The Science of Leaky Gut with Dr Michael Camilleri MD (Mayo Clinic)

Ғылым және технология

There’s still a lot we don’t understand about the science of leaky gut. Does it cause disease or is it a symptom? What’s the best way to test for it? Which treatments actually work to repair it?
Today’s guest is one of the best people to begin to answer these questions.
Dr. Camilleri is a renowned gastroenterology researcher and professor at the Mayo Clinic.
Tune in to hear about cutting-edge innovations and informed understandings around leaky gut testing and treatment.
If you have any additional questions you would like answered in the future, let me know in the comments!
Watch/Read Next…
What is Leaky Gut: drruscio.com/what-is-leaky-gut/
Leaky Gut Suplements: drruscio.com/leaky-gut-supple...
Probiotics for Stomach Issues: drruscio.com/probiotics-for-s...
Learn more about Dr. Camilleri’s work: www.mayo.edu/research/faculty...
Timestamps
00:00 Intro
03:25 Dr. Camilleri’s background with leaky gut
05:05 Bile-acid supplementation
07:20 The small intestine
11:07 The prevalence of leaky gut
14:25 Leaky gut & diseases
20:08 Leaky gut & inflammation
30:18 Treatment: Where to start
36:09 Biomarkers of leaky gut
48:53 Leaky gut testing
53:24 Gluten intolerance prevalence
59:52 Food elimination & reintroduction
01:04:47 Prebiotics & FODMAPs
01:15:26 Probiotics
Featured Studies
What to do about the leaky gut: pubmed.ncbi.nlm.nih.gov/34509...
Leaky gut: mechanisms, measurement and clinical implications in humans: pubmed.ncbi.nlm.nih.gov/31076...
Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults: pubmed.ncbi.nlm.nih.gov/33865...
A case for improved assessment of gut permeability: a meta-analysis quantifying the lactulose:mannitol ratio in coeliac and Crohn's disease: pubmed.ncbi.nlm.nih.gov/35012...
Food Emulsifiers and Metabolic Syndrome: The Role of the Gut Microbiota: pubmed.ncbi.nlm.nih.gov/35892...
Food Additive Emulsifiers and Their Impact on Gut Microbiome, Permeability, and Inflammation: Mechanistic Insights in Inflammatory Bowel Disease: pubmed.ncbi.nlm.nih.gov/33336...
Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity: pubmed.ncbi.nlm.nih.gov/32060...
Psychological and Gastrointestinal Symptoms of Patients with Irritable Bowel Syndrome Undergoing a Low-FODMAP Diet: The Role of the Intestinal Barrier: pubmed.ncbi.nlm.nih.gov/34371...
Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials: pubmed.ncbi.nlm.nih.gov/37168...
Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome: pubmed.ncbi.nlm.nih.gov/30108...
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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.
Music featured in this video: "Modern Technology" by Andrew G, audiojungle.net/user/andrew_g
*Full transcript available on KZread by clicking the “Show transcript” button on the bottom right of the video.

Пікірлер: 65

  • @DrRuscioDC
    @DrRuscioDC5 ай бұрын

    Get practical, science-based insights straight to your inbox: drruscio.com/signup/

  • @beautifulwaterfall222

    @beautifulwaterfall222

    5 ай бұрын

    Fabulous channel. Just found you recently. I love your approach. It's refreshing to see someone covering medical studies and really keeping up-to-date on all of the recent findings.

  • @mariajadoonandan3383

    @mariajadoonandan3383

    5 ай бұрын

    😢😂😅y😮😊😂😅🎉😮😊😂😮😊😢😂o😂rtq😂🎉😊i😮😅😢🎉😂😂😅🎉i 0:23 tw

  • @mariajadoonandan3383

    @mariajadoonandan3383

    5 ай бұрын

    😊😂​@@beautifulwaterfall222

  • @mariajadoonandan3383

    @mariajadoonandan3383

    5 ай бұрын

    ​😢🎉😂😢😊w13🎉e😅😂😂@@beautifulwaterfall222😊😂😮😮😂😮😂

  • @user-oq4ow9rr6z

    @user-oq4ow9rr6z

    5 ай бұрын

    Can you say the names of the pre and probiotic doctor said to try I did hear the glutamine. Thank you

  • @armed_but_blind2768
    @armed_but_blind27682 ай бұрын

    When he mentioned emulsifiers this was like instant gratification for me. I have cut them out of my diet and noticed a drastic improvement in gut health. Turns out eating chemicals isn't good for human consumption. Who knew.

