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What is the Role of Norepinephrine in Depression?

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  • @buttaflyski
    @buttaflyski17 күн бұрын

    Bupropion is a life changer and it's role as a norepinephrine reuptake inhibitor makes so much more sense now... Thank you Dr. Jain. That medicine combined with exercise and healthy food is life changing. Really wish it was prescribed more often

  • @abrohamproductions8263
    @abrohamproductions82632 жыл бұрын

    I took zoloft for a year and it messed up my norepinephrine. Started an ADHD med to help with that and I feel like my self again.

  • @swopeboi

    @swopeboi

    2 жыл бұрын

    what medication if i may ask? on the same path rn

  • @abrohamproductions8263

    @abrohamproductions8263

    2 жыл бұрын

    @@swopeboi strattera

  • @Hanson032

    @Hanson032

    Жыл бұрын

    If you were prescribed Zoloft then it's possible that your Norepinephrine was already low

  • @christopher_ecclestone

    @christopher_ecclestone

    Жыл бұрын

    @@swopeboi I take Reboxetine which is a Norepinephrine reuptake inhibitor. Apart from the odd way all Antidepressants make you feel, the only other effect it had on me was to stop me falling asleep in the day, which in turn was helpful with my nighttime sleeping. It had no noticeable effects on my mood, but every person is different. I don't know if this is the medication the OP was referring to, but I do know Reboxetine is sometimes used as an off-label treatment for ADHD. Hope that helps

  • @Daemoknife

    @Daemoknife

    19 күн бұрын

    Usually, anxiety depletes noradrenaline because of being too much on fight or flight all day long, it causes adrenal fatigue (sometimes), I find that beta blockers is the ultimate way to control it so it doesnt spike and impacts cognition, mood, heart etc. It has an important role but too much can cause your heart to elevate too much, presenting symptoms of fatigue, lethargy, depression and much more. So both extremes leads to poor life quality. Propranolol is what actually what really helped me and I had been suffering from GAD since I was 13 years old and I am know 34, it doesn't control thoughts, but the physical symptoms just vanishes, you can't even get yourself a panic attack even if you wanted to (i have the ability to do so), this will eventually lead to a better psychology, better thoughts pattern which can actually help so much to go over anxiety and enjoy your day without the fear of feeling like crap somewhere. Elevated heart rate due to Norepinephrine has the tendency to excarbate anxiety, Sertraline elevates serotonin and has dopamine binding affinities too in order to make you feel more comfortable and happy, which helps you to feel in control of your emotions. They both work in synergy its just crazy how the body is a perfect symphony, it just blows my mind.

  • @LaymanAcademee
    @LaymanAcademee4 жыл бұрын

    It makes sense in some cases the anxiety can be caused by low norepinphrine instead high. I am experimenting on myself

  • @vectorx2907

    @vectorx2907

    Жыл бұрын

    epinephrine makes the anxiety the metabolite norepinephrine is the opposite

  • @mohdnasir5140
    @mohdnasir5140 Жыл бұрын

    Page 97 The sympathetic nervous system, through liberation of norepinephrine, plays a central role in the mobilization of free fatty acids by exerting a tonic influence.

  • @dianamonicamanta9289
    @dianamonicamanta92892 жыл бұрын

    Norepinphrine is altered by exercice? How come? I thought that by doing sports and being active one increases it's noradrenaline and dopamine.

  • @nebojsa1976
    @nebojsa19769 жыл бұрын

    What if I have a lot of norephinephrine? How do I reduce it? After exercise, I don't always feel good and the following day I feel anxious. I have problems talking in the morning and it appears like I can't have full breath, but just short breaths. I sweat a lot if social situations. My blood pressure is very good. If I stand and talk, it is extra effort. Essentially, I do social situations not naturally but forcefully. And my face if frowned. People sometime get scared. I do feel much better when taking Xanax. My short term memory is not good, but my logical thinking is perfect (too bad one can't work good without the other). The best position for me is when I'm laying in the bed. I feel the most relaxed at that time. If someone would yell at me, I'd choke and my voice would be very shallow and weak or no sound would come up and I'd be sweating profusely. Any help would be appreciated. Thanks.

