What is Life? - with Paul Nurse

Ғылым және технология

Living things are extraordinary and our quest to define life is one of the most fundamental questions in biology.
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Watch the Q&A: • Q&A: What is Life? - W...
Sir Paul Nurse is a geneticist and cell biologist whose discoveries have helped to explain how the cell controls its cycle of growth and division. Working in fission yeast, he showed that the cdc2 gene encodes a protein kinase, which ensures the cell is ready to copy its DNA and divide. Paul’s findings have broader significance since errors in cell growth and division may lead to cancer and other serious diseases. He was awarded the 2001 Nobel Prize in Physiology or Medicine, alongside Tim Hunt and Leland H. Hartwell.
This Discourse was filmed in the Ri on 25 October 2019.
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Пікірлер: 712

  • @MilesDavisKDAB
    @MilesDavisKDAB4 жыл бұрын

    Paul was one of my tutors when he was just a post- doc researcher. He was/is a lovely man as well as being a very good scientist.

  • @StaringCompetition

    @StaringCompetition

    4 жыл бұрын

    Miles Davis I clicked on this one bc he reminded me of a nice teacher lol and I was thinking I bet students like this guy

  • @pansepot1490

    @pansepot1490

    4 жыл бұрын

    He looks a character out of a Christmas tale! 😁 A hobbit, elf or something like that. Perhaps because of his round nose and red cheeks. Btw no offense meant.

  • @laurenth7187

    @laurenth7187

    2 жыл бұрын

    And a not so good philosopher

  • @MilesDavisKDAB

    @MilesDavisKDAB

    2 жыл бұрын

    @@laurenth7187 Is it possible to be a good philosopher?

  • @laurenth7187

    @laurenth7187

    2 жыл бұрын

    @@MilesDavisKDABIt's difficult, i know only one living, myself. So yes for scientists it's hard because they didn't study phil, so no background.

  • @bouncybounce4589
    @bouncybounce45894 жыл бұрын

    What a remarkable lecture. Incredible that he was able to lay out all the principles of life, in such detail and clarity, considering the complexity, in just an hour. Bravo, Paul Nurse!

  • @joselama6739

    @joselama6739

    2 жыл бұрын

    [[[Looo[oooooo

  • @joselama6739

    @joselama6739

    2 жыл бұрын

    [O

  • @joselama6739

    @joselama6739

    2 жыл бұрын

    L[[o[0mooo[o[[[oo[o[o[[oo

  • @kevinshort3943
    @kevinshort39434 жыл бұрын

    "Life, don't talk to me about life" -- Marvin

  • @MilesDavisKDAB

    @MilesDavisKDAB

    4 жыл бұрын

    Here I am, brain the size of a planet....

  • @kevconn441

    @kevconn441

    4 жыл бұрын

    "The first million years were the worst"

  • @kevinshort3943

    @kevinshort3943

    4 жыл бұрын

    @@kevconn441 “The first ten million years were the worst," said Marvin, "and the second ten million years, they were the worst too. The third ten million years I didn't enjoy at all. After that I went into a bit of a decline.”

  • @kevconn441

    @kevconn441

    4 жыл бұрын

    @@kevinshort3943 Should have left the quote marks off, I wasn't even close. Thanks for the correction though, always funny.

  • @kevinshort3943

    @kevinshort3943

    4 жыл бұрын

    @@kevconn441 "I wasn't even close" Only 9 million years out, I bet you were distracted by those pesky doors :)

  • @krishiprasad1730
    @krishiprasad17303 жыл бұрын

    A befitting work which should probably termed Masterpiece. Hands of to you Mr. Nurse. Infinite respect and love from India.

  • @healthyone100

    @healthyone100

    2 жыл бұрын

    you probably don't really know what love is!

  • @hopegold883
    @hopegold8834 жыл бұрын

    Unusually well-written as well typically informative. The structure illustrates the content. So glad I clicked! Usually I’m more drawn to the physics ones. But then it is!

  • @nangtran4504

    @nangtran4504

    3 жыл бұрын

    L

  • @merrickjagger1704

    @merrickjagger1704

    2 жыл бұрын

    Instablaster.

  • @zetacrucis681
    @zetacrucis6814 жыл бұрын

    Paul Nurse is always a pleasure. Thank you RI!

  • @toni4729
    @toni47292 жыл бұрын

    This was the most interesting talk I've ever had the privilege to hear. Thank you very much Paul. Please, let us hear more.

  • @laurenth7187
    @laurenth71872 жыл бұрын

    Regarding the principle underlying life, it's amazing that such a knowledgeable person seems to ignore Bichat : « La vie, dit-il, est l'ensemble des fonctions qui résistent à la mort. » Life is a set of functions resisting to death.

  • @deepstrasz

    @deepstrasz

    2 жыл бұрын

    You can't just happen to know everything though. Some things you are bound to miss, many actually.

  • @gjovanovic
    @gjovanovic3 жыл бұрын

    For someone who so many times (unnecessarily) emphasizes "without a need for a creator" Sir Paul expresses astonishing admiration for BEAUTY of the building blocks of life :-)

  • @deepstrasz

    @deepstrasz

    2 жыл бұрын

    So then the universe created itself, then evolved to us who can create within it. If we could create a universe of our own, then we might end up creating an infinite loop. Virtual reality and computers... oh wait...