  • @SamShank175
    @SamShank1755 ай бұрын

    I appreciate what you're saying about not assuming that the Dr doesn't want to help you just because they don't want to do a test. The problem is that everyday you hear people that found out they had some disease that was discovered late because a doctor didn't want to do a test. It's hard to trust these days.

  • @DrRuscioDC

    @DrRuscioDC

    5 ай бұрын

    It's a challenging balance to strike

  • @SamShank175

    @SamShank175

    5 ай бұрын

    @@DrRuscioDC on a side note. I recommend Healthy Gut, Healthy You any time I'm talking to someone with digestive issues that they can't seem to figure out. I like that your goal is to get people to be able to eat the widest variety of foods and to take the fewest number of pills and your practical step by step approach.

  • @DrMichaelRuscio

    @DrMichaelRuscio

    5 ай бұрын

    Thank you!@@SamShank175

  • @raewise6345
    @raewise63455 ай бұрын

    Enjoying this conversation very much! Thank you 💪

  • @DrRuscioDC

    @DrRuscioDC

    5 ай бұрын

    Thank you!

  • @joyelle7578
    @joyelle757822 күн бұрын

    This was a great talk! Cheers from Brazil 🇧🇷

  • @TheTattooedSoul24
    @TheTattooedSoul245 ай бұрын

    Very educational. Thank you, doctors.

  • @tessie5393
    @tessie5393Ай бұрын

    A very good podcast I've ever watch. Thanks Doc

  • @MrSunnyBhoy
    @MrSunnyBhoy3 ай бұрын

    What an amazing and extremely interesting podcast. Thank you both for your knowledge. As someone who suspects I have leaky gut, this is just what I needed to listen to 🙏🏾

  • @yvonnel7777
    @yvonnel77775 ай бұрын

    Can’t wait to watch- been dealing with gut issues also. They seem to be food intolerance related which was never a problem for me before. Was it having Covid, the vaccine, or going through perimenopause 🥺. So many questions very few answers.

  • @gutmicrobiomequeen
    @gutmicrobiomequeen3 ай бұрын

    @53:00 Man, there are so many good nuggets in here, but this has to be one of my favorites. I've seen this many times, but the two that frustrate me the most is *supposedly* elevated yeast markers on the OAT and *supposedly* normal Bifido levels on the GI Map. After a while, you HAVE to start asking about the validity of the tests (assuming that you're paying attention). I get that we see special cases, but I refuse to believe that 100% of them have candida or that 0% of them have low Bifido. Wanna get megaphones and crash the next IFM conference with me, doc? 🤣 We need to spread the word!

  • @DrRuscioDC

    @DrRuscioDC

    3 ай бұрын

    Haha absolutely! And thank you for your compliment. You're doing great work on your channel, so your feedback means a lot :)

  • @yurynsk3533
    @yurynsk35335 ай бұрын

    Very interesting. As usual.

  • @yosefsugi1808
    @yosefsugi18084 ай бұрын

    thanks doc.

  • @Carlos-fh8wk
    @Carlos-fh8wk5 ай бұрын

    After the jab and Covid I developed rheumatoid arthritis. 48 hour fasting and pre/pro biotics have helped immensely. Anyone else ? Also coffee ? I’m not sure if it hinders my leaky gut. I love my coffee.