  • @dynamictechllc7810

    @dynamictechllc7810

    9 жыл бұрын

    nebojsa1976 Please, don't ask youtube users, but a doctor or more specifically a psychiatrist.

  • @Ben-gp2fi

    @Ben-gp2fi

    8 жыл бұрын

    +nebojsa1976 Do more exercise not less and skip all these medication. Get Creatine, so you can do more sport. Go do a doctor or severals and let you check in and out. There is obviously something wrong.

  • @Matt-pi9jo

    @Matt-pi9jo

    4 жыл бұрын

    Adaptogenic herbs like ashwaghonda and rhodiola

  • @YZFMANIAC08

    @YZFMANIAC08

    4 жыл бұрын

    Coming from experience, strainous exercise creates more cortisol, more cortisol = more adrenaline simple as that!

  • @Crusae

    @Crusae

    3 жыл бұрын

    That sounds like me!

  • @jayton580
    @jayton5802 жыл бұрын

    So does SNRI increase norepinephrine? And is it good for GAD and SOCIAL ANXIETY?

  • @genji7536

    @genji7536

    Жыл бұрын

    It does anxiety and anti depression, it should help with social shyness, prestique or other drugs classed under,SNRI should be more effective then SSRI. But I'm only on NRI, I dont consider myself depressed but I notice if my serotonin levels are low it effects dopamine and Norepinehrine which causes co morbid symptoms of depression, its only from malnutrition of the brain synapses and body with active substance that can relief those symptoms. If it's related to adhd the medication for adhd helps but also herbs for adhd, like ginseng and vitamin D, I read up it's good to stimulate frontal lobe and limbic system. Problem in my country the adhd medication I'm on doesnt stimulate very well for females, it fails limbic system, so I have to take a lot of other medications, instead a 3 in one combo like adderal... what's ideal is less side effects for each drug you take that effects positively, I would prefer a drug that does d, S, N rather then just only dopamine. Does not always work if your levels are low, I dont want to take multiple medications all the time. If you have immune disorders like diabeties, insulin resistance, metabolic issues SNRI or NRI works to rebound negative effects such as depletion , depletion = horrible ass cycle of self medicating by binge eating or alchohol, nictotine... so many people are medicating that way, rather then a doctor diagnosing and treating an immune disorder/adrenal issues and kidney. I would actually recommend everyone to check up on auto immune disease or disorders, certain viruses in the body effects the body functions, which causes anxiety and stress on the person, best to keep it standstill then deal with symptoms. There is also no cure for what I got and I'm on hormonal tablets just to live a happy life. Better then ripping my head off lol. Final say I do think inflamation is involved with these flare ups and reactions, they can impact on a persons life, there are ways to reduce flare ups then you increase in other areas of the CNS. I have to do all of this to function otherwise I'm a vegetable from fatigue, chronic fatigue syndrome I've had this when I was 12, now with treatments I'm a lot better and feel energetic but I have to keep things scheduled. and staying active, both are first priority then just a normal diet. At first it's a lot of work but it takes a couple of years then it becomes easy, and then your able to go for a run, be more active/confident.

  • @Vectorman2X

    @Vectorman2X

    Жыл бұрын

    from my experience when i was on snri they make you unstoppable confidence no social anxiety the drawback was sexual side effects

  • @milatripzonInstagram

    @milatripzonInstagram

    Жыл бұрын

    👆👆👆 best in delivery

  • @quaquaqua-s9t
    @quaquaqua-s9t Жыл бұрын

    AMAAAAZING vídeo! Thank you for spending time on it.🙏🏼 I was about to k*ll myself when a Dr figured out I had ‘NORADRENALINE’ deficiency and it changed my life completely after that - My SEVERE headaches and diarrhoea disappeared and I became a sort of “professional” optimistic and I even moved to another country. After 10 years I’m feeling that I should start to reduce the current dosage = VENLAFAXINE 300mg/day, as I’m feeling VERY tired without will to do anything. Or I needed to find something natural to feed my brain with ‘noradrenaline’. I really appreciate any suggestions.

