Best video on YT on this topic. I'd like to add something about the weird terminology here, just details but might help someone: 1) haptocorrin = transcobalamin I (and I think formerly aka transcobalamin III) = cobalophilin = R-protein = R-factor = R-binder ["R" stands for "rapid electrophoretic mobility"]. 2) The intrinsic factor receptor in the terminal ileum is also called "cubilin"; the receptor in the kidney that's responsible for the B12 reabs. is the same like the one in the terminal ileum (it is also cubilin!) with the small difference that megalin was added to this receptor (which means this receptor is more "elaborate" than the one in the terminal ileum). Also, in order for cubilin to work, you need a membrane protein that will make cubilin stay put (and will help in the endocytosis, once B12 bound), this protein being called "amnionless". 3) A mutation in cubilin or amnionless (autosomal recessive) leads to the Imerslund-Gräsbeck syndrome (syn.: defect of enterocyte intrinsic factor receptor, enterocyte cobalamin malabsorption, megaloblastic anemia 1, juvenile pernicious anemia with proteinuria due to selective intestinal malabsorption of vitamin B12), 1:200k in Finland/ Norway --> patients will have problems with both, B12 abs. AND reabs (remember, cubilin/ amnionless is present in both organs). 4) B12 bound to transcobalamin II (the transporter in the blood) is called "Holotranscobalamin" ("active B12"). 5) Haptocorrin is also produced in the stomach, not only by the salivary glands; and, as said in the vid, haptocorrin can bind 80% of the B12 in the blood making it unavailable for use. Source(s): Boron, wiki, GHR, countless research papers until I found out what "R" in "R-factor" stands for. Motivation: When I first studied B12 abs. I was frustrated because people would either be SHIT in explaining it (i.e., didn't know the exact mechanism), or would provide incomplete explanations; the fkd up terminology wouldn't improve things... Thank you

@foreveryouwillbe1233

4 жыл бұрын

Thank you. You have answered my questions.

@user-hg2gf1jh9i

3 жыл бұрын

Thank you, very informative.

@fitybux4664

3 жыл бұрын

How do we get "Holotranscobalamin" ("active B12") blood tests in the US? It's weird, every reference to this seems to bring up UK web pages. I can get a Vitamin B12 and Vitamin B-12 Binding Capacity, Unsaturated (Transcobalamin) blood test in the US. Would I literally have to do medical tourism just to get this test? Hahahaha.

@yourremarkablyaveragepal781

3 жыл бұрын

Thank you for this!

@wSpaceArt

26 күн бұрын

Abbott Diagnostics had an Active B12 assay before. Not sure if they still have. If no, check on Roche.

I shudder to think how long you've had this up and I did not know. Thank you for the mission you are on. I appricate the detail and simplcity of your explanations. I feel fortunate to be exposed to your vast and up to date knowledge. Thank you, thank you!! Oh, plus you have a good voice. I've had to leave many sites because of irritating or condecending voices. I hope to see more.

This is the most perfect informational video I have come across on Vitamin B12,good job keep it up.

Chiming in with the others. You’re very easy to understand and informative. Thank you so much. I’ve been injecting B12 half my life, it nice to understand the importance. ☺️

@FREE_Indeed_

14 күн бұрын

Hi, do you mind sharing what kind/brand? of B12 you have been injecting and how often? I suspect that my 77 yr old mom may need injections. Hoping to have her levels checked. Thank you in advance.

Absolutely amazing explanation, you’re quite literally saving my grades thank you 👏🏻🙏🏼

Very informative!! Thank you for your work. Can you upload the Digestion, Absorption, and Metabolism processes and pathways for 1. Fish Oils (DHA / EPA) and 2. Extra Virgin Olive Oil ?

Very helpful! Thank you!

Fantastic video and easy to follow. Though as usual the super rich world of enzymes makes it easy to get lost for a newbee.

I learned alot from your video sir. Thank you!

