If you like this video, dig deeper into the science of the topoisomerase by watching this video with biochemist Joe Deweese: kzread.info/dash/bejne/fIeBmLdsYqS8qcY.html

I'm really loving all your research, may God bless you all for doing this and bringing the truth for all to see

Wow, the only thing I wish they would have explicitly pointed out is that the structure of that enzyme is coded for by the very DNA that it untangles. But without that untangling, the DNA quickly wouldn't be able to be read to build the molecule that untangles it. One of the 800 gazillion chicken or the egg problems in Biology that naturalistic explanations fall prey to but design explanations explain.

@KenJackson_US

2 жыл бұрын

I'm hoping to hear a defense of the chance hypothesis.

@rubiks6

2 жыл бұрын

@@KenJackson_US - They can't touch this. This is another one the atheists have to just close their eyes to and hang on to their faith.

@AhirZamanSairi

2 жыл бұрын

Thank you very much for pointing this out, awesome point. And I know exactly what you mean when you said "800 gazillion chicken and egg problems," let me give another awesome example: you can't have the carbs in order without enzymes, you can't have the enzymes without nucleotides, and you can't have the nucleotides without the carbs mentioned in the beginning 😂 this chicken and egg stuff is baffling, it completely humiliates materialist arguments

@zacharysylvester8349

2 жыл бұрын

What’s amazing is that you have networks of machines that work in unison, for example the kinetics of the topoisomerase is driven partially by ATP… which itself requires multiple complexes (F1FO ATPase) to synthesise in sufficient quantity.. which of-course are themselves gene products, so what we have is a beautiful labyrinth of closed loop systems that are interdependent.

@ronaldmorgan7632

2 жыл бұрын

@@KenJackson_US More like, "But given a billion years, anything can happen!" They don't explain anything, but walk away like they have.

It would be great if you make more of this kinda molecular machine animations. Such animations would help open-minded people to rethink their current beliefs on evolution.

@DiscoveryScienceChannel

2 жыл бұрын

Thanks! We actually have a playlist of additional molecular machine animations we've done. You can see them here: kzread.info/head/PLR8eQzfCOiS3L98qRoQ6CqpCQbsdEgqQ- We hope to do more in the future, but they take a lot of time (and funding!) to get them right.

@mtman2

Жыл бұрын

Well that mindset shows they never actually thot about it in the 1st place or would've easily dismissed "accidental life" = emanating from rock 3rd from the Sun...lol

Can't wait to show this to my students. Thank you Discovery Institute!

What a brilliant design!

@Rafayhailerrr

2 жыл бұрын

Statements of awe over wonderful discoveries aren't reasonable basis for meaningful conclusions.

@luboshcamber1992

2 жыл бұрын

@JUST ONEWORLD This then, would be just another one of your wrong conclusions. Person said "what a brilliant design." Your fallacious conclusion from this, that it is made based on awe points to problems in your thinking because statement at best tells us that the person made it based on observations showed in the video.

@rsrt6910

8 ай бұрын

Cellular evolution IS amazing isn't it?

I've taken to calling Topoisomerase "scissor molocule" since I'm done with big words. "Absolutley fascinating" doesn't even begin to describe this process. And, in my view, solidly puts a final nail in the naturalistic mechanism. Definitely a boost to Intelligent Design theory. Just get ready for "aliens did it" from the evo's. Peace and God Bless

@Bossmodegoat

Жыл бұрын

Really I’m curious. How does god offer a better explanation of our existence when now you have to explain god’s existence as well. If us being very complex being demands a creator to explain our existence. How much more so would the existence of a fabulously complex being like god demand a creator. It seems to me the simplest answer seems more likely

Intelligent design... You can say that again. "A little science distances you from God, but a lot of science brings you nearer to Him" - Louis Pasteur

Stuff like this is why I start every pray with " thank you Father for your amazing Creation and for the chance to experience it". Grateful for this KZread channel!!💞

Amazing. Absolutely amazing.

