The Body After Eating Several Pounds Licorice Candy

Patient VP portrayed by John Posner
@chubbyemu version • A Man Ate 2 Pounds Lic...
Based on N Engl J Med 2020; 383:1263-1275. Link below.
Audio-only version: anchor.fm/chubbyemu
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Licorice candy has glycyrrhizin which increases cortisol (stress hormone) levels in the body. This causes hypokalemia. Hypo- low. Kal- kalium (potassium). emia- presence in blood. Potassium signals muscle relaxation. Low potassium, low relaxation. Heart can't relax, then it stops.
Real licorice candy is not easy to get in the United States. It's not at big chain grocery stores. Most of what you can buy from the big brands is licorice flavored, and won't do this.
These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.
References:
A 54-Year-Old Man with Sudden Cardiac Arrest. N Engl J Med 2020; 383:1263-1275. www.nejm.org/doi/full/10.1056...
The Pharmacological Activities of Glycyrrhizinic Acid (“Glycyrrhizin”) and Glycyrrhetinic Acid. Sweeteners. 2018 : 245-261. www.ncbi.nlm.nih.gov/pmc/arti...
Sustained Leukocyte Count during Rising Cortisol Level. Acta Haematologica 118(2):73-6. www.researchgate.net/publicat...
www.nobelprize.org/prizes/med...
Licorice-Induced Hypermineralocorticoidism. N Engl J Med 1991; 325:1223-1227. www.nejm.org/doi/full/10.1056...
Young WF, et. al. Apparent mineralocorticoid excess syndromes (including chronic licorice ingestion). In: UpToDate, Post, TW (Ed), UpToDate, Waltham, MA, 2019.
Quinkler M, Stewart PM. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 2003; 88:2384.
Funder JW. Apparent mineralocorticoid excess. J Steroid Biochem Mol Biol 2017; 165:151.
Funder JW. 11 beta-Hydroxysteroid dehydrogenase: new answers, new questions. Eur J Endocrinol 1996; 134:267.

Пікірлер: 604

  • @chubbyemu
    @chubbyemu3 жыл бұрын

    Hello! Welcome to Chubbyemu's (is mine!) second channel! This is a more in-depth version of the case in my video!

  • @TierZoo
    @TierZoo3 жыл бұрын

    I ate a whole bag of licorice candy in college once. Don't remember any symptoms other than that my poop was neon green the next day.

  • @roycezaro1998
    @roycezaro19983 жыл бұрын

    This is the other video except it's in "hard" mode

  • @colorgreen8728
    @colorgreen87283 жыл бұрын

    The actor does a great job with the I’m seizing like a bomb look

  • @lautreamontg
    @lautreamontg3 жыл бұрын

    As a lover of licorice, I wondered a couple things:

  • @mommywithnokidsss
    @mommywithnokidsss3 жыл бұрын

    Almost every case that I’ve heard of in which somebody’s pupils are different sizes, has ended in brain death. A very disturbing pattern.

  • @chestersnap
    @chestersnap3 жыл бұрын

    Huh. I suddenly have a much better understanding as to why I had to get regular blood tests to check my potassium levels when I was taking spironolactone for my acne

  • @centrifugedestroyer2579
    @centrifugedestroyer25793 жыл бұрын

    My parents are physicians and I'm a biochemistry Master student. We love to watch your videos together. Thanks you for putting so much effort into your great videos : )

  • @downstream0114
    @downstream01143 жыл бұрын

    Darn electrically neutral urine. I wish I could piss lightning :(

  • @oliverskoglund4690
    @oliverskoglund46903 жыл бұрын

    I have a theory of where he got his licorice. My guess is that the patient might have had some connection to the Nordic countries (Scandinavia). Licorice candy is very abudant here and is frequently enjoyed throughout the population. As a Med student in Sweden, or profs have told us many times about the picture: Young patient, hypokalemia, hypertension, syndrome of apparent mineralcorticoid excess -> Licorice fanatic, most likely.

  • @christianas
    @christianas3 жыл бұрын

    Oh, I like the scientific version!

  • @HemeReview
    @HemeReview3 жыл бұрын

    🍬

  • @briannenurse4640
    @briannenurse46403 жыл бұрын

    I'm gonna be honest, most of the extra info in these videos goes completely over my head but I just like watching you talk, and I think you're doing incredibly important work here.

  • @pinktooth5473
    @pinktooth54733 жыл бұрын

    I'm so glad that Heme Review is a page now. I love the science breakdowns of these case studies. Shame there isn't something akin to this for neurochemistry/pharmacology. Cheers all!

  • @hairyfrankfurt
    @hairyfrankfurt3 жыл бұрын

    This is a biiittt more advanced than your other account, but I think I’m following

  • @birdielein9636
    @birdielein96363 жыл бұрын

    You must be the best prof because you explain things in the most understandable way. I'm not a medical person- I'm a writer who has written on some medical topics- and I really learn from how you present things. Both this and your Chubby Emu channel are my fave on youtube. :)

  • @harmony331000
    @harmony3310002 жыл бұрын

    I’m an OR RN and we had a lady that got a bowel obstruction from eating so many gummy bears at once….it was over a pound😱😳…..that said, it barely even registers on the scale of the bizarre things I’ve seen at work in 21 years of nursing….it gets way crazier than this by far😬✌️

  • @sweetprimrose
    @sweetprimrose3 жыл бұрын

    Banana by Mouth - All I see is me shoveling banana into a passed out man surrounded by gross candy - LIVE DAMN YOU!!

  • @kinocchio
    @kinocchio3 жыл бұрын

    I really enjoy heme review .. in-depth

  • @ayobruhbruh
    @ayobruhbruh3 жыл бұрын

    Dutch liquorice contians a significant amount of Glycyrrhizin! This kind of case is actually one we get taught in a lot of dutch medical schools as it is a rare-but-possible case in especially pediatrics, as sometimes children get access to liquorice with high amounts of Glycyrrhizin and consume far too much. Also a very good case for Dutch people to understand symptoms associated with mineralocorticoid syndromes, as it is very relatable to dutch people. It could also come from Scandinavia or other nordic countries, as another guy already commented a very similar thing but in Swedish medical school. Considering the fact that there are a few communities that are still very in touch with the Dutch culture, the patient could have Dutch heritage and maybe buying "Dutch liquorice" from a Dutch specialty store could be the origin.