Great! Thank you 🙏🏻

Nyzz programming and structuring... Easy to understand 🤩 thnq🤝🤝

Excellent teacher

Thank you for info

Thx that was very useful 😊

Thank you very much. Your explanation is simple and informative 👍 .

Lovely to understand

thank you so much!!!

Nice update on vitamin B12

I like your videos very much. I guess you're studying to be a doctor, which is super full on anyway, let alone uploading videos too. But I think you might be able to remember more about important subjects if you do the videos on the real important stuff. I dont know, I just thought I'd comment to say that it could be a good idea for memory retention. Cheers, have a good one.

Thank you

um very informational

How does sublingual vit b12 work??

It's Very important....

What about IF blocking anti-body ? Can you make a video on that ?

what about the one who is diabetic on insulin will supplement absorb ?

Hi, JJ ! Question: When is it best to take V12, early in the morning or in the evening, or it doesn't matter when ? Thank you.

Please provide more info on hereditary absorption deficiencies, Transcobalamin I, II & III. Tia!

Question..... can anyone explain or give clarity on the following ... does any change to typical Purine & Pyrimidine, folate, B6 or B12 pathways during pre or early post natal periods result in heritable genetics that could be passed from that baby should they procreate in later life?

Well, I sorely missed a chapter about passive diffusion (B12 absorptioin without the need of Intrinsic Factor) and the transcobalamins I, II and III. Maybe next time?

thanks

Nice 👍

If I had a normal to high level of Serum B12 but a very low (half the lower reference range) of Vitamin B-12 Binding Capacity, Unsaturated (Transcobalamin), is this a problem? If I supplemented orally B-12, would that raise Transcobalamin? Or maybe I'm not understanding it well enough. Is it an issue if my Transcobalamin is low, even if my serum B12 is normal? What kind of a doctor should I talk to? It's hard to get one that cares. Hematologist? (It seems like "Transcobalamin Deficiency" is a pretty specialized thing and most doctors only care if you are bleeding out so they can stitch you up. Not about complex metabolic deficiencies that might just make you feel slightly crappy or have other risk factors later in life.) I have a few TCN2 gene variants, but I don't even know what kind of doctor I can get to care about something like that. Most of those variants do not have any pubmed/research papers associated with them. 6:46 I've never taken an MMA blood test, but it's definitely on my list of things to do! :-D

have you made a video about homocysteine methyl transferase?

Thank you for the great videos! If someone has compromised B12 absorption should they get it via injections and if so how often is safe for an elderly woman of age 77? Thank you in advance. 🙏🏼

It was very easy to understand, thank you so much!

@parshuramsoni1170

4 жыл бұрын

Hy

@Mr_Zeal1001

3 жыл бұрын

Yup really

Wonder if radioactive cobalt tracing from B12 has been examined

Hey! I came here to know the why does vitamin b12 get stored in body. Does anyone know the reason?🤔

And again, the lesson here is chewing your food and taking time eating is key. I think one the reasons why I was deficient in nutrients in general was eating too fast and drinking too much coffee. The latter makes your stress levels go high which makes you chew less and faster. Oh boy!

Do you have video in Vitamin A

So do b12 make you gain weight or not

I am not sure of Methionine getting converted to MMA at 6:10. I think it is propionic acid to MMA?

Hi, great video! So if I take a capsule, the b12 doesn’t get a chance to bind to the Haptocorrin, does that mean my supplement is just getting disintegrated in my stomach acid?

@Amandaklint

4 жыл бұрын

That is why b12 supplements don't come in capsule form, they come in sublingual form. Which means they go under the tongue and dissolve with your saliva. Otherwise, yes, that would be the case.

@harrycurrie9664

3 жыл бұрын

Not necessarily, I take a 1000mcg tablet and find it works best if taken with the first mouthful of food at breakfast every day. My B12 levels are around 750 so it appears to be getting there. Perhaps a tablet is better to bypass the stomach acids.