So, these untangling things, made of proteins, would have had to have been around before there was a double-helix, or made at the same time. There is no possibility that they were made after. And, since the DNA contains the instructions for building proteins...my head officially hurts now. It's almost as if someone knew what they wanted the finished product to do first, then designed the mechanisms to get it done.

@rsrt6910

8 ай бұрын

Could have ben a different protein that had a different purpose and evolved into the more efficient topoismerase .

True Miracles of Life!

Fascinating. I so appreciate all these videos. Being a system design engineer for umpteen years this videos make the need for a Designer SO CLEAR. And discovery science channel has marvelous videos from numerous fields, in each of which the evidence is mounting daily for ID. == Darwinistic materialism is already a fossil of a bygone era - but the media and many others still cling to it because the alternative of 'purpose' might imply 'responsibility' for their actions to such a Designer.

Excellent video. I'm thankful for the hard work of those who made it. Even more excellent design of proteins to keep us alive. I'm far more thankful for the One who designed them thus allowing me to live!!

Insane!

Awesome. And this is only a sample of the countless molecular machines in nature. Glory to God in the highest.

@rubiks6

2 жыл бұрын

They're not "countless." In people, it is around 20,000 different types of molecular machines. That does not in any way diminish God's awesomeness :)

All is saw was one thing: An arrangement of complex parts each having a meaningful purpose in the end. Which is the way, the only way we distinguish a design by an inteligent mind and some thing that arises by chance.

@christopherduncan6823

4 ай бұрын

it's not the only way look up the Turing model for morphogenesis

سبحان الله Looking at the world around us from a biased perspective no way you would think that there is anything but a wise designer behind it and to the ones that try to escape to DNA and evolution these kind of videos should show them that the wise one still showing off his design Hopefully they start listening before judgment day

@rubiks6

2 жыл бұрын

It is vitally important that you identify the real designer and not be fooled into believing in someone who is a fraud and not the true, living Designer.

@stevves4647

2 жыл бұрын

Its sad knowing to convice someone of intelligent design you have to get even more deeper when its already evident all around us.

Without a doubt best apologetics channel I've found on tube.May God bless whoever runs it.

Absolutely mind-blowing. Stunning. Fabulous.

The best explanation ever!

When one watches something like this, one must conclude that evolution theory is as fatuous as flat-earthism.

Great video. Thanks.

Intelligent design at its finest.

And yet people still state that this all came about by chance. Sick. I'm glad you mentioned intelligent design at the end of the video. Indeed it is.

WOW!!! Speechless.

Great animations; very helpful for any student of college level or advanced biology. What a wonder! So much about cells just blows the mind.

What a brilliant feat in biological engineering!

How does it even know where the knots are, and how does it even get to the knot? Amazing.

@joelthomastr

2 жыл бұрын

This video seems to show the topoisomerase traveling along the DNA ahead of the replication gubbins kzread.info/dash/bejne/ZmZlz7SEYaatYLg.html In which case I guess it just waits until the top gate snags a second strand. And thinking about that makes me realize how critical the choreography of it all is. The topoisomerase must not engage unless and until it has the second strand and then each of the steps must happen in exact order.

@Rafayhailerrr

2 жыл бұрын

It's fascinating to me really too TBH

nice animation with good explanation excellent job

Oh my gosh. This is brilliant!!! But if course it is. Praise our creator.

For me, this kind of things are just amazing and suggest design.

nice that's amazing!! So glad I found this video :)

The amazing thing is, if just one step in this process is missing, the whole process breaks down. Evolutionists would say this process would require millions upon millions of years to evolve but then DNA would never survive beyond the first "knot"...Topoisomerase had to foresee the knots, in order to form the mechanisms needed to untangle them. Nature is wonderful but not all knowing...this had to be designed by an ALL KNOWING DESIGNER! Science is wonderful but even more wonderful when we know the DESIGNER personally and His love for us, when when we are twisted up in knots. John 1:14 The Word became flesh and made his dwelling among us. We have seen his glory, the glory of the one and only Son, who came from the Father, full of grace and truth. 15 (John testified concerning him. He cried out, saying, “This is the one I spoke about when I said, ‘He who comes after me has surpassed me because he was before me.’”) 16 Out of his fullness we have all received grace in place of grace already given. 17 For the law was given through Moses; grace and truth came through Jesus Christ. 18 No one has ever seen God, but the one and only Son, who is himself God and[b] is in closest relationship with the Father, has made him known.