  • @ioannisstermougkou8015

    @ioannisstermougkou8015

    10 ай бұрын

    How are you now

  • @quaquaqua-s9t

    @quaquaqua-s9t

    10 ай бұрын

    @@ioannisstermougkou8015 Hi there! I’m still taking VENLAFAXINE but half of the dosage = 150mg/day. I also started to have supplements to fight against tiredness such as: ✅ Taurina 1500mg (+B6 +B3 +D3) ✅ Ácido Fólico 1000mcg ✅ Co-enzima Q10 300mg ✅ Omega 3 2000mg ✅ Vitamina D 4000i ✅ K2 - MK7 200mcg ✅ Pycnogenol ✅ Emblica Officinalis ✅ Vitamin C 3000mg ✅ Citrulina Malate 750mg ✅ L-Tyrosine 500mg I’m already 52 y.o and I spent two much time of my life feeling bad, wasting opportunities, so I need a lot of energy to fulfil my goals while I’m still breathing. GOOD HEALTH to you as well. 🙏🏼🫡

  • @vsalukir7019
    @vsalukir70194 жыл бұрын

    Unfortunately the clinical nature of the description meant that there were no exact descriptions of outcome. When are we getting too much, when are we not getting enough? Do the other factors that effect it produce too much or not enough?

  • @johnely5050
    @johnely50503 жыл бұрын

    I am taking Venaflaxine 70mg with Mitazapine 30mg for major depression. Is this a good combination?

  • @Lookatmeshine

    @Lookatmeshine

    2 жыл бұрын

    Yes. There's a lot of studies available online to read about that combination and it's considered a very good combination.

  • @Vectorman2X

    @Vectorman2X

    Жыл бұрын

    venlafaxine is a killer of depression and anxiety

  • @burnice3901
    @burnice39016 жыл бұрын

    Is it involved in Fight or flight? Can it be depleted from stress?

  • @Matt-pi9jo

    @Matt-pi9jo

    4 жыл бұрын

    Burnice Pursuing Health and Happiness yes and yes

  • @davidwaine32

    @davidwaine32

    2 жыл бұрын

    @Stéphane Mallette hi hope your well! This is potentially game changing information to my medication routine this! I was thinking I’m lacking some sort of vitamins and I’ve been taking magnesium in the morning and mid day with my meds, which I’ve started to think could maybe be effecting me badly or how the meds work.. I thought maybe take it at night like you say! I only really take magnesium for pain management in my neck, although I do know it plays a positive role how the mind functions. I’m severely depressed and anxious at the moment. Constantly keep telling myself I don’t have long left… I’m on 75mg sertraline. 12mg Edronax. 40mg propronal. Maybe this tweak you mentioned could save my life as I’m very close to losing hope. I’m in touch with Samaritans at the moment.. I’ll give it a go anyway and god bless you for writing it!

  • @user-be2yk7bq5q
    @user-be2yk7bq5q2 ай бұрын

    @psych congress Network, for my depression if ssri failed and snri producing extreme side effects what should I ask to my psychiatrist, please help me

  • @youtubealiasoriginal
    @youtubealiasoriginal5 жыл бұрын

    What's the outcome when only taking reboxetine?

  • @thelostjournalofmystifying354
    @thelostjournalofmystifying3546 жыл бұрын

    can norepinephrine cause people to get angry ?

  • @Tomohiko_JPN_1868

    @Tomohiko_JPN_1868

    5 жыл бұрын

    it is listed as one of the side-effects for SNRIs. "irritability". While i had been prescribed for SNRI (Duloxetine), Sometime i had irritability wit No reason like a child. and i took a half size of a Tranquilizer (Ethyl loflazepate).

