For more discussion about the topic of glucose metabolism, see the companion video called: SPU (Soleus Push Up) Q&A for Dr. Hamilton: Weight Loss vs Raising Metabolism

Wringing from Taiwan, thank you very much for the video.

@marchamiltonphd

4 күн бұрын

@@rchen3418 you are welcome; hopefully you learn to fully take advantage of what your own muscles can do to for your long term health

Dr. I tried the soleus pushup today for 30 minutes and the result was incredible. Thank you very much for helping humanity

@marchamiltonphd

18 күн бұрын

@@WilliamsEsther-e2m you are welcome and don’t forget that any kind of muscular activity has its greatest physiological influences during the moments you are actually working the muscles. There are also long lasting effects. But the direct effects during contractions require enormous increases in fat or glucose use to fuel the work compared to when resting. Finally remember that the body (Soleus especially) only sometimes prioritizes glucose but often prioritizes fat to get its energy. However the cardiovascular and inflammatory benefits seem to be present in a more common way (independent of which fuel type is used).

Thank you Dr. Hamilton! I have seen many posts from doctors demonstrating this movement incorrcetly, and of course posts on FB. I think a video series for the "layman" would be helpful.

@marchamiltonphd

Жыл бұрын

You are right. Misinformation is a problem in general. Here are some interesting observations and practical ways everyone can help other people. - It’s not that there is any controversy about SPUs. Everyone knows people will benefit from a transition from sitting inactive 70 hours/week to instead using a lot more of that time to benefit from muscular activity! - Misinformation spreads rapidly, but so can truthfulness. When polite about it, people should sometimes speak up. -My sense is that many of the doctors who are teaching about SPUs and metabolism generally mean well. But none bother to “fact check”. That’s the process journalists from the past used to do in previewing their work with the experts who did the original study. Mistakes left unchecked spread. People tend to think doctors would be more careful to become educated before giving commentary to their patients or the public. - Creating an international network through the website newsletter is key. So anyone who wants to continue learning about muscle and metabolism in general should take part in that free service from the website. Videos like you requested will be included.

If this is working as you mentioned then youre GOD to lot of diabetics out there 🎉❤

Hi Doc, I was reviewing your paper this morning and sorry for the stupid question but what's the difference between SPU1 and SPU2? I tried a search on it and I can't find it stated on the document what differences are between the two?

@marchamiltonphd

Жыл бұрын

2 different levels of soleus energy demand and carbohydrate oxidation (glucose burning). **Glad you asked because Fig 4B is perhaps the most important figure for everyone to print on paper, and study so frequently, that it is imprinted in your brain forever. (I won’t editorialize about Fig4B more here. Just think deeply about it.) SPU1 = when the soleus caused a 50% greater whole body energy expenditure than sitting inactive. SPU2 = 100% increase total energy expenditure. Remember this: In Experiment 2, subjects were tested 3 times while drinking the exact same glucose tolerance test. This allowed us to test glucose regulation at 3 metabolic rates (in random order on different days): once sitting inactive after drinking the glucose (sedentary control test day), once while doing SPUs at the lowest metabolic rise of soleus metabolism we studied (SPU1, 50% greater whole body energy expenditure than sitting inactive) and once with double the metabolic rate (SPU2, 100% greater energy expenditure than sitting inactive). The tables and figures (and the text of the paper) give additional explanations about SPU1 vs SPU2. A You may want to listen again at about 9-10 minutes of this video, when the difference between SPU1 and SPU2 was also explained.