@ronaldmorgan7632

2 жыл бұрын

Exactly. Chemical reactions without goals can't foresee anything.

@jost2741

2 жыл бұрын

Well explained, good service

Each of our cells is endowed with intelligence. Our body is a universe and we are a mini I Am to that universe.

The written commands inside of us order us to be humans instead of chinchillas.

@ericgreen3030

2 жыл бұрын

But chinchillas are soooo cute.

@BingoBongo227

8 ай бұрын

i’d like to write back calling for a strike until we get chinchilla rights

Amazing!

شرح رائع شكرا جزيلا ❤

I reaaaaaally wish you could have zoomed out at the end to help us to visualize how exactly this solves the supercoiling problem

Wow amazing

Superior intelligent design 😎

This is amazing and wonderful! How long does one of these cycles take? Is it seconds, minutes, hours?

There are no words. That is absolutely incredible. There's no way this stuff just happened through unguided processes.

Awesome

and to think, this all came about by random processes (LOL)

@rubiks6

2 жыл бұрын

(hiccup) Sorry, I have the (hiccup) hiccups.

@rsrt6910

8 ай бұрын

It probably started as a simpler protein, such as a messenger protein, and evolved into something more efficient.

It's mind boggling to think that inanimate molecules could create such a complex molecular mechanism by itself for such a specific purpose with the same sophistication and capability of modern "Designed , Engineered and Programmed"" quality control equipment which is used to both analyze and then remove any defective parts and replace with new materials. Who would have realized how absolutely brilliant inanimate molecules can actually be.

And science struggles to explain the formation of simple amino acids , but yet have no problem explaining away the specified information required to build a multitude of purpose specific nano machines at the same exact time .In this case it has to have the ability to proof read thousands to billions of DNA , correct any mistakes and physically remove entanglements.If there's any area of science that lacks any critical insight , it has to be the origins of life with the main tenents of evolution a close second.

God Bless

I was just untangling my sons' kite strings the other day. Spent a lot of time wondering if there's an algorithm for it and guessed there isn't. Very difficult. Should have had some of those molecules to help.

Just how can anything like this have randomly self assembled by chance? It's impossible. Anyone prove me wrong? I'm waiting to learn. Bonne journée 👍

such an incredible animation and explaination.thanks a lot. I wonder how these high quality animations are made..can anyone suggest where to learn making scientific animation videos?..it would be a great help!!

Etoposide: allow me to introduce myself

Simple logic indicates that this could have not arrived by unguided, random processes

Incredible! Is this theory? If not, how can all this be known, and where can one begin in the published research?

@garsayfsomali

2 жыл бұрын

This is actually basic Molecular Biology taught at any decent University. Only problem is the students are studying for an exam and not for God

But no man...a completely random chance mutation was selected...by something we don't care to explain, because of a reason we don't care to elaborate on, by a process that we don't want to reveal the origin of (being that the mechanism of selection infers a modicum of intelligence at the least). That's how all of these super complex machines and processes developed... Even though they, by default, required themselves to pre-exist themselves in order to be formed to begin with... Look, I'm trying my hardest to play devil's advocate here but to even remotely believe in the nonsense I just typed infers a level of infantile hubris that I can't fathom. When you can explain to me what the first selection mechanism was that created the first selection mechanism then I'll listen... Until then we have to assume it was intelligence.

@ronaldmorgan7632

2 жыл бұрын

I can imagine God having a workshop and happily spending his time tinkering with things.

@wheresmycar9559

2 жыл бұрын

@@ronaldmorgan7632 Why wouldn't god create a DNA polymerase that doesn't spin the double helix rather than creating a whole protein complex to correct it?