  • @stephanieparker1250
    @stephanieparker12502 жыл бұрын

    Wow, brilliant lecture, well done! Even with only a few simple slides and reading from paper notes stapled together instead of a fancy laptop, he delivered a hugely informative and fascinating presentation. 🙌

  • @OnlineMD
    @OnlineMD2 жыл бұрын

    SUCH a coincidence...I just got done reading his superb book "What Is Life." Sir Paul Nurse has more titles and accomplishments than most authors I've read lately. Five of the chapters in his book have these chapter headings: Cell; Gene; Evolution by Natural Selection; Chemistry, and Information. Next on my reading list is "What Is Life" by Lynn Margulis and Dorion Sagan.

  • @Doctor_Subtilis

    @Doctor_Subtilis

    2 жыл бұрын

    Read lily e Kay's books The molecular vision of life, and who wrote the book of life? Brilliant historian of life science if you want to know the serious history

  • @Doctor_Subtilis

    @Doctor_Subtilis

    2 жыл бұрын

    Also reading Kay's works will teach you how to fdo book research like a pro if you look into the notes

  • @mdb1239
    @mdb12392 жыл бұрын

    The machines within our cells are living and intelligent entities. Actually visually seeing them at work shows they are alive, reacting to the environment, and making purposeful decisions.

  • @j0hnX44
    @j0hnX448 ай бұрын

    Probably one of the best lectures about life I've seen!!

  • @gondwana6303
    @gondwana63034 жыл бұрын

    This is a brilliant framework of principles by Sir Paul on how analyze what is life? Hope it becomes a course that he can teach. The other brilliant scientists such as Schrodinger, Mendel, Darwin and Pasteur are amazing that they could have surmised so much from so little observable things, since they didn't have any of our current sophisticated tools.

  • @Doctor_Subtilis

    @Doctor_Subtilis

    2 жыл бұрын

    And Schrodinger's importance in the history of biology is mostly a retcon

  • @lucyhanks500

    @lucyhanks500

    Жыл бұрын

    There are these phrases such as ‘What is a faux pas?’ and ‘what is considered as ill manners?’

  • @lucyhanks500

    @lucyhanks500

    Жыл бұрын

    @@Doctor_Subtilis then there is ‘what is a community?’

  • @asrmail2009
    @asrmail20092 жыл бұрын

    Brilliant exposition. Thank you for posting this.

  • @Garcia-elf
    @Garcia-elf4 жыл бұрын

    He was awarded an Honoris Causa during my MSc convocation at McGill, June 2017 :)

  • @lukekubat3882
    @lukekubat38824 жыл бұрын

    The Schrodinger uncertainty principle: “you can never be 100% certain I’m not Heisenberg” :-)

  • @bernardofitzpatrick5403

    @bernardofitzpatrick5403

    4 жыл бұрын

    nice one! LOL

  • @theuniques1199

    @theuniques1199

    4 жыл бұрын

    Luke Then you must 100% also believe you are Heisenburg to believe you are 100% not Heisenburg and you must believe you are 100% not Heisenburg to believe you are 100% Heisenburg because you can't have one concept without the other.

  • @doubleirishdutchsandwich4740

    @doubleirishdutchsandwich4740

    4 жыл бұрын

    I was listening to this on my way to work and I almost pulled over to leave this comment. How can you get something so fundamentally wrong in your presentation to the royal academy. Not a big deal as to the substance of the presentation, just a tiny hiccup. Schrodinger created the wave equation while Heisenberg created the uncertainty principle. Ugh.

  • @quadlearningstudios1216

    @quadlearningstudios1216

    4 жыл бұрын

    Perhaps they climbed into Schrodinger's cat box together and became a Schroberg-Heisendinger superposition...

  • @Sophiedorian0535

    @Sophiedorian0535

    4 жыл бұрын

    Strange ... when I am NOT watching this video, it seems like the uncertainty principle is both from Heisenberg and Schrödinger, AT THE SAME TIME!

  • @StormedX2
    @StormedX24 жыл бұрын

    This man looks like 3 people: 1: Old guy from Up! 2: Robin Williams 3: Close relative of Patton Oswalt

  • @stumccabe

    @stumccabe

    4 жыл бұрын

    4. Alcoholic uncle.

  • @corretorescompartilhados385

    @corretorescompartilhados385

    4 жыл бұрын

    5. Ronnie Barker.

  • @furbs9999

    @furbs9999

    4 жыл бұрын

    Can not unsee.

  • @LearningWithSuj

    @LearningWithSuj

    4 жыл бұрын

    I was about to say Robin Williams and Joe Pesci :)

  • @e-t-y237

    @e-t-y237

    4 жыл бұрын

    fusiform gyrus is good at lookalikes, I have it too and it goes with jumble/unscrambling skillz ... just saying

  • @kevinwilliams5873
    @kevinwilliams58733 жыл бұрын

    God bless the Royal Institution. Information provided by the informed, without bias, for public consumption. God bless you all.

  • @yadibalderlou1443
    @yadibalderlou14432 жыл бұрын

    I was expecting a definition from the lecturer for life ,all he gave me was a description of a living things. Not the life itself

  • @Thom3748

    @Thom3748

    2 жыл бұрын

    Exactly.

  • @whizkid235
    @whizkid2353 ай бұрын

    If only college courses were taught like this… students would be much more excited to study the material. For some reason I fully understood and remembered all the small details (names, dates, biochemistry concepts, etc..) in this lecture from listening to it once, and I walk out of my college classes being more confused than before and learning nothing

  • @baseeraslam436
    @baseeraslam4363 жыл бұрын

    What an amazing lecture!

  • @TheBoatmad
    @TheBoatmad2 ай бұрын

    What an awesome talk. If I was still a teacher I would want to share that talk with all my students!

