The Smallest Pathogen on Earth: Viroids Explained

Viroids are tiny, infectious, replicating bits of RNA that can be quite serious-but how did we discover them? It's more interesting than you might have though! Join Michael Aranda for a new episode of SciShow and let's unpack these tiny pathogens!
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Sources:
www.ars.usda.gov/oc/timeline/...
agresearchmag.ars.usda.gov/19...
www.apsnet.org/publications/ap...
www.ncbi.nlm.nih.gov/pubmed/2...
www.els.net/WileyCDA/ElsArticl...
journal.frontiersin.org/articl...
medlineplus.gov/ency/article/...
www.sciencedirect.com/science/...
biologydirect.biomedcentral.c...
www.pnas.org/content/86/23/937...
exploringorigins.org/ribozymes...
mcmanuslab.ucsf.edu/node/246
www.nature.com/nrmicro/journa...
www.sciencedirect.com/science/...
www.apsnet.org/publications/P...

Пікірлер: 669

  • @d_wang9836
    @d_wang98367 жыл бұрын

    Viroids sounds like a disease for viruses

  • @frankschneider6156

    @frankschneider6156

    7 жыл бұрын

    +[Yoshikage_Kira] Viruses aren't alive, so they can't have a "disease", just like a stone can't get ill.

  • @mrexists5400

    @mrexists5400

    7 жыл бұрын

    viruses are the closest thing to the current definition of life without it being life

  • @RetentiveCloud

    @RetentiveCloud

    7 жыл бұрын

    Or steroid'd viruses

  • @MrFappington

    @MrFappington

    7 жыл бұрын

    ObesityHitMeOnceMore they're called virophages. Like you said, they attack large viruses (Nucleocytoplasmic Large DNA Virus NCLDV).

  • @wenxuanzhou5823

    @wenxuanzhou5823

    7 жыл бұрын

    +Frank Schneider Actually, they can. They have RNA which other viruses can take advantage of, so they definitely can get infected and destroyed by another virus. They're called virophages. Just like bacteria can also get infected by viruses called bacteriophages.

  • @MrMysticphantom
    @MrMysticphantom7 жыл бұрын

    I expect this video to go viroid

  • @narcotic702

    @narcotic702

    7 жыл бұрын

    Stop

  • @godspeed2145

    @godspeed2145

    7 жыл бұрын

    *Rolls eyes*

  • @Tautolonaut

    @Tautolonaut

    7 жыл бұрын

    videos go viral, I imagine still pics go viroid.

  • @Scarachus

    @Scarachus

    7 жыл бұрын

    Viroidal?

  • @aidanc4719

    @aidanc4719

    6 жыл бұрын

    HA!

  • @TheRogueWolf
    @TheRogueWolf7 жыл бұрын

    "Hop Stunt Viroid" sounds like a KZread video of someone botching a pogo-stick trick.

  • @doubtfulsausage

    @doubtfulsausage

    7 жыл бұрын

    Or a mad scientists way to make beer

  • @pyro226

    @pyro226

    6 жыл бұрын

    Jalapeno on a stick? (Jeff Dunham)

  • @stabulouskoda834
    @stabulouskoda8347 жыл бұрын

    every time it zooms in on Michael's face I just really appreciate his hair

  • @haithummohsin6273

    @haithummohsin6273

    2 жыл бұрын

    Yes lol but earings don't suite tbh... no offence though

  • @TheConnor12500
    @TheConnor125007 жыл бұрын

    The incredible complexity and beauty of life never ceases to amaze me.

  • @EmmaR
    @EmmaR7 жыл бұрын

    It's 2am and I'm watching a video about viroids

  • @2intheampm512

    @2intheampm512

    4 жыл бұрын

    Emma R. This hit

  • @commentsanitizer7929

    @commentsanitizer7929

    3 жыл бұрын

    Good gal

  • @stuartrussell8572

    @stuartrussell8572

    3 жыл бұрын

    What could be better?

  • @ezachleewright2309

    @ezachleewright2309

    3 жыл бұрын

    I stayed up to 7:00 AM yesterday morning

  • @EmmaR

    @EmmaR

    3 жыл бұрын

    @@ezachleewright2309 Nice

  • @lizgichora6472
    @lizgichora64727 жыл бұрын

    Thank you!

