The Root Cause Of Heart Disease & How To Tell If You're At Risk | Dr. Ronald Krauss

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Heart disease is still the number one killer in the world, yet most people don’t actually understand what markers put them most at risk.
The general consensus is there are two types of cholesterol-the good and the bad-the good is thought to be high-density lipoproteins or HDL, and the bad is low-density lipoproteins or LDL. But we now know from research that it's much more complicated than that-there are actually various sizes and densities of these lipoproteins.
Today on The Doctor’s Farmacy, I’m excited to talk to one of the leading lipidologists, Dr. Ronald Krauss, all about lipoproteins, what they do in the body, what they mean for heart disease risk, and why a typical lipid panel alone is insufficient.
Dr. Krauss is a Senior Scientist at Children’s Hospital Oakland Research Institute, a Professor of Medicine at UCSF, and an Adjunct Professor of Nutritional Sciences at UC Berkeley. Dr. Krauss’s research aims to understand how to best prevent cardiovascular disease through early detection and management of its major risk factors: most notably, elevated levels of blood cholesterol and lipoproteins. He has published over 450 research articles and reviews on metabolic, genetic, dietary, and drug effects on plasma lipoproteins and the risk of coronary artery disease, with over 100,000 citations of this work.
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Research mentioned in this episode: pubmed.ncbi.nlm.nih.gov/37425...
00:00 Intro
01:17 The History of Heart Disease
03:39 Cholesterol vs Lipoproteins
08:15 Normal Cholesterol Levels
12:53 LDL Particles
15:00 Saturated Fat
19:43 Meats
20:43 Is Meat a Concern
22:08 Observational Studies
30:00 ApoB Test
33:30 Statistics
37:15 LDL
46:15 Lean Mass Hyperresponsive vs Poor Metabolic Health
51:35 Lipid Testing
54:35 Low Carb Diet

Пікірлер: 92

  • @km-bo3zx
    @km-bo3zx11 ай бұрын

    Wow! Great stuff spread throughout the entire interview, including his dietary recommendations, at the 55:00 minute mark!

  • @a_woman_who_loves_to_lift
    @a_woman_who_loves_to_lift9 ай бұрын

    💯 Fantastic episode! I've been ordering an advanced cardio IQ fractionated lipid panel for myself ever since I found out about the severe limitations to the standard lipid panel. Despite always having healthy results in the standard panel, the advanced panel revealed why people in my family die of heart disease more than any other condition. Please have more guests like Dr. Krauss!🙏

  • @HeyHeyAlabama
    @HeyHeyAlabama11 ай бұрын

    I understand from other dr.s that what you eat doesn't add to your cholesterol, it's how the liver makes what it needs. Many carnivores don't have a cholesterol problem, and there are indigenous tribes in Africa that eat only meat and a few fermented foods who have no cholesterol, stomach or bowel problems. There are also those on ketogenic diets for over 20 years with no problems.

  • @johntatman9168
    @johntatman916811 ай бұрын

    When you only have a hammer everthing looks like a nail!!! Fits perfectly with LDL and statins.

  • @oibal60
    @oibal6011 ай бұрын

    Thanks again.

  • @marygrogan6101
    @marygrogan610111 ай бұрын

    Thanks for this. Luckily I have an ayurveda doctor who helps me as my pcp kept saying I needed statins and then some other new drug, which if I had taken would have made things worse, especially the new drug which the fine print said not to take if you have low thyroid. My ayurveda doctor suggested 2 tests to see if the cholesterol was a problem, or not. Fortunately the tests showed that my veins were squeaky clean.

  • @AnnTsungMD

    @AnnTsungMD

    11 ай бұрын

    I'm delighted to hear that you found a solution with your Ayurveda doctor that helped you avoid potential medication complications. It's important to explore different options for your health. Keep up the good work!

  • @richardlast5850

    @richardlast5850

    2 ай бұрын

    Sorry, veins seldom, if ever, get plaques, only arteries do. Possibly to do with blood pressure differences.

  • @dminarsch
    @dminarsch11 ай бұрын

    I asked the Lab Core lady how often the NMR test order comes in. She said she just did four that cardiologists ordered the previous day. So more docs are ordering these more informative tests.

  • @dminarsch

    @dminarsch

    11 ай бұрын

    Hay Mark…do you do telemedicine?

  • @a_woman_who_loves_to_lift
    @a_woman_who_loves_to_lift9 ай бұрын

    Also, I found it instructional that he doesn't order Apo B tests because the advanced lipid panel gives him that picture. I knew of both tests, including the nuclear one, and I enjoyed learning about the origins of each!

  • @suzanneb5572
    @suzanneb55726 ай бұрын

    Very hard to catch (due to bad audio akd mumbling!) the recommended tests if someone has high cholesterol in the standard tests. Could you please write them out?

