Treat feline infectious peritonitis (FIP) with pills, not injections

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Audience: veterinary surgeons, veterinary students and nurses.
Relapses are more likely to occur if you begin treating feline infectious peritonitis (FIP) with injections, rather than pills. Feline coronavirus, the virus that causes FIP, replicates in the intestines: first in the epithelium of the tips of the villi of the small intestine, and later in the ileum and colon. Pills get right to where the virus replicates in the intestines, stopping the virus dead in its tracks, whereas injectable antivirals, such as GS-441524 or remdesivir, do not enter the gut well, so cats can still shed coronavirus in their faeces, even though they may appear to have recovered from FIP. Antiviral injections may appear to heal feline infectious peritonitis temporarily, but they predispose to a relapse, especially a neurological relapse if too low a dose of antiviral has permitted virus to persist in the brain.
Key messages:
1. do NOT use injections to treat FIP: use pills.
2. start treatment with a high dose of antiviral (exact dose will depend upon what you're using).
To download the 10 Rules to Prevent FIP relapses, or to make a donation to support films like this one, please visit my website: www.catvirus.com.
Antiviral drug resistance video: • Resistance to antivirals
Please support me in making more educational videos by becoming a subscriber to my channels on this and other video platforms:
Odysee: odysee.com/@Catvirus
KZread channel: / drdianedaddie
Bitchute: www.bitchute.com/channel/ZEk9qdH9iDzm/
Rumble is no longer available in France due to censorship, so I am unable to post new videos there.
Twitter: Dr Diane D Addie @FIPvet
Bastyon: pocketnet.app/catvirus?msocia...
Link to Dr Addie’s FIP treatment paper: www.mdpi.com/1999-4915/14/4/744
Link to Dr Pedersen’s GS-441524 paper: journals.sagepub.com/doi/10.1...
Link to Dr Roy’s molnupiravir paper: www.mdpi.com/2076-0817/11/10/1209
Disclaimer: please note that I (Diane Addie) have received no funding from Bova and WILL NOT take funding from them should they offer any in future, just as I refused an offer from Mutian: my patients come first, and it is important to me to not to have any conflicts of interest. Such independence is made possible by clients paying for their consultations, and most especially by the incredible generous and altruistic subscribers who keep food on my table: if you are one of my subscribers or donors then a HUGE THANK YOU TO YOU!

Пікірлер: 45

  • @missalana12
    @missalana128 ай бұрын

    Hi Dr Diane, I would like to consult with you via your website and am hoping you have some spaces? our 6 month old Ragdoll is currently undergoing treatment, she was given injections of Remdesivir for about 3 days (I’m not sure of the dosage but will find out) and she has been on pills from this Monday of 20mg (7 days of treatment so far). Currently there is not much improvement, nor have her bloods changed since she has started the treatment. They are now going to up the dosage of the pills to 30mg . She is presumed to have dry FIP, she has neurological signs, can hardly stand and as of the other day is starting to have seizures. I’m based in the UK and would really appreciate your advice, thank you

  • @DrDianeDAddie

    @DrDianeDAddie

    7 ай бұрын

    I am so sorry to hear this and I am also sorry that I haven't seen your comment before now. Email me at draddie@catvirus.com for advice. Is she on Bova GS-441524 pills? At 30 mg per kg? I hope I'm not too late.

  • @DrDianeDAddie
    @DrDianeDAddie9 ай бұрын

    I would like to just point out that it is KZread and not me who has put advertisements on my video. I have no control over that - they don't give me the ability to prevent ads.

  • @user-oo9pl3sp5p

    @user-oo9pl3sp5p

    2 ай бұрын

    You are awesome ❤

  • @andygordon6880
    @andygordon688010 ай бұрын

    Fantastic video for all sorts of reasons

  • @DrDianeDAddie

    @DrDianeDAddie

    10 ай бұрын

    Thank you, Andy. :-)

  • @aliceinbooklander
    @aliceinbooklander6 күн бұрын

    hi dr, I started molnupiravir treatment for my cat and its been one week into the treatment. He thankfully gained weighed, my vet also said he needs a minimum of 5 weeks treatment, if by then the virus went back to sleep, we can stop the treatment and hopefully no relapse. I was told to keep my cat stress free to prevent relapse 😊

  • @PavelVet
    @PavelVet10 ай бұрын

    Thanks Diane, I agree! I think so too. 🤝

  • @DrDianeDAddie

    @DrDianeDAddie

    10 ай бұрын

    Many thanks for your supportive comment! :-) God bless you and your cats and patients.

  • @elenati6684
    @elenati668410 ай бұрын

    If the dose is high enough, the risk of relapse is lower, no matter pills or injections. 4mg/kg is way too low dose! We start treating the wet form on 8-10mg/kg, all others above 10. No relapses in 9 cats.

  • @DrDianeDAddie

    @DrDianeDAddie

    10 ай бұрын

    Well done! I agree completely: 4mg/kg is way too low especially at the start of FIP treatment. However, we have to bear in mind that Prof. Pedersen was wary of side effects, which was probably why he began with a cautious low dose. The literature on remdesivir shows that it is very toxic to kidneys, and he probably bore than in mind when working out how to cure cats of FIP. His study was a major breakthrough.