  • @patrickboudreau3846
    @patrickboudreau38462 жыл бұрын

    It is easy to visualise birds evolving but entirely something else to grasp the evolution of molecular machines without whom nothing works anymore. How did particules jump from wave matter duality to agglomerate into what would eventually become the human brain ? Evolution is certainly one of our universe’s most myserious acheivement. Thank you for this lecture. This subject is facinating.

  • @santiagomarshall1447
    @santiagomarshall14474 жыл бұрын

    I was expecting the George Harrison hit “what is life” but I actually found a great video I will remember for a long time! Thanks

  • @nipudas1771
    @nipudas17712 жыл бұрын

    And now I have watched two interviews regarding this book!

  • @chrissmith7259
    @chrissmith72593 жыл бұрын

    Beautifully explained.

  • @dominicvijayanand1971
    @dominicvijayanand19712 жыл бұрын

    SIR THANK YOU FOR UNDERSTANDING LIFE AND HELPING US TO APPRICIATE LIFE ON EARTH AND PERHAPS SOMEWHERE ELSE, WE ALL NEED TO RESPECT LIFE . WITH LIFE . IN LIFE THERE IS EVERYTHING ELSE WHATEVER.

  • @muthuk
    @muthuk4 жыл бұрын

    What an amazing lecture! The amount of fundamentals covered here is just amazing. Learning from first principles, understanding the basics clearly are extremely important...I am glad i watched this! Thank u guys!

  • @muthuk

    @muthuk

    4 жыл бұрын

    @@waltermoss7718 ok maybe u can suggest me a couple

  • @sgatea74
    @sgatea742 жыл бұрын

    Science (chemistry/physics) of life at explained at it's best using common sense arguments. Thank you !

  • @troygarfieldtravels
    @troygarfieldtravels2 жыл бұрын

    A brilliant instructor and an amazing tie.

  • @quinoline3865
    @quinoline38654 жыл бұрын

    2:36 Schrodinger was not the guy who discovered uncertainty principle. It was Heisenberg.

  • @kevinshort3943

    @kevinshort3943

    4 жыл бұрын

    You tell his cat that ! :)

  • @frhe1970

    @frhe1970

    4 жыл бұрын

    Heisenberg did not discover the principle,like you find something that was hidden.He discovered a problem in the way that the basic physical properties of a particle in a quantum system could be measured.Then DEVELOPED the uncertainty principle to explain the problem..

  • @rad858

    @rad858

    4 жыл бұрын

    @@frhe1970 Schrödinger developed Heisenberg's principle into his own much more general uncertainty relation, which is much more useful

  • @quinoline3865

    @quinoline3865

    4 жыл бұрын

    ​@@frhe1970 I meant the same thing. I anticipated somebody is going to nitpick.

  • @bernardofitzpatrick5403

    @bernardofitzpatrick5403

    4 жыл бұрын

    @@rad858 interesting ...

  • @genghisgalahad8465
    @genghisgalahad84654 жыл бұрын

    A wonderfully concise and excellent primer lecture on cellular biology by Paul Nurse! Love the playlists by science topics!

  • @John777Revelation

    @John777Revelation

    6 ай бұрын

    DNA is "Coded" and "Digital" Information. *_"Language: All Digital communications require a formal language, which in this context consists of all the information that the sender and receiver of the digital communication must both possess, in advance, in order for the communication to be successful."_* (Wikipedia: Digital Data) During an interview, when asked if the genetic code is really a code, Dr. Richard Dawkins answered, *_“It [the genetic code] IS a code. It's definitely a code.”_* (Source: Jon Perry - Genetics & Evolution Stated Casually KZread Channel Interview with Dr. Richard Dawkins on 4-2-2022. Dr. Richard Dawkins is widely regarded as the world’s foremost expert on Darwinian Evolution) *_"After Watson and Crick, we know that genes themselves, within their minute internal structure, are long strings of pure digital information. What is more, they are truly digital..."_* (Richard Dawkins, River out of Eden, 16. Dr. Richard Dawkins is widely regarded as the world’s foremost expert on Darwinian Evolution) What prebiotically relevant or even modern chemical process has been observed in nature or experimentally demonstrated to be capable of producing coded digital functional information / language? Modern scientific discoveries in Genetics (i.e. biology) have shown that functional / coded / digital Information (i.e. DNA code) is at the core of All Biological Systems. Without functional / coded / digital information, there is No biology. The only known source (i.e. cause) in the universe that has been Observed (i.e. Scientific Method) in nature to be capable of producing functional / coded / digital information, such as that found even in the most primitive biological systems, is mind / consciousness / intelligence.

  • @vjnt1star
    @vjnt1star4 жыл бұрын

    I am always baffled by the complexity of a cell which is like a factory. It is very hard to imagine that the first cell has been put together by chance

  • @MrWhiteav6

    @MrWhiteav6

    4 жыл бұрын

    Who says the first cell was ad complex as a bacteria or eukaryotes? It could be as simple as a micelle.

  • @bremayak

    @bremayak

    4 жыл бұрын

    I'm with you on this preposterous idea that life accidentally self assembled. Arrogance and vanity seem to blind them to the obvious problem with that world view. There is an airplane junkyard in the middle of nowhere America and not once has a 747 put itself back together again from its pieces.

