The Michael J. Fox Foundation for Parkinson's Research
The Michael J. Fox Foundation for Parkinson's Research
The Michael J. Fox Foundation is dedicated to finding better treatments and, ultimately, a cure for Parkinson's disease.
Find us at
www.michaeljfox.org
www.teamfox.org
foxtrialfinder.michaeljfox.org/
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Michael J Fox you're so cool still a funny man.Thank you.
Congratulations, great effort! Volevo condividere queste ricerche italiane: "New hope for patients suffering from Parkinson's disease. An innovative anti-neuroinflammation therapy manages to counteract involuntary muscle movements and reduce motor blockage. But other benefits concern the quality of sleep, paresthesias and mood, restoring a good quality of life. This is what emerges from a study conceived by Stefania Brotini, a neurology specialist and expert in degenerative diseases and sleep disorders, from the Empoli hospital, published in the international scientific journal CNS & neurological disorders drug targets From a molecular point of view, the neuroprotective role of the endocannabinoid system was highlighted, which has the ability to reduce the release of the excitatory neurotransmitter glutamate and the production of pro-inflammatory molecules - continues the expert - And in this sense ultramicronized Palmitoylethanolamide (PEA -um), an endogenous lipid molecule acts as a cellular balancer. Hence the idea of evaluating the exogenous administration of PEA-um, the ultra-micronized formulation of PEA in a group of parkinsonian patients. «The results were exciting, the dyskinesias were significantly reduced and there was also an increase in the duration of the dopamine effect - states Brotini - In addition to the classic therapy, in fact, Pea-um can act as an effective adjuvant to reduce involuntary movements or the duration of the motor block. It therefore reduces the side effects of the disease and traditional therapy and delays the course of the disease even in an advanced stage. In summary, the addition of ultra-micronized PEA demonstrated a notable improvement in motor symptoms, but also in many non-motor symptoms." It takes about two months to start experiencing the first beneficial effects of the PEA supplement, after which it is possible to evaluate a possible change in the daily dosage. Generally, as symptoms decrease, daily intakes of palmitoylethanolamide are also reduced. In general, for PEA it is not the daily quantity consumed that is so important, but long-term use; in fact, to fully exploit its potential, it is important to take it for a fairly long period of time.This is an ultramicronized PEA supplement, which is already on the market. Being naturally produced by our body, PEA is always well tolerated and we can take it in the form of a supplement to obtain benefits.
Thanks to Michael, you are a kind person. There is a need for so much kindness. I hope that this natural instance named with an acronym PEA, discovered by Rita Levi Montalcini, can help you, there are positive experiments. "What emerged from the study is that, contrary to what we believed in the past, the neuroinflammatory process arises before the degeneration of neuronal synapses, which means that it is not the consequence as we believed in the past. Therefore the degeneration of Parkinson's is secondary to chronic neuroinflammation and not vice versa", explains the expert Stefania Brotini. This discovery has led to the study of lipid molecules that can play an essential primary role in combating chronic neuroinflammation. "Among these, ultramicronized Palmitoylethanolamide (PEA- um), an endogenous lipid molecule that acts as a cellular balancer and has the ability to be produced 'on demand' mainly by non-neuronal cells (mast cells, astrocytes and microglia), manages to counteract harmful phenomena affecting the central nervous system. Endogenous PEA counteracts the onset of neuroinflammatory phenomena through the inhibitory control of non-neuronal cells, i.e. neuroglia, when these are hyperactive" ... Ciò che è emerso dallo studio è che, al contrario di quanto credevamo in passato, il processo neuroinfiammatorio insorge prima della degenerazione delle sinapsi neuronali, il che significa che non è la conseguenza come credevamo in passato. Quindi la degenerazione del Parkinson è secondaria alla neuroinfiammazione cronica e non viceversa", spiega l'esperta. Questa scoperta ha portato allo studio di molecole lipidiche che possono svolgere un ruolo primario essenziale per combattere la neuroinfiammazione cronica. "Tra queste la Palmitoiletanolamideultramicronizzata (PEA-um), una molecola lipidica endogena che agisce da equilibratore cellulare e ha la capacità di essere prodotta 'on demand' principalmente dalle cellule non neuronali (mastociti, astrociti e microglia), riesce a contrastare i fenomeni lesivi a carico del sistema nervoso centrale. La PEA endogena contrasta l'insorgenza di fenomeni neuroinfiammatori attraverso il controllo inibitorio delle cellule non neuronali, cioè della neuroglia, quando queste risultano iperattive", spiega "Nuove speranze per i pazienti affetti dalla malattia di Parkinson. Un’innovativa terapia anti-neuroinfiammazione riesce a contrastare i movimenti muscolari involontari e a ridurre il blocco