#TomorrowsDiscoveries

Ғылым және технология

Dr. Christopher Ross and his lab are studying the complementary approach to treat Huntington’s disease by developing mouse models, which have progressive symptoms that are similar to those of patients.
Discover more videos at hopkinsmedicine.org/research/about-faculty/discoveries-for-a-better-tomorrow.

Пікірлер: 74

  • @michaelhood5221
    @michaelhood52214 жыл бұрын

    Thank you for the amazing work you do 😊

  • @doblejota9651
    @doblejota96512 ай бұрын

    I am here after watching Dr House, just needed more information about this disease. Thanks!

  • @Purplehaste

    @Purplehaste

    14 күн бұрын

    hah same here.. Its truly a horrible disease...

  • @S_NRIO
    @S_NRIO5 жыл бұрын

    7/18 people in my family have this.. It's sad to see them get to some of the lowest points.

  • @562.anthony2

    @562.anthony2

    5 жыл бұрын

    My dad got it, it sucks and I wish you the best. I just hope I don’t got it

  • @jasonok1436

    @jasonok1436

    4 жыл бұрын

    Wow 7 people in your family have it? That’s really rough.. I’m sorry you have to go through that

  • @S_NRIO

    @S_NRIO

    4 жыл бұрын

    Html. Anthony don’t ever worry about having it! The worst thing you can do is ponder on that thought. I had an uncle commit suicide because of his fears; live your best life! Huntington’s does not define you or your family :) good luck!

  • @562.anthony2

    @562.anthony2

    4 жыл бұрын

    Savannah McClung thank you, I wish you the best of luck too

  • @salvadorhirth1641

    @salvadorhirth1641

    4 жыл бұрын

    One sign of Huntington's disease potential, is the existence of a number of repetitions of the sequence of nitrogenous bases cytosine-adenine-guanine ( CAG triplets ) above a threshold ( 36 repeats or more ); if my hypothesis for the molecular mechanism of Huntington's disease is right, then maybe the existing drugs DNA methyltransferase (DNMT) inhibitors azacytidine and decitabine could help to slow down the onset of the disease, maybe even alleviate the symptoms, in spite of the drugs side effects. In short, I noticed that an inadvertent methylation of the 5-carbon in a cytosine, followed by spontaneous deamination of that citosine, would create a STOP codon (TAG instead of CAG amid many CAG triplet repeats), as you can see in a DNA genetic code table: @t A STOP codon would of course interrupt the protein synthesis and if that is indeed the cause of fragmented proteins, DNA methyltransferase (DNMT) inhibitors could help. Here it is a DNA genetic code table where one of the possible STOP codons ( TAG ) can be seen above the codon CAT: Google dna genetic code I've found an article about the formation of a similar STOP codon from another triplet sequence that begins with cytosine: google: Arginine CGA codons as a source of nonsense mutations: a possible role in multivariant gene expression, control of mRNA quality, and aging. Talk to doctors about this, until you find someone who will examine my idea. I hope I can help. Good luck.

  • @amymdez
    @amymdez5 жыл бұрын

    This disease reminds me so much of battens disease. Seriously one of the scariest diseases, god bless those who have it

  • @user-em4rk4qo1f
    @user-em4rk4qo1f3 жыл бұрын

    cool stuff hope you manage to find a new treatment approach

  • @rachelhopkins9432
    @rachelhopkins94323 жыл бұрын

    My dad has Huntington’s disease, I’ve never been tested for it, and I’m scared to find out. I also have four siblings that don’t know. My dad is starting to deteriorate and I take care of him, but I’m leaving for basic training for the Air Force next month and I’m worried for him.

  • @doctorpanigrahi9975

    @doctorpanigrahi9975

    6 ай бұрын

    How old are you?

  • @oliviatalbot5435

    @oliviatalbot5435

    5 ай бұрын

    I recommend you Google Mayo clinic/Huntington's disease. The Mayo is a world renound clinic in Minnesota, Scottsdale, Florida. I promise you'll learn so much. Also, there are clinical trials going on at John Hopkins creating medication to help with the nerve cells in the brain. So... hope is on the way. One more thing, have a strong faith in God. He works profound miracles well beyond our comprehension. Ask Him to take away your worries and fears and trust Him with all your heart.