@ShadesofViolet8

2 жыл бұрын

@@wheresmycar9559 I'm not sure, but I'm grateful He created it this way because it makes us see how incredibly finley tuned it is. The fact there is an enzyme specifically designed and purposed to untangle where untangling is needed through such a complex, logical and purposeful sequences leaves me speechless.

@andoapata2216

2 жыл бұрын

Playing devil's advocate i'd say that you can rate intelligence from zero to some upper limit , then microorganisms have intelligence close to zero but not zero, as epigenetics show that environnent influences genetic expression of the offspring . Let's say a bacteria has a "will" to metabolize A in an ambient full of B , then it starts "willing " to metabolize B too , so its offspring begins to try and metabolyze B with varied results until one "learns" the trick and shares it like bacteria do . It would be a materialistic "intelligent" design but with limited intelligence .

@Rafayhailerrr

2 жыл бұрын

Your end statement was an absurd demotion to what was a relatively intelligent build-up. What if rather than infer intelligent design, you just try yourself to try to keep learning more and more and discovering new things. Don't you think that would probably have put the cherry on the cake for you. Also, by intelligent designer, are you also supossing the "God of the bible" did it?

We are wonderfully designed by God. Hallelujah!!!

Where does the topoisomerase live before it's needed? How does it know it's needed and where to go? How does it get there? What happens to it after it untangles the DNA?

Is this protein found in all animal and plant life?

"هذا خلق الله فأروني ماذا خلق الذين من دونه " سبحان الله العظيم ❤

whoa

And you're going to tell me that his process came about by random selection over millions of years? Let's give credit to Whom it is due....glory to God!

Great video explanation; however i do take issue with the final comment of intelligent design. Regarding ID’s specific claims, scientists object that the concept of "irreducible complexity" relies upon a mischaracterization of biological mutation as a relatively linear process involving only the addition of more and more "parts," rather than a dynamic process that can also reshape, rearrange, or fundamentally alter existing elements and features. Systems that must be fully formed to serve their current function could have developed from earlier forms that served a different function, or could be significantly reorganized versions of an earlier form that served the same function. The human eye is a fine example of and lack of ID....The squid and the octopus, for example, have a lens-and-retina eye quite similar to our own, but their eyes are wired right-side out, with no light-scattering nerve cells or blood vessels in front of the photoreceptors, and no blind spot!

What an amazing GOD we serve! It is such a blessing to see things like this. It really helps to put things into perspective for me. The total power of "In the beginning GOD" is evident in evrything around us, and more or His amazing power is being shown and proven every day! Thank you to those that put this together for the rest of us!

Incredible that all this may have all started as RNA. I mean, the switch to DNA likely occurred because NRA is exposed to the rest of the machinery within the cell while a nucleus has a relatively pristine environment giving DNA based life a natural advantage over RNA based. Hence why you'll only find RNA based cells to be extremely simple in nature. The drawback being that, as this video shows, keeping all the items in the "RNA vending machine" that is DNA exposes it to dangers that RNA likely didn't have to deal with. No doubt, the topoismerase started off as another protein, perhaps as one of the messenger proteins that travel across microtubules that somehow managed to untangle "protoDNA" strands and became more specialized as natural mutations found a more efficient means of entangling DNA. I'm wondering what it might have started out as, but unfortunately, that's hard to figure out at the atomic level since there are no fossils at this level as all the atoms are scavenged and nothing is left from previous mutations to compare it to. It still makes me wonder what it evolved from.

You forgot to give credit to the Creator; it's not difficult, you can do it...

"What is responsible for life on earth?" Discovery Science: 4:18

as long as you have enough "faith" in the not so enough time for evolution , everything is possible. may the farce be with us all.

Just WOW! God is awesome 😎

As the apostle Paul wrote, "God's invisible qualities are clearly seen from the world’s creation onward because they are perceived by the things made, even his eternal power and Godship." (Romans 1:20) The more one peers into creation the more clearly one sees that Jehovah is an excellent designer, architect, builder - creator. Thank you for presenting this video! Excellent!

