What your ANA Pattern means

Is your ANA test leaving you with more questions than answers? (Yikes! Is it lupus?!) Today's video dives deep into ANA patterns and their implications. In this video you'll gain a clearer understanding of how the results are reported and what they do, and don’t, mean. *2024 update
🔗 Links:
Your Appointment Home Run Handbook - connectedrheumatology.com/app...
The guide you need to be able to tell your doc your story -and find get answers once and for all!
⏱Time Stamps:
00:00 Intro
00:40 What is the ANA test?
03:00 What does the ANA pattern mean?
04:35 Homogenous pattern
05:19 Speckled pattern
05:56 Dense Fine Speckled pattern
07:02 Centromere pattern
07:34 Cytoplasmic pattern
09:27 Convo Starters (Qs for you and your doc)
🎥 watch more:
5 things you need to know about your positive ANA - • 5 Things You Need To K...
Top 3 Facts about the anti-centromere Antibody - • Top 3 Facts about the ...
Top 10 Things to know about lupus - part 1 - • Top 10 Things to Know ...
Top 10 Things to know about lupus - part 2 - • Top 10 things to know ...
📖 References:
Damoiseaux, J. et al. Clinical relevance of HEp-2 indirect immunofluorescence patterns: the international Consensus on ANA patterns (ICAP) perspective. Ann Rheum Dis 2019; 78: 879-889.
Pisetsky, D. et al. New Insights into the role of antinuclear antibodies in systemic lupus erythematosus. Nat Rev Rheumatol. 2020 Oct; 16(10): 565-579.
⌨️ Contact us for business inquiries: info@connectedrheumatology.com
*Connected Rheumatology is not currently taking new patients
**Please note - we do not provide medical advice, opinions or diagnosis via email, phone or social media messaging.
👩🏻‍⚕️ About me:
Hello! I am Dr. Elizabeth Ortiz and I’m so happy you are here. I am a double board certified Rheumatologist with over 15 years experience practicing Rheumatology and am passionate about teaching & empowering patients to partner with their doctor.
Want more Connected Rheumatology?
✏️ BLOG : connectedrheumatology.com/blog/
🖥 WEBSITE: www.connectedrheumatology.com
🤝 LinkedIn: Connected Rheumatology, PLLC
* The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional. Any comments and/or recommendations made in the comment section by anyone other than Connected Rheumatology does not reflect the opinion or recommendation of Connected Rheumatology.*

Пікірлер: 65

  • @ElainesAutoimmuneAdventure
    @ElainesAutoimmuneAdventure4 ай бұрын

    Welcome back to KZread, Dr. Ortiz! Your great information and videos were truly missed by our community. So happy to see you back!

  • @katelawrence7445
    @katelawrence74454 ай бұрын

    I was a lab technician who worked in autoimmune and reading ANAs was one of my jobs. Interesting to learn how things have changed in the 10 years since I retired.

  • @jessicabracho8509
    @jessicabracho85094 ай бұрын

    Great new video!

  • @hegilento
    @hegilento2 ай бұрын

    Love the depth of discussion ❤

  • @honeyjewel333
    @honeyjewel3332 ай бұрын

    Thank you. This was very helpful. 🙏

  • @nicet.4388
    @nicet.43883 ай бұрын

    Thank you so much for your information. Very helpful!!❤

  • @SA-cb1fb
    @SA-cb1fb3 ай бұрын

    So good to see u here again. These videos r really helpful

  • @inkynfrost3183
    @inkynfrost31833 ай бұрын

    My pattern keeps changing. Speckled, then homogenous, then both speckled & homogenous, then speckled, then nuclear/dense fine speckled, all from Quest Lab. 1:320 for some years, now staying at 1:80. I keep asking about the pattern changing, told it probably doesn’t mean anthing (brushing me off). Low C3 complement, C4 is ok. Sensitive Sjogren’s panel negative. Lupus 12 panel was ok except ANA’s and Low c3. Severely unwell since 2012 with recurrent cluster of systemic lupus-like symptoms, tendon/connective tissue problems in my whole body. Recurrently peeing blood, no infection-bright red blood or microhematuria, leukocytes, protein, and “mild acute inflammation” in my urine tests. Scope was fine. Getting brushed off, being disbelieved then told “you’re doing something to make this happen there’s nothing wrong with you” when I show photos. It’s been a nightmare.

  • @camillebambi6449

    @camillebambi6449

    Күн бұрын

    Did they run a protein electrophoresis on you? If they did, did you have elevated IGA? I'd check that.