  • @anusreetravel

    @anusreetravel

    4 ай бұрын

    Hello, hope you are ok… it’s ok to test.. I was scared too.. I lived with tension for months and finally tested.. I hope you have courage to do the test.

  • @denisebreeden825

    @denisebreeden825

    Ай бұрын

    Don't get tested pr tell the military you may have it until later. They won't ever test for that or find out. Don't get tested until your stable and older in your career. I have it, my mother has it. Lots of cousins and my mother made it to 74 this year and she's just starting to shake and get bad. Just do not have any children unless your tested first the gene passed from a man to their children is worse then a female.

  • @denisebreeden825

    @denisebreeden825

    Ай бұрын

    I'm 45 and I've known for 3 years I have it cause I got my mother tested , my uncle died from it. Anyways I have 5 children and I'm scared to death for them. I would of never had children had I known I have this horrible disease. I also wish I didn't know that i was dying. It messes with your mental for sure. But at least I know now what was wrong with me and why I behave the way i do.

  • @MelanieCeline
    @MelanieCeline3 жыл бұрын

    This is heartbreaking.

  • @bruhahaish
    @bruhahaish3 жыл бұрын

    Would this present with someone losing control of motor function in their arms and neck? My dad is being told he has a upper motor neuron disease and I think it’s ALS but from what I read this seems similar.

  • @shuatastic

    @shuatastic

    2 жыл бұрын

    Huntington's normally presented with loss of motor control, yes. It generally is not "ticks" or repetitive motions - it's called "chorea" and is more of a random/dancing like movement. If he is experiencing that - I'd recommend getting it looked into.

  • @jelycupz
    @jelycupz4 жыл бұрын

    My mum’s got it and I’m considered a young career for her.

  • @nancywalker-keay8361

    @nancywalker-keay8361

    3 жыл бұрын

    4 years ago I was diagnosed of HUNTINGTON DISEASE and I have tried all I can to get cured but all to no avail, until i saw a post in a health forum about a herbalist man who prepare herbal medication to cure all kind of diseases including HUNTINGTON DISEASE , at first i doubted if it was real but decided to give it a try, when i contact this herbalist via his email and he prepared an HUNTINGTON DISEASE herbal cure and sent it to me via UPS delivery company service,when i received this herbal cure, he gave me step by directions on how to apply it, when i applied it as instructed, i was totally cured of this deadly disease within 1 months of usage, I am now free from HUNTINGTON DISEASE ,all thanks to Dr Joshua Ighalo. you can also reach this great herbal doctor for help . He can help get rid of yours permanently.. Also specialize in treating all kinds of illness, HERPES VIRUS, HEPATITIS B, CANCER, BRAIN DISEASE, INFERTILITY, DIABETES AND MORE. ....

  • @kokocipher685
    @kokocipher6852 ай бұрын

    any improvements after 6 yrs?

  • @goldeninfamous
    @goldeninfamous5 жыл бұрын

    This is my doctor. I have the disease

  • @latinlatino5146

    @latinlatino5146

    3 жыл бұрын

    I wish you all strength in the world and a slow development of the disease. Never give up, you are not only what your DNK says, you're much more.

  • @nancywalker-keay8361

    @nancywalker-keay8361

    3 жыл бұрын

    That's so sad to hear you are still suffering from this same disease. Am feeling for you right now, I know of a doctor who can help you get rid of this. He also help me from this same disease, He can also help cure yours permanently

  • @nancywalker-keay8361

    @nancywalker-keay8361

    3 жыл бұрын

    4 years ago I was diagnosed of HUNTINGTON DISEASE and I have tried all I can to get cured but all to no avail, until i saw a post in a health forum about a herbalist man who prepare herbal medication to cure all kind of diseases including HUNTINGTON DISEASE , at first i doubted if it was real but decided to give it a try, when i contact this herbalist via his email and he prepared an HUNTINGTON DISEASE herbal cure and sent it to me via UPS delivery company service,when i received this herbal cure, he gave me step by directions on how to apply it, when i applied it as instructed, i was totally cured of this deadly disease within 1 months of usage, I am now free from HUNTINGTON DISEASE ,all thanks to Dr Joshua Ighalo. you can also reach this great herbal doctor for help . He can help get rid of yours permanently.. Also specialize in treating all kinds of illness, HERPES VIRUS, HEPATITIS B, CANCER, BRAIN DISEASE, INFERTILITY, DIABETES AND MORE. ....