@Saintjohn2711

Жыл бұрын

@@marchamiltonphd Thank you Doc

@lindaperry9238

Жыл бұрын

Hello Dr Hamilton, Thank you for this additional information! I’d like to make sure I understand the SPU1/SPU2 difference. Did you create the 1.3 METs/1.7 METs difference by simply raising the angle of motion from 15% to 30%? You make it clear that doubling the frequency of the SPUs didn’t have the same effect, I think? The opportunity to hear all this explained by you is really wonderful; there are many people out there clearly excited by the promise of what you’ve discovered, who are trying to explain through youtube segments their understanding of the muscle and the method (some describing the “jiggling” and “fidgeting”) but I don’t find they mostly do justice to the concept. I was introduced to your work by Dr Javier Gonzalez, Prof. of Nutrition and Metabolism, Univ. of Bath in England, speaking about it on a Zoe Project podcast, on youtube. He’s a serious researcher but although he sounded intrigued and enthusiastic, his information was a bit incomplete. Thank you again for your work! These videos of yours need to be seen by a lot more people!

@marchamiltonphd

Жыл бұрын

We will provide MUCH more instruction in the continuing series of videos. I will post more specific replies about the SPU1 and SPU2 in the study later. First make sure and see (and re-watch occasionally) this channel’s introductory videos already available. You are correct that there have been many millions of people commenting about why and how to do SPUs. But second hand information is NOT a good clear way to spread trustworthy knowledge! I can not control what others say. So it’s best for you and others to keep returning to this recent video channel and the SoleusMetabolism.org website. My lab members and I will do our best to provide the most trustworthy education. For example, you asked for technical help how to obtain a good metabolic response by the soleus muscle with the SPU movement. In the instructional video notice I explained that “leg shaking/fidget ring” etc is NOT what we teach research subjects! SPUs are significantly more effective.

@lindaperry9238

Жыл бұрын

Yes! Your explanations are very clear and you make your important discovery about the special qualities of the soleus muscle quite understandable. I wish you the quickest way forward in getting this information to as many medical practitioners and their patients, as soon as possible. Otherwise, the folks other than you, who try to explain by calling for “fidgeting”, will continue to unwittingly misinform. I’ve added my address to the mailing list on the website and I’ll continue to watch for new videos. Thank you so much!

Professor Hamilton, I don't know if this is amusing but I have been doing SPUs since March and when I went for blood work for my lipid profile. My tests show the following: I have a VLDL of 11.20, HDL Cholesterol of 49.30 and Trigylcerides 56.00, but my Total Cholesterol is 254.00 and LDL Cholesterol is 193.50. Been doing a low carb diet though. Cheers!

Really great vid, helpful, interesting, and useful! Do you think that this exercise would help with fasting blood glucose levels as well? Has there been any research done on this?