  • @patriciap.9034
    @patriciap.90344 ай бұрын

    It’s great to have you back doctor. I was just looking for you on the web last week and this first episode today has really made me feel great. You look good. I hope you are feeling well. Patricia.

  • @user-ed5jp3zf9m
    @user-ed5jp3zf9m4 ай бұрын

    I am so happy to see you on KZread again. It feel like I just went to visit my Rheumatologist which I wish it was you. I am Maria the one who did the painting for you. Hope to see you soon.

  • @tammymckeever5527
    @tammymckeever55272 ай бұрын

    I love your presentation! You give serious and helpful information but add a touch of humor and a refreshing amount of honesty! Appreciate you!

  • @LauriePetersonkk13
    @LauriePetersonkk133 ай бұрын

    I'm so thankful for this particular video and l was so stressed out with my ANA Centromere patters, and your video has calmed me. I am hoping on Thursday when my doctor reads my test results that he will pay clear attention to these results and pay attention to how l have been feeling. And most importantly that he will care. Thank you so much for being available for us all with your informative videos.

  • @dragonqueen3027
    @dragonqueen30272 ай бұрын

    Hi, thanks for this video! Very helpful! What does the titre result mean, please?

  • @shelliecreighton4032
    @shelliecreighton40324 ай бұрын

    Can you tell me anything about the Centriole Mitotic pattern? Thank you for posting♥️🤗

  • @thereserandolph6699
    @thereserandolph66994 ай бұрын

    Thanks

  • @iloveshaakah
    @iloveshaakah3 ай бұрын

    You rock!

  • @nancyrudisill5404
    @nancyrudisill5404Ай бұрын

    Thanks got diagnosed with a titer and pattern

  • @DJ-nk4dq
    @DJ-nk4dqАй бұрын

    My ANA comes out 1:1280 homogeneous pattern with a lot of symptoms. Further tests came back with elevated RF and Chromatin. I was diagnosed with Lupus. This was 6 years ago. Since then, I’ve developed a few other AI conditions that go hand in hand with Lupus, as well as Lupus complications. Good job in explaining ANA

  • @lavanyathammineni6200

    @lavanyathammineni6200

    15 күн бұрын

    Do we need to stop vitamin c supplements before ANA panel

  • @robinmoore4994
    @robinmoore49943 ай бұрын

    Is the IFA standard for the anti-ds dna? Thank you.

  • @pamandharoldyates1120
    @pamandharoldyates11203 ай бұрын

    I have a positive ANA, dense fine speckled pattern and 180 titer. I was diagnosed with autoimmune hypothyroidism with multi nodules and enlarged thyroid. I feel like I have another auto immune disease because I have extreme fatigue, joint pain, facial rash and many more symptoms. My endocrinologist referred me to a rheumatologist and the rheumatologist said my chances of having another autoimmune disease were low. My dsdna and smith were negative. C3 was normal but c4 was elevated. I was feeling good at the time of those blood test. Had just finished taking amoxicillin for a UTI. Any thoughts or maybe a different rheumatologist. He seems very disinterested in everything. Thanks

  • @mariahvigil9850
    @mariahvigil98502 ай бұрын

    Does it matter if you take the ANA test when you are in a flare up or not?

  • @RollinWithRosie
    @RollinWithRosie4 ай бұрын

    Mine was positive and speckled, positive SSA but negative SSB, IM CONFUSED sjogrens was positive

  • @shannonbraun5038
    @shannonbraun50383 ай бұрын

    Can you please possibly help me understand my results. I am currently diagnosed with Ehlers danlos syndrome, POTS, SLE, then IC. My ANA pattern is always speckled however, I am always also positive for centromere antibodies. My rheumatologist is confused because my ANA pattern is not centromere. She has redone blood tests for this three times and it's always positive. She's doing one more test in April to check for the centromere antibodies again. Any thoughts on what could be going on? I questioned her about if my Speckled ANA pattern could change into the Centromere pattern in which she said no. I also remember an older video in which you said blood work can show signs of things to come up later in life, so I'm concerned about the Centromere antibodies that have been consistently showing up. I'm not sure if I need to go to another rheumatologist for a second opinion. Any advice would be so incredibly helpful thank you.

  • @Intwodeep902
    @Intwodeep90220 күн бұрын

    I'm negative on everything except antihistone any words or wisdom on drug induced lupus? Thxss

  • @JenniferAdkins-tt7im
    @JenniferAdkins-tt7imАй бұрын

    Is a positive ANA A way of testing for Celiac Disease?