motorio. Ma altri benefici riguardano la qualità del sonno, parestesie e tono dell’umore, restituendo una buona qualità della vita. E’ quanto emerge da uno studio ideato da Stefania Brotini, medico specialista in neurologia e esperta in malattie degenerative e disturbi del sonno, dell’ospedale di Empoli, pubblicato sulla rivista scientifica internazionale CNS & neurological disorders drug targets. Da un punto di vista molecolare si è evidenziato il ruolo neuroprotettivo del sistema endocannabinoide, che ha la capacità di ridurre il rilascio del neurotrasmettitore eccitatorio glutammato e la produzione di molecole pro-infiammatorie - prosegue l’esperta - E in questo senso la Palmitoiletanolamide ultramicronizzata (PEA-um), una molecola lipidica endogena agisce da equilibratore cellulare. Da qui è nata l’idea di valutare la somministrazione esogena di PEA-um, la formulazione di ultra-micronizzata di PEA in un gruppo di pazienti parkinsoniani. «I risultati sono stati entusiasmanti, le discinesie si sono notevolmente ridotte e si è verificato pure un incremento della durata dell’effetto della dopamina - afferma Brotini - In aggiunta alla terapia classica, infatti, la Pea-um può fare da efficace coadiuvante per ridurre i movimenti involontari o la durata del blocco motorio. Riduce quindi gli effetti collaterali della malattia e della terapia tradizionale e ritarda il decorso della malattia anche in fase avanzata. In sintesi, l’aggiunta di PEA ultra-micronizzata ha dimostrato un miglioramento notevole dei sintomi motori, ma anche di molti sintomi non motori». TRASLATION: "New hope for patients suffering from Parkinson's disease. An innovative anti-neuroinflammation therapy manages to counteract involuntary muscle movements and reduce motor blockage. But other benefits concern the quality of sleep, paresthesias and mood, restoring a good quality of life. This is what emerges from a study conceived by Stefania Brotini, a neurology specialist and expert in degenerative diseases and sleep disorders, from the Empoli hospital, published in the international scientific journal CNS & neurological disorders drug targets From a molecular point of view, the neuroprotective role of the endocannabinoid system was highlighted, which has the ability to reduce the release of the excitatory neurotransmitter glutamate and the production of pro-inflammatory molecules - continues the expert - And in this sense ultramicronized Palmitoylethanolamide (PEA -um), an endogenous lipid molecule acts as a cellular balancer. Hence the idea of evaluating the exogenous administration of PEA-um, the ultra-micronized formulation of PEA in a group of parkinsonian patients. «The results were exciting, the dyskinesias were significantly reduced and there was also an increase in the duration of the dopamine effect - states Brotini - In addition to the classic therapy, in fact, Pea-um can act as an effective adjuvant to reduce involuntary movements or the duration of the motor block. It therefore reduces the side effects of the disease and of traditional therapy and delays the course of the disease even in an advanced stage. In summary, the addition of ultra-micronized PEA demonstrated a notable improvement in motor symptoms, but also in many non-motor symptoms." pubmed.ncbi.nlm.nih.gov/35625595/ The ultramicronized PEA supplement is already on the market. Being naturally produced by our body, PEA is always well tolerated and we can take it in the form of a supplement to obtain benefits. It has no interactions with drugs.
I love you Michael,Your a great human being brother 👍🏾
Mjf what a dude !!!❤ 😊
It's really intriguing watching this about people with parkinsons and michael j fox interviewing them. Simultaneously, it's very real that anyone could get it and that the human body is not indestructible. Thank God for Michael J Fox's beautifully crafted film and TV work before being robbed of his talent and basic life skills. Awesome short doco.
Hello! My husband has lived with Parkinson Disease 🦠 🦠 all his life and it has caused him lots of pain and discomforts which are unbearable. He has undergo so many therapy and none helped except for Dr Madida Sam natural protocol he undergo and after the treatment plans my husband PD 🦠symptoms was all reversed and my husband is now 48yrs and he looks strong, he is healthy and very okay now… All thanks to Dr Madida on KZread👍🎉
Hello! My husband has lived with Parkinson Disease 🦠 🦠 all his life and it has caused him lots of pain and discomforts which are unbearable. He has undergo so many therapy and none helped except for Dr Madida Sam natural protocol he undergo and after the treatment plans my husband PD 🦠symptoms was all reversed and my husband is now 48yrs and he looks strong, he is healthy and very okay now… All thanks to Dr Madida on KZread👍
My life story isn’t sweet because all my life i have been suffering, even when i properly got diagnosed with Parkinson Disease everything changed and complicated but all through the journey and the person I must thank is Dr Madida Sam i later found on KZread who changed my life for good, He cured my neurological disease(Parkinson Disease) completely with their Parkinson herbal medicine. I recommend them 100% to anyone sick, they will help you and cure you. Again they’re so caring and loving ❤❤️❤️..