@marchamiltonphd

Ай бұрын

Glad it helps teach you more about how your body works. The short answer is that SPUs do not change the blood glucose when fasting in most people during the “acute response” (ie the immediate response in people who aren’t yet habitually trained to do SPUs on a regular daily basis). Once people integrate SPUs into a large part of their lifestyle (SPUs can be done whenever you normally sit), then there are many other “chronic responses” that I’ll discuss in the future. But for now, I suspect you and all other wise readers will benefit a lot from learning the key issues about HOW the body works (physiology) to be able to think through many good interrelated questions like you had. Below is a short lesson that’s not hard to master, but can help you understand a lot of related things (and avoid the many land mines planted by pseudo-experts or even well meaning family and friends). It’s wise to read all of the following points and return to it to take it to memory. It helps you apply a much needed logical understanding of how the body works than just the “do this and don’t do that” kind of advice that causes a flood of confusion. 1. Fasting blood glucose is obviously regulated differently than the kind of hyperglycemia during the “postprandial period” (after an oral glucose tolerance test or some high carb meals). The fasting glucose is largely controlled by how much glucose secretion is coming from the liver (as opposed to the gut after drinking or eating sugar). 2. In the fasted state, the brain keeps using large amounts of glucose but the muscle slows down how much energy it gets from glucose. That’s actually a good thing because it avoids “hypoglycemic” (low blood sugar) that many people with diabetes must worry about daily. As explained below, it’s also a good thing because fat that’s in the bloodstream, arteries, and that builds up in muscle can cause many pathological processes and common aging-associated diseases. Even insulin resistance and diabetes is can be caused in large part by a sluggish fat metabolism of inactive muscle. It only takes hours to experimentally cause muscle insulin resistance from microscopic amounts of fat inside of muscle cells. 3. Even some non-diabetics can get symptoms of a little bit of hypoglycemia in the hours of the day the body is fasting, mostly because the brain relies heavily on blood glucose to work correctly. Neurons don’t use fat to make much energy like the heart and SOME highly oxidative muscles can. We showed the soleus can sustain remarkably high levels of fat oxidation all day long (see Supplement Figure 7A and 7B) and there is a substantial decrease in the “heart disease causing fat” that circulates in the bloodstream (VLDL in Supplement Figure 8); the figures and text are all available in the link of the Description to this video and on “Soleus metabolism dot org). 4. It’s very important for people with poor fasting glucose levels (diabetes and some prediabetes), to sustain a healthy level of fat oxidation (especially by burning blood fat inside of packages called VLDL and LDL) when fasting. It’s important also for anyone wanting to avoid heart disease, stroke, and dementia for maintaining healthy blood vessels. 5. In the postprandial period (IF someone is doing SPUs correctly and ingests enough glucose to become hyperglycemic), the soleus can quickly switch back on blood glucose oxidation. My research found that the “acute” (immediate or nearly immediately) response to soleus contractions (with SPUs because it is a high energy type of Soleus specific activity) is to begin lowering glucose sometime within the first hour after a test sugar drink (compared to sitting inactive on another day after the same test drink), and then to SUSTAIN that lower glucose level until the glucose concentration starts to decrease close to the fasting levels. That while glucose excursion takes about 2-3 (or more) hours depending on the individual. Given that background, here is what THEN happens as the body starts to re-enter into the semi-fasted to fully fasted state. One glucose gets close to fasting the soleus “switches over” the kind of fuels it uses. It gradually slows down the burning of blood glucose, even though it still has a very high energy demand (compared to sitting inactive). Our studies demonstrate FAT is the main fuel for SPU activity once your post meal hyperglycemia passes. Read the other comments about the kind of fat in the blood that we see is reduced, and read about how the soleus demonstrates a high level of “metabolic flexibility”. This remarkable flexibility is shown in a figure within our iScience publication.

@jlight368

29 күн бұрын

@@marchamiltonphd this exercise is so simple and awesome! Thanks for the explanation of how fasting levels can be lowered over time if we reduce the fats in our bloodstream, helped along by doing this exercise all throughout the day. Wish I knew about this when I took my pregnancy gd glucose test. Just kidding! Im sure it wouldve helped me maybe pass the test! But good to know now during those times when I am just too exhausted to exercise but still need to bring down my sugars. I've been trying spus out. Did it for just ten minutes fasted and it brought my levels 5 points down which makes a huge difference during pregnancy when it comes to being diet controlled or having to take insulin for slightly elevated fasting levels. I also do the exercise everytime i wake up in the middle of the night to use the bathroom, which is frequent. Any little bit helps.

@marchamiltonphd

29 күн бұрын

@@jlight368 Often people realize the following key concept (like you may have too) once they start to make SPUs a daily habit. We all sit a lot each day. Why would we not want to turn all that unhealthy inactivity time into a large amount of healthy muscle metabolism time. A quote for this that was pretty powerfully said: “…at first I just was going to do SPUs for an hour while watching TV. Then afterwards, when I was just sitting there inactive, I realized “what am I doing?! I can keep going. Why not do all I can to keep my body soaking in a high blood flow in my body to fuel my soleus!”. Fact: everyone sits for dozens of hours per week (95% of all people sit >4 hrs and the average is often 9-11 depending on age and weight). No one believes all that muscular inactivity TIME does the body any good. As a footnote, I do SPUs when I sit for just a few minutes (as I’m doing now before starting work). I do SPUs when I sit for a couple hours at a time (to work or relax in the evening). But each little bit of SPU time in 2-3 min bouts or 30 min bouts all adds up to more muscular activity time than any other “exercise” possible.