  • @Sai.venkat7

    @Sai.venkat7

    5 ай бұрын

    hello, keep a 72 hours fast and humble yourself before GOD .confess your sins and ask GOD to show the mistakes you've done ,correct yourself. Cut out the gluten ,Night shades ,omega 6 ,sugar , intermittent fasting and empty your stomach every morning. try this for at least 3 months (or 1month). Strictly no gluten. not recommending but l glutamine ,vit d , cod liver oil and probiotics helps a bit. JESUS has delivered me from all the auto immune diseases by his grace. now i can eat everything and have no pains at all . humans sin and sin catches by diseases . Always lean on GOD .Glory to JESUS. amen

  • @doccox27
    @doccox275 ай бұрын

    Thank you for this comprehensive summary. I’m going to move to a selective low fodmap approach to improve my ibs/bloating. I already get good benefit from a goats milk probiotic.

  • @DrMichaelRuscio

    @DrMichaelRuscio

    5 ай бұрын

    awesome!

  • @TheTattooedSoul24
    @TheTattooedSoul245 ай бұрын

    Interesting urine tests mentioned. My daughter only had tests for protein in her urine when her inflammation was high.

  • @zaidtosha6562
    @zaidtosha65625 ай бұрын

    Dr , can FODMAP diet help in “ Seborrheic Dermatitis “ ?

  • @kristinrader4978
    @kristinrader49785 ай бұрын

    High caliber video 👍

  • @DrRuscioDC

    @DrRuscioDC

    5 ай бұрын

    Thanks!

  • @kaitlananderson4302
    @kaitlananderson43025 ай бұрын

    Do you have a video explaining why your probiotics don't need to be refrigerated?

  • @Acordeonistain805
    @Acordeonistain8055 ай бұрын

    My leaky gut comes with constipation bloating indigestion fatigued sometimes hot and cold flashes low stamina insomnia restless nights sometimes headaches sleepiness brain fog slow reaction hard to loose weight and I just found out with an oats test that I do indeed have Candida albicans 😢 if I do a detox of metals and take biofilm buster supplements then take nystatin dosage of 100,000 for a 7 days will and should be cured ? Tired of these horrible symptoms had them for about 3-4 years it’s hell inside your body

  • @PurpleAce5

    @PurpleAce5

    5 ай бұрын

    That’s exactly how I felt. When I cut out gluten, dairy, and high histamine food I felt a lot better.

  • @JackAShepherd

    @JackAShepherd

    4 ай бұрын

    Sounds like you're experiencing insulin resistance/hyperinsulinemia, which can happen due to a vicious metabolic-GI cycle... The high-FODMAP food sits in the gut, the pancreas pumps out more n' more insulin, you gain weight (due both to the nature of insulin itself, as well as its affect on hunger), you become more insulin resistant, the pancreas works harder, and so on... This leads to pretty much every symptom you mentioned. Have you had an oral glucose tolerance test (OGTT)? Ask for it, perhaps. If that's the issue, you might try: metformin (ask for extended-release so it doesn't hurt your already-sensitive tummy), dietary changes (FODMAP for digestion, low-insulinogenic* to prevent hyperinsulinemia) and exercise (which is really a game-changer, sorry to say... I know it's easier said than done 🥴) Highly recommend The Glucose Revolution... I haven't read the book, but I've read/watched some summaries. She gives the best-ever advice, IMO, for overcoming insulin resistance and glucose spikes... *When it comes to insulinogenic foods, everyone's a little different, so trust your own body and how you feel after each food. Obvi candy's probably always gonna cause a postprandial hyperinsulinemic reaction, but, e.g., legumes can be great for some and triggers for others...