I cannot understand how someone can look at the amazing and complex processes of the human body and think it came from random processes.

@karlbach1451

Жыл бұрын

You just lose me at the part where a magical book has all the answers from a god that just doesn’t talk to us anymore

@Bossmodegoat

Жыл бұрын

Good thing molecular biology a rigorously studied and peer reviewed field and not just some random process

@ajstunts2402

11 ай бұрын

You guys lost me at the part where you trust blind chance and forces to create information

@garethhughes2826

9 ай бұрын

This is the most amazing video I have ever seen it makes you think about whats going on inside you it's so amazing but so scary at the same time but its what makes us US

@rsrt6910

8 ай бұрын

Because the starting point for discovery in all of cellular biology comes from assuming the observation of the machinery in naturally occurring, forming a number of disprovable hypothesis for the observation, then rigorously testing them until you're left with one that has failed to be disproven and going with that until a better test/hypothesis replaces it.

But how do they discover this?

@rubiks6

2 жыл бұрын

That is not a question that can be answered in KZread comments. You must go to university and also do a lot of lab work and compare notes with many other researchers. It is a scientific endeavor.

Does the Topoisomerase have a brain? How the heck does it know what it's doing? What guides it? And that goes for all the other molecular machines. *WHAT GUIDES THEM?*

@rubiks6

2 жыл бұрын

We were not simply created on the sixth day and then left to fend for ourselves. God sustains the life in us in every cell moment by moment from conception to earthly rest.

@ronaldmorgan7632

2 жыл бұрын

And what makes them? Chicken and egg indeed.

@rsrt6910

8 ай бұрын

They just travel up the DNA chain ahead of the replicating protein and wherever the DNA strand is tangled it just slams headlong into the knot, then it does it's thing and continues on. As long as it has ATP to power it it'll just blindly keep doing it until it's to damaged from random electromagnetic interactions to do it's job anymore.

Why, its almost like there was a plan or something. Of course that's just crazy talk. Everyone Knows this all just happened by accident. :-)

@anameichose8854

2 жыл бұрын

And we're all still reluctant to discuss this freely in public for fear of being labeled nut cases. The power of public opinion is extraordinary.

Our Creator is awesome and aw inspiring!!!

Then we have to imagine how it "knows" something is twisted, where to go, and the control step logic, where is all this programming and is it local control or remote and what is the wifi control network, as there Has to be one?

@rsrt6910

8 ай бұрын

It just blindly travels ahead of the replicating proteins and slams headlong into a knot, does it's thing and continues on as long as it doesn't get damaged and has ATP to power it. Like a snow plowing locomotive with no driver on board racing down the train tracks to clear them.

НОО топ❤

Nobody is going to convince me that this complex mechanism was formed by chance over billions of years! I’ve always believed that it takes MORE FAITH to accept and believe that chance chemical reactions resulted in “accidental life” than to believe that we were intentionally and intelligently designed!

@edwardmacnab354

3 ай бұрын

more primitive lifeforms do not have such a complex mechanism. It is not so much by chance than it is by numbers . There are an uncountable number of fails and oddities that are created. It is sort of like when you wiggle string around and get knots you can't figure out how to untie , or tie !

🧬

If you don't believe in intelligent design after learning how this works, idk what your doing?

@KenJackson_US

2 жыл бұрын

Please explain. I can't imagine _not_ believing in intelligent design. Or are you joking?

@rubiks6

2 жыл бұрын

@ياا اخي اتق الله و استعن بالقرآن The allah of the Qu'ran is not the designer. He is no god and has no life in him. He is a dead, man-made god.

@hennoc63

2 жыл бұрын

@ياا اخي اتق الله و استعن بالقرآن Allah is no God. His prophet is dead! I read Koran and Bibel... Compare too each other. Bibiel more evidence! 332 prophecys in the old testament for Jesus as a Messiah an for his claim to be God in the flesh amen John. 16 ✝️ 📜 please compares both life's of Jesus Christ of the gospel and the Life of Mohammed and you will finde the truth. Salvation only in chist Jesus ✝️ I pray for you 🙏🏻

Wow. Just, wow. The atheists can't touch this. This is another one they have to just close their eyes to and hang on to their faith.