You responded to a question about applicability to those with MetSyn in your "how-to" video comments, referencing table 4. I'm curious about a friend of mine who has MetSyn, but also has problematically LOW blood glucose levels. Do you this exercise is advisable for people like this, or is more information needed?

@marchamiltonphd

Жыл бұрын

Metabolic syndrome is in large part related to insulin resistance. That’s why one of the criteria for it is higher glucose and triglycerides. Subjects that improved those variables included some people with Metabolic Syndrome. You mentioned the friend had lower than normal blood glucose, which obviously is the opposite of the more common diagnostic criteria for that condition. Regardless, notice the other 2 recent questions where I answered that SPUs switch to using fat oxidation when glucose is not at high levels. That helps to explain the lowering in triglyceride we reported on. In fact, the isolated soleus under the low stress conditions of doing prolonged contractile activity (SPUs) is the perfect biochemical situation for fueling muscle by fat instead of glucose. One other related thing to notice. SPUs reduce insulin by a large amount. This lower than normal insulin helps to reduce blood glucose uptake by various body tissues. This also helps to promote less fat storage and more fat use. These actions together help to avoid hypoglycemia when doing SPUs.

I greet you from Tunisia North of Africa thank you Dr all my respects for you for taking the time to clear our minds. A little question is my 14 year old son can do this exercice ? thank you

@marchamiltonphd

Жыл бұрын

Yes, the body of children and teenagers need as much muscular activity as do their parents and grandparents. We have studied pre-teens and teens doing SPUs and their bodies are thirsty each hour of the day they are awake for keeping muscle metabolism above resting levels. We will share a project led by people of that age where it was demonstrated in teenagers that the soleus (when doing SPUs) did not fatigue after 7 hours of nearly constant activity!

Great video. Thank you. Will 15-20 mins per day of SPUs create any positive impact? That is what is not clear to me.

@marchamiltonphd

Жыл бұрын

Great question and here is the way to think about it so you start to make it a habit. Start with any amount. You can stick with it and you will be writing back asking about 60 min/day, and eventually even more. But here is the best mindset! Similar to some behaviors like spending quality time with the family you love or close friends; we don’t think “how LITTLE time can I spend doing it?” It wouldn’t make sense to ask how little quality time can I spend with my loved ones. Nor do we ask our boss at work “how little can we make my next annual pay raise”. With some things in life, we don’t say “it is good for me and safely achievable, but I will take as little of it as possible”. That is also the way your body works physiologically. So 15-20 minutes is a great start and definitely not a waste of time. Just like spending 15-20 minutes of quality time with loved ones is meaningful. But it is also correct to develop the mindset that if it’s safe and feasible to spend more time helping yourself with muscular activity time, that’s even better. There isn’t a ceiling of too much time with some things. The nice thing to remember is that every minute you are raising the muscle metabolism, it is a healthy minute.

@jkid4855

Жыл бұрын

I just did this with my CGM - 20 min of SPU, 30 point drop, 40 min of SPU, 45 point drop. Did this after a big meal, this kind of rapid drop never happened to me before.

How is it different from doing a standing or sitting free weight calf raise done in any good strength program?

@marchamiltonphd

Жыл бұрын

Glad you asked it so clearly because I’ve seen things like this asked to other scientists and doctors who haven’t studied it like my lab does. I’m assuming someone with the “weekend warrior” nickname loves to lift weights. Great, it’s one of my favorite things to do every day too. I bet when you lift, including doing a seated or calf raise or standing one leg heel lifts you do go to failure with as high of load as it takes to fatigue quickly. Maybe 10 reps, maybe 30 reps per set? If you go hog wild you might do a total of 200 reps. And you might give your soleus and other leg muscles 2-3 days per week of that heavy training, knowing that any more and you won’t adapt and over time risk serious injury. Now consider this. I do at minimum 60,000+ daily (7 days/week) soleus contractions. No need to take a day off. Which is a good thing because I want optimal metabolism every day. I also don’t take a day off from drinking water! In fact I try to drink water more than one time a day, because I know the human body thrives on staying well hydrated all day, every day. The cardiac muscle and diaphragm are 2 muscles that also don’t take a day off. Soleus muscle metabolism is sort of the same way! The human body thrives on some kinds of muscular activity, done frequently. SPUs are the only kind of muscular activity that I’ve seen to be developed specifically to raise soleus metabolism to very high levels, for inducing benefits of very prolonged contractile activity, specifically to optimize the health and metabolism of the rest of your body.