  • @user-em4rk4qo1f

    @user-em4rk4qo1f

    3 жыл бұрын

    @@nancywalker-keay8361 oh my god. I hope you're doing well. Herbal medicine is not exactly the best approach. Hope you get other treatment as well

  • @nancywalker-keay8361

    @nancywalker-keay8361

    3 жыл бұрын

    @@user-em4rk4qo1f am fine now and am free i don't have it anymore

  • @deputymike4149
    @deputymike41495 жыл бұрын

    How did this disease first appear? Can you develop it?

  • @JohnsHopkinsMedicine

    @JohnsHopkinsMedicine

    5 жыл бұрын

    HI, you can learn more here: www.hopkinsmedicine.org/health/conditions-and-diseases/huntingtons-disease.

  • @DowntownTasty

    @DowntownTasty

    5 жыл бұрын

    It’s genetic. If you don’t have a family member with it you’re fine.

  • @deputymike4149

    @deputymike4149

    5 жыл бұрын

    Craig Richard how did the first person who ever had it got it?

  • @kwenachoshi8527

    @kwenachoshi8527

    4 жыл бұрын

    It is caused by the repeat in the CAG sequence

  • @mazharahmad3331

    @mazharahmad3331

    4 жыл бұрын

    @@deputymike4149 sir it's disease strat from 30or 35 age

  • @kristenrushing9077
    @kristenrushing90773 жыл бұрын

    I have hd

  • @harpreetratol589
    @harpreetratol5894 жыл бұрын

    Plz someone can help me to find solution from this problem

  • @nancywalker-keay8361

    @nancywalker-keay8361

    3 жыл бұрын

    That's so sad to hear you are still suffering from this same disease. Am feeling for you right now, I know of a doctor who can help you get rid of this. He also help me from this same disease, He can also help cure yours permanently

  • @harpreetratol589

    @harpreetratol589

    3 жыл бұрын

    Thax alot sis to suggesting

  • @nancywalker-keay8361

    @nancywalker-keay8361

    3 жыл бұрын

    @@harpreetratol589 yeah you're welcome so kindly send me your whatsap number and email address so I can help you forward it to the doctor okay

  • @RollinsTM

    @RollinsTM

    3 жыл бұрын

    @@nancywalker-keay8361 i want contact you

  • @toddgilmore118
    @toddgilmore1184 жыл бұрын

    Thanks.. but work faster before It takes my life to...

  • @amyerdman2564

    @amyerdman2564

    4 жыл бұрын

    Prayers !!

  • @justfahmi4437
    @justfahmi44375 жыл бұрын

    I came from dr prisoner.

  • @gunterliam7411
    @gunterliam74112 жыл бұрын

    All thanks to dr Stanley who cured me from my Huntington’s disease I am forever grateful

  • @liberalismisamentaldisease8233

    @liberalismisamentaldisease8233

    2 жыл бұрын

    That's amazing considering there is no cure🤦🏻‍♂️🤦🏻‍♂️

  • @Meechstik

    @Meechstik

    5 ай бұрын

    Exactly, How do you say you were cured?

  • @j.m.6733
    @j.m.67335 жыл бұрын

    This doesnt explain the effects of the disease

  • @kierstanfaulks

    @kierstanfaulks

    5 жыл бұрын

    @@TaytayteamTaytay also the whole losing control of your body and mind too.

  • @marlinbundo2409

    @marlinbundo2409

    5 жыл бұрын

    Neurons start to die off, generally the symptoms present themselves around age 40 and get worse and worse. Most will die from the disease by age 60 or so. As the disease progresses, the patients lose more and more motor control, resulting in twitchy erratic movements that have a severe impact on quality of life (harder to eat and walk, impossible to drive, etc.). End stage of disease affects cognition as well. Similar to diseases like parkinsons and alzheimers, it just takes away your life bit by bit. Dreadful disease. Luckily research is making great strides, we may see a cure within our lifetimes.

  • @todd7684
    @todd76845 жыл бұрын

    MoUsE MAdels

  • @rabiashakoor1766

    @rabiashakoor1766

    4 жыл бұрын

    Not the time or the place my dude

  • @thefreckledgamer2940

    @thefreckledgamer2940

    4 жыл бұрын

    That’s sick, you realize that? I come to read comments of others dealing with this disease like my father and you write that? Sad.

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