I wish scientists could invent a de - tangling machine, for all my extension chords.

I am constantly in awe at the works of our Heavenly Father, so amazing.

Another of many Chicken/Egg solutions at molecular scale;

@wheresmycar9559

2 жыл бұрын

Who created god

@rsrt6910

8 ай бұрын

Probably irrelevant. It likely started from a simple messenger protein and evolved into the more efficient and effective topoisomerase protein.

Meaning for a child growing up, millions of such activities is happening on the body?

Praise you God!

More nails in the coffin for Darwinism.

@mtman2

Жыл бұрын

It was scientifically "OVER" once discovering DNA: only the Globalist overlords can't have a "God fearing. Jesus Loving, Scripture Honoring public - to get their Atheist Marxisy NWO in place...0oops

@christopherduncan6823

4 ай бұрын

How? This is the epitome of Darwinistic explanation. Those proto cells that could untangle had a much higher survival and reproductive rate.

atheists have to say 'everything happens by chance no design' because otherwise they might have to find out who the designer is and if he has any commandments that need to be followed

All Theory?

@rubiks6

2 жыл бұрын

Ummm ... no.

Subbanarabbi, imagine these machines in a size visible to the human eye. We'd think we're invaded by the highest tech aliens or something xD.

Great video. The video of DNA replication isn't accurate as one strand of DNA is copied backwards in sections.

Phone cords used to twist up exactly the same way. Frustrating.

Technically those are not knots, they’re twists.

Seems the chicken and the egg is the answer.

God is great

سبحان الله

Very intelligent design. This machinery doesn't just occur randomly by chance. Amazing evidence for God's existence

@midnighthymn

2 жыл бұрын

It takes more faith to believe this all came together by accident under a rock somewhere than it does to believe it was intelligently designed. Molecules-to-man evolution is nothing but a glorified fairytale.

@oskarsitarz569

2 жыл бұрын

@@midnighthymn Evolution is the biggest lie ever.

@michami135

2 жыл бұрын

I've tried using these great 3D videos of how cells work as evidence of intelligent design. Some people try saying these molecular machines evolve to this point. But they can't. These machines are made by the programming in our DNA and it all has to work perfectly for our DNA to copy itself. No machines, no cell division. They all have to be in place and working perfectly BEFORE life can exist. It'd be like finding a planet full of robots that believe they evolved to that point through random mutations in their code. Without the machine, the code has no function.

@TonyTooTuff

2 жыл бұрын

My thoughts exactly. Complex information comes only from a mind.

@leonardmasano312

2 жыл бұрын

I am waiting to see how the evolutionists counter this and explain how nature and change facilitated the perfection observed at molecular level.

A mousetrap for Darwin

@stevves4647

2 жыл бұрын

Too bad for Darwin, he probably had no clue about this LOL

@christopherduncan6823

4 ай бұрын

Darwin didn't know anything about DNA... and it seems most of the people here don't know much about RNA

Was God also created by Intelligent design? If so who is his creater?

@stephenkaake7016

2 жыл бұрын

God is similar to a supreme mind, no 'parts' so he is not 'built' but everything is based off his existence, nothing is 'difficult' for him, its either possible or not possible, everything was created to enjoy existence, earth is more like a detour, heaven is our home in the spirit world, the common objection to God is 'why would he allow pain and suffering' the answer is he allows it in this world, not in the spiritual heaven domains, people chose to have a 'real life' here to experience difficulty, everyone has free will so they can choose to grow towards God or the other way, into debauchery

Intelligent Design, indeed. The book of nature it seems contains even more compelling evidence of God than the book of scripture.

I'm so tired of agnostic biologists and beginning of life researcher ignoring the appropriate implications.

@rsrt6910

8 ай бұрын

How do you think they managed to accumulated all this knowledge in the first place?