@marchamiltonphd

Жыл бұрын

Also see the first video we published about fatigue resistance. We explain why the unfit research subjects tested over the critical 180 min postprandial period after ingesting carbohydrate were able to comfortably maintain SPU activity each of those 180 minutes. We also tested other even more unfit volunteers in a 270 min test. In the video we demonstrate how you can try a simple experiment to see how the soleus feels much less fatigue than another neighboring muscle used while sitting.

If soleus pushups are performed in a fasted state and blood glucose is already low (let's say 80 or so), what will be the response of continuous SPUs? Will they still use glucose from the blood as a fuel source (causing the pancreas to release glucagon) or start burning through more glycogen?

@marchamiltonphd

Жыл бұрын

Great question. Notice in the published research article that the soleus uses fat to fuel SPUs, not muscle glycogen, when not challenged with high blood glucose. There was negligible soleus glycogen use (2% of the activity energy expenditure to be exact!) in between the two biopsies when people were relatively fasted between meals. ***everyone can remember this easily as follows: “the soleus is opportunistic when doing SPUs!” 1) it will burn blood glucose when the blood glucose delivery is high; 2) it will use fat when it’s best to burn fat. BTW- here is a careful caveat; this is true about the soleus when doing SPUs. In contrast, we also know the soleus will burn lots of muscle glycogen when walking because it’s a large muscle mass exercise and metabolic control isn’t the same as when targeting only the soleus by SPUs (1% of body weight).

Is this as efficient as blood glucose lowering drugs like metformin? Since these drugs have side effects, a safe alternative would be great

@marchamiltonphd

Жыл бұрын

The answer is yes, but even more important is HOW (the mechanistic process) it is different than drugs or nutritional weight loss methods. I was recorded recently answering similar questions so I’ll paste that below. Not sure what day it will be posted so I will paste a couple parts of the transcript. But also for everyone interested in these kinds of Q&A, if you subscribe to the KZread channel and sign up for the free newsletter in the website, we can provide more than here. I’m not sure when those will be posted in the next couple weeks. Here is part of that answer, which is easy to remember if you have it in writing to review over the coming weeks. Plus knowing this will help motivate people to keep doing SPUs often when sitting. 1. When sitting at rest to do SPUs, the Soleus (1% body wt) can steadily (for hours that you sit, not minutes like most exercise) burn more (2.9X more) carbohydrate by oxidative metabolism than all other muscles combined, plus also all other body tissues combined. In fact, my laboratory published results showing SPUs could raise and SUSTAIN oxidative metabolism of glucose steadily high for 180 minutes after ingesting 75 g glucose. How high? High enough to steadily burn 71 g of the total carbohydrate over the 180 min testing time. 2. Drugs (and weight loss) work by different mechanisms than how SPUs work. Most help the body store the calories of glucose in the body as something called glycogen or fat. That’s important to remember. Obviously drugs aren’t made by the body naturally and thus will have side effects like you mentioned. But also because glucose lowering drugs do not work by raising muscle metabolism, it means some drugs can add to the glucose lowering of SPUs. I’m also often asked if pharmaceuticals may one day replace physical activity. My answer is not likely, at least not with near the same potency for raising oxidative metabolism of glucose and fat as much as SPUs. The follow up question is always about the public health recommendations for physical activity. My work differs from the opposite trend by others that emphasize “how low can you go” (how little time per day can have some effect). My lab work has been unique in having mostly focused on prolonged contractile activity since the 1990s. This is different than the way most researchers prefer to focus on questions like “how little activity time can we recommend”. Or “can we find a way with drugs, without raising muscle metabolism”. I’d prefer to offer something different for people who are hungry to stimulate health by raising muscle metabolism optimally by asking “how much time can anyone safely raise muscle metabolism, to optimize health as much as possible”. Doctors and experts should just be honest with people and explain staying active (for hours, not minutes) is best for raising and sustaining oxidative metabolism. Our first article about SPUs explained twice, with references from published studies by other labs to also look up, that exercise only raises glucose oxidation in the minutes the muscles are active. In summary, remember this! If the body isn’t given something like SPUs to burn glucose (and fat) as a fuel for oxidative metabolism, then that sugar and fat is stored inside the body.