  • @inkedseahear
    @inkedseahear7 жыл бұрын

    That's a nice definition of life you got there. It would be bad if… …something simple appeared

  • @anastasiacarvalho401
    @anastasiacarvalho4017 жыл бұрын

    My professor finished this topic in my class today. what a coincidence this is!

  • @Articulate99
    @Articulate99 Жыл бұрын

    Always interesting, thank you.

  • @AbbeyAnn
    @AbbeyAnn7 жыл бұрын

    I know I'm a bit late to the party but your hair looks so good 😍

  • @nicanornunez9787
    @nicanornunez97877 жыл бұрын

    I love scishow as much as I love scihub. Keep it up whit the good work, and thanks.

  • @weshard1
    @weshard17 жыл бұрын

    Aren't prions a smaller pathogen?

  • @patrickssj6

    @patrickssj6

    7 жыл бұрын

    Probably depends on how you define smaller. Molecular weight?

  • @myky992

    @myky992

    7 жыл бұрын

    Also likely depends on how you define pathogen. Possibly we are referring to live pathogens? But if something blurs the line between alive and death more than viruses, it's definitely viroids...

  • @bigbenhebdomadarius6252

    @bigbenhebdomadarius6252

    7 жыл бұрын

    Prions are proteinaceous particles, similar to viruses and viroids, but lacking a genetic component. This may be out of date, but I think prions attack animals, and viroids affect plants.

  • @myky992

    @myky992

    7 жыл бұрын

    I do wonder why that is. I looked quickly on the wiki for viroids and it seems none affect animals. I don't know about prions. yet we both use proteins, and we both use RNA... maybe it's the difference in immune systems? Animals drove animal viroids extinct by being supergood at eliminating them and plants did the same for plant prions? Obviously just spitballing hypothesis with no substance here :D

  • @patrickssj6

    @patrickssj6

    7 жыл бұрын

    No organism wants to take in external RNA from an unknown source. Most organisms have defense mechanisms for that but it seems that plants are an easy target (insects transfer these viroids by damaging cells). Also plants are much older than animals which could also be the reason for this old coevolution. Prions result from a special type of protein which exists only in animals. Not every protein has this special property which is why these pathogens only exist in animals.

  • @hakari_kinjiofficial
    @hakari_kinjiofficial3 жыл бұрын

    Nice explanation

  • @himanisharma8507
    @himanisharma85073 жыл бұрын

    Best sci channel I have ever seen.

  • @MonkeyspankO
    @MonkeyspankO7 жыл бұрын

    very cool...would love a more in depth video on this topic

  • @aweirdpizza2249
    @aweirdpizza22497 жыл бұрын

    An episode on virusoids would be pretty interesting.

  • @tfsheahan2265
    @tfsheahan22657 жыл бұрын

    Outstanding. For those of us who do not have out finger on the throbbing pulse of biology, this is a big help. Might you do an update on the other end of the topic. Virus or virus-like things that are bigger and more complex than viruses, but are not stand alone organisms?

  • @homemobile8362
    @homemobile836210 ай бұрын

    Thank u ❤

  • @jamesh625
    @jamesh6257 жыл бұрын

    If the viroid is circular, how does the RNA Polymerase know when to stop replicating (and join the replicated RNA into a circle)? Is there some sequence of nucleotides on the viroid that signal to the RNA Polymerase to terminate?

  • @anotherhappyday93
    @anotherhappyday937 жыл бұрын

    I love it when Guy with Haircut looks like he just got a haircut

  • @eyuin5716
    @eyuin57167 жыл бұрын

    I initially misread the title and I thought I read "Smartest Pathogen".

  • @Xoediac
    @Xoediac7 жыл бұрын

    Love your hair :)

  • @DavidFrostbite
    @DavidFrostbite6 жыл бұрын

    Epic hair as always.

  • @BrokebackBob
    @BrokebackBob7 жыл бұрын

    Michael is rocking his hair!!

  • @RichardASalisbury1
    @RichardASalisbury17 жыл бұрын

    Very cool!

  • @studioMYTH
    @studioMYTH3 жыл бұрын

    OOOOH THE HAIRCUT! I like it.

  • @eliscerebralrecyclingbin7812
    @eliscerebralrecyclingbin7812 Жыл бұрын

    Cool thanks

  • @xWood4000
    @xWood40007 жыл бұрын

    This is cool, I would have liked to learn this in elementary school.