  • @JackAShepherd

    @JackAShepherd

    4 ай бұрын

    @@PurpleAce5It's probably not *gluten*, which's the protein molecule in wheat, which Celiacs are allergic to... It's probably *fructans* -- the carbohydrate molecule in wheat, which is a FODMAP. If it is indeed fructans, you might check out the Monash FODMAP guide so you can see what else is high in fructans, and what you might reintroduce that has gluten but is low-fructan (e.g., soy sauce)

  • @Acordeonistain805

    @Acordeonistain805

    4 ай бұрын

    @@JackAShepherd I noticed it’s constipation due to candida I took a laxative the other day felt clean for the next 4-6 days then again kinda feel constipated again I must get rid of the root cause which indeed is candida overgrowth

  • @TheTattooedSoul24
    @TheTattooedSoul245 ай бұрын

    We know that you highly promote the use of probiotics on your podcasts, but what specifically is the objective of increasing the biodiversity and quantity of good gut bacteria? Is it the efficacy of the conversion of fiber or quantity of butyrate produced by the bacteria that is important? And if it is butyrate of the byproduct of bacteria, then why not just focus on increasing levels of butyrate to improve the gut lining faster to achieve a better tight junction? Then, increasing probiotics would be a secondary objective. My focus would just be on decreasing inflammation and lessening pain first.

  • @consistentme22
    @consistentme225 ай бұрын

    33:49 Hmm, just learned a new term

  • @user-qy3th8yb2q
    @user-qy3th8yb2qАй бұрын

    Is almond butter bad for leaky gut/Sibo? I noticed i get a bit more inflamed after eating it. I only eat the one that says almonds are the ingredients and nothing else. I’ve been doing low fodmap for 1 month but started adding almond butter and bananas back in recently to curb the sugar cravings

  • @Chip_head
    @Chip_head5 ай бұрын

    what about fasting and autophagy will that help heal leaky gut?

  • @raewise6345

    @raewise6345

    5 ай бұрын

    YES.😊

  • @shantinaturechild3239

    @shantinaturechild3239

    5 ай бұрын

    You need to get rid of the root causes which can be various. Mine were antibiotics and mercury toxicity and mold. So l, holistic dentist and trying to restore the microbiome and also trying to get rid of the critters that took over. Fasting can definitely help heal the gut but it needs cleansing as well

  • @Chip_head

    @Chip_head

    5 ай бұрын

    mine was ibuprofen high doses, and yes i've cut everything for a month, only meat and fruit and honey, it has made a difference but still i get bloated and still have issues, 1 month of meat fruit cured my chronic acid reflux so thats a good thing, im gonna try 1 meal a day and black seeds for 1-2 months hopefully that cures it@@shantinaturechild3239

  • @wizzo65

    @wizzo65

    5 ай бұрын

    @@shantinaturechild3239Can you be kind enough to share process of the cleaning?

  • @raewise6345

    @raewise6345

    5 ай бұрын

    When you fast, it triggers autophagy. This is when your body does all the clean up work

  • @zaidtosha6562
    @zaidtosha65625 ай бұрын

    Can I drink green tea twice a day In FODMAP diet?.

  • @JackAShepherd

    @JackAShepherd

    4 ай бұрын

    Yessss just don't brew it too strongly! I call myself a FODMAP Barometer -- my gut is as precise as the Monash lab LOL -- and I am great with green tea but it's no good when it's strongly brewed, and matcha will kill meeee

  • @amarvoice6471
    @amarvoice64714 ай бұрын

    can I eat together immunoglobulin and oregano oil

  • @JackAShepherd

    @JackAShepherd

    4 ай бұрын

    Sounds delicious 😹😋

  • @ndjekagedeon6468
    @ndjekagedeon64685 ай бұрын

    Can we use psyllium when having leaky gut ?

  • @DrRuscioDC

    @DrRuscioDC

    5 ай бұрын

    I feel its worth a trail.

  • @ndjekagedeon6468

    @ndjekagedeon6468

    5 ай бұрын

    @@DrRuscioDC thanks , and what about excercise ( resistance training) ?

  • @nick42023
    @nick420235 ай бұрын

    A lot of auto immune diseases at least start in the gut and healing a leaky gut will have a profound effect in putting them into remission!

  • @dinosemr8141
    @dinosemr81415 ай бұрын

    💖❤️💖🙏💖❤️💖

  • @DrRuscioDC

    @DrRuscioDC

    5 ай бұрын

    :-)

  • @user-pt7bv6li6d
    @user-pt7bv6li6d5 ай бұрын

    You’re charming you two

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