  • @AliceFarmer-bg4dw
    @AliceFarmer-bg4dw5 ай бұрын

    Dr. Hyman. Great information. Great interview. Obviously this guest is an advocate for drug therapy on lipids. Can you cover the mitochondrial effect of lipid lowering drugs? We would like to know things like CoQ10, and other effects that these drugs have on the mitochondria. Is mitochondrial dysfunction the root cause in the first place?

  • @burnhamv
    @burnhamv11 ай бұрын

    how do you get a pdf file of this video - thanks

  • @Droidzi
    @Droidzi11 ай бұрын

    1:00:52 - the "Is it really that bad to just take a statin" showdown ⚔ nicely restated, your position Mark on the subject

  • @adamjohnson402
    @adamjohnson40211 ай бұрын

    This is great, but still don't know what the best approach for me is. I am 43 years old and had a heart attack while I was working out in January. My total cholesterol has always been in the 200's so nothing crazy. I did recently get cardioIQ test completed. I am on a low statin dose of 5mg of Crestor Mon, Wed, Fri. My LDL particle number was 2070 and my LDL small was 490 and my LDL medium was 520. I have LDL pattern B. At this point, not sure if I should try Niacin or not. I eat very healthy and workout 5-6 times a week. Any advice?

  • @jimig399

    @jimig399

    11 ай бұрын

    You said you workout 5-6 days a week. What does your workout routine consist of Adam?

  • @georgefurman2234
    @georgefurman223411 ай бұрын

    I've used niacin for decades, at levels between 1000 to 3000 mg daily for mood adjustment and the extra benefit is that my cholesterol went down to around 220 and I feel great! Start taking it at low levels, it's a vasodilator so it increases the diameter of blood vessels and can cause a redness and a warmth under the skin. New studies show a relationship between niacin and NAD+. Very interesting, it appears to be a precursor of NAD+ and that is good for the mitochondria.

  • @kanugupta1515
    @kanugupta151511 ай бұрын

    Any recommendation for vegetarians diet for ALL Tcell leukemia patients ..for teenager !!

  • @maplenook
    @maplenook6 ай бұрын

    Please send guests a microphone

  • @christopherseekins7680
    @christopherseekins768011 күн бұрын

    Regarding the Keto and Lean mass hyper responders. I wonder if it has to do with gut microbial diversity, which high fat can hinder. In cases with SIBO and low diversity, it seems to limit the bad anaerobic bacteria from festering, or perhaps enhances the bodies homeostasis, which the diversity would otherwise manifest. Just a thought. I would suggest the studies incorporate a microbial DNA profile, as well as other factors. Perhaps a TRIAD at the very least for the amino acid profiles.

  • @michaelhashimoto1650
    @michaelhashimoto16502 ай бұрын

    Have you seen people that were not LMHR and were seeing good lipid levels, but became a LMHR after using Keto over time?

  • @cgArtsy5
    @cgArtsy52 ай бұрын

    If all the ldl particles measure the same as apo b test, then why is my LDL small particles and my LDL medium particles both high but my Apo b is low? My total cholesterol is normal.(@. 54:00)

  • @breakalegfpv9532
    @breakalegfpv953211 ай бұрын

    what do you think about the new investment in vaccine "s and PPE Frome capitol hill?

  • @percybyssheshelley8573

    @percybyssheshelley8573

    11 ай бұрын

    Obviously it's all about money-making..

  • @kenswanston820
    @kenswanston82011 ай бұрын

    @markhyman - Dr. Hyman - You briefly touched on genetic predisposition for heart issues...which I've got, along with my 3 brothers and sister, and potentially my 4 kids and 3 (so far) grandkids. What treatments (if any) are available to deal with genetic issues? The LIPID clinic at St. Paul's Hospital in Vancouver, BC has started me on EZETIMIBE (10mg) and ATORVASTATIN (10mg) and baby ASA....I'm a 71 (soon 72) year old male, 6'4", 210-215lbs. A CAC (Coronary Artery Calcium) scan a few months ago came back with over 1000. The blood tests ordered so far have not broken down the particle size and I detect a distinct hesitance to deviate from their processes. What, if anything could/should I be suggesting/demanding for a better testing analysis and/or treatment?

  • @bassetto1603

    @bassetto1603

    11 ай бұрын

    I think they've mentioned an APOB test around 30:00 to determine the amount of small LDL particles.

  • @kenswanston820

    @kenswanston820

    11 ай бұрын

    @@bassetto1603 Thanks for that reference but I was hoping for specific references to genetic predisposition and found an older article of interest...see my reply to @MarkHaymanMD814...I'm not sure that is really 'the guy' (being ?spoofed?)!

