Treatment Options for ER/PR Positive or Negative Breast Cancer
What are the ER/PR hormone receptors? Why are they so important? And how do they affect your breast cancer treatment options? In this video, Dr. Jennifer Griggs explains everything you need to know about hormone receptors and breast cancer treatment.
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Thanks for being part of this conversation 🌷💝🌷💝 god bless
@yerbba
Жыл бұрын
And thank you!
Outstanding information 🌺
@yerbba
Жыл бұрын
Thanks for watching and your positive feedback!
Let’s all endeavour to help those in need. We can all play our part even if it is something small. It is said that if we see someone in need and do nothing it is a sin. Let’s all show our love for one another and for our our Lord Jesus Christ!!
@yerbba
2 жыл бұрын
Thanks for watching.
@naththomas9946
Жыл бұрын
Thank you for your continuous support.
Thank-you so very much! Dr.Griggs, because I am +,+,- I, am ER, PR positive and HERS2-Negative
@yerbba
Жыл бұрын
Thank you for watching and we wish you the best!
Good video 💯
@yerbba
Жыл бұрын
Thank you for watching.
Very good explanation Madam 🙏
@yerbba
2 жыл бұрын
Thank you
Madam In core needle biopsy, the pr status is positive and in surgical specimen negative. Kindly advise which report is accurate and correct and what to do.
@yerbba
8 ай бұрын
Thanks for writing. In a case like this, we usually work with the pathologist to help us decide which is more accurate.
What about er allred score 4 .pr score 3 .her 2 was negative.this was a lobular cancer. It was mentioned er focal weak positive and pr weak positive .since for lobular is this rare because usually er most ppl have high estrogen but in this case the allred score is low.is this considered like triple neg. Neo adjuvant chemo did not have any effect on the tumour it remained same size
@yerbba
Жыл бұрын
Great question. The ER and PR would have to be negative, along with the HER2, for it to be triple-negative. You are right--ER and PR being low is uncommon for lobular carcinoma. We are wishing you the best through your treatment and beyond.
im confused please help,, if the amount of estrogen in the body doesnt matter,,WHY are all the drugs geared to slow or shut down the ovaries from making estrogen,,thank you
@yerbba
7 ай бұрын
It's understandable that this is confusing. The distinction is that one's own level of estrogen is not related to having breast cancer. Sometimes people tell us that they believe they have "too much estrogen" in their body as if there is something wrong with them. That is not the case. There is a normal physiologic level of estrogen. When treating breast cancer, however, we do either block estrogen (tamoxifen) or decrease the production of estrogen (aromatase inhibitors). This basically uses the fact that doing so will decrease the risk of cancer coming back or developing in the first place or decrease the amount of cancer in the body for many people with metastatic breast cancer. But none of this is related to how much estrogen your body makes. We hope this helps!
Please discuss triple negative breast cancer for someone age 69 and the survival rate.
@yerbba
3 жыл бұрын
We have a Triple-Negative breast cancer video slated to come out in a few weeks!
Hi, my mother is ER positive allred score 8. PR positive allred score 7. Her2 positive 2.60 sigmal strength. Would trastuzumab and pertuzumab added to chemotherapy for 6 cycle benefit her.
@yerbba
Жыл бұрын
If the pathology lab is interpreting this as a HER2-positive tumor, we generally do recommend chemotherapy with trastuzumab. The particular treatment depends on the size of the tumor and the status and number of lymph nodes that are positive.
My biopsy showed Er weak positive and pr negative. Her2 negative. Since lumpectomy the pathology on the tumor said Er,Pr,her2 all negative. How can 4 sites on biopsy stain er +, but the excised tumor shows er-. ? I thought we had a treatment course all plotted out but now I'm totally lost as to what we will be doing. Triple negative is quite different than er positive treatment wise. ☹️😢
@yerbba
9 ай бұрын
With a low level of estrogen receptors, it is not surprising that other parts of the tumor are ER-negative. We do see differences between the biopsy specimen and the surgical specimen frequently enough that this is not surprising. Wishing you the best as you sort out both the treatment plan and your own emotional response to everything going on.
I was told that my breast cancer was 2% estrogen receptor positive but I want to have another baby. Will I likely have to take tamoxifen for such a low positive? TIA
@yerbba
Жыл бұрын
The decision about tamoxifen will be based on your risk of the cancer coming back, but in general, the desire to have another child will outweigh the benefits of tamoxifen in your case. Please talk this over with your medical team and let them know your wishes.
Estrogen Receptor : Percentage of tumor cells with nuclear positivity 81-90%. Allred score - 8/8. Progesterone Receptor: Percentage of tumor cells with nuclear positivity 51-60%. Allred score - 7/8. Her2neu: Negative.
