Video 15 Ig Antibodies and Immunoglobulin Function
15) The core of adaptive immunity: immunoglobulin antibodies
The immune system depends on special binding molecules known as immunoglobulins, also referred to as "antibodies" or "Ig" for short. Immunoglobulins are "Y" shaped molecules that connect on one end to invading microbes (antigens) and on the other end they bind with various white cells that effectivley block and destroy the antigen. These specialized antibody molecules come in different shapes and sizes in order to provide flexibility in matching and destroying targeted antigens. Antibody molecules are found floating in the plasma as well as on the surface of specialized B-cells.
Immunoglobulins are constructed from two types of amino acid chains, heavy chains and light chains. Ig molecules contain two identical strands of heavy chains and two identical strands of light chains. The end with the two heavy chains forms a stable non-variable receptor point called an effector, which is the part of the Ig molecule that binds with our own immune system cells.
On the opposite end of the antibody are two antigen binding sites, each with a light chain and heavy chain combination. This combination of light and heavy chains forms highly variable tips that can adapt to match a specific antigen.
Immunoglobulins come in five basic types: IgA, IgD, IgE, IgG and IgM. Each type targets a specific type of antigen, which determines the make-up of the Y chain structure of each.
IgD, IgE and IgGs all use a single Y chain whether as stand alone antibodies or as receptors connected to white cells.
IgAs use a double Y chain, called a Dimer.
IgMs are unique in that they form a single Y chain when expressed on the surface of a B-cell, but the stand alone version of the IgM molecule forms a combination of five Y chains, known as a pentamer. Consequently, stand alone IgMs form a very large antibody molecule.
Пікірлер: 107
I SEARCHED 2 HOURS ON INTERNET AND HERE IT IS, A NORMAL EXPLANATION, I CANNOT THANK YOU ENOUGH
@taratateah14
3 жыл бұрын
LITERALLLLLYYYY
@syedwaqasshah5744
8 ай бұрын
Watch antibodies Lecture given by Dr Najeeb kzread.info/dash/bejne/h3aEyduMe6ind5s.html
@Drobalar-Drsebi
2 ай бұрын
Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..
Thanks for sharing this informative video. The immunoglobulin superfamily (IgSF) is a large group of transmembrane glycoproteins with multiple extracellular disulfide bonded loops. These regions are homologous to ones in immunoglobulin molecules. IgSF molecules are 70-110 amino acids and associate with their ligands in a Ca2+-independent manor. There are two major types of IgSF: the C1-type is responsible for antigen recognition and the C2-type is responsible for non-antigen specific functions such as cell adhesion. Members of the latter type have a variable number of extracellular Ig-like domains with conserved cysteine residues which form intra-chain disulfide bonds to stabilize the β-sheets of the tertiary structure. Five members of the C2-type of IgSF mediate leukocyte adhesion and these are expressed on endothelium: ICAM-1 (CD54), ICAM-2(CD 102), VCAM-1 (CD106), PECAM (CD31), and MadCAM-1. -Creative BioMart
Very useful overview, thanks so much!!
Thanks for this very helpful and concise video.
I can understand these concepts much better in a video like this. You helped me a lot.
@Drobalar-Drsebi
2 ай бұрын
Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..
When 8 year old vids explain WAYYY better and more concise than most shi- out there
@Drobalar-Drsebi
2 ай бұрын
Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..
Great explanation!!
Thank you for the explanation. I have CVID and I’m on IVIG via infusion through a central line every 28 days (occasionally is 5 weeks if it falls on a holiday. My IGG is low as well as must of the subclasses. My hematologist said I have a more severe form of CVID apparently which is why I still get bad pneumonia’s and sepsis even while on IVIG but it has reduced the number of pneumonia’s I’ve had. If I can get to below once per year I would be happy. Have had it twice this year and both were pretty bad requiring IV antibiotics to treat and one took a total of 4 (1 oral and 3 others were IV form and a week hospitalized, again).
Best understanding concept...good luck🥀🥀
you're amazing- thank you!
Very good explanation
Excellent, thank you
Thanks ! It's informative !
can't believe it took me these two minutes to know what this is about... thank u so much
@Drobalar-Drsebi
2 ай бұрын
Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..
Great video, thanks!
Thanks for the brief overview! 🙌🏼 Could you consider adding the youtube links of each separate antibody video into the description section? If you're not able to edit, then add a comment with them and pin it! I just think it would be easier for other users to have quick access to your videos(:
Very helpful. Thank you so much!