  • @imustbeames3727
    @imustbeames37272 жыл бұрын

    Thank you Mr. Elizondo

  • @quinton1630
    @quinton16304 жыл бұрын

    Who suddenly has this in their recommended feed in March 2020?

  • @mickmickymick6927
    @mickmickymick69277 жыл бұрын

    The Irish Potato Famine was caused by Blight by the way, a common potato and plant disease which farmers still have to manage today, they should have just mentioned the disease.

  • @jebosamvasjako
    @jebosamvasjako7 жыл бұрын

    The moment when you understand the big words behind this video

  • @YiGzit
    @YiGzit7 жыл бұрын

    This is was a good video on this topic. Liked by a biotechnologist student!

  • @emilybe8652
    @emilybe86527 жыл бұрын

    Very interesting

  • @Art_Fox894
    @Art_Fox8943 жыл бұрын

    Too good👍👍

  • @BrentBarnard
    @BrentBarnard7 жыл бұрын

    It would be intriguing to see an episode dedicated to counting down the oldest mountain chains on the planet. In "4 Billion Years in Under 10 Minutes," you mention that the Appalachians are far older than the Rockies. It would be interesting to see a sequential countdown of the top 5 or 10 oldest mountains/mountain chains.

  • @notlun
    @notlun7 жыл бұрын

    fresh cut

  • @Alexieto
    @Alexieto7 жыл бұрын

    love your hair. so how do farmers fight viroids? i mean is there a cure or is it mostly just prevent the spread of the viroid?

  • @LuisAldamiz

    @LuisAldamiz

    3 жыл бұрын

    He sounded like there is no cure but that methodical cleaning of gardening tools (with alcohol, I guess) is a good prophyllactic measure. I doubt there is a cure, just as there are no cures for viruses in general (can treat the symptoms, maybe prevent with a vaccine, but can't kill what is not really alive).

  • @evanbecraft8201

    @evanbecraft8201

    2 жыл бұрын

    @@LuisAldamiz careful man mentioning whether a virus is alive or not will start a nuclear war viruses, by the generally universal definition that is a major subject to debate, are not alive. Technically, destroying the structure of the virus/viroid could be considered killing it if we allow parasitic reproduction and alternative evolutionary paths to be considered a form of life. I do believe that the definition of life is not broad enough, and I also believe that anything that self replicated through processes through encoded information is in fact a living organism.

  • @LuisAldamiz

    @LuisAldamiz

    2 жыл бұрын

    @@evanbecraft8201 - I'm aware of the debate: there's no consensus on whether viruses are alive or not. I would say they are, sorta, because they do reproduce, while rocks or other inanimate objects do not. Computer viruses are also alive, sorta. My old school definition of life was that a living being is one that "is born (check), grows (?), reproduces (check) and dies (check)". The virus only dubiously does not grow, although it does as the RNA/DNA chain does grow in numbers and accumulating the protein structure around it is a form of growth. So I'd say that viruses are alive by the primary school definition. They are not alive by Basque language usage, but trees aren't either, only animals.

  • @sharktamer7306
    @sharktamer73067 жыл бұрын

    The 3 dislikes are viroids.

  • @pranavmahadikar2147

    @pranavmahadikar2147

    7 жыл бұрын

    sharktamer no viruses

  • @conf1rmed819

    @conf1rmed819

    6 жыл бұрын

    98 viroids dislike dis vid

  • @sharktamer7306
    @sharktamer73067 жыл бұрын

    Non-notification squad where you at!

  • @TRexPhilbo

    @TRexPhilbo

    7 жыл бұрын

    +

  • @surya8891

    @surya8891

    5 жыл бұрын

    here

  • @ganeshfulkari9334
    @ganeshfulkari93345 жыл бұрын

    Nice sir

  • @SlyPearTree
    @SlyPearTree7 жыл бұрын

    Are viroids responsible for graboids? Nice subject for a video, I never heard of viroids before, thanks.

  • @CorbinChancellorTV
    @CorbinChancellorTV7 жыл бұрын

    Great video, RNA world hypothesis might make a good video

  • @mva2997
    @mva29977 жыл бұрын

    Newer, sexier Michael Aranda upgrade

  • @theextraterrestrialsscienc7122
    @theextraterrestrialsscienc71226 жыл бұрын

    And here we have it: A molecule that at the same time is a living organism, impressing.