  • @bremayak

    @bremayak

    4 жыл бұрын

    Only a fool can be deceived into thinking that random proteins can magically self assemble into complex DNA and RNA. Especially since there has never been a repeatable experiment done that demonstrates the hypothesis of random self assembly of organisms. If you are so clever and I am so foolish, then please recreate the genesis of complex life in a lab. If this theory were true, everyone on the planet should be able to combine the ingredients needed for life and then magically get these ingredients to become a complex life form. You can't do it, nor can anyone on this planet. It has never happened and will never happen, because it's an incorrect hypothesis. The data does not support the notion that life just happened to happen. Or, put into simple terms that a child can understand - 747s do not build themselves even when all of the pieces are present. Apparently, that analogy is over your head or beyond your cognitive capabilities since you felt the need to attack it. Maybe you can get a distinguished biologist to prove that random chemicals and proteins can be brought to life in a lab. If that ever happens, I will rescind my opinion and apologize for my error. I doubt that you will ever prove that but anything is possible.

  • @MrWhiteav6

    @MrWhiteav6

    4 жыл бұрын

    @@bremayak so because we dont completely understand abiogenesis, it goes to divine creation by default? Hey, life is crazy, we find it so amazing that we are mystified by it and naturally substantiate its existence due to divine resources. The history of science shows everything has a natural explanation eventually and I dont think abiogenesis is any different.

  • @z42O

    @z42O

    4 жыл бұрын

    Jesus planted coconuts and that is how you have life on earth Google it lol

  • @mehdibaghbadran3182
    @mehdibaghbadran31822 жыл бұрын

    Thanks for your explanation on the easy ways.

  • @walkabout16
    @walkabout168 ай бұрын

    In words of wisdom, Paul Nurse did share, The core principles of life, a truth so rare, Nobel Prize-winner, in science's brilliant glare, He unveiled life's secrets, beyond compare. Principle one, the heart of all existence, Information's flow, a grand persistence, Genetic code, in cells it finds its stance, Life's blueprint, in every single instance. Principle two, diversity's graceful dance, Variation's key, in each life's advance, Evolution's art, through time's expanse, Survival's essence, in nature's romance. Principle three, the mighty energy's exchange, In every cell, a balance we arrange, Metabolism's dance, so intricate and strange, Life's spark, in every molecule's change. Principle four, the cells, life's building blocks, Complexity emerges from simple locks, From molecules to tissues, in paradox, Life's beauty in cells, where harmony docks. Principle five, the generations' thread, Reproduction's gift, where life is spread, Inheritance's tale, from ancestors led, Life's tapestry, in the DNA's spread. Paul Nurse, in science's quest profound, Unveiled these principles, on fertile ground, In Nobel's glory, his knowledge unbound, Life's mysteries, in his wisdom found. So let us heed these principles five, In nature's grandeur, let us derive, The essence of life, where mysteries thrive, In Paul Nurse's wisdom, let us survive.

  • @manifold1476

    @manifold1476

    8 ай бұрын

    I'd guess he made an impression on you.

  • @haitranb3383
    @haitranb33834 жыл бұрын

    So premative, just survived and hopping one day when compassion realised then we must what is life....

  • @glynndraper437

    @glynndraper437

    4 жыл бұрын

    Learn to spell fro fcuks sacke

  • @NeoStoicism
    @NeoStoicism4 жыл бұрын

    The importance of polymers in connecting information to chemical reaction will be an interesting indicator of other life forms as we push further into the universe.

  • @miodragomir

    @miodragomir

    4 жыл бұрын

    We are not pushing anywhere. Forever bound to tiny Earth.

  • @deepstrasz

    @deepstrasz

    2 жыл бұрын

    I think we would have a chance with biophoton detection.

  • @walkingmap
    @walkingmap4 жыл бұрын

    Very nice lecture, wonderful tie.

  • @safarscience6835
    @safarscience68352 жыл бұрын

    Though I was knowing most of the things he was telling because I'm from a plant sciences background.... Still I found this lecture very interesting and I listened very carefully. Thank you so much Ri for uploading this. 🙏

  • @pradnyasaravade8934
    @pradnyasaravade8934 Жыл бұрын

    Totally enlightening! Loved the idea of turning inside out the lifeless information stored in the DNA to the reactive machines-proteins-which do the work. In that case, maybe ribozymes or the ribosomes are the first step to life? Viruses being a case in point-storing only the information without the ability to translate that information as living beings on their own.

  • @jayarava
    @jayarava3 жыл бұрын

    There's really nothing here that I didn't learn at school 40 years ago. The one thing I learned post-school was that symbiosis gave us eukaryote cells and complex life. RIP Lynn Margulis.

  • @michaelawford7325

    @michaelawford7325

    2 жыл бұрын

    I achieved A Level Botany and Zoology 60 years ago and found this new and fascinating

  • @mdb1239
    @mdb12392 жыл бұрын

    Visually being able to see the smallest parts/living-machines at work within a cell and it is shocking. The smallest workings in our cells are intelligent and alive. Seeing them at work is astonishing. They are intelligent and alive. Seeing them visually doing their work is a wonderment. This is not just a chemical reaction in a test tube, but living intelligent machines responding to its environment and doing purposeful work.

  • @marioesposito4050
    @marioesposito40503 жыл бұрын

    Amazing lecture!!

  • @guidobachi952
    @guidobachi9524 жыл бұрын

    Great lecture ! Thank you very much, Mr. Nurse. I wish you all the best for the future and I am keen to listen to your next lecture! Greetings from Switzerland.

  • @caricue
    @caricue2 жыл бұрын

    I'm beginning to think that the reason it is so hard to answer this question, what is life, is because it isn't actually a thing in itself. We see a part of the universe moving around and doing stuff and we call it life, but this is a concept or even a category that we have in our heads. You can say the same about tornadoes or hurricanes. They are self-assembled structures that form due to an energy imbalance, but they are not really a thing. That is why nothing is lost when a whirlwind finally dissipates, because it was never really more than an identity put on it by some human mind. If life is like this, and it seems to be, then the most you can ever do is describe it and work out its dynamics, but you will never really be able to say what it is.