@malikfayaz2542
8 жыл бұрын
yea bb
good lecture.thank you
Superb short and to the point.. please clear one thing what are B cells.. thanks
This video was very helpful for my A & P exam - thank you!
@stompinknowledge3968
Жыл бұрын
What's A & P?
@riefilms
Жыл бұрын
@@stompinknowledge3968 anatomy and physiology
@stompinknowledge3968
Жыл бұрын
@@riefilms danke
very good concept
thank you doctor
So clear!
Thank you doctor
aslamm o alikum . sir . your all videos are just stunning ...plzzz continue your work.. why you leave this ..your all videos are very helpfull .... plz comple the main concept of biology by your spectacular way ... we are waiting for your next video !!!!❤️❤️❤️❤️
it makes so much sense
Thank you 🙏🏾
This video was very helpful for my Exam 4. Komite thank you! 😊
@syedwaqasshah5744
8 ай бұрын
Watch antibodies Lecture given by Dr Najeeb kzread.info/dash/bejne/h3aEyduMe6ind5s.html
Thank you
Good video ❤️
MAY GOD BLESS YOU
This is awesome 😅
@Drobalar-Drsebi
2 ай бұрын
Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..
This video is CLUTCH😎😎
Thanks ✨
Thanks sir 😊
Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..
very thanks
thank youuu.
Yesterday i had a Antibody test for Covid19 and the report of my test was igG positive and igM negative.
thanks you
usefull many thanks
hello sir, my ige value is 1.00 mm/mL in every blood test I give and i have recurring infections, is it because my ige level is low thank you
splended thanks
Good information thank u
Nice
My doctor has asked me to do a full blood test but only mentioned ig E and ig A only
Great
splendid
Thanku💛
like how did they discover it ?? I always ask how did they discover this stuffs but no answer
@omnipenne9101
5 жыл бұрын
Poster summarising the discoveries, you could try googling for the papers (papers are listed under references. Some require paid subscriptions to access but you could try requesting the papers on ResearchGate. It may take a while before you get a response): www.biolegend.com/media_assets/literature/images/MilestonesPoster_small.pdf
Hey why you stopped posting videos?
@simrankahlon50
2 жыл бұрын
Praying that you are fine and will be back soon❤️
Does ivig work for polymyositis?
I suffering ige level 1025 from 5 years please give me yours solution doctor.
IgE other 2000 che significa ? Sono due anni che il mio esame del sangue risulta così alto , purtroppo non solo questo o anche problemi alle gambe e braccia con duroni e prurito.
Thank you help me in this matter very good thanks i like you
I suffering ige 358 from 3years . please give me solution
It's good
2 minutes and long topic irs realy praisable
أشهد أن لا إله إلا الله و أشهد أن محمداً عبده و رسوله صلى الله عليه و سلم
I got ige connecting to my red blood cells help please please
my mother in law is suffering from ige her level is 590
There's more to it by now?
@Drobalar-Drsebi
2 ай бұрын
Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..
What is difference between antibodies and anti antibodies
@smilyyyflower175
5 жыл бұрын
anti antibodies are the ones who attacks antibodies. they're our immune system cells
Great Video! (Jesimiel Millar Fernåndez) 1M948
Ig is instagram you must be kidding me
@MonkeyDLuffy-xr4fl
9 жыл бұрын
Troll
@anudhiman5122
6 жыл бұрын
rajifusama
@caribaez5711
6 жыл бұрын
rajifusama dumb 😂
@negativeiq3792
6 жыл бұрын
And yes,you are one of those idiot
@Ahmed-tu3ms
5 жыл бұрын
Lol
Hi
immunoglobulin
seriously, who came up with this shit? WHY ARE HUMANS SO SMART!?
@Fati.chaine
4 ай бұрын
I asked my self same question
GAMED, igG,igA,igM,igE,igD
@Drobalar-Drsebi
2 ай бұрын
Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..
حح^دد. 5tu K:230,X:554,Y:5896
thanks a lot for this helpful video , i really benefited , god bless you 🤍🤍🤍🤍
Thank you
@Drobalar-Drsebi
2 ай бұрын
Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..
Hey Dr OBALAR ! Thanks for your work on my Genital Herpes case. I couldn't have done this without your help. You were awesome at my checkpoint! I couldn't thank you enough. Appreciate that you help me stay healthy. God bless you Dr OBALAR ❤..