  • @LuisAldamiz

    @LuisAldamiz

    3 жыл бұрын

    Sorta. Biologists don't really agree on saying that viruses are "living organisms" or "life" at all. They lack self-sufficiency, they are rather weird organic chemistry that is only somewhat life-like. This would be even more clear for viroids.

  • @complex314i
    @complex314i2 ай бұрын

    There is one detail of the RNA first hypothesis that I have never seen answered: the U to T transition. DNA is comprised of the four bases adenine, cytosine, guanine, and thymine. However, in RNA uracil is utilized in place of thymine. How was this fundamemtal base switched when life transitioned from RNA to DNA?

  • @jasonharrison25
    @jasonharrison255 жыл бұрын

    Looks like he's just about going to burst right out of his shirt

  • @davebashford3753
    @davebashford37536 жыл бұрын

    "... when they extracted samples of [the viroid] ..." So much in one simple phrase. How do you extract a sample of anything, let alone an unknown substance?

  • @gaburieruR

    @gaburieruR

    8 ай бұрын

    Extraction of the infected plant material in solvent, and sucessive filtrations, with better and better filters, and analysis by microscopy of the samples to see if you encounter a strange body

  • @davebashford3753

    @davebashford3753

    8 ай бұрын

    @@gaburieruR Thanks

  • @anthonybeervor2265
    @anthonybeervor22656 жыл бұрын

    This is the scariest thing I have heard since I learned about bacteriophages.

  • @TheNinjutsustudent
    @TheNinjutsustudent6 жыл бұрын

    I know what next year's Halloween costume is going to be.

  • @n124lp
    @n124lp6 жыл бұрын

    I don't find diseased potatoes to be narley, but the one in the picture looked gnarled. ;-)

  • @stanfordsweird4607
    @stanfordsweird46077 жыл бұрын

    o wow I feel so bad for patatos now sad story

  • @EpicSelenium34
    @EpicSelenium346 жыл бұрын

    how did you get that plant cell diagram at 1:56? I can find one like it but it's labeled.

  • @abedfadila9266
    @abedfadila92667 жыл бұрын

    whoa!

  • @bigbenhebdomadarius6252
    @bigbenhebdomadarius62527 жыл бұрын

    Like the new haircut.

  • @triplemgaming5103
    @triplemgaming51032 жыл бұрын

    0:27 ‘It can infect potatoes’ *two seconds later* 0:35 ‘A clue to how life started on Earth’ 😂😂😂

  • @AlexandrKovalenko
    @AlexandrKovalenko4 жыл бұрын

    Adding sour cream to potatoes? Are you nuts?

  • @jesusramirezromo2037
    @jesusramirezromo20377 жыл бұрын

    What about Prions?

  • @zed1stwizard

    @zed1stwizard

    7 жыл бұрын

    Prions are infectious (agents) composed entirely of a protein material that can fold in multiple, structurally abstract ways, at least one of which is transmissible to other prion proteins, leading to disease in a manner that is comparable to the spread of viral infection. Not a life form.

  • @LeoMRogers

    @LeoMRogers

    7 жыл бұрын

    While you're on wikipedia, take a look at the 'pathogen' page. Being a life form isn't a prerequisite of being a pathogen, and prions are listed as pathogens.

  • @TheGrandMasterPotato

    @TheGrandMasterPotato

    7 жыл бұрын

    But do pathogens necessarily have to be considered living?

  • @josiahklein70

    @josiahklein70

    7 жыл бұрын

    Jesus Ramirez Romo Infectious, malformed proteins.

  • @zed1stwizard

    @zed1stwizard

    7 жыл бұрын

    I stand corrected.

  • @dg-hughes
    @dg-hughes7 жыл бұрын

    I have personal knowledge of the power of the ribosome/ribozyme in the form of Creeping Charlie lawn weeds, those things are indestructible and I think grow in seconds!

  • @josephcole8102
    @josephcole81027 жыл бұрын

    prions might be smaller, but they are more like cell corrosion or rust than an infection

  • @aniekanumoren6088
    @aniekanumoren60887 жыл бұрын

    Does this count as evidence towards the RNA world hypothesis in the theory of Abiogenesis? If so, then were one step closer to figuring how life on earth came to be. So exciting!!!!

