Video 15 Ig Antibodies and Immunoglobulin Function

15) The core of adaptive immunity: immunoglobulin antibodies
The immune system depends on special binding molecules known as immunoglobulins, also referred to as "antibodies" or "Ig" for short. Immunoglobulins are "Y" shaped molecules that connect on one end to invading microbes (antigens) and on the other end they bind with various white cells that effectivley block and destroy the antigen. These specialized antibody molecules come in different shapes and sizes in order to provide flexibility in matching and destroying targeted antigens. Antibody molecules are found floating in the plasma as well as on the surface of specialized B-cells.
Immunoglobulins are constructed from two types of amino acid chains, heavy chains and light chains. Ig molecules contain two identical strands of heavy chains and two identical strands of light chains. The end with the two heavy chains forms a stable non-variable receptor point called an effector, which is the part of the Ig molecule that binds with our own immune system cells.
On the opposite end of the antibody are two antigen binding sites, each with a light chain and heavy chain combination. This combination of light and heavy chains forms highly variable tips that can adapt to match a specific antigen.
Immunoglobulins come in five basic types: IgA, IgD, IgE, IgG and IgM. Each type targets a specific type of antigen, which determines the make-up of the Y chain structure of each.
IgD, IgE and IgGs all use a single Y chain whether as stand alone antibodies or as receptors connected to white cells.
IgAs use a double Y chain, called a Dimer.
IgMs are unique in that they form a single Y chain when expressed on the surface of a B-cell, but the stand alone version of the IgM molecule forms a combination of five Y chains, known as a pentamer. Consequently, stand alone IgMs form a very large antibody molecule.

Пікірлер: 107

  • @larsmolema3270
    @larsmolema32703 жыл бұрын

    I SEARCHED 2 HOURS ON INTERNET AND HERE IT IS, A NORMAL EXPLANATION, I CANNOT THANK YOU ENOUGH

  • @taratateah14

    @taratateah14

    3 жыл бұрын

    LITERALLLLLYYYY

  • @syedwaqasshah5744

    @syedwaqasshah5744

    8 ай бұрын

    Watch antibodies Lecture given by Dr Najeeb kzread.info/dash/bejne/h3aEyduMe6ind5s.html

  • @Drobalar-Drsebi

    @Drobalar-Drsebi

    2 ай бұрын

    Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..

  • @carolinegreen4771
    @carolinegreen47717 жыл бұрын

    Thanks for sharing this informative video. The immunoglobulin superfamily (IgSF) is a large group of transmembrane glycoproteins with multiple extracellular disulfide bonded loops. These regions are homologous to ones in immunoglobulin molecules. IgSF molecules are 70-110 amino acids and associate with their ligands in a Ca2+-independent manor. There are two major types of IgSF: the C1-type is responsible for antigen recognition and the C2-type is responsible for non-antigen specific functions such as cell adhesion. Members of the latter type have a variable number of extracellular Ig-like domains with conserved cysteine residues which form intra-chain disulfide bonds to stabilize the β-sheets of the tertiary structure. Five members of the C2-type of IgSF mediate leukocyte adhesion and these are expressed on endothelium: ICAM-1 (CD54), ICAM-2(CD 102), VCAM-1 (CD106), PECAM (CD31), and MadCAM-1. -Creative BioMart

  • @Bimpstar
    @Bimpstar10 жыл бұрын

    Very useful overview, thanks so much!!

  • @aimeewalnofer8391
    @aimeewalnofer83919 жыл бұрын

    Thanks for this very helpful and concise video.

  • @callmema14
    @callmema149 жыл бұрын

    I can understand these concepts much better in a video like this. You helped me a lot.

  • @Drobalar-Drsebi

    @Drobalar-Drsebi

    2 ай бұрын

    Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..

  • @astha_yadav
    @astha_yadav Жыл бұрын

    When 8 year old vids explain WAYYY better and more concise than most shi- out there

  • @Drobalar-Drsebi

    @Drobalar-Drsebi

    2 ай бұрын

    Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..

  • @mimiendlovu8390
    @mimiendlovu83908 күн бұрын

    Great explanation!!

  • @debrakleid5752
    @debrakleid5752 Жыл бұрын

    Thank you for the explanation. I have CVID and I’m on IVIG via infusion through a central line every 28 days (occasionally is 5 weeks if it falls on a holiday. My IGG is low as well as must of the subclasses. My hematologist said I have a more severe form of CVID apparently which is why I still get bad pneumonia’s and sepsis even while on IVIG but it has reduced the number of pneumonia’s I’ve had. If I can get to below once per year I would be happy. Have had it twice this year and both were pretty bad requiring IV antibiotics to treat and one took a total of 4 (1 oral and 3 others were IV form and a week hospitalized, again).

  • @wahi3250
    @wahi32502 жыл бұрын

    Best understanding concept...good luck🥀🥀

  • @nicoleteufel6118
    @nicoleteufel611810 жыл бұрын

    you're amazing- thank you!

  • @tingbatuuka7278
    @tingbatuuka72782 жыл бұрын

    Very good explanation

  • @WholeFuture
    @WholeFuture9 жыл бұрын

    Excellent, thank you

  • @rittenbrake1613
    @rittenbrake16135 жыл бұрын

    Thanks ! It's informative !