  • @kevinsmith-qj1bz

    @kevinsmith-qj1bz

    2 жыл бұрын

    This is the most well-reasoned thought on this blog, something that seems to elude even the noble laureate who, I suppose, has been working on the topic for a long time, if not his entire career.

  • @avonsternen6034
    @avonsternen60348 ай бұрын

    The cell is an organizational functional unit. The efficacy of chemistry is based on its subject, dealing with consistent patterns of relations and interactions. However, describing life in terms of chemicals is like describing a picture in terms of colors. 👍:)

  • @KURDinEXILE
    @KURDinEXILE4 жыл бұрын

    Beautifully said

  • @simonbassett818
    @simonbassett8189 күн бұрын

    Excellent talk Sir, thank you.

  • @JobANable
    @JobANable2 жыл бұрын

    I kept imagining Robin Williams talking about what is life throughout this talk; that would be hilarious and also very illuminating!

  • @palmbeach4825

    @palmbeach4825

    11 ай бұрын

    Yeah, ame too. I kept thinking about Flubber. The movie with the green blob.😂🟢

  • @nonindividual
    @nonindividual2 жыл бұрын

    What a great lecture.

  • @dave-ux1iu
    @dave-ux1iu4 жыл бұрын

    thanks,good video lots of information

  • @adon2424
    @adon24242 күн бұрын

    Great information! I must say that at the end of the monolog you contradicted yourself. You said parasitic and symbiotic life is aware of the environment. Then, at the end, you stated that humans are the only life which sees the connectivity of life. Symbiotic life also "sees" the connection. Otherwise it wouldn't know which life it needs a symbiotic relationship with.

  • @patrickm8316
    @patrickm83164 жыл бұрын

    For a bit of a fool like me, this talk was a thing of beauty.

  • @janlang8605
    @janlang86053 жыл бұрын

    Superb lecture!

  • @MohamedElsheikh22
    @MohamedElsheikh223 жыл бұрын

    Nothing pisses me off more than searching youtube for "what is life" and finding most of search results are about shallow songs.. and it shows this video in the 10th page. It shows how shallow our society is

  • @plrndl

    @plrndl

    2 жыл бұрын

    Has it occurred to you, that you may be looking in the wrong place?

  • @MohamedElsheikh22

    @MohamedElsheikh22

    2 жыл бұрын

    @@plrndl Maybe , do you suggest a better place

  • @elsef6798
    @elsef67982 жыл бұрын

    Thank you for this poetic lecture full of insights and knowledge. The importance of the central and final message: to care for all life on this planet, seems too easily overlooked by people in general. I am not sure the science, the data and the understanding is key to solving the problem. In comparison knowing precisely how harmful cigarettes are often does not stop smoking. I wonder: what creates caring?

  • @CZorba
    @CZorba2 жыл бұрын

    Meaning of life => meaning of meaning of live => meaning of meaning of meaning of life .... = factorial meaning of life, a recursive path to go .... ; Thank you for your video

  • @grmalinda6251

    @grmalinda6251

    2 жыл бұрын

    Life is the ability to respond.

  • @sawa2754
    @sawa27544 жыл бұрын

    Baby don‘t hurt me... don‘t hurt me, no more

  • @Nazgul3001

    @Nazgul3001

    4 жыл бұрын

    came here for this, thanks and have a nice day

  • @horuslux8441

    @horuslux8441

    4 жыл бұрын

    Also came here to post this, glad to see it here already

  • @IETCHX69

    @IETCHX69

    4 жыл бұрын

    0000... 00...Baby don‘t hurt me... don‘t hurt me, no more... 0000...Arabelle Briar1 month ago Baby don‘t hurt me... don‘t hurt me, no more Reply 45 Hide 2 replies Heiko Fricke Heiko Fricke1 month ago came here for this, thanks and have a nice day Reply 9 Horus Lux Horus Lux1 month ago Also came here to post this, glad to see it here already Reply 3

  • @IETCHX69

    @IETCHX69

    4 жыл бұрын

    IETCHX691 second ago 0000... 00...Baby don‘t hurt me... don‘t hurt me, no more... 0000...Arabelle Briar1 month ago Baby don‘t hurt me... don‘t hurt me, no more Reply 45 Hide 2 replies Heiko Fricke Heiko Fricke1 month ago came here for this, thanks and have a nice day Reply 9 Horus Lux Horus Lux1 month ago Also came here to post this, glad to see it here already Reply 3......0000... 00...0000... 00...0000... 00..Baby d...

  • @michaelmwm222

    @michaelmwm222

    Жыл бұрын

    What is love? Baby don't hurt me...don't hurt me...no more

  • @therealzilch
    @therealzilch Жыл бұрын

    Nicely done. I would say that it's quixotic to try to define "life" exactly. Order merges imperceptibly with life.

  • @jonathanbethune9075
    @jonathanbethune90758 ай бұрын

    I'm am humbled in the presence off our nature.

  • @robertphillips93
    @robertphillips932 жыл бұрын

    Such a comprehensive review of biochemistry and really, all current scientific POVs! Alas, the titular question contains a paradox that is not addressed -- namely, what is the role of life in a cosmos that appears to be inanimate? He comes close to this in his summation, noting the interdependence of living organisms -- but apparently the balance of the universe is simply "stuff" . . .

  • @pjsteinsongs

    @pjsteinsongs

    2 жыл бұрын

    We may someday understand the pathway from how, from the first RNA strand several billion years ago, to the present moment, we came to be, but there may never be an understandable “role” or “purpose” in nature, other than for living things to make copies of themselves.