  • @elgatoguapo88
    @elgatoguapo887 жыл бұрын

    what did those ancient viroids use to replicatd themselves without the plants they use now?

  • @mechanizedape2998
    @mechanizedape29987 жыл бұрын

    The funny thing is, rna could not have formed in the conditions of the early earth environment. The reason is because rna uses molybdenum oxide to self assemble. Molybdenum oxide could not have exsists in the environment of the early earth. Even more interesting is that Mars did have the proper conditions for molybdenum oxide to form.

  • @jackdavids2723
    @jackdavids27234 жыл бұрын

    Prions are the smallest pathogens, and the most resilient

  • @Ryn-yf8oe
    @Ryn-yf8oe3 жыл бұрын

    Nice

  • @brookeh2635
    @brookeh26357 жыл бұрын

    Someone really clicked this just to dislike it and it was uploaded 2 minutes ago

  • @cup_check_official

    @cup_check_official

    7 жыл бұрын

    haters gonna hate. potatoes gonna potate

  • @HEXVeKtAr1

    @HEXVeKtAr1

    7 жыл бұрын

    i know, it's quite saddening and puzzling to try understand what pushes people to dislike something that they havent even seen the intro to

  • @gnarthdarkanen7464

    @gnarthdarkanen7464

    7 жыл бұрын

    There are some people who (for various reasons not entirely understood) will chase down every upload from a certain source because some past offering or resource citation didn't seem to suit them. It's a chance (at least on YT) to "get back" at the people who posted such "disheartening" or "personally irritating" information of whatever quality. In the case of YT, it might serve the entire community really well, to require a minimum time spent actually watching the video before you got the "power" to activate a like or dislike on it. This tiny change (adding a timer in the interface to activate controls only after a time-out) would help to dissuade some people from perpetually bombarding themselves for the simple task of leaving a dislike... In further development, the timer added could be set and established based on the time of the video in question, say a 55% ratio just to ensure you watch more than half the thing before getting controls like "comment" "like" "dislike" and "subscribe"... An added benefit to keep us from making quite too random or quick and misjudgment too easily. Of course, it's just a suggestion, and yes, I know. Haters hate. It's what they do. :o)

  • @xiangmusic210

    @xiangmusic210

    6 жыл бұрын

    gnarth d'arkanen remember the bullies? people enjoy the sane thing on internet.

  • @yeahkeen2905

    @yeahkeen2905

    4 жыл бұрын

    Brooke H it was uploaded two minutes ago but the video is 4 minutes long. I don’t see the problem here.

  • @thelastcube.
    @thelastcube.7 жыл бұрын

    Viroids are like Yoda - small and legendary ALL HAIL HOLY VIROIDS

  • @LejaLexiphanic

    @LejaLexiphanic

    7 жыл бұрын

    Chaitanya Singh your profile pic made me think there was a hair on my screen lol

  • @uranus_crunch_cake87

    @uranus_crunch_cake87

    6 жыл бұрын

    I just blew on my screen....smh

  • @edi9892
    @edi98927 жыл бұрын

    How does the viroid rna get into the target cells? Viruses need sensors and injection needles for it...

  • @robertcarlyon6076
    @robertcarlyon60767 жыл бұрын

    scishow my dad found this new remedy called Bachs pastilles and he wants our while family to try it. but I am very skeptical and I really need your help.

  • @geopixels6886
    @geopixels68867 жыл бұрын

    Okay okay. I have a real question related to this important issue. Who tops their sour cream with potatoes?

  • @ChainsawDunDeez
    @ChainsawDunDeez6 жыл бұрын

    Excellent... I remember reading an early 2000 science article about viruses being possibly the key to the origin of life/ RNA world... And when Viroids were mentioned and described briefly....I was thinking? Wait ? Aren't these things even simpler then viruses ?? Couldn't these be a possible key component to the origins of life/ or 'living Fossils' of 'The RNA world' (Theory)?? Glad That possibility been shared to other thinkers and learners...good job Scishow!

  • @JKH133
    @JKH1337 жыл бұрын

    SciShow! I have a question to ask you, so what's the best way of submitting it? Leave it here or what?