Perhaps showing my ignorance, but in figure 4A and B, why does one graph say carb oxidation and the other glucose oxidation? Are they the same thing? Are those two graphs basically showing similar results (that SPUs burn more energy) but over different units/time scales (mg/min vs total g)?

@marchamiltonphd

Жыл бұрын

The data from the 2 graphs in Figure 4 are the most fascinating results to some people. I’ll explain it more in an upcoming article where we go into more depth. But here are some easy helpful tips to use when studying 4A and 4B. 4A is showing individual results. See how there is a wide variation between individual people at the start when fasted overnight. Then when ingesting the 75 gram glucose load, when sitting INACTIVE some people are unable to raise carbohydrate oxidation much, and no one raised it nearly as much as could be done when sitting the same 3 hours but doing SPUs. In fact, everyone could quickly and profoundly raise carbohydrate oxidation with SPUs. This means the soleus metabolism is “flexible” (burn fat when it’s the right time while fasted, then switch to burning carbs after ingesting carbs). Cool huh! Notice in 4a also that SPU2 was a higher SPU metabolic rate than SPU1, and you see there was an expected dose-response. SPU2 burned more of the sugar than did SPU1 because it needed more fuel to do more work. Fig 4B was calculated from the data in 4A and shows a mathematical model of what is happening. Knowing that SPUs didn’t use glycogen, the carb oxidation was assumed to be almost entirely from blood glucose. Now remember that the video (and article) explained a hugely important background fact everyone should know (but often don’t); there is not very much glucose in the blood, even during diabetic hyperglycemia, if you compare that blood glucose to the amount that can be burned to fuel the Soleus metabolism during SPUs! In summary, SPUs are a potent physiological method to burn up (ie oxidative metabolism) whatever the rise in glucose happens to be during hyperglycemia after ingesting a moderately large glucose load. Simplified, this means the soleus may only be 1% of the whole body weight, but it can easily burn down blood sugar to reduce hyperglycemia. It can do this DESPITE at the same time reducing the body’s dependency on insulin by more than half normal. Lower insulin is healthier for many reasons, but only when the muscle can extract lots of glucose despite lower insulin concentration.

Can you achieve the same goals with standing SPUs compared to sitting SPUs?

@marchamiltonphd

Жыл бұрын

No. First of all, most people sit inactive with a low metabolic rate for 70 hours a week. That’s a great time to use productively to raise muscle metabolism by also doing SPUs. Secondly, even if you did stand a bunch more than most people, the weight on your feet (and this load lifted by the Soleus) is 4X greater when standing than when sitting. That high load does at least 3 things that DEcreases the optimization of Soleus energetics. 1) a high load decreases the shortening velocity and range of motion, which we showed was a key to how high the soleus energy demand is for SPUs, 2) there is much eccentric stress on the Soleus in the standing variety to lower body weight that doesn’t happen in the seated kind (eccentric contractions don’t use much energy but damage muscle), 3) even athletes fatigue within minutes of the standing kind but our research showed that even unfit people can sustain >4-5 hours of a high local energy demand above walking or running by doing SPUs when done correctly.