  • @robertphillips93

    @robertphillips93

    2 жыл бұрын

    @@pjsteinsongs Can't dispute that -- but it is interesting to note that there can be two very different meanings of "understand". One, as you use it, refers to knowledge and its manipulation. Another is perhaps more personal, bringing the knower's character or state to bear on his knowledge. Think of a great musician engaging an audience, or one who is technically just as proficient but doesn't quite deliver the same experience.

  • @pjsteinsongs

    @pjsteinsongs

    2 жыл бұрын

    @@robertphillips93 The musician metaphor is excellent. Can you expand on how this relates to your original comment, i.e., the relationship, if any, between life (the biosphere), and the inanimate cosmos?

  • @robertphillips93

    @robertphillips93

    2 жыл бұрын

    @@pjsteinsongs We study cells and stars with similar instruments and methods. For stars there may be few other options -- but for a certain kind of organism, of our own phenotype, there is another instrument available to us -- the first-hand observation of the inhabitant. It is easy to dismiss such a notion as unscientific fantasy, but it is probably a safer bet that few have tried it because it is extraordinarily difficult and quite possibly dangerous to our comforting notions and preconceptions. Nevertheless, there have been notable examples of those who apparently have done just this. One thing to consider that any scientist will agree with -- any valid principles discovered in this way must have a corresponding analogue in the macro world. Laws are everywhere the same -- so this micro-investigation can yield results transferrable on a cosmic scale. Thus, under-standing . . . or, pie in the sky. So, is musician A a scientist? Not in the ordinary sense, but he has apparently identified certain "elementals" in his experience and can instinctively or consciously put them in a relationship that (in a repeatable manner) yields a new result. You don't really think "music of the spheres" was the invention of savages?!

  • @pjsteinsongs

    @pjsteinsongs

    2 жыл бұрын

    @@robertphillips93 I think that you are suggesting the use of some quality or qualities of subjective experience that may serve as an instrument or gauge of some kind, but different from the observations of a “naturalist”?

  • @daiduongdaviddinh140
    @daiduongdaviddinh1404 жыл бұрын

    Very academic talk from a very scholastic scientist.

  • @scottkoshland2475
    @scottkoshland24752 жыл бұрын

    Life must be in terms of information defined as an intelligent sustaining information system. Simply life meets all the definitions of an intelligent system.

  • @McLKeith
    @McLKeith4 жыл бұрын

    This a very informative lecture on how cells function. Paul Nurse is very good lecturer. Far better than my first genetics 101 lecturer. But Nurse has not answered the question "What is life?" To answer that question, I believe we need an up-to-date Miller-Urey type experiments showing how those chemical reactions got started.

  • @grmalinda6251

    @grmalinda6251

    2 жыл бұрын

    Life's the ability to respond.

  • @ewigeliebe4690
    @ewigeliebe46902 жыл бұрын

    Life, as WE consider t to be live, is popping out automatically wherever the circunstances are favourable

  • @sparky80569
    @sparky805693 жыл бұрын

    Very informative..

  • @Gabrielhlc
    @Gabrielhlc4 жыл бұрын

    Yeah, we are mechanisms that stores information, after all... But why? I think that life comes to us with a intrisic need to survive, and that is life, we eat to survive, we have kids to survive for us, we make computer to survive our ideas. Its very important thinking about it, because sometimes we are so instinctive for surviving that we start wars, we tend to defend territory and our fake sense of property. Everyone is connected, we need the efforts of every type of life to survive. We need to stop thinking that we are apart of everthing! We have to have faith in ourselfes but most of all we have to have faith in everyone to live better!! Thank you for this awesome time, it opened my mind for a lot of things

  • @deepstrasz

    @deepstrasz

    2 жыл бұрын

    We are not apart from everything but we are individual entities within one entity. You can the greed of existence by looking at the deep dark space. Planets have formed, basically, as separate entities, some bigger, some smaller, some solid, some gaseous. So, while the universe might have unity inside in what celestial body and ultimately life form organization is concerned, its constant expansion and separation of galaxies doesn't help this we are all one philosophy. It seems, that what actually stays together and seems likely to win, is entropy.

  • @user-ew1uo5ev4e
    @user-ew1uo5ev4e3 жыл бұрын

    can’t stop looking at his tie

  • @kn9ioutom
    @kn9ioutom Жыл бұрын

    LIFE IS SOMETHING TO DO !!!

  • @SparkBerry
    @SparkBerry4 жыл бұрын

    The biggest question ever posted by RI... My other plans are cancelled for tonight

  • @guillermozuluaga5643
    @guillermozuluaga564310 ай бұрын

    Machinery, communication, programming, purpose? Yes Dr Nurse: Maybe a computer doesn't need a creator after all. Or, does it?

  • @1o1s1s1i1e
    @1o1s1s1i1e4 жыл бұрын

    Fascinating lecture!

  • @-_Nuke_-
    @-_Nuke_-4 жыл бұрын

    Life is a very stubborn illusion of our circumstances. Either 1) Nothing is life or 2) Everything is. At the most fundamental level, everything is nothing more than, quantum indeterminacies on some fundamental mathematical fields. (like the EM, Gluon, Higgs fields etc)

  • @terrytibbs

    @terrytibbs

    4 жыл бұрын

    lol what

  • @-_Nuke_-

    @-_Nuke_-

    4 жыл бұрын

    @@terrytibbs There is no way to distinguish life from non-life . The Earth itself could be viewed as a living organism and if the Universe is teeming with life, then the entire Universe should be considered a living organism too. Or otherwise, since there is no real distinction (down to the fundamental levels of QM) from life and non-life, nothing should be considered "living". We Humans believe that living things have some kind of special property to them (soul) but such thing doesn't exist when we examine their fundamental quantum parts. Everything is just a collection of atoms, a rock and a Human brain share no distinction. The laws of physics make the one collection of atoms act as a rock and the other as a human brain. Some complicated collection of atoms might look alive (collections of atoms like animals and humans) but they are not, they are just inanimate matter drifted away by the laws of physics. Nothing is really alive.