  • @eholden3
    @eholden34 ай бұрын

    I’m so confused. I was diagnosed with Antiphospholipid Syndrome in 2000 after PEs , stillborn daughter at 36 weeks, migraine and TIA symptoms as well as other symptoms. After years of being followed at Cedar Sinai I was finally diagnosed with Lupus by a rheumatology attending dr in 2011. By that time I had already had PE x 5 , bunches of TIAs and numerous superficial clots. I moved in 2020 and the new rheumatologist doesn’t think I have Lupus. I have symptoms of Lupus as well. Thing is that he’s convinced I don’t because I have dense fine specked patten 1:320 and I think one was 1:6 something. Any suggestions would be greatly appreciated. As far as I know even Antiphospholipid Syndrome is an autoimmune disease so how can I not have an autoimmune disease?

  • @ericapoe

    @ericapoe

    4 ай бұрын

    I can totally relate I’ve had a few ANA results back positive 1:320 homogenous pattern. My Rheumatologist doesn’t think I have lupus because I don’t present all the “classical” symptoms of lupus. It’s frustrating because I have a lot going on and with no specific answer.

  • @tessmoore3762

    @tessmoore3762

    2 ай бұрын

    My mother was diagnosed with Lupus back in the early 1980's. She was put on medication for it, but later was told it was a misdiagnosis, that she did not have it but actually some rare form of Cirosis of the liver. Seems its one they still have a hard time diagnosing.

  • @shellyw6086
    @shellyw608614 күн бұрын

    Can somebody answer what does a negative Ana ifa/ cytoplasmic staining present mean?

  • @nopressurenodiamonds5566
    @nopressurenodiamonds55662 ай бұрын

    I’m Ana positive with cytoplasmic pattern and my doctors act confused. Why is it they don’t know it can be associated with Lupus, Hepatitis, dermatomyositis?? So frustrating. I already meet the Lupus point criteria. I have major weight loss, severe stomach pain, numbness, Raynauds, joint pain, muscle weakness photosensitive rashes, burning knuckle rash, dry mouth and eyes, blood vessel inflammation, blood in urine from my kidney bleeding and still no diagnosis! After 3 years that finally suspect Lupus but won’t say for sure. I just want to feel better! Any tips or advice from anyone is appreciated! The burning knuckle rash has me thinking more Dermatomyositis.

  • @DJ-nk4dq

    @DJ-nk4dq

    Ай бұрын

    Ask them to give it a try and treat you as if you have Lupus, just to see if it works. For example, get on Plaquenile for a few months and see if it helps your symptoms. Don’t push for diagnosis but rather for treatment of your symptoms.

  • @nopressurenodiamonds5566

    @nopressurenodiamonds5566

    Ай бұрын

    @@DJ-nk4dq thank you, I was wondering why they haven't tried that route yet but ironically was just diagnosed today via lymph node biopsy. Of course I didnt want any disease but I knew I was sick just a matter of what it was or what they could do to treat me and get my quality of life back.

  • @nopressurenodiamonds5566

    @nopressurenodiamonds5566

    Ай бұрын

    @@DJ-nk4dq Lupus that is.

  • @CallOnJesus
    @CallOnJesus4 ай бұрын

    I have an ANA of 1:320, high esr and crp. Multiple joints with pain and multiple other conditions. My first round of antibody test have come back neg. Should my rheumatologist continue with more lab tests? I've been suffering for over 5 years now.

  • @DJ-nk4dq

    @DJ-nk4dq

    Ай бұрын

    My understanding is that 320 points to possible AI condition but it doesn’t have to mean that one is present. Your # is sort of a cut off point for suspicion. If you have other conditions, antibodies can be a little elevated but, most importantly, if you have joint pain with high ESR and CRP that should be treated. Hope you are getting some help already.

  • @CallOnJesus

    @CallOnJesus

    Ай бұрын

    I do have joint pain and both my CRP and ESR are elevated but the doctors seem to blow me off so I have given up and will have to deal with it myself.

  • @DJ-nk4dq

    @DJ-nk4dq

    Ай бұрын

    @@CallOnJesus sorry to hear. Hope you find some relief

  • @jillhontz3145

    @jillhontz3145

    20 күн бұрын

    Check into AVISE testing by Exagen. It is a highly sensitive test. If you call the company, they can tell you names of doctors in your area who are familiar with the testing and the results. You’ve been suffering for five years, so that should tell you something. You know your body.

  • @CallOnJesus

    @CallOnJesus

    20 күн бұрын

    ​@@jillhontz3145 thank you so nuch!

  • @Brunellesp
    @Brunellesp16 күн бұрын

    I got ANA pattern golgi apparatus and no one seems to know what this means. I have so many symptoms.