I'd love to know how this is being applied clinically. It is apparent that you (and likely everyone in your lab) has immediately adopted this as a daily practice. What is you ideal vision for how this is used by various healthcare providers?

@alyssamac35

Жыл бұрын

Out of curiosity, do you wear a CGM to do any self-experimentation with real time effects?

@marchamiltonphd

Жыл бұрын

This comment is a great conversation starter. We will try to write about it on the website so keep using that as a resource. Below we will start a string on it for other comments related to yours. You will see examples of this in related videos like the one pinned above. There are definitely many interesting medical cases where different kinds of medical specialists are taking advantage of being able to raise soleus metabolism with SPU activity.

Maybe I am getting confused on terms here but I thought that studies on non-insulin mediated glucose uptake has shown that skeletal muscle can absorb massive amounts of glucose without insulin when contracting and this is why endurance athletes like the Tour de France riders can have tons of simple carbs and still be metabolically healthy. Even if their muscles are consuming glycogen the carbs they have go right into the muscle. I still like the SPU because it’s easy and you can do it in the office.

@marchamiltonphd

11 ай бұрын

You will get some good references and some key points in the “Discussion section” of our article. The free link is provided in the description of our videos. I’ll just list a few easy to understand things here. 1. Excellent studies have shown with a wide range of exercise intensities and muscle groups that muscle glycogen (not blood glucose) accounts for most of the carbohydrate energy for exercise (about 70-90+ percent). The exception is when muscles are glycogen depleted (if you first use up the muscle glycogen). 2. The soleus muscle does contain normal amounts of glycogen, and we provided a good reference showing it will definitively use a lot of glycogen during treadmill walking (unlike during SPUs). 3. The most overlooked and important fact is this. Pay attention everyone! : It’s one of those rare indisputable facts in science! Muscles immediately raise their local metabolic rate more than any other tissue when recruited to contract, and this high rate of fuel use plummets quickly when you sit back down after exercising. The article’s discussion section pointed out that neither animal nor human studies have found glucose oxidation remains elevated once muscles stop contracting. Actually, glucose oxidation usually is less after exercises like cycling than in normal rested muscle. This means blood glucose extraction after exercise ends is not to fuel the muscle, but for glycogen synthesis (non-oxidative metabolism). P.S. as you think about these points, also remember that Tour de France contestants often get in 4-5 hours of muscular activity in a long race day. Now with SPUs, anyone of us ordinary humans can get in that much muscular activity any and every day we want to! Think of SPUs as “soleus endurance training”.

@richardfricke6806

11 ай бұрын

@@marchamiltonphd wow amazing.Thank you Marc

The best part is the fuel that feeds this muscle - fat and sugar! I'd have to do spus, constantly and for YEARS to run out of fat and sugar for it to consume!!

So you burn around 91kcal per hour from the spu activity? I saw it on the slide but want to confirm.

@marchamiltonphd

8 ай бұрын

That number is 91 kcal/min above normal (ie net kcals) which was 124% increase whole body energy expenditure above normal over the 4.5 hours the volunteers were taught how to do SPUs in their first day of it.

c tu toi le gars de radio x

Is Subjects metabolic score is taken prior

@marchamiltonphd

Жыл бұрын

We don’t understand your question. But it seems 2 key issues are good to know about that may relate to your question. Some have asked what is the metabolic response to soleus activity in the overnight fasted condition before ingesting carbohydrate. Short answer: the activity doubles fat metabolism (how fast the body can burn fat to provide fuel to the body). Another good question is what are people doing in the “sedentary control” trial. Answer: the same people were tested during normal metabolic rate while sitting in a chair, and on other test days when doing soleus activity while sitting the exact same amount.

Is this movement the same that is used when sitting in a rocking chair?