  • @NetAndyCz

    @NetAndyCz

    4 жыл бұрын

    @@-_Nuke_- Just because people do not agree about at which wavelength the light is still red does not mean that the blue life and the red light are the same.

  • @robertopedrosolazzo9324
    @robertopedrosolazzo93242 жыл бұрын

    Inspiring!

  • @TheThunderSpirit
    @TheThunderSpirit4 жыл бұрын

    Very nice idea of wetwares

  • @klausgartenstiel4586
    @klausgartenstiel45864 жыл бұрын

    "it goes a little bit like this. well, *actually* it goes completely like is." you gotta love the british. 😎

  • @Silly.Old.Sisyphus

    @Silly.Old.Sisyphus

    4 жыл бұрын

    actually, you gotta hate the British because they hate everyone else - just look how isolationist they are

  • @klausgartenstiel4586

    @klausgartenstiel4586

    4 жыл бұрын

    @@Silly.Old.Sisyphus well, i don't know about you, but i don't hate any humans. because in the end, they are not really responsible for what they are. i *do* however hate god. *if* he exists.

  • @Jesse__H

    @Jesse__H

    4 жыл бұрын

    @@Silly.Old.Sisyphus that was a very silly thing you just said.

  • @PeterPete

    @PeterPete

    4 жыл бұрын

    Quote - you gotta love the british Huh? They are a right miserable unhappy bunch of people. I wouldn't recommend anyone to live in UK unless they want to lose their peace of mind. I see lots of unhappy people here. The only fun they get is laughing at others misfortunes!! You want to visit a care home in UK, not many people laugh there!!

  • @Sophiedorian0535

    @Sophiedorian0535

    4 жыл бұрын

    Everything that goes completely like this, starts with going a little bit like this. Nothing, ever, goes completely like this all at once. Nothing that goes like the, goes like that!

  • @anotherindividual5799
    @anotherindividual57994 жыл бұрын

    👍🏼 well done

  • @AnkitSingh-xg2uv
    @AnkitSingh-xg2uv10 ай бұрын

    A very precise lecture but without considering epigenetic control.....

  • @Heart-Core
    @Heart-Core Жыл бұрын

    ❤Life is movement on itself♥️Movement creates life & time❤️Without movement neither life nor time would exist❤

  • @indricotherium4802
    @indricotherium48024 жыл бұрын

    Moderately interesting but this lecture really ought to have been titled 'What are the Mechanisms of Life?'

  • @indricotherium4802

    @indricotherium4802

    4 жыл бұрын

    @@piefiuma ; so is plate tectonics, so is the Solar System.

  • @olmostgudinaf8100

    @olmostgudinaf8100

    4 жыл бұрын

    @@indricotherium4802 correct. Life is yet another example of a mechanism.

  • @indricotherium4802

    @indricotherium4802

    4 жыл бұрын

    @@olmostgudinaf8100 : are you seriously saying that 'What mechanisms do we find in living organisms?' poses the same question as 'What is life?'

  • @olmostgudinaf8100

    @olmostgudinaf8100

    4 жыл бұрын

    @@indricotherium4802 yes, that is _precisely_ what I am saying. Figuring out what makes a thing alive equals figuring out what life is.

  • @indricotherium4802

    @indricotherium4802

    4 жыл бұрын

    @@olmostgudinaf8100 : does that work then for, say, 'figuring out what makes a thing think equals figuring out what thought is?'

  • @nivlek2538
    @nivlek25384 жыл бұрын

    The "explanation" about life and the second law of thermodynamics seems to be very spurious.

  • @MrWhiteav6

    @MrWhiteav6

    4 жыл бұрын

    Could you elucidate on that?

  • @sallyforth2955

    @sallyforth2955

    4 жыл бұрын

    Nivlek he is really on to something there though. Life requires the evolution of membranes. Saline solution in Cell different from out, creating a pump which must be fueled by electron exchanges, etc. He could have elaborated his point.

  • @davidgould9431

    @davidgould9431

    4 жыл бұрын

    I agree. At about 10 minutes in, he said something about the 2nd law of thermodynamics not being a problem because the cell is separated from the environment. This seems arse-about-face to me: the 2nd LoT isn't a problem precisely because the cell *isn't* a closed system and is constantly exchanging materials and energy with the rest of the environment. I suspect he's one of the "old school" of great biologists who weren't so hot on physics (I know: I could google him). Especially given his Schrödinger/Heisenberg Uncertainty Principle whoopsie. Still that's not really why I'm watching, and it's been interesting so far.

  • @dalton6173
    @dalton61732 жыл бұрын

    Charles Darwin being famous for the theory of evolution after his grandfather was essentially run out of business for having that idea is kind of an amazing story I mean I do wish that his grandfather would have gotten the credit whenever it was his idea but still inspiring in its own unique way

  • @cdb5001

    @cdb5001

    2 жыл бұрын

    There's a book.coming out this week which contends that Darwin was a fraud and plaigirized everything from contemporary Patrick Matthew. Gonna check it out, sounds pretty interesting.