  • @grandtheo
    @grandtheo10 жыл бұрын

    can't believe it took me these two minutes to know what this is about... thank u so much

  • @Drobalar-Drsebi

    @Drobalar-Drsebi

    2 ай бұрын

    Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..

  • @AnneScrubsFan
    @AnneScrubsFan10 жыл бұрын

    Great video, thanks!

  • @treyquintanilla3746
    @treyquintanilla37462 жыл бұрын

    Thanks for the brief overview! 🙌🏼 Could you consider adding the youtube links of each separate antibody video into the description section? If you're not able to edit, then add a comment with them and pin it! I just think it would be easier for other users to have quick access to your videos(:

  • @brendagomez8593
    @brendagomez85939 жыл бұрын

    Very helpful. Thank you so much!

  • @malikfayaz2542

    @malikfayaz2542

    8 жыл бұрын

    yea bb

  • @drasadkhan129
    @drasadkhan1298 жыл бұрын

    good lecture.thank you

  • @mujeebgaming7912
    @mujeebgaming79122 күн бұрын

    Superb short and to the point.. please clear one thing what are B cells.. thanks

  • @athenajohnston
    @athenajohnston6 жыл бұрын

    This video was very helpful for my A & P exam - thank you!

  • @stompinknowledge3968

    @stompinknowledge3968

    Жыл бұрын

    What's A & P?

  • @riefilms

    @riefilms

    Жыл бұрын

    @@stompinknowledge3968 anatomy and physiology

  • @stompinknowledge3968

    @stompinknowledge3968

    Жыл бұрын

    @@riefilms danke

  • @kiranmaychauliya9979
    @kiranmaychauliya99797 жыл бұрын

    very good concept

  • @mahdimahdikassim1592
    @mahdimahdikassim15928 жыл бұрын

    thank you doctor

  • @brad4908
    @brad49084 жыл бұрын

    So clear!

  • @nermeenpal6034
    @nermeenpal60346 жыл бұрын

    Thank you doctor

  • @bint-ehwa9681
    @bint-ehwa96813 жыл бұрын

    aslamm o alikum . sir . your all videos are just stunning ...plzzz continue your work.. why you leave this ..your all videos are very helpfull .... plz comple the main concept of biology by your spectacular way ... we are waiting for your next video !!!!❤️❤️❤️❤️

  • @larsmolema3270
    @larsmolema32703 жыл бұрын

    it makes so much sense

  • @priscillalk5324
    @priscillalk532410 ай бұрын

    Thank you 🙏🏾

  • @muhammedozdemir1571
    @muhammedozdemir15714 жыл бұрын

    This video was very helpful for my Exam 4. Komite thank you! 😊

  • @syedwaqasshah5744

    @syedwaqasshah5744

    8 ай бұрын

    Watch antibodies Lecture given by Dr Najeeb kzread.info/dash/bejne/h3aEyduMe6ind5s.html

  • @FatimaMD7
    @FatimaMD7 Жыл бұрын

    Thank you

  • @shaunamcelvogue6755
    @shaunamcelvogue6755 Жыл бұрын

    Good video ❤️

  • @jazzminemonroee
    @jazzminemonroee Жыл бұрын

    MAY GOD BLESS YOU

  • @user-gg4ty3xf2s
    @user-gg4ty3xf2s8 ай бұрын

    This is awesome 😅

  • @Drobalar-Drsebi

    @Drobalar-Drsebi

    2 ай бұрын

    Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..

  • @BB-hm9mq
    @BB-hm9mq Жыл бұрын

    This video is CLUTCH😎😎

  • @atheerzak4599
    @atheerzak45995 жыл бұрын

    Thanks ✨

  • @diksha3267
    @diksha3267 Жыл бұрын

    Thanks sir 😊

  • @Drobalar-Drsebi
    @Drobalar-Drsebi2 ай бұрын

    Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..

  • @Anas-uh6lo
    @Anas-uh6lo7 жыл бұрын

    very thanks

  • @diaherawati1335
    @diaherawati13356 жыл бұрын

    thank youuu.

  • @kiranpatil3262
    @kiranpatil32623 жыл бұрын

    Yesterday i had a Antibody test for Covid19 and the report of my test was igG positive and igM negative.

  • @user-oe5rw8bb8t
    @user-oe5rw8bb8t8 жыл бұрын

    thanks you

  • @karamelbadry7222
    @karamelbadry72229 жыл бұрын

    usefull many thanks

  • @ByTurkoglu
    @ByTurkoglu2 жыл бұрын

    hello sir, my ige value is 1.00 mm/mL in every blood test I give and i have recurring infections, is it because my ige level is low thank you

  • @r.f9962
    @r.f99622 жыл бұрын

    splended thanks

  • @gurusoma3169
    @gurusoma31697 жыл бұрын

    Good information thank u

  • @dishadidi3000
    @dishadidi300011 ай бұрын

    Nice

  • @pianoLee-sx9dx
    @pianoLee-sx9dx6 жыл бұрын

    My doctor has asked me to do a full blood test but only mentioned ig E and ig A only