  • @zedward
    @zedward7 жыл бұрын

    Hey, question: are our bones always wet? Thanks

  • @fredriks5090
    @fredriks50906 жыл бұрын

    Thumbnail made me think of another kind of virus - the red "click here to find the answer"-circles on thumbnails.

  • @rkpetry
    @rkpetry7 жыл бұрын

    What's the difference between "phage" (the term in use ca 1960's) and "viroid" (herein)....

  • @GodlikeIridium
    @GodlikeIridium6 жыл бұрын

    poor potatoes 😢

  • @bonhomhongon2794
    @bonhomhongon27946 жыл бұрын

    Does anybody else feel an overwhelming sense of affection towards viroids

  • @pigcatapult
    @pigcatapult5 жыл бұрын

    I somehow still wasn't expecting these guys to be even smaller than prions.

  • @kieferfarrer4734
    @kieferfarrer47347 жыл бұрын

    so why cant we fully digest corn?

  • @rickorefice9417
    @rickorefice94177 жыл бұрын

    what is the difference between this and a phage/prions?(ie mad cow)

  • @germimonte
    @germimonte7 жыл бұрын

    but wait, how could rna be fist, if it needs all that comlex structure from a host to replicate?

  • @theviniso
    @theviniso6 жыл бұрын

    How do these guys get inside plant cells?

  • @apostle333
    @apostle3336 жыл бұрын

    Can viroids effect other viruses? Thus altering or even causing the rapid course of mutation?

  • @jacc6532
    @jacc65323 жыл бұрын

    nice

  • @MaddTheSane
    @MaddTheSane5 жыл бұрын

    So what's the difference between viroids and prions? Perhaps that could be a subject of a future episode.

  • @krzysztofczarnecki8238

    @krzysztofczarnecki8238

    5 жыл бұрын

    Viroids are RNA and prions are proteins, a different class of compounds. Prions also don't really get replicated, they just cause a protein that is the same sequence of amino acids as them but folded differently and already existing to change shape. Viroids are more like a computer virus than a real virus- just bare data in the form that it actually is represented with in a given system that tells it to copy just itself, not grow an entire fancy thumb drive around it, complete with a keychain and an end cap and then leave it on a pavement so that someone else picks it up out of curiosity.

  • @vishensivparsad
    @vishensivparsad5 жыл бұрын

    How does the rna survive the environment? Shouldn't uv light and other strong stimuli destroy it

  • @listen2164
    @listen21645 жыл бұрын

    there's also prions!

  • @MsSqueashy
    @MsSqueashy7 жыл бұрын

    Boi when did he get his hair cut

  • @redcoat4348
    @redcoat43487 жыл бұрын

    So I'm doing a project, right? On the "moon" of Venus known as Neith. I'd like you to make a video on that, it's quite interesting, but I can never find sources on it.... :(

  • @mianfazlerazik3636
    @mianfazlerazik36367 жыл бұрын

    Hey virus show some skin..... Ok now I am a viroid

  • @BrianFrichette
    @BrianFrichette7 жыл бұрын

    I actually thought it was prions (~10nm), but if viroids are really a tenth the size of a small virus that's significantly smaller!

  • @dsc4178
    @dsc41787 жыл бұрын

    Viriods, Prions, and more. Have they done a video on why bacteria (eubacteria) are not related to other forms of life on Earth (left vs. right handed DNA, one proof).

  • @bobbyharper8710
    @bobbyharper87107 жыл бұрын

    Maybe this is the aliens we've been expecting

  • @patrickflynn1013
    @patrickflynn10135 жыл бұрын

    These viroids are killing me.

  • @tonyhernandez331
    @tonyhernandez3317 жыл бұрын

    I thought they were trying to make a click bait video with all the circles lmao

  • @milesstone2501
    @milesstone25017 жыл бұрын

    I'm thinking this would make a good new pathogen for Plague Inc.

  • @thatjillgirl
    @thatjillgirl7 жыл бұрын

    What about prions? Do we not count them as pathogens since they are pure protein?

  • @AtlanticPicture
    @AtlanticPicture7 жыл бұрын

    Make a vid about "Sci Show Hand Tremors" aka "Shaking Hands like a Sound Wave" :) then a sequel, about the Bouncy SSHT version.. :)

  • @FonVegen
    @FonVegen7 жыл бұрын

    Looks like Theodor *served* a *vital* purpose here! Get it? Because his last name is "Diener", and this is about pathogens...