  • @pmehta4452

    @pmehta4452

    Ай бұрын

    I am in Vancouver too. I think they mentioned LP (a) test marker which is a genetic marker. This is know as LP little "a". This is a trouble maker Lipo protein! You have to get this done just once in a lifetime. I believe they don't do NMR or CardioIQ type of tests here. I was actually thinking about going to Bellingham to get it done there. CT angiogram is a good test (more accurate than CAC) to figure out calcium/blockages in your artery. Wish you well with your challenges.

  • @lilytea3
    @lilytea311 ай бұрын

    0:00: 📉 The current focus on LDL and statins for predicting heart disease may not be accurate, as it ignores the prevalence of the most common lipid pattern in America. 6:49: 🔑 Small LDL particles have properties that make them more toxic to the arteries, regardless of their cholesterol content. 12:37: 📊 Cholesterol levels can be measured quantitatively or qualitatively, with the latter being more indicative of heart disease risk. 18:33: 🧠 There is evidence that certain whole fat products like yogurt and cheese may have heart health benefits unrelated to saturated fat. 23:55: 🔬 The speaker discusses two methods for measuring particles in the blood and their importance in understanding metabolic and pathologic effects. 30:05: 💉 The ApoB test measures the total number of LDL and VLDL particles, which is a good indicator of heart disease risk. 36:15: 💡 The speaker discusses the importance of measuring different lipoproteins and biomarkers for accurate risk assessment. 41:18: 🔍 The speaker discusses different medications for lowering LDL cholesterol. 46:57: 📈 Weight loss and low carb diet can help lower triglycerides and LDL cholesterol, despite the potential rise in LDL cholesterol levels. 52:15: 💉 The speaker discusses the importance of measuring liver function tests and hemoglobin A1c in patients with belly fat and metabolic health issues. 58:08: 🩺 A patient with high lipid levels and small LDL particle size had clean arteries, despite expectations of plaque buildup. Recap by Tammy AI

  • @user-qq5du7iv4t
    @user-qq5du7iv4t3 ай бұрын

    Why does saturated fat increase ldl? What is the actual mechanistic event that drives this?

  • @EileenKerr
    @EileenKerr11 ай бұрын

    Mark, my husband and I have a good diet. We juice kale spinach etc in the morning and eat a lot of greens. In February my husband who’s 57 took unwell and turns out he had multiple clots in both lungs. Doctor said his blood was very thick and it took 2 weeks in hospital to bring it back to normal. We were told because he had covid 6 months previously was the cause. He was also told to eat less Vitamin K. We have all been told to eat our greens it just doesn’t make sense now we have to cut down. Do you think more tests on how think yr blood is is the answer.? Thanks

  • @elishevajones6730

    @elishevajones6730

    11 ай бұрын

    Vax.

  • @chandrikakakad4146

    @chandrikakakad4146

    11 ай бұрын

    Your husband needs liver treatment when liver is inflamed all these kind of problems come , i think you should take personal consultation with Dr Hyman, acupressure helps a lot, do check ph level of blood & urine very crucial test all kind of serious health issues we get coz of acidic blood and keep yourself hydrated 3 to 4 liters of water.

  • @tomrhodes1629

    @tomrhodes1629

    11 ай бұрын

    RAW Vegetables are the healing foods, so you are on the right track. If you did the Covid vaccine, that could be the problem. Keeping your body ALKALINE with raw veggies is the best preventative for every disease from the common cold and Covid to cancer. Raw veggies also CURE these diseases due to their alkaline-forming nature and nutrient density.. And as for heart disease... Heart disease is entirely a MALNUTRITON disease and has NOTHING to do with cholesterol! (Arterial plaque consists mostly of CALCIUM, not cholesterol.) Your body manufactures more cholesterol than you eat, because EVERY CELL in your body requires cholesterol in its structure - and when you use statins and tell your body not to make cholesterol, YOU TELL YOUR BODY NOT TO MAKE NEW CELLS. And this is why statins do NOTHING but maim and kill. Dr. Matthias Rath's book on this subject is great, as is Paul Stitt's. The answer to ALL disease is eat REAL food - not manmade food. This is a Spiritual lesson that is being taught through physical means: GOD'S WAY, NOT MAN'S WAY! Elijah has returned, as prophesied, and testifies.

  • @LauraB.335

    @LauraB.335

    11 ай бұрын

    Eat fatty meat and eat less often, getting some more fasting in there. Stop eating greens; they have lots of anti-nutrients, which can lead to inflammation and a host of symptoms.