My prayers are with you all and I know how you all feels, my Dad suffered same illness for 13 years until madida herbal center came to his aid and cured him with their natural PD herbal medicine, Click and search #DrMadida, and let your Parkinson Disease be taken care of and be cured just same way my Dad’s own was taken care of and cured👌👌…
&u000
Doctors caused my MIL's Parkinson's disease...😐
Perkinson is a very awful disease My father has it and it's very painful to see him in this condition.. Because there is no cure till now but yoga and exercises with medication helps my father to fight with this disease.. Pray for him ❤
My comment The app you have to sign up for the study doesn't allow voice recognition well since my hands don't stop shaking I'm not sure how you expect me to fill out the form by the way I'm using speech recognition to write this response I've already emailed you guys hopefully you'll get back to me
MJF IS A FAKE… he looks more like he’s acting and acting as a spastic than someone with Parkinson’s… why was he paid off to end his career with this disease? What monetary figure was enough for him to pretend that he has this disease ? What does the elite gain from it? Oh that’s right Big Pharma… 😮😮
wow youre out of touch with reality
My life story isn’t sweet because all my life i have been suffering, even when i properly got diagnosed with Parkinson Disease everything changed and complicated but all through the journey and the person I must thank is Dr Madida Sam i later found on KZread who changed my life for good, He cured my neurological disease(Parkinson Disease) completely with their Parkinson herbal medicine. I recommend them 100% to anyone sick, they will help you and cure you. Again they’re so caring and loving ❤❤️❤️
anyone has evidence that Parkinson's could be reversed as stated by the person in this video kzread.info/dash/bejne/hq1pzpeTdpSWobw.html&lc=UgyUNNrOBEVBtIeOETZ4AaABAg.A4mYWEA2WXNA4pUN3vgpP0
The background music is distracting sorry 😔
Marijuana works for my symptoms of Parkinson's without side affects with one exception and that is munchies! I trust the plant more than something from big pharma. By the way, I have been living with Parkinson's for over twenty years. Four years ago I received a recumbent tadpole trike as a gift and started riding. The exercise in conjunction with medical cannabis have improved thee quality of my life and the lives of my family, my caregivers.
Because you are a Dr I'm 🧐 I've started it today for dystonia i hope it helps 🙏🏽 i don't want to need the increase of baclophin 😢
As an early onset PD patient, I cannot adequately express my appreciation for the MJF Foundation and MJF, himself has helped my in my journey. Thank you.
Il n’y a que Coldplay qui accompagne Michael j Fox ’
Salam! Ərim bütün həyatı boyu Parkinson Xəstəliyi ilə yaşayıb və bu, ona çoxlu ağrı və dözülməz narahatlıqlara səbəb olub. O, çoxlu müalicələrdən keçdi və Dr Madida Sam təbii protokolundan başqa heç kim kömək etmədi və müalicə planlarından sonra ərimin PD simptomları tamamilə dəyişdi və ərimin indi 48 yaşı var və o, güclü görünür, sağlamdır və indi çox yaxşıdır... KZread-da Dr.Madidə təşəkkürlər.
My life story isn’t sweet because all my life i have been suffering, even when i properly got diagnosed with Parkinson Disease everything changed and complicated but all through the journey and the person I must thank is Dr Madida Sam i later found on KZread who changed my life for good, He cured my neurological disease(Parkinson Disease) completely with their Parkinson herbal medicine. I recommend them 100% to anyone sick, they will help you and cure you. Again they’re so caring and loving ❤❤️.
He is a good person and a great actor we wish him well.
I am a Scottish author who was diagnosed with Parkinson's four years ago. My next book, a charity book for PD, is about Parkinson's stories and I'd love an entry from the USA. This is what I am looking for. INTRODUCTION This book gathers stories from the Parkinson's community. With more than 40 symptoms, no two Parkinson’s sufferers seem the same. I decided to make this book a useful expression of Parkinsonian experiences. I have asked these questions to people with Parkinson’s Disease: What did you do before you got PD? Recall the moment you were diagnosed. Were you working at the time and, if so, did your work put in place any adjustments? How are you coping now? What can you still do? What can't you do now? Please finish your narrative (3 or 4 pages) with a section entitled CURIOUS FACTS about yourself or your experiences. Please send them to me at [email protected] and the book will emerge. Thank you to all who contribute. I can send you the four chapters | have already if you contact me. Thank you.