@yerbba
3 ай бұрын
Thanks for sharing your story with the Yerbba community. High levels of ER and PR predict for a good response to endocrine therapy.
@MargaritaDeMaligaya
2 ай бұрын
j
If you have chemo.. can you still work if your on chemo theraphy or stay rest
@yerbba
19 күн бұрын
Whether you can work during chemotherapy varies greatly depending on your individual reaction to the treatment and the nature of your job. Rest is important, but many continue to work as they feel able. We have a video on this topic you may find helpful: kzread.info/dash/bejne/ZqVhpddsgtq1fdo.html.
high mam im er-pr+her2- is considered tripple negative or not
@yerbba
Жыл бұрын
Thanks for the question. Technically, this is not a triple-negative breast cancer because the PR is positive. We do tend to offer more treatment to people with ER-negative, PR-positive disease than in people with breast cancer that is both ER and PR positive.
@sudeshnachowdhury1488
Жыл бұрын
@@yerbba is there any chance to get cured??
@angelaregaspi4016
Жыл бұрын
im stage 2b breast cancer er-pr+her2- i finish 6 cycle chemo but i have no maintenance because im er- my onco said im considered tripple negative im so worried
Mine is ER negative/ PR negative/ Her 2 negative....I am going through Chemo before surgery...I am 46 years old
@yerbba
Жыл бұрын
Thank you for writing. Chemotherapy before surgery is often given in people who have a so-called "triple negative" tumor. It can be so gratifying to see the tumor get smaller while you're on chemotherapy. It can take several weeks to see a difference, so don't worry if it doesn't seem to be getting smaller.
@meiw8358
Жыл бұрын
I have exactly same as you do have, I will hear sentence tomorrow from oncologist for if I will have chemo. May we contact to each other for how are we doing? How long your chemo takes? Runmei
Thank you so much for your video, learned a lot! I am now 46 years old and diagnosed with multifocal micro-invasive cancer with high-grade DCIS, (pT1mi(m)pN0(sn)), ER-negative, PR positive 5%, HER2 positive, left mastectomy, no chemotherapy, and radiotherapy. May I ask if a PR positive 5% benefit is only 5%, considering the side effects, especially the stroke (my mother died of a stroke), is it worth taking it for 5 years? Does not eating increase the risk of relapse? Does HER2-positive require treatment? Hope you can give some advice, thanks a lot!
@yerbba
2 жыл бұрын
The benefits of hormonal (also called endocrine) therapy depend on several things, specifically what type of surgery a person has had. If there is remaining breast tissue (because the person had a lumpectomy), there's more benefit to taking endocrine therapy, but the benefit is still quite small in people with DCIS. If someone wants to feel that they are doing "everything," we offer endocrine therapy. If the side effects are not manageable or if there is a reason not to use endocrine therapy, not taking it is also an option. Trastuzumab (Herceptin) is not used in the treatment of DCIS.
@dq5146
2 жыл бұрын
@@yerbba Thanks Reply! I had a left mastectomy and currently no endocrine therapy. Does multifocal micro invasion (more than 20) require chemotherapy? Will it be beneficial? Thanks again!
Hi iam stage 4 breast cance I have ER + PR+ and her2-.
@yerbba
2 жыл бұрын
We hope that things are moving in the right direction for you.
@sree9302
Жыл бұрын
tisaykuno How is now hope you are good
What food to avoid when ur breast cancer was ER PR positive and her2 negative. I am done with chemo surgery and radiations. It’s just finished. I want to focus on safe food. Any suggestions pls 🙏
@tigertiger3872
Жыл бұрын
Avoid red meat, sugar, carbohydrates and eat in moderation, exercise is must whatever exercise you can do, walking is a good option, search on KZread a diet for breast cancer patient and also the keto diet .
@yerbba
Жыл бұрын
Thanks for your question. In general, the guidance about diet after breast cancer is the same as with other health conditions. We recommend avoiding alcohol, eating a lot of fruits and vegetables, and keeping portion sizes for meat smaller than many of us eat. There are no specific foods that you need to avoid. Everything in moderation is also good guidance.