  • @ethimself5064

    @ethimself5064

    11 ай бұрын

    @@elishevajones6730 Could be

  • @linrachelsc5564
    @linrachelsc556411 ай бұрын

    I checked out on environmental concerns with meat. 🚀

  • @beaubolinger1521
    @beaubolinger152111 ай бұрын

    So Bottom Line--How/What do we EAT

  • @chriswhitehouse8982

    @chriswhitehouse8982

    11 ай бұрын

    Apparently, no one knows 😀

  • @ankurdebbarma6363
    @ankurdebbarma636311 ай бұрын

    Looks like someone invested in the cheapest microphone that's present on planet earth.

  • @jolemere479
    @jolemere47911 ай бұрын

    What a hodgepodge of information… maybe misinformation…. Lots of confusion… I’m sticking with low carb, good, clean food and staying as far away from the standard health sources. I’ve lost confidence in most physicians!

  • @tomrhodes1629

    @tomrhodes1629

    11 ай бұрын

    Here's the answer: Heart disease is entirely a MALNUTRITON disease and has NOTHING to do with cholesterol! (Arterial plaque consists mostly of CALCIUM, not cholesterol.) Your body manufactures more cholesterol than you eat, because EVERY CELL in your body requires cholesterol in its structure - and when you use statins and tell your body not to make cholesterol, YOU TELL YOUR BODY NOT TO MAKE NEW CELLS. And this is why statins do NOTHING but maim and kill. Dr. Matthias Rath's book on this subject is great, as is Paul Stitt's. The answer to ALL disease is eat REAL food - not manmade food. This is a Spiritual lesson that is being taught through physical means: GOD'S WAY, NOT MAN'S WAY! Elijah has returned, as prophesied, and testifies.

  • @samulmagnus1

    @samulmagnus1

    11 ай бұрын

    Name something that is confusion or misinformation.

  • @percybyssheshelley8573

    @percybyssheshelley8573

    11 ай бұрын

    It appears from your comment that you did not listen to the conversation. There was a very good discussion of lipoprotein fractionation testing, the role of carbs and diabetes as as factor in developing heart disease, statins as not addressing high triglycerides, etc. That said, Krauss is basically "old school," and his reliance on statins, we can hope is reserved for the very hardest cases, and not for long. He says he is "very concerned" about muscle wasteing so he strangely knows nothing about taking CoQ10 to replace it from the statin depletion...hmm.. that's not so up-to-date... Cardiologist Pradip Jamnadas looks at a greater range of nutritional ills and fixes, pointing out the dangers of (and avoiding) seed oils (YES!). Strangely, Hyman doesn't discuss this...

  • @donamiceli8470

    @donamiceli8470

    11 ай бұрын

    I guess we have to test deeper to see what works best for us. One size does not fit all. No easy answer.

  • @SyberMath

    @SyberMath

    11 ай бұрын

    @@samulmagnus1 jolemere479 is right! Everything they are talking about is confusing. Cut to the chase, man! 🤣

  • @Mass-jab-death-2025
    @Mass-jab-death-202511 ай бұрын

    How to tell if you are at risk of heart disease. Regularly check you upper arm for a pin prick mark. It could be on your left arm or on your right arm so check carefully.

  • @catherinemahone8841
    @catherinemahone884111 ай бұрын

    Triple bypass in 2022. Total cholesterol 155 triglycerides 49!

  • @km-bo3zx

    @km-bo3zx

    11 ай бұрын

    Before or after the bypass?

  • @tomrhodes1629

    @tomrhodes1629

    11 ай бұрын

    Heart disease is entirely a MALNUTRITON disease and has NOTHING to do with cholesterol! (Arterial plaque consists mostly of CALCIUM, not cholesterol.) Your body manufactures more cholesterol than you eat, because EVERY CELL in your body requires cholesterol in its structure - and when you use statins and tell your body not to make cholesterol, YOU TELL YOUR BODY NOT TO MAKE NEW CELLS. And this is why statins do NOTHING but maim and kill. Dr. Matthias Rath's book on this subject is great, as is Paul Stitt's. The answer to ALL disease is eat REAL food - not manmade food. This is a Spiritual lesson that is being taught through physical means: GOD'S WAY, NOT MAN'S WAY! Elijah has returned, as prophesied, and testifies.

  • @catherinemahone8841

    @catherinemahone8841

    11 ай бұрын

    @@km-bo3zx right before.

  • @percybyssheshelley8573

    @percybyssheshelley8573

    11 ай бұрын

    W..T...?

  • @HAL-1984

    @HAL-1984

    11 ай бұрын

    ya ok but health history? smoking/age/excercise/sugar/diet/crp/other chronic disease.... the list goes on

  • @Droidzi
    @Droidzi11 ай бұрын

    👍🏻402

  • @srilakshmiachanta6392
    @srilakshmiachanta63922 ай бұрын

    Nmr test

  • @Nonessential888
    @Nonessential8888 ай бұрын

    Whole food plant based diet has less heart disease risk without statins. These doctors like meat and statins.

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