  • @raphaelkenyuri8420
    @raphaelkenyuri84207 жыл бұрын

    Great

  • @mads5965
    @mads59652 жыл бұрын

    splendid

  • @dr.jijivijayan5365
    @dr.jijivijayan5365 Жыл бұрын

    Thanku💛

  • @medicallaboratory3722
    @medicallaboratory37226 жыл бұрын

    like how did they discover it ?? I always ask how did they discover this stuffs but no answer

  • @omnipenne9101

    @omnipenne9101

    5 жыл бұрын

    Poster summarising the discoveries, you could try googling for the papers (papers are listed under references. Some require paid subscriptions to access but you could try requesting the papers on ResearchGate. It may take a while before you get a response): www.biolegend.com/media_assets/literature/images/MilestonesPoster_small.pdf

  • @simrankahlon50
    @simrankahlon502 жыл бұрын

    Hey why you stopped posting videos?

  • @simrankahlon50

    @simrankahlon50

    2 жыл бұрын

    Praying that you are fine and will be back soon❤️

  • @jugabratdeka2191
    @jugabratdeka21915 жыл бұрын

    Does ivig work for polymyositis?

  • @asithsahul6903
    @asithsahul69036 жыл бұрын

    I suffering ige level 1025 from 5 years please give me yours solution doctor.

  • @Roberto-nk3ed
    @Roberto-nk3ed2 жыл бұрын

    IgE other 2000 che significa ? Sono due anni che il mio esame del sangue risulta così alto , purtroppo non solo questo o anche problemi alle gambe e braccia con duroni e prurito.

  • @qudratullahibrahimi6947
    @qudratullahibrahimi69476 жыл бұрын

    Thank you help me in this matter very good thanks i like you

  • @souravsarkar6982
    @souravsarkar69826 жыл бұрын

    I suffering ige 358 from 3years . please give me solution

  • @anudhiman5122
    @anudhiman51226 жыл бұрын

    It's good

  • @Viratgupta___11
    @Viratgupta___114 жыл бұрын

    2 minutes and long topic irs realy praisable

  • @nadasalah4343
    @nadasalah4343 Жыл бұрын

    أشهد أن لا إله إلا الله و أشهد أن محمداً عبده و رسوله صلى الله عليه و سلم

  • @jaydem3624
    @jaydem36244 жыл бұрын

    I got ige connecting to my red blood cells help please please

  • @afiyabegum8192
    @afiyabegum81925 жыл бұрын

    my mother in law is suffering from ige her level is 590

  • @guytelfer1353
    @guytelfer13534 ай бұрын

    There's more to it by now?

  • @Drobalar-Drsebi

    @Drobalar-Drsebi

    2 ай бұрын

    Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..

  • @vinothsk1809
    @vinothsk18096 жыл бұрын

    What is difference between antibodies and anti antibodies

  • @smilyyyflower175

    @smilyyyflower175

    5 жыл бұрын

    anti antibodies are the ones who attacks antibodies. they're our immune system cells

  • @soamazing7027
    @soamazing70272 жыл бұрын

    Great Video! (Jesimiel Millar Fernåndez) 1M948

  • @rajifusama
    @rajifusama9 жыл бұрын

    Ig is instagram you must be kidding me

  • @MonkeyDLuffy-xr4fl

    @MonkeyDLuffy-xr4fl

    9 жыл бұрын

    Troll

  • @anudhiman5122

    @anudhiman5122

    6 жыл бұрын

    rajifusama

  • @caribaez5711

    @caribaez5711

    6 жыл бұрын

    rajifusama dumb 😂

  • @negativeiq3792

    @negativeiq3792

    6 жыл бұрын

    And yes,you are one of those idiot

  • @Ahmed-tu3ms

    @Ahmed-tu3ms

    5 жыл бұрын

    Lol

  • @margaretpok9679
    @margaretpok96792 жыл бұрын

    Hi

  • @Epicgamer-fw4cn
    @Epicgamer-fw4cn3 жыл бұрын

    immunoglobulin

  • @112hidde112
    @112hidde1127 жыл бұрын

    seriously, who came up with this shit? WHY ARE HUMANS SO SMART!?

  • @Fati.chaine

    @Fati.chaine

    4 ай бұрын

    I asked my self same question

  • @samnsami6004
    @samnsami600411 ай бұрын

    GAMED, igG,igA,igM,igE,igD

  • @Drobalar-Drsebi

    @Drobalar-Drsebi

    2 ай бұрын

    Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..

  • @poke3r
    @poke3r3 жыл бұрын

    حح^دد. 5tu K:230,X:554,Y:5896

  • @Yotay597
    @Yotay5972 жыл бұрын

    thanks a lot for this helpful video , i really benefited , god bless you 🤍🤍🤍🤍

  • @user-sr9is6px1j
    @user-sr9is6px1j5 ай бұрын

    Thank you

  • @Drobalar-Drsebi

    @Drobalar-Drsebi

    2 ай бұрын

    Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..

  • @Drobalar-Drsebi
    @Drobalar-Drsebi2 ай бұрын

    Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..