@mehvishaftab6687
Жыл бұрын
Hello sumiti How r u feeling now Mine r same breast cancer just recently diagnosed r u cancer free now
@AngeLola1003
Жыл бұрын
@@mehvishaftab6687 Hi Doll, hope all is well. I was diagnosed with the same last week. I'm trying to figure out what treatment options are best, I don't want to DO the hormonal therapy at all. The side effects are horrible. I rather them zap it and keep it moving. I'm not sure whats the best option for me yet. I'm 44 and just did the genetic testing yesterday. I wish you the best of luck! God bless you all❤
Love your channel, music is distracting in this video though.❤️😊
@yerbba
3 жыл бұрын
Much appreciated. I’ve passed your suggestion to our editor ❤️🤗
@reeceandrew2349
2 жыл бұрын
i dont mean to be off topic but does someone know a method to log back into an instagram account..? I was dumb lost my account password. I would appreciate any tricks you can give me
@aaronbobby3819
2 жыл бұрын
@Reece Andrew instablaster ;)
@reeceandrew2349
2 жыл бұрын
@Aaron Bobby Thanks for your reply. I got to the site through google and Im in the hacking process now. I see it takes quite some time so I will get back to you later when my account password hopefully is recovered.
@reeceandrew2349
2 жыл бұрын
@Aaron Bobby It worked and I finally got access to my account again. I am so happy:D Thanks so much you really help me out !
@Yerbba - Breast Cancer Apologies, for asking, just I am feeling a little unsure and scared. I am living in a Foreign Country and about to start treatments after lumpectomy. I was just looking through your questions and saw you answered a question that sounded similar to my questions. I found the lump on Dec. 22nd which turned out to be HER2 HR+ and PR+ with a 2.2cm tumor, I had a lumpectomy which confirmed the findings, and six lymph nodes were removed one confirmed... I don't know, I am in a foreign country and am not fluent. Does this sound reasonable to you? 1. Lumpectomy - Check 2. Six Sessions of Chemo with Trastuzumab - starts June 9th 3. Six Sessions of Radiotherapy 4. Six Sessions of Trastuzumab 5. Five Years of treatment you mentioned
@yerbba
Жыл бұрын
Thanks for your question. This overall approach is in line with what the data from multiple studies would support. In other words, without knowing all of the details, the quality of your care appears to be excellent.
@JDeonicio
Жыл бұрын
😊
@JDeonicio
Жыл бұрын
Mmk
@JDeonicio
Жыл бұрын
😮
@JDeonicio
Жыл бұрын
😮
Whats the meaning of er pr negative score 0
@yerbba
2 ай бұрын
Great question. A score of 0 for ER (estrogen receptor) and PR (progesterone receptor) means the tumor tested negative for these receptors. This indicates that hormonal therapies are not likely to be offered.
Wait.. are these side effects for the 5 to 10 years of taking the pill???
@yerbba
Жыл бұрын
As with any medication, as long as you are on it, the side effects can be present. With tamoxifen, side effects tend to be the worst at 3 months but will often persist. Letting your medical team know about your side effects is therefore important because we can make changes to the medication and also help manage some of the side effects.
@Moon0552
Жыл бұрын
@@yerbba and is it a must? I dont want to be suffering after cancer is gone :(
Hi! my mom is diagnosed with stage 1 breast CA. She had already undergone mastectomy. ER positive/ PR negative/ Her2 negative. she is 67 years old. What will be the best treatment option?
@yerbba
3 жыл бұрын
There are quite a few factors that help us make treatment recommendations. Without knowing your mother or other details of the tumor, it is not possible for us to make recommendations. If your mother lives in the US, she can use a Yerbba report from www.yerbba.com to get more information on specific diagnoses and treatment options.
What if you have ER positive PR negative HER2 negative? No one ever mentions this type. Is this more aggressive?
@yerbba
3 жыл бұрын
Hi Lucille - ER-positive tumors are considered hormone receptor-positive even if the PR is negative. In general, these tumors respond well to treatment with hormone therapy (with or without ovarian function suppression if the person is premenopausal). We do see higher “recurrence” scores in people whose tumors are PR-negative, suggesting that chemotherapy may be considered more frequently in tumors that are PR-negative. Because the prognosis is excellent, however, we generally do not consider PR-negative tumors to be aggressive.
@gdwitch
3 жыл бұрын
@@yerbba thank you. It was so hard to find any information on this.
@ms.kathleencurry7220
11 ай бұрын
Yes, I can not find any information about this as well. I am Er+ PR- Her 2 - Can you make a video on mammaprint and blue print? I scored high risk luminal B
@siofra3819
3 ай бұрын
@@ms.kathleencurry7220hi I am from Ireland I am the same. I am 35 breastfeed all my kids. Do not drink alcohol and still got breast cancer with no family history of it. I feel so alone because I don’t know anyone with the same type as me. I am due for left breast removal next week. I am a 2cm and 7mm tumour, so far from what they can see its not in my nodes
@shathaomar1516
4 күн бұрын
@@siofra3819Hope you had a successful surgery and recovery.