@marchamiltonphd

8 ай бұрын

Not the way most people use a rocking chair. But it can be done when using a rocking chair. It’s all about a nice good range of motion of the ankle, done consistently during the high amount of sitting time everyone does most every day. **See the other video that shows how to do this range of motion. But people who develop the SPU habit do say it is as relaxing as using a rocking chair. So that’s a good analogy you made.

@martinhamilton4636

8 ай бұрын

The reason I ask is that my recliner is a rocking chair. If I am rocking in it instead of reclining am I performing the soleus push?

What about soleus isometrics with a band ?

@marchamiltonphd

9 ай бұрын

It’s not just that you are working the soleus, but the specific way it is being used matters a lot. Standing still at a desk also uses the soleus but doesn’t change the metabolism enough to matter.

@MehdiBouricha

9 ай бұрын

thank you @@marchamiltonphd

@marchamiltonphd

8 ай бұрын

See also the comment made on November 17 to the question what happens when load (resistance) is added in the other video about@@MehdiBouricha

11:26

How long does the glucose lowering benefit last once the exercise is stopped and is it dose dependent? For example, if I did 4hrs of SPUs would the prolonged benefit be greater than if I did it for only 1hr? It would be interesting to see graphs like figure S10 that continue for a few hours after SPUs have stopped to see the glucose/insulin response.

@alyssamac35

Жыл бұрын

Additionally, table 3 shows the numbers and statistical significance for glucose concentration but there is there an equivalent table for the insulin information (other than just S10). Is insulin statistical significance beginning at 1hr?

@marchamiltonphd

Жыл бұрын

@@alyssamac35 yes insulin concentration is significantly less in the first hour.

@marchamiltonphd

Жыл бұрын

First let me encourage you and all readers to read the Introduction and Discussion again. Your questions raise broader general concepts that are discussed in more detail in that text. Everyone is welcome to also comment on the text of the published article. Yes this SPU study clearly showed a statistically significant dose response. The same people were tested 3 days each with the identical 75 g glucose challenge over 3 hours. The 3 tests compared different level of muscle energy demand (2 levels of SPU intensity, and in a sedentary control trial). SPU2 was at twice the soleus metabolic rate as SPU1, and on average it reduced glucose and insulin more than SPU1. As for your other question about the timing, there are several things to consider. One is the time course of hyperglycemia after ingesting the glucose. SPUs performed during the glucose tolerance test reduced glucose throughout the entire 3 hour period. We tested that duration because that is how long these kind of people are hyperglycemic (high blood glucose) after ingesting glucose. The Discussion of the article explained in more detail than I can here some of the reasons for the failures of more heavy “whole body” types of treadmill or cycling exercise to improve glucose tolerance. Acute exercise performed before ingesting the glucose generally does not improve glucose tolerance, and sometimes makes it worse than just being sedentary. Finally, in other studies we and others have done, it is clear that the more time you work muscle, the more you will benefit all of the processes improved by oxidative metabolism (glucose, insulin, blood lipids, blood flow, etc.). **It doesn’t matter what kind of exercise you do, muscle has a low rate of oxidative metabolism when it is not working! (That’s why my lab has had the goal of developing a way anybody can keep muscle metabolism high for hours, not minutes each day). THAT POINT IS A GOOD TAKE HOME MESSAGE!

Hi, Dr. hamilton, every time I do this exercise, even for just 10 minutes, I feel dizziness. By your opinion, why does this happen? Thank you?

@marchamiltonphd

Ай бұрын

I’ve never observed this and wonder if you are doing something incorrect that we can quickly correct. If you want to email me, indicate this clearly in the website email and someone will forward it to me.

Aren't these experiments done in rats? Any human trial completed that mimics the effects seen in rats?

@marchamiltonphd

Ай бұрын

Humans were studied in everything being discussed! Not sure why you thought otherwise. But maybe it’s because we have studied animals in order to develop this, including work that can’t be done in humans because it requires removal of the entire soleus and taking vital organs like the heart and liver too. Some molecular biology research was done in rodents that can’t be done in humans.