  • @DrDianeDAddie

    @DrDianeDAddie

    10 ай бұрын

    There are other reasons why I don't recommend injections if pilling is at all possible: they are very painful and inflammatory, which is a risk for feline injections site sarcoma, and people who used them reported to me that it destroyed their bond with their cat: the cat lost all trust in them for inflicting so much pain on them. I know there are ways of mitigating the pain, but why do GS injections unless pilling is absolutely impossible? Also, as I said in the film, they don't reliably prevent FCoV shedding in faeces, which puts other cats at risk.

  • @AikikamiO
    @AikikamiO5 ай бұрын

    You are such a godsend. We sent you an email regarding Nirmatrelvir and Ritonavir pills as another optiom for treament. Is this viable?? We would love to hear from you!! Many thanks!!

  • @lionkingsafaris
    @lionkingsafaris10 ай бұрын

    danke.

  • @DrDianeDAddie

    @DrDianeDAddie

    10 ай бұрын

    You're very welcome. Thank you for watching. God bless you and your cats.

  • @emmafrisbie6611
    @emmafrisbie66117 ай бұрын

    Hi Diane, thank you for putting this information out there. I was hoping you could answer a few questions for me. My cat's spinal fluid was tested for FIP, the results were 10 mRNA copies per sample (not sure if that is helpful to you) and my vet said it is extremely unlikely that the test could produce a false positive. My cat's symptoms are very mild compared to other stories I have seen. It's been about a week since his first neuro episode; he was walking hunched over with his tail between his legs for 2 few days, but after that his posture went back to normal. He has refused food once since his diagnosis (very unlike him) and has been vomiting clear liquid occasionally (1x a day at most) with some mild GI upset (runny poop). My question is, can a cat have FIP and not have severe symptoms or for the symptoms to not present for days or weeks? My vet was shocked that the test was positive, but still suggested I treat him just in case.

  • @emmafrisbie6611

    @emmafrisbie6611

    7 ай бұрын

    I also wanted to see what dosage you may recommend for a cat who is 11.5 pounds? The company I ordered the GS pills from is recommending 12mg per 2.2 lbs of body weight per day

  • @DrDianeDAddie

    @DrDianeDAddie

    7 ай бұрын

    I agree with your vet about treating him to be on the safe side, but I would like to know more, both about the test and which treatment you are using. Would you contact me on draddie [at] catvirus.com? Non-effusive FIP can indeed incubate for a long time - even many months.

  • @DrDianeDAddie

    @DrDianeDAddie

    7 ай бұрын

    @@emmafrisbie6611 That dose sounds too low to me: to adequately reach the brain I'd want at least 20mg/kg (i.e. 2.2lbs). What brand?

  • @emmafrisbie6611

    @emmafrisbie6611

    7 ай бұрын

    @@DrDianeDAddie Yes, I will reach out to you on your website. Thank you kindly for your response

  • @DrDianeDAddie

    @DrDianeDAddie

    4 ай бұрын

    Thank you and I'm sorry to take so long to reply. My ABCD colleague Dr Hartmann has just had great success using 15mg/kg for 6 weeks. I've been using 20mg/kg for the first 2 weeks of non-neurological cases, to clear the brain. However, there is a risk of bladder stones, so I am learning all the time and changing my recommendations as we gather more data worldwide. Also remember that pills sold online can have varying amounts of GS-441524 in them. Please watch my FIP Treatment page on www.catvirus.com to get the latest information. @@emmafrisbie6611

  • @MonicaSealeyGuerrero
    @MonicaSealeyGuerrero6 ай бұрын

    Hey, I have just started my treatment with my sweet Chunky, I took him in for a teeth cleaning where my vet ended up extracting all his teeth. After the surgery my cat was fine until the second week when I started noticing a constant fever. I took him him for a recheck and his blood work was all wrong as well as one eye was a different color. Long story shoe he got ocular FIP 😢 I have already started the injections but I really want to start the pills (I already ordered some) as of day one he seems to be himself again 🩷 I am very confused on understanding how much he needs to take. Chunky is weighing 12lbs how many pills would he need to take ? Thank you!!

  • @DrDianeDAddie

    @DrDianeDAddie

    4 ай бұрын

    I'm really sorry that I didn't notice your comment until now. How is Chunky doing? The dose you use will depend on which brand of pills you got. My email is draddie@catvirus.com if you have more questions.

  • @maddie2382
    @maddie23822 ай бұрын

    My cat started on injections in January but quickly moved over to pills after about 3 weeks in. On day 79 of his treatment he got very sick and was showing signs of a regression. Our team believe it was another virus or infection though because it was SO late into treatment. Out of precaution they made us change over to injections again on a very high dose. That is what we are currently doing and he has gotten better for the time being. We are seeing a specialist next week to get a better idea of what happened but do you have any opinion on this?

  • @ahmeterenispir8362

    @ahmeterenispir8362

    12 күн бұрын

    Any updates about your cat?