Does the body store B12 for years of use ????

Sir I want to know that our sperm contains vitamin b12 or not??? Pls reply sooner

Great explanation of things! Question: if someone gets a B12 injection, is that easier for the body to accept and use than taking oral methylcobalmin?

@cammyfayes

Жыл бұрын

And also, is sublingual methylcobalmin ok to use?

@denisethomson7685

9 ай бұрын

Injection is best for me ,pills don't work for me .

Pills verses injection benifits please exsplain.

Doctor told me to consider this cause I’m vegetarian😁 Will it really help me with anything

B12 produced by Propionibacterium and this is not big problem for vegetarians. We can drink fermented coconut kefir from Propionibacterium or consume probiotics.I assume that in sufficient quantities these bacteria can synthesize B12 right in intestines.

It helping my metabolism, will it help me lose weight ?

I wonder if I'm a poor absorber of b12 because I was taking 25mcg of b12 a day and had a little tingling in my legs and hands occasionally. I was not eating animal protien. Now I take 1000mcg a day. I might go down to 250mcg like dr. Michael Greger recommends. But I feel good now.

@techlearnings4732

6 жыл бұрын

Mr. S hi I do have same symptoms

@sandrostumpo3779

6 жыл бұрын

I cut back on the b6 supplements as this could disrupt the absorption of b12, I believe because b6 affects homocysteine levels. I try to eat lots of healthy food and get it naturally now. I only supplement a couple of milligrams, like 6-12mg of b6. I bumped up my b12 to 2500mcg of b12 a week. I take the cyanocobalamin. I no longer get those tingles in my legs. I also do not cook with salt. I sprinkle 1/4 teaspoon of sea salt on my food a day. Too much salt is bad for circulation. I read in Mayoclinic that we do not need to even add extra salt because it is our food. I sprinkle a little for insurance because a little is vital, but adding too much adds water volume to our blood and constricts our veins which makes our heart work harder. My circulation is so much better now that I eat no animal protein. I still take a half teaspoon of fish oil a day for vein and brain health. Also, potassium rich foods lower blood pressure and help circulation. Check out the nutrition facts.org videos and get a used copy of "The china study". by T. Colin Campbell. It cost 4dollars on eBay with free shipping.

@awanier786

6 жыл бұрын

VitB6 is important as well as vitamin B6 is the cofactor in the first step of heme synthesis,

@db60615

5 жыл бұрын

If you feel good on the 1000mcg why go to the 250mcg??? He said its water soluble, so if you have extra it will release itself......

@fireyflower6643

4 жыл бұрын

Yr on pills thats why yr not absorbing, and if you dont take cofactors then b12 wont work

Will a B complex vitamin help me lose weight ?

What type of bacteria produces B12? Bifidobacillus or lactobacillus?

Most people vegan Vegetarian or not do not ingest B12 at all unless its fortitfied in the food its self why do you treat B12 as a Plantbased diet problem? If you dont wash your fruits and vegetables in nature (No GMO's and no pesticides ) you'll get B12 or if you eat animal large intestines.... And you dont need that much of it.

I take B12 250mcg

excess b12 is stored in liver

I have 1000 mcg vitamins. Is that a 1.0 on the scale ?

@harrycurrie9664

3 жыл бұрын

1000 micrograms is equal to 1 milligram. 1000 milligrams is equal to 1 gram.

It’s water soluble but store in liver*

Can the body produce vitamin B12?

Will it help me lose weight ?

Sir, I am suffering for b12 deficiency. Our body not absobptio b12.

@chris_sndw

3 жыл бұрын

Eat some liver, my friend. You need to eat beef liver!

@harrycurrie9664

3 жыл бұрын

Read up on "Pernicious anemia". Get a B12 injection, take a B12 tablet daily with your first mouthful of food each day. Eat liver ...lambs ( lightly fry slices, dusted with seasoned flour ) liver has a greater concentration of B12 than beef.

