This is amazing, it's impossible to find quality pharmacology content like this on youtube.

@booksgaming1426

3 жыл бұрын

I'm really loving the journal references at the bottom, as well.

@vegetossgss1114

Жыл бұрын

What about microglia?

With 5htp people take way too high of a dosage! It's nice to start out low like 10-20mg and taking it around 12-1pm is best because the serotonin boost is actually stimulating, have it with green tea for the ECGC. Later on, the serotonin will be able to be converted to melatonin and you will have better sleep as well! This is a good time because 5htp can raise cortisol levels, and we start to trickle down cortisol in the afternoon!

Excellent explanation. I couldn't find such a clear and thorough yet concise information on this topic elsewhere.

I found the video to be quite helpful. Thank you and keep up the good work. You've earned a new subscriber

I am so glad I found this channel ❤️

This was so good I subscribed. Quality content 👌 amazing British voice. Intelligent, authoritative and mature. I was looking for a very deep, scientific explanation and I found it. I will be exploring more of your channel and content. Thanks.

a very well done video, great information content. crisp delivery!

Such a helpful explanation. I had to go check out David Nutt and his research, as well as the Institute. So helpful for outlining the difference for 5ht1a and 5ht2a for me

I wish they had much more information on what exactly dxm does to the brain and body

Thanku

Super informative, thanks!

amazing

Thank you so much.

PERIOD

GREAT INFO

I would like to suggest this lecture demonstrates why a person's diet should be examined before going the pharmaceutical rout. For example how much tryptophan is in a vegan diet vs a diet that includes animal products: milk, beef, fish, chicken. These are the highest foods in tryptophan. Look at the actual milligrams per gram, not just weather or not a food contains tryptophan.

loved the video. What Uni year is this supposed to target?

You had me at mdma

I have a high 5-hiaa urine result. I’m trying to understand why.

What about microglia?

im waiting for the 1a's to be classified as a nootropic

@2:16 5HT1A -is it presynaptic or postsynaptic??? .... I thought it is presynaptic as it is a reuptake auto inhibitor via the feedback

@leahwhite1712

2 жыл бұрын

It is my understanding, and I may be wrong so someone correct me If I am: basically, it is both. It is a presynaptic receptor on serotonergic neurons, so neurons whose primary role is to release serotonin. In this way, it is inhibitory and autoregulates (so if 5ht bound to the presynaptic 5ht1a autoreceptor, it inhibits further release of 5ht..negative feedback loop, self-regulating). There are also 5ht1a receptors, primarily in limbic system, that are postsynaptic receptors on neurons whose primary role is to release modulators that are NOT serotonin. This postsynaptic 5HT1A heteroreceptor is also inhibitory, in that it can dampen the limbic system response by ceasing / lessening firing rates, regulating stress/anxiety in that way. So basically, it is found in the brain as both, both a presynaptic autoreceptor and postsynaptic heteroreceptor. Hope this helps!

5-HTP provides a great source of serotonin for the brain to munch on. It is extremely affordable as well.

@SItgix

3 жыл бұрын

please be careful when you spout out misinfirmation online, 5HTP is NOT a good source as it raises systemic serotonin and not only in the brain. 5HTP bypasses tryptophan hydroxylase (the amount of tryptophan metabolized is limited by the body with that process) and can therefore lead to too high serum serotonin levels in the body which have shown to be carcinogenic.

@thealgorithm4429

3 жыл бұрын

@@SItgix do you have a source for this information? Are you talking about short-term, or long-term use? People who use 5-HTP are already in the "low serum-level" category, they would need heavy long term exposure to face a dangerous level, if taken correctly, under the watch of a physician. I won't believe that high serum-serotonin levels are carcinogenic in humans either, until some reliable source is provided.

@lebest8415

3 жыл бұрын

Its actually bad for the heart because some of the 5htp is converted to sertonin in the blood which cause heart problems

@BaconNCereal

2 жыл бұрын

That shit hurt my kidneys

Are thete natural ways to increase 5-HT e.g. MDMA ?

@philipm3173

Жыл бұрын

Meditation. MDMA will actually leave your 5-ht levels lower (well technically it will downregulate the receptors) afterwards if used to excess.

so how can u enhance 5ht if it is depleted ?? how can you replenish it first ?? from my understanding it release it but if it depleted you get a headache

@NSachs-tx8xb

4 жыл бұрын

By taking SSRIs and 5htp.

@taaj4403

4 жыл бұрын

N. Sachs yes. It’s worked for me.

@daveland2653

3 жыл бұрын

I use L-Tryptophan as a supplement.

@thealgorithm4429

3 жыл бұрын

@@NSachs-tx8xb never take those at the same time. Both are effective, but potentially deadly in combination.

I was thinking that anxiety is learned behavior not chemical imbalance?

@msgirl01

3 жыл бұрын

Like most mental health issues it's usually both.

@-Datboijj-

3 жыл бұрын

@@msgirl01 no its all chemical imbalance

@msgirl01

3 жыл бұрын

@@-Datboijj- what about people who get ptad related anxiety, or other situational anxiety. There are also hard wired changes that take place over time (like OP said learned behavior) to increase a propensity for anxiety. And hard wired genetic issues. There's also chemical imbalances resulting from chronic trauma. And sometimes it is purely an organic chemical imbalance. But that's certainly not the only cause.

@r.l.mcdermid6034

3 жыл бұрын

@@-Datboijj- didn't know that you were a psychologist lel. Anywho, if it were all chemical unbalances then no amount of cognitive behavioral therapy would work. Guess what? It does! If it can be unlearned than it can be learned. :)

@user-jm3ob3hl2t

3 жыл бұрын

It's a learned behavior because no one is born with chronic anxiety. Anxiety causes chemical changes in the brain when it happens. The amygdala releases nenorephorine and addernaline and if it happens constantly those pathways in the brain are more easily activated which is an inappropriate response. Basically a chemical imbalance due to the way some people's brain developed and is caused by stress and trauma previously.

why stimulation of serotonin receptor a2 lead to depression

@mwaqask1

18 күн бұрын

Because it inhibits the release of dopamine and norepinephrine in the prefrontal cortex.

To complex I don’t understand it.):

@philipm3173

Жыл бұрын

You can't jump in and expect to understand it if you don't have any background. First you need to read up on what receptors actually are and how they work on a basic level.

ok my serotonin is very low. wtf do I do

@chickenmuffin

2 жыл бұрын

Take some 5htp

Bapak susah

Thanku