  • @sundance2005
    @sundance20054 ай бұрын

    >>>>PLEASE RESPOND

  • @DrDianeDAddie

    @DrDianeDAddie

    4 ай бұрын

    Yes I do, and would likely stop the diarrhoea, which is also probably caused by the coronavirus. Please give it a try and let us all know how you get on. God bless you and your cat.

  • @wansworld27
    @wansworld277 ай бұрын

    Hi, is it possible to stop treatment before the 84 days or is 84 days absolutely necessary? My cat has wet FIP and appears to be back to normal, i've done 50+ days of treatment so far with oral GS but I'm running out of funds for the next batch of pills...

  • @DrDianeDAddie

    @DrDianeDAddie

    7 ай бұрын

    We showed that 84 days is not usually necessary: please show our paper to your veterinary surgeon and ask for the AGP blood test that determines whether your cat is truly cured or only in remission. The paper is here: www.mdpi.com/1999-4915/14/4/744/htm# If you copy that link and paste it the paper should come up.

  • @wansworld27

    @wansworld27

    7 ай бұрын

    Ok sure will have a look and thank you so much, really appreciate it@@DrDianeDAddie

  • @jerkface38

    @jerkface38

    5 ай бұрын

    Hey I have a cat we cured from FIP. Another cat of ours got out and never came home. Roommate adopted a cat he thought was ours but when we got him home it was very obviously not him. Unfortunately shelters don't allow much interaction. The cat he adopted has FIV but I'm now worried he has contracted FIP from the cat who previously had it. I know FIP itself isn't contagious but the virus that causes it still is. So I guess my question is how do I find out? I can't afford heavy vet bills. Just lost both my jobs unfortunately. He certainly has a URI. The cat we cured of FIP has had a URI on and off for a few months. We believe it to be his dormant coronavirus. I believe the FIV kitty has contracted it that way as we have recently started letting him out of my room since he was crying so often. Please help its urgent. I'm taking him to vet in morning.

  • @eglevaitkiene
    @eglevaitkiene5 ай бұрын

    Hello! Our kitty was diagnosed with dry/neurological FIP in the end of December. Now it is our 41st day of treatment, we are doing 12mg/kg dosage injections. Also, we were giving him Prednisolone until 15th day of treatment. Now we would like to switch to pills. I wanted to ask if there is still something we can do to prevent possible relapse? Thank you!

  • @DrDianeDAddie

    @DrDianeDAddie

    4 ай бұрын

    Yes, change to pills as soon as possible and increase the dose to 20mg/kg. Prednisolone is a disaster and inhibits recovery. If your cat does relapse at least there's the chance to use molnupiravir, which has rescued a number of FIP relapses.

  • @NiicoleF
    @NiicoleF10 ай бұрын

    Hi! Thank you for the informative video. I’ve been wanting to start treatment with my 10 month old cat who was just diagnosed with FIP. She started showing symptoms (pleural effusion) a few days after her fist vaccine dose, which I believe was the stress factor that lead to the mutation. I was going to get started with injections but after watching the video I’ll go with the pills. The one that I have access to has 45mg of GS in 1 pill. Is that an enough amount in a dose? They suggest to start with the injection as they say the cats don’t absorb too much when on pills. I would appreciate your input.

  • @NiicoleF

    @NiicoleF

    10 ай бұрын

    Also, they say that if the cat has a neurological form of FIP the dose should be higher. I know hers is wet (because of the effusion) but about 1 month ago she had an episode that seemed like an eye infection (I though she was going blind as she couldn’t see properly) but I believe she fully recovered from that as her eyes are back to normal (I gave her medication). Is that possible with FIP? Does that mean she also has the neurological form?

  • @DrDianeDAddie

    @DrDianeDAddie

    9 ай бұрын

    I'm really sorry to take so long to respond to your comment. Can you tell me the brand of the pill you have access to? I actually believe that ALL FIP cases should begin treatment with a neurological level dose of GS-441524 or molnupiravir, which usually means a 20mg/kg dose. Please make certain about the diagnosis, especially if after a week of antiviral your cat isn't improving. God bless you and your cat! Diane@@NiicoleF

  • @DrDianeDAddie

    @DrDianeDAddie

    9 ай бұрын

    I agree: it was likely the vaccine stress which triggered FIP. I'm so sorry that you weren't advised to have a feline coronavirus antibody test before the vaccine, to check whether or not there was a risk of FIP. So sad you and your cat are going through this, but at least now it is curable.

  • @NiicoleF

    @NiicoleF

    8 ай бұрын

    @@DrDianeDAddieHi Dr Addie, thank you for your response! I chose to go with the pills, the one that I have access to here in my country (Brazil) is from CureFIP. I’m on day 50 of the treatment and she is almost healed! Her blood samples have improve dramatically and she showed signs of improvement after 2 days of taking the pills. I’m grateful for the information you shared. I read everything on your website. Thank you! I hope the info is spread so professionals don’t make the same mistakes they did with her that lead to the mutation in her body. She was also Felv positive at the time of the vaccination.

  • @yuliyak4117

    @yuliyak4117

    6 ай бұрын

    @@NiicoleF hello - will you please let me know how is your treatment going? Also, where does one get these pills? thank you so much!

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