  • @leighedwards
    @leighedwards4 жыл бұрын

    Heisenberg formulated the uncertainty principle, Schrodinger gave us wave mechanics with an equation for atomic wavefunctions

  • @antounsemaan
    @antounsemaan2 жыл бұрын

    Interesting, love it.

  • @qf1150
    @qf1150 Жыл бұрын

    2:42 "Schroedinger, he of the Uncertainty Principle". The Uncertainty Principle was formulated by Werner Heisenberg. Erwin Schroedinger formulated the equation . the wave function of a quantum system.

  • @davemmar
    @davemmar2 жыл бұрын

    These parameters fit well into the earth’s environmental changes. But on another planet, for sample, with no environmental changes there may be no need for evolution or reproduction, etc. This video should not and cannot be the only basis for our search for extraterrestrial intelligence. But this video does make one wonder how fantastic are the differences of life in our universe. And just how soon will we have the ability to connect with the universe’s other self aware entities? I only wish it could happen in my lifetime. Thank you, Paul.

  • @sonarbangla8711
    @sonarbangla87113 ай бұрын

    Life, consciousness, intelligence, intuition, faith etc., are metaphysical dimensions evolving out of matter (physics). These extra dimensions are what string theorists indicate.

  • @joqqy8497
    @joqqy84976 ай бұрын

    2:36 Werner Heisenberg formulated the uncertaintly principle, not Schrödinger(whose equation the principle was based upon because of the probabilistic interpretation of it).

  • @james6401
    @james64012 жыл бұрын

    Brilliant lecture, thanks. It seems that we often look for a definition of life using micro systems from ourselves down but in reality we reach a difficulty with that approach and end up going macro on our examples. Maybe a forest is alive, maybe humans are part of larger wholes or ecosystems and who knows how far it goes up?

  • @lisaalexander1824

    @lisaalexander1824

    2 жыл бұрын

    Around and around for infinity ?? Every species dies, but maybe other things are created...

  • @Thom3748
    @Thom37482 жыл бұрын

    This is a very well done lecture, and really worth an our of time, but something is missing--the proverbial Elephant in the room. Nurse describes the organization and processes of the cell quite nicely (and in some depth), but he doesn't give any explanation as to what starts the processes, and what drives them. In other words, what is the make up and character of the force behind the most fundamental aspect of biology? What is that life force?

  • @thomasbje3843
    @thomasbje38433 жыл бұрын

    A brave man.

  • @drgrahambeards9776
    @drgrahambeards97766 ай бұрын

    Excellent. He could have mentioned seeds, which look totally dead until placed in a nourishing environment. They are similar to viruses in this regard.

  • @Sophiedorian0535
    @Sophiedorian05354 жыл бұрын

    The uncertainty principle is from Heisenberg, not from Schrödinger, professor.

  • @richardtendyke3422
    @richardtendyke34222 жыл бұрын

    Two comments, I believe it was Heisenberg and not Schrodinger who developed the uncertainty principle. Second, certainly purpose evolves as a result of evolution, but I think it is a more significant element than that. It is purpose that drives evolution. It is purpose that provides a measure of success for a new birth to succeed and therefore reproduce. This concept of being able to measure the relative value of one option vs. another is the key to be able to create order from disorder. It applies in areas other than life.

  • @howardtaylor9114
    @howardtaylor91142 жыл бұрын

    Superb.

  • @davidford694
    @davidford6944 жыл бұрын

    I spent much too much of a long life trying to get some computer to do something useful. One thing that plagued me was that any error, no matter how slight, made my code fail. If, as Dr. Nurse says, life is based on coded information, where did it come from? We all know that DNA code is immensely complex and sophisticated. Yet it is present in all life we have ever found, no matter how old or how primitive. So, where did it come from? A side note. I am really interested in knowing why Dr. Nurse is so keenly intent on eliminating the possibility that there was an intelligent creator. What is the psychological need here?

  • @zinafandel3672

    @zinafandel3672

    4 жыл бұрын

    Who created the intelligent creator? Is he alive? Is he DNA based?

  • @davidford694

    @davidford694

    4 жыл бұрын

    @@zinafandel3672 No and no. Not a he either.

  • @caricue

    @caricue

    3 жыл бұрын

    David, life has a terrible and unforgiving logic to it that explains your question quite well. Anything that makes an error, no matter how slight, dies. Evolution is all about death. The reason all the wild animals almost always look perfect and error free is because the defective or weak die, either before birth or shortly after, sometimes by mom's appetite. If you see your creator around the coffee shop, you might inquire about his penchant for killing the weak in gruesome fashion.

  • @davidford694

    @davidford694

    3 жыл бұрын

    @@caricue Sorry, but the question I asked was "where does the code come from?".

  • @harmless6813

    @harmless6813

    2 жыл бұрын

    It evolved. I thought the lecture explained that rather well?

  • @sophistichistory4645
    @sophistichistory46452 жыл бұрын

    "WHAT IS LIFE?? BABY, DON'T HURT ME. DON'T HURT ME, NO MORE."

  • @MichaelJonesC-4-7
    @MichaelJonesC-4-74 жыл бұрын

    What is life? That brief period of time between our eternity of nonexistence.

  • @MichaelJonesC-4-7

    @MichaelJonesC-4-7

    4 жыл бұрын

    @Bob Trenwith Exactly. The "life" of a soap bubble. You are limiting your definition to *your experience* as a human being, alone in the universe, living on a spinning rock held up by _nothing._

  • @curtislocus195
    @curtislocus1955 ай бұрын

    Thank you

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