Season 7 Episode 3 - Randomized Trial of Oral Minoxidil vs Topical Minoxidil
The Evidence Based Hair Podcast was created by dermatologist & hair loss specialist Dr Jeff Donovan to highlight new, hot off the press, world-class research in the field of hair loss. The podcast was created for hair loss practitioners around the world who care for patients with all different types of hair loss. Each week, different hair loss research topics are covered in the podcast including new research related to androgenetic alopecia, alopecia areatea, telogen effluvium, traction alopecia, tinea capitis, trichotillomania, chemotherapy induced hair loss, lichen planopilaris, frontal fibrosing alopecia, dissecting cellulitis, folliculitis decalvans, discoid lupus, central centrifugal cicatricial alopecia, erosive pustular dermatosis.... and a whole lot more.
STUDIES REFERENCE IN THIS WEEK'S EPISODE
Penha MA et al. Oral Minoxidil vs Topical Minoxidil for Male Androgenetic Alopecia: A Randomized Clinical Trial. JAMA Dermatol . 2024 Apr 10:e240284. doi: 10.1001/jamadermatol.2024.0284. Online ahead of print
Panchaprateep et al. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment. Dermatol Ther. 2020 Dec;10(6):1345-1357
Пікірлер: 8
One thing to keep in mind is the likelihood of compliance and cost when it comes to oral minoxidil. It’s simply easier and cheaper for most people. Insurance doesn’t cover the topical products (in the U.S.)
@donovanmedical9780
Ай бұрын
There are actually four things that we must keep in mind at all times. They are safety, affordability, feasability and effectiveness. Cost is just one issue. Safety of oral minoxidil becomes an issue as the dose goes higher and higher and higher. At typical doses, it's reasonably safe. Long term safety is somewhat unknown. All four parameters need to be kept in mind. For many people, yes oral minoxidil has it's advantages. I agree with that. But a proportion of patients don't tolerate oral minoxidil very well.
Doctor, do you have any data ona oral minoxidil and prolactil levels ? I never have a sexual side effect ( 26 years none stop with topical minoxidil) but it was really hard to get an orgasm while on oral minoxidil ( 46 years old male , was on 2.5mg oral minoxidil , now back to topical ) . Could ‘t find much information about it . Thanks !
what's your thought on topical jak for ffa or lpp ? thanks
@donovanmedical9780
2 ай бұрын
does not help everyone - but it's a reasonable second line approach. donovanmedical.com/qow-posts/topical-jaks-ffa
Oral min is overrated do you think 10mg would work better
@donovanmedical9780
2 ай бұрын
Yes. it works better. Many of these benefits are dose dependent. Side effects are dramatically increased by going up. I rarely ever prescribe such doses. Many men can’t even tolerate 5 mg. 10 mg dramatically increases cardiovascular side effects, hypertrichosis, headaches and other issues. Not a dose I recommend!
@paulsmith2823
2 ай бұрын
@@donovanmedical9780 I get no sides on 5mg after 2 years, you think I could up titrate the dose up from 5mg with 1mg a day so 6mg then keep working up to a max dose ?