My life story isn’t sweet because all my life i have been suffering, even when i properly got diagnosed with Parkinson Disease everything changed and complicated but all through the journey and the person I must thank is Dr Madida Sam i later found on KZread who changed my life for good, He cured my neurological disease(Parkinson Disease) completely with their Parkinson herbal medicine. I recommend them 100% to anyone sick, they will help you and cure you. Again they’re so caring and loving ❤..
Parkinson disease is a very terrible illness🤢, my Dad suffered from it for 19 years until we finally got a help and a medicine from Dr Madida that truly works that helped treat, cure and reversed all his symptoms…”My Dad is well a gain”
Mi mom passed away 10 years ago she had Parkinson her legs was stiff ,now she is on heaven with Lord no more suffering for her. Thank God
Its. Tainted. If SCHUMER a part of it. Think. About Michael. They only do. For THEMSELVES
Thank God, I am suffering from this disease n I know that cure would be find n would stop other people from getting it 🎉
Parkinson's hurts the patient and the caregiver.... God Bless everyone diagnosed.❤
‘‘I am not only happy am alive but also glad that "DrMadida" was able treat and cure me with his herbal medication of my parosmia, Meniere disease and Parkinson disease(PD) with their herbal treatment. My smile is so bright because I am happy ‘’
My prayers are with you all and I know how you all feels, my Dad suffered same illness for 13 years until madida herbal center came to his aid and cured him with their natural PD herbal medicine, Click and search #DrMadida, and let your Parkinson Disease be taken care of and be cured just same way my Dad’s own was taken care of and cured👌👌…
No mention of stomach pain here... my husband was diagnosed 2 years and has constant stomach pain after eating, this has led to serious weight loss and depression
Debilitating disease, and so much to learn about it. My most watched episode on my channel is my brilliant interview about Parkinson's disease. Clear and accurate information is always really appreciated.
As a person suffering from Parkinson's Disease I am absolutely thrilled at this good news. There are millions in the USA with this awful plague. No two people with PD have the same set symptoms. It's like a smorgasbord of symptoms and all we have right now are symptom relievers. No cure in sight. With the funding of more research perhaps we can find something before more people succumb. PD is on the rise around the world. Please help support PD research so we can find a cure for this disease.
I wish my Mom would have lived to see this day come to fruition. All the trauma and abuse she and I have endured from a five alarm apartment fire added to her demise and exacerbated her Parkinson's. I wish the government would have come to our aid.
Thanks Chuck. Please Biden - sign the bill !
The passing of this bill brings new hope for those living with PD & their families. Thank you for hearing our stories!
Wonderful news! I'm at a loss for words of gratitude.
Great news.
Amazing! I’m so happy!!
I hope this bill brings great successes and encourages more efforts like this for other diseases as well.
🙏
Chronic disease and pain pd frozen shoulder
There are plenty of studies which indicate that endorphins play a role in enhancing the release of dopamine and we all know the role that dopamine (or the lack of it) plays in the symptoms of PD. Exercise promotes the release of endorphins and this, at least in some people, will lift your natural dopamine levels without the side effects levadopa/carvadopa. I'm 71 and was diagnosed with PD about 5 years ago. Since my diagnosis I've concentrated on resistance training and stead-state cardio (mainly brisk walking). Since I began a program which I've refined over the years, the progression of my symptoms has slowed markedly and my quality of life has improved. I'm now fitter and stronger than I have ever been. When I am unable to excercise for a period of more than a day or two I *really* notice an upturn in my PD symptoms. Another thing I discovered is that creatine monohydrate (suggested as protective in at least one study) has also made a huge difference, significantly improving my stamina both physically and mentally. Exercise is natural and (at least in my case) the single most effective mitigation against PD, at least at the stage I find myself on my PD journey.
Unfortunately we don’t learn much from the doctors, it was hard for my husband and I to find a doctor who diagnosed him with Parkinson’s disease We have been seeing this neurologist for 3 years and now I feel like the doctor is losing interest in my husband case, I remember an appointment with him that my husband refused to do physical therapy and the doctor got very upset. Parkinson’s desease is brutal 😢
Thank you, Michael J. Fox !! ❤❤❤