the opinion that his is the best model, is this incorrect? Or are you speaking of other "authorities"?
@paulblijkers1549
20 күн бұрын
There are other "experts" who are thinking like Dr Kendrick. He describes atherosclerosis in a way that makes sense to me.
Dr Bikman, I have high blood sugar and BP can you please tell me why my BS is high i watch everything I eat which are low carb under 50 grams of carbs per day I do intermittent i eat no sugar never had a sweet tooth. Intermittent fasting 18/6 per day but I cannot lose the weight its only around my tummy! I am thanking that maybe its my thyroids because I have no gallbladder or uterus due to a complete hysterectomy. My doctor only wants to put me on meds! Please help I even follow that new scientists who talk about eating salads, and veggies first then proteins and carbs last❤
@Habanero777
28 күн бұрын
Wake up, call. You are doing 50g of carbs a day. That is your sugar. Do you not understand the metabolic process?😮 All carbohydrates turned right into sugar glucose. No, Bueno dump your carbs.
@Habanero777
28 күн бұрын
Please listen to Doctor ovadia and also Doctor cywes. Also watch Doctor kenberry's videos. Because you're just not seeing the light and it's right in your face. You are eating carbohydrates. You cannot eat carbohydrates.
@insuliniq
28 күн бұрын
Thanks for sharing. Sorry that you are struggling. You may want to consider joining our community to get a little more support and some ideas from our coaching team and from other like-minded people working on their metabolic health. You can do a 10-day trial at no cost: www.insuliniq.com/insulin-iq-community-membership-signup
@Momtocam1997
28 күн бұрын
A deficiency of iodine and selenium can cause issues..that correlate with thyroid problems. Also carbs could be decreased lower..I do 20 or under grams per day. Until I cut out all grains, my weight loss stalled. I make cloud bread now..very simple..using eggs and cream cheese.
@quattr03
28 күн бұрын
Just share my own experience...I have about the same or a bit lesser carbs/daily like you. I do Zone 2 running (very easy, slow running, some people or most walk by me) at least 3-4 times/week, 40 min each. I also walk after meals for 1/2 hr. Every night before bed I meditate about 10 minutes. My BP was 130+/80 now every am is around 117/68 most times. The meditation for me helps a lot for BP. Went to see my nutritionist, even though I've gained 3 lbs since I've started the new meals plan, my body mass fat is decreasing (as I've gained more muscles) and BMI is still the same 21.3. If you can't do Zone 2, please try meditation before bed.
From advice from my doctor and indicative of blood tests I wont be gorging on cheese again
Bear in mind there is no such thing as an essential saturated fatty acid
Why use omega6??? Nobody dies due to ncolorectal cancer due to too much saturated fat??
Bacon is high in linoleic acid. Yet, it is saturated. Is there something in the structure of it or something?
@JasonBuckman
28 күн бұрын
Bacon fat is actually mostly unsaturated. It's the stearic acid and palmitic acid that are saturated. Oleic acid, the most predominant fat in pork, is unsaturated, and so is the linoleic acid.
@williammorgan7769
22 күн бұрын
Bacon has omega 6 AND saturated fat. The omega 6 in it isn’t saturated.
@JasonBuckman
22 күн бұрын
@@williammorgan7769 It's actually mostly oleic, monounsaturated.
Lesson is to all is, simply stop eating all carbs, and seed based oils. Carnivore all the way!
Funny thing is most information point to saturated fat as causation for oxidized cholesterol. No mention of omega 6 and polyunsaturated fats.
@hektor6766
24 күн бұрын
Study your basic chemistry. Saturated fat has no double bonds for oxygen species to attack. Polyunsaturated fats such as linoleic acid (Omega-6) have many double bonds susceptible to peroxygenation. The information you've been getting makes no sense.
@williammorgan7769
22 күн бұрын
Saturated fat isn’t the problem. It’s the least likely fat to oxidize.
@janetmcburney4582
22 күн бұрын
I agree that saturated fat is not the cause but polyunsaturated is, but if you Google oxidated cholesterol it points the finger at saturated fat.
Thank you