My blood test shows that I have over 1300 (PG/ML) of B12, my bilirubin over 1.7 (MG/DL), and high levels of bad cholesterol. Every year when I see those High levels of B12 on my yearly physical exams I ask my Doctor if that is OK, and I always receive the same answer. "No worries It is fine." I have a feeling that it is not fine.

@kacyb9249

5 жыл бұрын

It's okay! I study B12 and having too much B12 in the body is harmless. It stays in the system a more than other vitamins because it cannot be produced in the human body and we must obtain it from external sources. It also loves water (and we are 70% water) so having some of it residually in the body is to be expected.

@db60615

5 жыл бұрын

That means you aren't using the energy that the b-12 is providing you. You're sitting on energy. Start excercising to use the b-12 and it will lower the cholesterol.

@harrycurrie9664

3 жыл бұрын

@@kacyb9249 How are you getting your B12 ? through diet, injection, or supplement ?

This is oral ,how is cyanocobalamin absorbed by injection?

@harrycurrie9664

3 жыл бұрын

As a guess I'd say directly through the bloodstream to the liver and kidneys.

I get injections ,not having a gallbladder i cant absorb nutrients.

what if you are an overweight teenager and you took about 10 capsules of 1000mcg B¹² for 'metabolism' because you're depressed and want to stop eating??

@Simplicity_95

3 жыл бұрын

Read some self improvement books.

@fitybux4664

3 жыл бұрын

If you did this, you probably wouldn't die. Maybe. Definitely not great for you. Depression has about a bazillion causes. See a doc and be persistent. Good luck!

@ankhenaten2

3 жыл бұрын

You will start shitting

@pietrocantuccini5584

2 жыл бұрын

That means 95% of the costs go down the toilet bowl.

My B12 level is >2,000. I don’t supplement. Why would my B12 levels be so high?

My b12 is 240 and I’m tired. All the time. I’m not even vegan. I have acid reflux my stomach may be to acidic and killing the b12. But it’s strange.

@brandonxs9r659

Жыл бұрын

Acid reflux is usually caused by too little stomach acid: the LES(lower esophogeal sphincter), that sits between the opening of your stomach and the end of your esophagus, needs acid with a very low ph(high acidity) for it to close properly. If there's not enough acid, then it 'thinks' that there's no food being digested and that it can relax. Gut dysbiosis can cause a whole load of gastrointestinal issues - including acid reflux or GERD(gastroespohgeal reflux disease). For example, SIBO(Small Intestinal Bacterial Overgrowth) is when bacteria overgrow in your small intestine, they produce gasses that force the LES to relax. In addition, H. Pylori may actually directly cause SIBO: since it neutralises stomach acid by the means of production of ammonia by catalysing urea by the enzyme urease. In simple terms, gut imbalances make the usual acidic environment of the stomach less harsh and more alkaline, signalling the LES to open and back up acid or food contents into the throat, causing Heartburn, GERD, acid reflux and etc. Since strong acidity is required to absorb certain nutrients, that also explains your B12 deficiency.

@beingbenign2685

11 ай бұрын

try buying a b12 that contains 'intrinsic factor' some peoples body's don't make enough.

A little bit more information how B12 affects our bodies/mind would have been more useful

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To whoever is reading this Jesus loves you and he’s coming soon. All you need to do to be saved is believe that Jesus Christ died on the cross for your sins was buried and came back to life on the 3d day confess with your mouth Jesus is Lord and you’ll be saved. Today is the day of salvation tomorrow is not promised and you don’t want to miss the rapture it will be so bad like nothing ever seen before on earth. God

Vegans get B12 from Brewers Yeast. You also don’t know much here.

@Amandaklint

4 жыл бұрын

Brewers yeast contains Vitamin B, but not vitamin B12. www.healthline.com/health/brewers-yeast#what-it-does

Sir please change language this video in Hindi I don't understand English sir

You mean vegans