  • @phoenixrising7047
    @phoenixrising70475 жыл бұрын

    Thank you. Come again.

  • @robertivers4200
    @robertivers4200 Жыл бұрын

    Desvenlafaxcine really helped with anxiety for me

  • @NgocTran-hz5cz
    @NgocTran-hz5cz3 жыл бұрын

    Quan trọng

  • @markngu1211
    @markngu1211 Жыл бұрын

    cymbalta makes me zzz i take it for neuropathy

  • @milatripzonInstagram

    @milatripzonInstagram

    Жыл бұрын

    👆👆👆 best in delivery

  • @milatripzonInstagram
    @milatripzonInstagram Жыл бұрын

    👆👆👆 best in delivery

  • @desmomotodesmomoto2033
    @desmomotodesmomoto2033 Жыл бұрын

    Raw meat and carnivore diet, cures depression.

  • @milatripzonInstagram

    @milatripzonInstagram

    Жыл бұрын

    👆👆👆 best in delivery

  • @larrytroxler7017
    @larrytroxler70173 жыл бұрын

    If this were the case, then Norepenephrine reuptake inhibitors would help depression. But this not the case. SSRI's and SNRIs don't work on depression

  • @WaxMaiden

    @WaxMaiden

    3 жыл бұрын

    um what?

  • @ryandavies1661

    @ryandavies1661

    3 жыл бұрын

    I’d like to second the ‘umm what...’ Maybe they don’t ALWAYS work!?? It depends on what the patients is lacking ultimately

  • @david-csmhaltero77

    @david-csmhaltero77

    2 жыл бұрын

    @Stéphane Mallette they do work for depression. If your treatment didn't help for depression, that doesn't mean it doesn't work for anybody. Also very often depression and anxiety go hand in hand

  • @ella7513

    @ella7513

    Жыл бұрын

    Bro they saved me

  • @genji7536

    @genji7536

    Жыл бұрын

    Its NRI they only do adranaline, if you think its lacking SNRI in combination to stimulants is what your saying would be better, it depends on severity of your symptoms such adhd, or auto immune disorders that alter chemicals in adrenal/kidney and the hormones. It really does depend on the person whether they need those levels altered. Unfortunately not all countries going to do combined drugs, it would be good if they had some for all three, but usually this is how it goes, if your serotonin levels are low in the brain, it can alter the levels of dopamine and norepinephrine. It's best to work out if it's from the depletion of serotonin first, then work onto the others if you are really struggling to function. SNRI should work. As for SSRI they are apparently weaker but work for those that have other disorders to their health. There are also other ways of increasing those areas if you read up how to stimulate limbic system and frontal lobe but you must compare this to what disorder you carry or have been diagnosed with that would work better what options are useful to the client. Again there is a system of tolerance in the body which I think is a sign saying you actually dont need to increase that, its something else that's the problem. Tolerance to the point you think it's not working does work but symptoms elsewhere has to be targeted seperately to the issue, many people drop medicine without combining some methods to get a full round up, rather then switching if tolerance builds stay on it, figure out what else can curb the problem, it's coming from another source as medicine do bring side effects sometimes too, I dont think there is one medication that can do everything but they help do something, then you curb the other, that's the way it goes and it costs $$$... Alternative medicine can curb side effects, they work fine when you know the drug is out of your system, I dont take ibrophen or paracetamol...I cant imagine taking that each time I titrate my medicine, I use peppermint oils for headaches, ginseng, vitamin D and fish oil... couple other if needed (not weed or alchohol) start reading up folks. I do these but they work, better then doing nothing.

  • @calvinzhobbes1977
    @calvinzhobbes19772 жыл бұрын

    That was borderline useless. I could learn more from a non psychiatrist in a podcast.

  • @genji7536

    @genji7536

    Жыл бұрын

    Everything he mentioned was true, not sure what info he left out that could of been helpful. Only because I am on the same treatment, they work for obesity

  • @milatripzonInstagram

    @milatripzonInstagram

    Жыл бұрын

    👆👆👆 best in delivery