  • @charlottesettle8588
    @charlottesettle858813 күн бұрын

    It’s so depressing because I can’t even get in to see a rheumatologist😢 I’m living with the symptoms and it affects the quality of my daily life. My NP ran ANA and one came back positive. They did another with a panel. She said you do not have an autoimmune disease. It’s so hard when living with symptoms that has changed the quality and be told you’re fine. Any recommendations? Could an internal medicine doctor help?

  • @moniquemo2203
    @moniquemo2203Ай бұрын

    My ana and speckled pattern 1:160 came back positive. Drs did a 12 panel ana and all the panels were low positive. But Drs said it's negative and I don't have lupus.. I have a lot of musculoskeletal issues and psoriasis. Extreme fatigue, hair loss, lack of sleep and lots of nerve pain, numbness, tingling, prickly feeling and burning but the Drs say still no lupus.. esr, ana, CK and components c3,c4 elevated.

  • @jaco0712

    @jaco0712

    14 күн бұрын

    @moniquemo2203 what ever became if this?

  • @moniquemo2203

    @moniquemo2203

    12 күн бұрын

    @@jaco0712 nothing. I see my rheumatologist again this month but I believe they are going to refer me to another Dr out of state.. I'm also dealing with cervical radiculopathy

  • @moniquemo2203

    @moniquemo2203

    11 күн бұрын

    @@jaco0712 nothing.. I'm still waiting to see rheumatologist out of town that my rheumatologist is referring me to. I was just diagnosed with radiculopathy and fibromyalgia...

  • @machel9467
    @machel94673 ай бұрын

    Mine was Nucleolar 1:1280 I didn’t hear her list this one. Anyone have ideas?

  • @tessmoore3762

    @tessmoore3762

    2 ай бұрын

    That's what mine was too. I'm waiting to hear back from my doctor what this means. On the portal it says something about Sjogrens syndrome and systemic sclerosis/polymyositis. Have you heard anymore?

  • @machel9467

    @machel9467

    2 ай бұрын

    At this point I am being treated for Limited Cutaneous Scleroderma. Systemic sclerosis but a limited form of it. After further testing they found anti- centromere antibodies. Hopefully you find some answers

  • @tessmoore3762
    @tessmoore37622 ай бұрын

    My pattern was nucleolar, you didn't mention that one.

  • @nin5739

    @nin5739

    2 ай бұрын

    Mine was too

  • @sabipr18

    @sabipr18

    Ай бұрын

    Same :/

  • @DJ-nk4dq

    @DJ-nk4dq

    Ай бұрын

    I believe that’s homegeneous

  • @mohdhaseeb8009
    @mohdhaseeb80094 ай бұрын

    Are You Looking For Video Editor And Thumbnail Designer?

  • @AK-ur3xf
    @AK-ur3xf4 ай бұрын

    I am suffering from ankylosing spondylitis. I m 40 yr old. My penis is hanging down and is becoming very loose and soft. Is this happening because of my illness??

  • @johnsmith-ht3sy

    @johnsmith-ht3sy

    4 ай бұрын

    The two are not connected.

  • @vasthefox
    @vasthefox3 ай бұрын

    No REPLIES 😭

  • @daviddelguercio8458
    @daviddelguercio84583 ай бұрын

    Hi I had a positive Ana My Teter was 1:320 Pattern nuclear dense fine speckled I read that a nuclear dense fine speckled means I don’t really of autoimmune?

  • @MarthaDittman

    @MarthaDittman

    Ай бұрын

    I had a positive ana now 2 years later I have pulmonary fibrosis and RA. When I was in my 20's diagnosed with Addison's disease.

  • @lavanyathammineni6200

    @lavanyathammineni6200

    15 күн бұрын

    I got the same test result , how are you now

  • @daviddelguercio8458

    @daviddelguercio8458

    15 күн бұрын

    @@lavanyathammineni6200 hi I have the same symptoms I have been having. I recently saw a rheumatologist and I am scheduled for blood work next week to test specific antibodies. When I saw the doctor he wasn’t too concerned image anything but blood work will dig deeper.

  • @jaco0712

    @jaco0712

    14 күн бұрын

    @daviddelguercio8458 any updates? What are your #’s?

  • @charlottesettle8588
    @charlottesettle858813 күн бұрын

    It’s so depressing because I can’t even get in to see a rheumatologist😢 I’m living with the symptoms and it affects the quality of my daily life. My NP ran ANA and one came back positive. They did another with a panel. She said you do not have an autoimmune disease. It’s so hard when living with symptoms that has changed the quality and be told you’re fine. Any recommendations? Could an internal medicine doctor help?